アルカリ性洗剤による腐食性食道炎・胃炎に対しステロイドとトラニラストを併用した1例
症例は68歳,男性。自殺目的に家庭用アルカリ性洗剤を約200mL服用し,直後より嘔吐と心窩部痛を認め救急搬送となった。服用後10時間で気道狭窄症状が出現し気管切開術を行った。同日1回目の上部消化管内視鏡検査(以下,EGD)を行い,食道の潰瘍および胃前庭部の全周性潰瘍を認め障害度Ⅲ度と判断した。第7病日のEGDで下部食道亜全周性びらん,胃前庭部潰瘍による壁変形を認め瘢痕狭窄のハイリスクと判断しステロイドとトラニラストの内服を開始した。第17病日のEGDで食道びらん・胃前庭部変形の改善を認めた。経口摂取開始後は消化器症状なく経過し第22病日に退院となった。腐食性食道炎・胃炎による消化管障害は,服用...
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| Published in | Nihon Fukubu Kyukyu Igakkai Zasshi (Journal of Abdominal Emergency Medicine) Vol. 37; no. 5; pp. 803 - 807 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
日本腹部救急医学会
2017
Japanese Society for Abdominal Emergency Medicine |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1340-2242 1882-4781 |
| DOI | 10.11231/jaem.37.803 |
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| Abstract | 症例は68歳,男性。自殺目的に家庭用アルカリ性洗剤を約200mL服用し,直後より嘔吐と心窩部痛を認め救急搬送となった。服用後10時間で気道狭窄症状が出現し気管切開術を行った。同日1回目の上部消化管内視鏡検査(以下,EGD)を行い,食道の潰瘍および胃前庭部の全周性潰瘍を認め障害度Ⅲ度と判断した。第7病日のEGDで下部食道亜全周性びらん,胃前庭部潰瘍による壁変形を認め瘢痕狭窄のハイリスクと判断しステロイドとトラニラストの内服を開始した。第17病日のEGDで食道びらん・胃前庭部変形の改善を認めた。経口摂取開始後は消化器症状なく経過し第22病日に退院となった。腐食性食道炎・胃炎による消化管障害は,服用薬物の種類,濃度,量によって種々の病態を呈する。誤飲後早期に障害程度を把握し,狭窄のリスクが高いと判断した場合はステロイドとトラニラストの予防内服を考慮する必要がある。 |
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| AbstractList | 症例は68歳,男性。自殺目的に家庭用アルカリ性洗剤を約200mL服用し,直後より嘔吐と心窩部痛を認め救急搬送となった。服用後10時間で気道狭窄症状が出現し気管切開術を行った。同日1回目の上部消化管内視鏡検査(以下,EGD)を行い,食道の潰瘍および胃前庭部の全周性潰瘍を認め障害度Ⅲ度と判断した。第7病日のEGDで下部食道亜全周性びらん,胃前庭部潰瘍による壁変形を認め瘢痕狭窄のハイリスクと判断しステロイドとトラニラストの内服を開始した。第17病日のEGDで食道びらん・胃前庭部変形の改善を認めた。経口摂取開始後は消化器症状なく経過し第22病日に退院となった。腐食性食道炎・胃炎による消化管障害は,服用薬物の種類,濃度,量によって種々の病態を呈する。誤飲後早期に障害程度を把握し,狭窄のリスクが高いと判断した場合はステロイドとトラニラストの予防内服を考慮する必要がある。 A 68-year-old man drank 200 mL of an alkaline detergent in a suicide attempt and presented with vomiting and epigastric pain. Ten hours after ingestion, he underwent a tracheostomy because of respiratory difficulty. On day 1, an esophagogastroduodenoscopy (EGD) revealed erosions in the esophagus and ulcers in the gastric antrum. The mucosal burns were graded as stage Ⅲ. On day 7, a second EGD revealed an erosion in the esophagus and deformation of the gastric antrum. Medication with steroids and tranilast was started to prevent esophageal and gastric strictures. On day 17, a third EGD revealed an improvement in the erosions, deformation and ulcers. On day 22, the patient was discharged home. We report a patient with corrosive esophagitis and gastritis who was treated with steroids and tranilast to prevent strictures. 症例は68歳,男性。自殺目的に家庭用アルカリ性洗剤を約200mL服用し,直後より嘔吐と心窩部痛を認め救急搬送となった。服用後10時間で気道狭窄症状が出現し気管切開術を行った。同日1回目の上部消化管内視鏡検査(以下,EGD)を行い,食道の潰瘍および胃前庭部の全周性潰瘍を認め障害度Ⅲ度と判断した。第7病日のEGDで下部食道亜全周性びらん,胃前庭部潰瘍による壁変形を認め瘢痕狭窄のハイリスクと判断しステロイドとトラニラストの内服を開始した。第17病日のEGDで食道びらん・胃前庭部変形の改善を認めた。経口摂取開始後は消化器症状なく経過し第22病日に退院となった。腐食性食道炎・胃炎による消化管障害は,服用薬物の種類,濃度,量によって種々の病態を呈する。誤飲後早期に障害程度を把握し,狭窄のリスクが高いと判断した場合はステロイドとトラニラストの予防内服を考慮する必要がある。 |
| Author | 村田, 厚夫 本間, 祐子 田中, 公章 徳丸, 哲平 |
