口腔扁平苔癬の治療方法とその臨床評価に関する文献レビューとタスクフォースコンセンサス
本稿は，日本口腔内科学会OLP委員会内の第二期口腔扁平苔癬ワーキンググループが，公開されている論文（国際誌，国内誌）を基に，口腔扁平苔癬に対して，現在行われている治療方法をレビューし，タスクフォースコンセンサスとして，その治療方法と効果判定の方法を記述的総説としてまとめた。今後，本邦で臨床治験などを行う上で，臨床・病理学的効果を評価する指標となれば幸いである。口腔扁平苔癬は，病態としてあるいは自覚・他覚症状として，急性（acute phase）か慢性（chronic phase）か，慢性であれば，慢性活動性（chronic active phase）か慢性非活動性（chronic nonact...
Saved in:
| Published in | 日本口腔内科学会雑誌 Vol. 29; no. 2; pp. 21 - 35 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
日本口腔内科学会
2023
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 2186-6147 2186-6155 |
| DOI | 10.6014/jjsom.29.21 |
Cover
| Abstract | 本稿は，日本口腔内科学会OLP委員会内の第二期口腔扁平苔癬ワーキンググループが，公開されている論文（国際誌，国内誌）を基に，口腔扁平苔癬に対して，現在行われている治療方法をレビューし，タスクフォースコンセンサスとして，その治療方法と効果判定の方法を記述的総説としてまとめた。今後，本邦で臨床治験などを行う上で，臨床・病理学的効果を評価する指標となれば幸いである。口腔扁平苔癬は，病態としてあるいは自覚・他覚症状として，急性（acute phase）か慢性（chronic phase）か，慢性であれば，慢性活動性（chronic active phase）か慢性非活動性（chronic nonactive phase）かを判断する必要がある。したがって，治療のゴールを，癌化の阻止を念頭に置きながら，完全治癒を目指すのか，慢性非活動性の維持を目指すのか，を明確にしながら，種々の治療方法を選択，開発していかなければならないと考えられる。 |
|---|---|
| AbstractList | 本稿は，日本口腔内科学会OLP委員会内の第二期口腔扁平苔癬ワーキンググループが，公開されている論文（国際誌，国内誌）を基に，口腔扁平苔癬に対して，現在行われている治療方法をレビューし，タスクフォースコンセンサスとして，その治療方法と効果判定の方法を記述的総説としてまとめた。今後，本邦で臨床治験などを行う上で，臨床・病理学的効果を評価する指標となれば幸いである。口腔扁平苔癬は，病態としてあるいは自覚・他覚症状として，急性（acute phase）か慢性（chronic phase）か，慢性であれば，慢性活動性（chronic active phase）か慢性非活動性（chronic nonactive phase）かを判断する必要がある。したがって，治療のゴールを，癌化の阻止を念頭に置きながら，完全治癒を目指すのか，慢性非活動性の維持を目指すのか，を明確にしながら，種々の治療方法を選択，開発していかなければならないと考えられる。 |
| Author | 川又, 均 岩渕, 博史 和久井, 崇大 前田, 初彦 中村, 誠司 森山, 雅文 河野, 憲司 菅原, 由美子 小宮山, 雄介 白石, 怜 津島, 文彦 伊東, 大典 長谷川, 博雅 安彦, 善裕 杉田, 好彦 |
| Author_xml | – sequence: 1 fullname: 杉田, 好彦 organization: 日本臨床口腔病理学会委員 – sequence: 1 fullname: 白石, 怜 organization: 獨協医科大学医学部口腔外科講座 – sequence: 1 fullname: 川又, 均 organization: 獨協医科大学医学部口腔外科講座 – sequence: 1 fullname: 前田, 初彦 organization: 日本臨床口腔病理学会委員 – sequence: 1 fullname: 森山, 雅文 organization: 日本口腔内科学会 第二期口腔扁平苔癬ワーキンググループ（OLP委員会）日本口腔内科学会委員 – sequence: 1 fullname: 長谷川, 博雅 organization: 日本臨床口腔病理学会委員 – sequence: 1 fullname: 小宮山, 雄介 organization: 獨協医科大学医学部口腔外科講座 – sequence: 1 fullname: 伊東, 大典 organization: 日本口腔内科学会 第二期口腔扁平苔癬ワーキンググループ（OLP委員会）日本口腔内科学会委員副委員長 – sequence: 1 fullname: 津島, 文彦 organization: 日本口腔内科学会 第二期口腔扁平苔癬ワーキンググループ（OLP委員会）日本口腔内科学会委員 – sequence: 1 fullname: 安彦, 善裕 organization: 日本臨床口腔病理学会委員 – sequence: 1 fullname: 中村, 誠司 organization: 日本口腔内科学会 第二期口腔扁平苔癬ワーキンググループ（OLP委員会）日本口腔内科学会委員 – sequence: 1 fullname: 菅原, 由美子 organization: 日本口腔内科学会 第二期口腔扁平苔癬ワーキンググループ（OLP委員会）日本口腔内科学会委員 – sequence: 1 fullname: 岩渕, 博史 organization: 日本口腔内科学会 第二期口腔扁平苔癬ワーキンググループ（OLP委員会）日本口腔内科学会委員 – sequence: 1 fullname: 和久井, 崇大 organization: 獨協医科大学医学部口腔外科講座 – sequence: 1 fullname: 河野, 憲司 organization: 日本口腔内科学会 第二期口腔扁平苔癬ワーキンググループ（OLP委員会）日本口腔内科学会委員 |
| BookMark | eNo9kEtLAmEUhj_CIDNX_Y6x7zLXTRDSDYQ2tR4-x5ly8BKOmzbBzBBSBi1SwUWLikBJDBpamFE_5uQ4_YtGCzfvOec5F3jPKkpUqhUToXWCMzIm4oZtO9VyhmoZSpZQkhJVFmQiSYlFLiorKO04NsaYUSYrjCTR-eTmMbpohZfuZBREzda0OwB3GL6Op10v7IzCoA1uD9y7GEaN3uT9Kuq3vz_vwX3-6TyA2wWvGXYa0-sh-APwb8F_Av9jtuJ9gTcC7wX8Nnj9GZyVAfgBeOO5vsVkDS1bvOSY6f-YQkc724fZPSF3sLuf3coJNlUIFrjJCkzMG6opcqxJmFkWtfJMy1NLsrgWO1OIZBQ0bFCJECZSjKV4TIn9G5qhqiyFNv_u2k6dH5v6aa1Y5rUzndfqRaNk6vPf6VTT6VzIomGc8Jpuc_YLnDeX3g |
