自然穿孔がみられた空腸原発組織球性肉腫の犬の1例
8 歳、避妊雌のジャック・ラッセル・テリアに急性細菌性腹膜炎が認められた。開腹手術で空腸に2つの穿孔部位が見つかり、それぞれを切除し、病理組織検査と免疫染色から組織球性肉腫と診断された。術後は順調に回復し、カルボプラチンの投与を7回行い、術後185日目の慢性下痢による死亡時まで穿孔性腹膜炎や腫瘤の再発はみられなかった。本症例は犬の小腸原発組織球性肉腫の最初の報告例であるが、本腫瘍では小病巣でも自然穿孔が生じる可能性があり、それに対しては手術切除が有効であることが示唆された。...
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| Published in | Nihon jui masui gekagaku zasshi Vol. 48; no. 1+2; pp. 9 - 13 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
Tokyo
一般社団法人 日本獣医麻酔外科学会
01.01.2017
Japan Science and Technology Agency |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2189-6623 2189-6631 |
| DOI | 10.2327/jjvas.48.9 |
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| Abstract | 8 歳、避妊雌のジャック・ラッセル・テリアに急性細菌性腹膜炎が認められた。開腹手術で空腸に2つの穿孔部位が見つかり、それぞれを切除し、病理組織検査と免疫染色から組織球性肉腫と診断された。術後は順調に回復し、カルボプラチンの投与を7回行い、術後185日目の慢性下痢による死亡時まで穿孔性腹膜炎や腫瘤の再発はみられなかった。本症例は犬の小腸原発組織球性肉腫の最初の報告例であるが、本腫瘍では小病巣でも自然穿孔が生じる可能性があり、それに対しては手術切除が有効であることが示唆された。 |
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| AbstractList | 8 歳、避妊雌のジャック・ラッセル・テリアに急性細菌性腹膜炎が認められた。開腹手術で空腸に2つの穿孔部位が見つかり、それぞれを切除し、病理組織検査と免疫染色から組織球性肉腫と診断された。術後は順調に回復し、カルボプラチンの投与を7回行い、術後185日目の慢性下痢による死亡時まで穿孔性腹膜炎や腫瘤の再発はみられなかった。本症例は犬の小腸原発組織球性肉腫の最初の報告例であるが、本腫瘍では小病巣でも自然穿孔が生じる可能性があり、それに対しては手術切除が有効であることが示唆された。 An 8-year-old spayed female Jack Russell Terrier presented with acute bacterial peritonitis. Laparotomy revealed two jejunal perforation sites, both of which were surgically resected. Histopathology and immunohistochemistry revealed that both lesions were histiocytic sarcomas. The dog recovered uneventfully, and received seven treatments of intravenous carboplatin. There were no recurrences of visible tumors or perforative peritonitis until the dog died at postoperative day 185 due to chronic diarrhea of unknown causes. This is the first report of canine primary jejunal histiocytic sarcoma; the present case suggests that spontaneous perforation may occur even in small lesions for which surgical resection is useful. |
| Author | 内田, 和幸 伊東, 輝夫 椎, 宏樹 チェンバーズ, ジェームズ 柑本, 敦子 |
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| References | 5) Ide, T., Uchida, K., Kagawa, Y., Suzuki, K. and Nakayama H. (2011): Pathological and immunohistochemical features of subdural histiocytic sarcomas in 15 dogs. J. Vet. Diagn. Invest. 23: 127-132. 9) Wagter, H.W., Vos, A.J. and van den Ingh, T. (2009): A localised histiocytic sarcoma in the stomach of a dog. Tijdschr. Diergeneeskd. 134: 526-528. 6) Rassnick, K.M., Moore, A.S., Russell, D.S., Northrup, N.C., Kristal, O., Bailey, D.B., Flory, A.B., Kiselow, M.A. and Intile, J.L. (2010): Phase II, open-label trial of single-agent CCNU in dogs with previously untreated histiocytic sarcoma. J. Vet. Intern. Med. 24: 1528-1531. 3) 越後良介，安東真里，中山裕之，西村亮平，松永 悟，佐々木伸雄(2006): バーニーズマウンテンドッグの悪性組織球症に カルボプラチン投与と放射線療法の併用が 効果を示した一例．獣麻外誌 37: 11-14. 4) Fant, P., Caldin, M., Furlanello, T., De Lorenzi, D., Bertolini, G., Bettini, G., Morini, M. and Masserdotti, C. (2004): Primary gastric histiocytic sarcoma in a dog—a case report. J. Vet. Med. A Physiol. Pathol. Clin. Med. 51: 358-362. 7) Skorupski, K.A., Clifford, C.A., Paoloni, M.C., Lara-Garcia, A., Barber, L., Kent, M.S., LeBlanc, A.K., Sabhlok, A., Mauldin, E.A., Shofer, F.S., Couto, C.G. and Sørenmo, K.U. (2007): CCNU for the treatment of dogs with histiocytic sarcoma. J. Vet. Intern. Med. 21: 121-126. 