| Author_FL | Homma Yuko Tanaka Kimiaki Tokumaru Teppei Murata Atsuo |
| Author_FL_xml | – sequence: 1 fullname: Homma Yuko – sequence: 2 fullname: Tanaka Kimiaki – sequence: 3 fullname: Tokumaru Teppei – sequence: 4 fullname: Murata Atsuo |
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| Copyright | 2014, Japanese Society for Abdominal Emargency Medicine |
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| DocumentTitleAlternate | A Patient with Corrosive Esophagitis/Gastritis Because of Alkali Ingestion Treated with Steroids and Tranilast to Prevent Stricture Formation |
| DocumentTitle_FL | A Patient with Corrosive Esophagitis/Gastritis Because of Alkali Ingestion Treated with Steroids and Tranilast to Prevent Stricture Formation |
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| References | 6) Sweed AS, Fawaz SA, Ezzat WF, et al: A prospective controlled study to assess the use of mitomycin C in improving the results of esophageal dilation in post corrosive esophageal stricture in children. Int J Pediatr Otorhinolaryngol 2015; 79: 23-25. 10) Uno K, Iijima K, Koike T, et al: A pilot study of scheduled endoscopic balloon dilation with oral agent tranilast to improve the efficacy of stricture dilation after endoscopic submucosal dissection of the esophagus. J Clin Gastroenterol 2012; 46: e76-e82. 12) Matsuyama T, Aiko S, Yoshizumi Y, et al: A case of esophageal stricture after corrosive esophagitis successfully treated by frequent endoscopic balloon dilation. Esophagus 2004; 1: 193-197. 5) Howell JM, Dalsey WC, Hartsell FW, et al: Steroids for the treatment of corrosive esophageal injury: a statistical analysis of past studies. Am J Emerg Med 1992; 10: 421-425. 1) 上條吉人:Ⅱ洗浄剤などa腐食性物質.相馬一亥監, 臨床中毒学, 東京, 医学書院,2009:301-308 2) Di Costanzo J, Noirclerc M, Jouglard J, et al: New therapeutic approach to corrosive burns of the upper gastrointestinal tract. Gut 1980; 21: 370-375. 7) Gümürdülü Y, Karakoç E, Kara B, et al: The efficiency of sucralfate in corrosive esophagitis: a randomized, prospective study. Turk J Gastroenterol 2010; 21: 7-11. 11) Jain D, Singhal S: Esophageal stricture prevention after endoscopic submucosal dissection. Clin Endosc 2016; 49: 241-256. 3) Kamijyo Y, Kondo I, Watanabe M, et al: Gastric stenosis in severe corrosive gastritis: Prognostic evaluation by endoscopic ultrasonography. Clin Toxicol (Phila) 2007; 45: 284-286. 4) Kamijyo Y, Kondo I, Kokuto M, et al: Miniprobe ultrasonography for determining prognosis in corrosive esophagitis. Am J Gastroenterol 2004; 99: 851-854. 8) Uno K, Iijima K, Koike T, et al: Useful strategies to prevent severe stricture after endoscopic submucosal dissection for superficial esophageal neoplasm. World J Gastroenterol 2015; 21: 7120-7133. 9) Tamai H, Katoh K, Yamaguchi T, et al: The impact of tranilast on restenosis after coronary angioplasty: the Second Tranilast Restenosis Following Angioplasty Trial (TREAT-2). Am Heart J 2002; 143: 506-513. |