| ContentType | Journal Article |
| Copyright | 2023 日本口腔内科学会 |
| Copyright_xml | – notice: 2023 日本口腔内科学会 |
| DOI | 10.6014/jjsom.29.21 |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| EISSN | 2186-6155 |
| EndPage | 35 |
| ExternalDocumentID | article_jjsom_29_2_29_21_article_char_ja |
| GroupedDBID | ALMA_UNASSIGNED_HOLDINGS JSF KQ8 RJT |
| ID | FETCH-LOGICAL-j2710-ae3d34bc8e4a09503ff2fb39b2f5fa9147715cd90c25113420059507615c9c883 |
| ISSN | 2186-6147 |
| IngestDate | Wed Sep 03 06:30:44 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | false |
| IsScholarly | false |
| Issue | 2 |
| Language | Japanese |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-j2710-ae3d34bc8e4a09503ff2fb39b2f5fa9147715cd90c25113420059507615c9c883 |
| OpenAccessLink | https://www.jstage.jst.go.jp/article/jjsom/29/2/29_21/_article/-char/ja |
| PageCount | 15 |
| ParticipantIDs | jstage_primary_article_jjsom_29_2_29_21_article_char_ja |
| PublicationCentury | 2000 |
| PublicationDate | 20230000 |
| PublicationDateYYYYMMDD | 2023-01-01 |
| PublicationDate_xml | – year: 2023 text: 20230000 |
| PublicationDecade | 2020 |
| PublicationTitle | 日本口腔内科学会雑誌 |
| PublicationTitleAlternate | 日口内誌 |
| PublicationYear | 2023 |
| Publisher | 日本口腔内科学会 |
| Publisher_xml | – name: 日本口腔内科学会 |
| References | 84） Chainani-Wu N, Collins K and Silverman SJ: Use of curcuminoids in a cohort of patients with oral lichen planus, an autoimmune disease. Phytomedicine 19：418-423, 2012. 55） Goel S and Khurana N: Effects of Mycophenolate Mofetil, Methotrexate and Pimecrolimus on cdk4 and p16 in Erosive Oral Lichen Planus. Indian Journal of Dermatology 66：490-495, 2021. 4） Mankapure PK, Humbe JG, Mandale MS, et al: Clinical profile of 108 cases of oral lichen planus. Journal of Oral Science 58：43-47, 2016. 49） Polizzi A, Santonocito S, Lo Giudice A, et al: Analysis of the response to two pharmacological protocols in patients with oral lichen planus: A randomized clinical trial. Oral Diseases 29：755-763, 2023. 112） 岩本 修，轟 圭太，青木修子，他：口腔粘膜疾患に対するオゾンナノバブル水の臨床効果―口腔扁平苔癬と口腔白板症への応用―．日本口腔診断学会誌 24：389-396，2011. 126） Kozakai A, Ono K, Nomura T, et al: Usefulness of objective evaluations by fluorescence visualization device for differentiating between superficial oral squamous cell carcinoma and oral lichen planus. Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 32：26-32, 2020. 157） Tao X, Xia J, Chen X, Wang H, et al: FOXP3 T regulatory cells in lesions of oral lichen planus correlated with disease activity. Oral Diseases 16：76-82, 2010. 75） Momota Y, Takano H, Kani K, et al: Oral Lichen Planus Well-Treated with Kampo Medicines: Two Case Reports. IOSR Journal of Medical Sciences 18：68-72, 2019. 73） Hashimoto T, Fukuda A, Himejima A, et al: Ten cases of severe oral lichen planus showing granular C3 deposition in oral mucosal basement membrane zone. European Journal of Dermatology: EJD 25：539-547, 2015. 61） Joshy A, Doggalli N, Patil K, et al: To evaluate the efficacy of topical propolis in the management of symptomatic oral lichen planus: a randomized controlled trial. Contemporary Clinical Dentistry 9：65-71, 2018. 