8) Takahashi, M., Tomiyasu, H., Hotta, E., Asada, H., Fukushima, K., Kanemoto, H., Fujino, Y., Ohno, K., Uchida, K., Nakayama, H. and Tsujimoto, H. (2014): Clinical characteristics and prognostic factors in dogs with histiocytic sarcomas in Japan. J. Vet. Med. Sci. 76: 661-666. 1) Clifford, C.A., Skorupski, K.A. and Moore, P.F. (2013): Histiocytic diseases. In:Withrow & MacEwen’s small animal clinical oncology. pp. 706-715. Elsevier saunders, St. Luis. 2) Coomer, A.R. and Liptak, J.M. (2008): Canine histiocytic diseases. Compend. Contin. Educ. Vet. 30: 202-204, 208-16. |
| References_xml | – reference: 5) Ide, T., Uchida, K., Kagawa, Y., Suzuki, K. and Nakayama H. (2011): Pathological and immunohistochemical features of subdural histiocytic sarcomas in 15 dogs. J. Vet. Diagn. Invest. 23: 127-132. – reference: 7) Skorupski, K.A., Clifford, C.A., Paoloni, M.C., Lara-Garcia, A., Barber, L., Kent, M.S., LeBlanc, A.K., Sabhlok, A., Mauldin, E.A., Shofer, F.S., Couto, C.G. and Sørenmo, K.U. (2007): CCNU for the treatment of dogs with histiocytic sarcoma. J. Vet. Intern. Med. 21: 121-126. – reference: 6) Rassnick, K.M., Moore, A.S., Russell, D.S., Northrup, N.C., Kristal, O., Bailey, D.B., Flory, A.B., Kiselow, M.A. and Intile, J.L. (2010): Phase II, open-label trial of single-agent CCNU in dogs with previously untreated histiocytic sarcoma. J. Vet. Intern. Med. 24: 1528-1531. – reference: 1) Clifford, C.A., Skorupski, K.A. and Moore, P.F. (2013): Histiocytic diseases. In:Withrow & MacEwen’s small animal clinical oncology. pp. 706-715. Elsevier saunders, St. Luis. – reference: 3) 越後良介，安東真里，中山裕之，西村亮平，松永 悟，佐々木伸雄(2006): バーニーズマウンテンドッグの悪性組織球症に カルボプラチン投与と放射線療法の併用が 効果を示した一例．獣麻外誌 37: 11-14. – reference: 8) Takahashi, M., Tomiyasu, H., Hotta, E., Asada, H., Fukushima, K., Kanemoto, H., Fujino, Y., Ohno, K., Uchida, K., Nakayama, H. and Tsujimoto, H. (2014): Clinical characteristics and prognostic factors in dogs with histiocytic sarcomas in Japan. J. Vet. Med. Sci. 76: 661-666. – reference: 9) Wagter, H.W., Vos, A.J. and van den Ingh, T. (2009): A localised histiocytic sarcoma in the stomach of a dog. Tijdschr. Diergeneeskd. 134: 526-528. – reference: 2) Coomer, A.R. and Liptak, J.M. (2008): Canine histiocytic diseases. Compend. Contin. Educ. Vet. 30: 202-204, 208-16. – reference: 4) Fant, P., Caldin, M., Furlanello, T., De Lorenzi, D., Bertolini, G., Bettini, G., Morini, M. and Masserdotti, C. (2004): Primary gastric histiocytic sarcoma in a dog—a case report. J. Vet. Med. A Physiol. Pathol. Clin. Med. 51: 358-362. |
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| Snippet | 8 歳、避妊雌のジャック・ラッセル・テリアに急性細菌性腹膜炎が認められた。開腹手術で空腸に2つの穿孔部位が見つかり、それぞれを切除し、病理組織検査と免疫染色から組織球... An 8-year-old spayed female Jack Russell Terrier presented with acute bacterial peritonitis. Laparotomy revealed two jejunal perforation sites, both of which... |
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| SubjectTerms | Carboplatin Diarrhea Dogs Histopathology Immunohistochemistry Intravenous administration Lesions Perforation Peritonitis Sarcoma Surgery Tumors 犬 空腸原発組織球性肉腫 自然穿孔 |
| Title | 自然穿孔がみられた空腸原発組織球性肉腫の犬の1例 |
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