| References_xml | – reference: 3) Kamijyo Y, Kondo I, Watanabe M, et al: Gastric stenosis in severe corrosive gastritis: Prognostic evaluation by endoscopic ultrasonography. Clin Toxicol (Phila) 2007; 45: 284-286. – reference: 11) Jain D, Singhal S: Esophageal stricture prevention after endoscopic submucosal dissection. Clin Endosc 2016; 49: 241-256. – reference: 1) 上條吉人:Ⅱ洗浄剤などa腐食性物質.相馬一亥監, 臨床中毒学, 東京, 医学書院,2009:301-308. – reference: 8) Uno K, Iijima K, Koike T, et al: Useful strategies to prevent severe stricture after endoscopic submucosal dissection for superficial esophageal neoplasm. World J Gastroenterol 2015; 21: 7120-7133. – reference: 5) Howell JM, Dalsey WC, Hartsell FW, et al: Steroids for the treatment of corrosive esophageal injury: a statistical analysis of past studies. Am J Emerg Med 1992; 10: 421-425. – reference: 4) Kamijyo Y, Kondo I, Kokuto M, et al: Miniprobe ultrasonography for determining prognosis in corrosive esophagitis. Am J Gastroenterol 2004; 99: 851-854. – reference: 12) Matsuyama T, Aiko S, Yoshizumi Y, et al: A case of esophageal stricture after corrosive esophagitis successfully treated by frequent endoscopic balloon dilation. Esophagus 2004; 1: 193-197. – reference: 9) Tamai H, Katoh K, Yamaguchi T, et al: The impact of tranilast on restenosis after coronary angioplasty: the Second Tranilast Restenosis Following Angioplasty Trial (TREAT-2). Am Heart J 2002; 143: 506-513. – reference: 6) Sweed AS, Fawaz SA, Ezzat WF, et al: A prospective controlled study to assess the use of mitomycin C in improving the results of esophageal dilation in post corrosive esophageal stricture in children. Int J Pediatr Otorhinolaryngol 2015; 79: 23-25. – reference: 7) Gümürdülü Y, Karakoç E, Kara B, et al: The efficiency of sucralfate in corrosive esophagitis: a randomized, prospective study. Turk J Gastroenterol 2010; 21: 7-11. – reference: 2) Di Costanzo J, Noirclerc M, Jouglard J, et al: New therapeutic approach to corrosive burns of the upper gastrointestinal tract. Gut 1980; 21: 370-375. – reference: 10) Uno K, Iijima K, Koike T, et al: A pilot study of scheduled endoscopic balloon dilation with oral agent tranilast to improve the efficacy of stricture dilation after endoscopic submucosal dissection of the esophagus. J Clin Gastroenterol 2012; 46: e76-e82. |
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| Snippet | 症例は68歳,男性。自殺目的に家庭用アルカリ性洗剤を約200mL服用し,直後より嘔吐と心窩部痛を認め救急搬送となった。服用後10時間で気道狭窄症状が出現し気管切開術を... A 68-year-old man drank 200 mL of an alkaline detergent in a suicide attempt and presented with vomiting and epigastric pain. Ten hours after ingestion, he... |
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| SubjectTerms | ステロイド トラニラスト 腐食性食道炎 |
| Title | アルカリ性洗剤による腐食性食道炎・胃炎に対しステロイドとトラニラストを併用した1例 |
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