68） Elshenawy HM, Eldin AM and Abdelmonem MA: Clinical Assessment of the Efficiency of Low Level Laser Therapy in the Treatment of Oral Lichen Planus. Macedonian Journal of Medical Sciences 3：717-721, 2015. 143） Rezazadeh F and Haghighat S: Serum vitamin profile in oral lichen planus patients in southwest of iran. BioMed Research International 2021：8627435, 2021. 63） Arcuri F, Stellin L, Gatti A, et al: Surgical approach to oral lichen planus by submucosal autologous fat grafting. The Journal of Craniofacial Surgery 24：e258-e260, 2013. 43） Lee YC, Lee JS, Jung AR, et al: Factors Affecting the Result of Intralesional Corticosteroid Injection in Patients With Oral Lichen Planus. Clinical and Experimental Otorhinolaryngology 11：205-209, 2018. 79） 菅原由美子，神部芳則，笹野高嗣，他：口腔扁平苔癬に対するCepharanthineの臨床効果に関する後方視的多施設共同研究．日本口腔内科学会雑誌 22：59-67，2016. 42） Sonthalia S and Singal A: Comparative efficacy of tacrolimus 0.1％ ointment and clobetasol propionate 0.05％ ointment in oral lichen planus: a randomized double-blind trial. International Journal of Dermatology 51：1371-1378, 2012. 150） Khattab FM and Said NM: Chitinase-3-like protein 1 （YKL-40）: novel biomarker of lichen planus. International Journal of Dermatology 58：993-996, 2019. 113） de Carvalho MM, Hidalgo MAR, Scarel-Caminaga RM, et al: Photobiomodulation of gingival lesions resulting from autoimmune diseases: systematic review and meta-analysis. Clinical Oral Investigations 26：3949-3964, 2022. 76） 佐藤田鶴子，吉成伯夫，宗村 治，他：口腔粘膜疾患に対する半夏瀉心湯の使用経験．歯科薬物療法 4：1-10，1985. 71） 青木実紀，神部芳則，大多和薫：口腔扁平苔癬のびらん病変に対するアルゴンプラズマ凝固療法．日本口腔粘膜学会雑誌 10：1-5，2004. 132） Ferri EP, Cunha KRL, Abboud CS, et al: Photobiomodulation is effective in oral lichen planus: a randomized, controlled, double-blind study. Oral Diseases 27：1205-1216, 2021. 36） Piñas L, García-García A, Pérez-Sayáns M, et al: The use of topical corticosteroides in the treatment of oral lichen planus in spain: a national survey. Medicina Oral, Patologia Oral y Cirugia Bucal 22：e264-e269, 2017. 6） Sridharan K and Sivaramakrishnan G: Interventions for oral lichen planus: A systematic review and network meta-analysis of randomized clinical trials. Australian Dental Journal 66：295-303, 2021. 96） Bender A, Fix C, Eubel V, et al: Adjuvant high-dose intravenous immunoglobulins for recalcitrant erosive oral lichen planus: mixed clinical responses. European Journal of Dermatology 28：496-501, 2018. 100） You Y, Huang X, Chen Y, et al: Efficacy and safety of traditional Chinese medicine for erosive oral lichen planus: A protocol for systematic review and meta analysis. Medicine 99：e23375, 2020. 154） Ghallab NA, Kasem RF, El-Ghani SFA, et al: Gene expression of miRNA-138 and cyclin D1 in oral lichen planus. Clinical Oral Investigations 21：2481-2491, 2017. 32） Zborowski J, Kida D, Szarwaryn A, et al: A comparison of clinical efficiency of photodynamic therapy and topical corticosteroid in treatment of oral lichen planus: a split-mouth randomised controlled study. Journal of Clinical Medicine 10, 2021. 147） Du J, Li R, Yu F, et al: Experimental study on 1,25（OH）（2） D（3） amelioration of oral lichen planus through regulating NF-κB signaling pathway. Oral Diseases 23：770-778, 2017. 175） Köse O, Lalli A, Kutulola AO, Odell EW, et al: Changes in the expression of stem cell markers in oral lichen planus and hyperkeratotic lesions. Journal of Oral Science 49：133-139, 2007. 48） 福永大二郎，吉川博政，吉田将律，他：口腔扁平苔癬に対するタクロリムスの使用に関する検討．有病者歯科医療 26：280-287，2017. 85） Ali S and Wahbi W: The efficacy of aloe vera in management of oral lichen planus: a systematic review and meta-analysis. Oral Diseases 23：913-918, 2017. 93） Rivas-Tolosa N, Requena C, Llombart B, et al: Antimalarial drugs for the treatment of oral erosive lichen planus. Dermatology （Basel, Switzerland） 232：86-90, 2016. 152） Lopez-Jornet P, Zavattaro E, Mozaffari HR, et al: Evaluation of the salivary level of cortisol in patients with oral lichen planus: a meta-analysis. Medicina （Kaunas, Lithuania） 55：2019. 33） Hashem AS, Issrani R, Elsayed TEE, et al: Topical hyaluronic acid in the management of oral lichen planus: a comparative study. Journal of Investigative and Clinical Dentistry 10：e12385, 2019. 103） Gabriella D, Klemens R, Xiao-Hui R-F, et al: Effect of personality traits on the oral health-related quality of life in patients with oral lichen planus undergoing treatment. Clinical Oral Investigations 25：2381-2389, 2021. 136） Muramatsu K, Nishie W, Natsuga K, et al: Two cases of erosive oral lichen planus with autoantibodies to desmoglein 3. The Journal of Dermatology 43：1350-1353, 2016. 180） Farah CS, Fox S, Shearston K, et al: Lichenoid dysplasia is not a distinct pathological entity. Oral Oncology 119：105362, 2021. 21） Park SY, Lee HJ, Kim SH, et al: Factors affecting treatment outcomes in patients with oral lichen planus lesions: a retrospective study of 113 cases. Journal of Periodontal ＆ Implant science 48：213-223, 2018. 107） Rakesh N, Clint JB, Reddy SS, et al: Clinical evaluation of photodynamic therapy for the treatment of refractory oral Lichen planus―a case series. Photodiagnosis and Photodynamic Cherapy 24：280-285, 2018. 122） Cosgarea R, Pollmann R, Sharif J, et al: Photodynamic therapy in oral lichen planus: A prospective case-controlled pilot study. Scientific Reports 10：1667, 2020. 12） Yousefi H and Abdollahi M: An Update on Drug-induced Oral Reactions. Journal of Pharmacy ＆ Pharmaceutical Sciences: A Publication of the Canadian Society for Pharmaceutical Sciences 21：171-183, 2018. 127） 酒巻裕之，藤本陽子，武田祥人，他：接触粘膜拡大鏡視検査による口腔扁平苔癬ならびに口腔白板症の診断に関する研究．日本口腔粘膜学会雑誌 17：7-16，2011. 92） Yeshurun A, Bergman R, Bathish N, et al: Hydroxychloroquine sulphate therapy of erosive oral lichen planus. The Australasian Journal of Dermatology 60：e109-e112, 2019. 29） El Shenawy HM and Eldin AM: A comparative evaluation of low-level laser and topical steroid therapies for the treatment of erosive-atrophic lichen planus. Macedonian Journal of Medical Sciences 3：462-466, 2015. 95） Jeong SH, Na HS, Park SH, et al: Topical sulfasalazine for unresponsive oral lichen planus. Quintessence International （Berlin, Germany） 47：319-327, 2016. 118） Sobral SS, da Silva Brandão EH, de Barros Gallo C, et al: Analysis of the psychopathological profile, quality of life, and cost-effectiveness of oral lichen planus patients treated with photobiomodulation. Clinical Oral Investigations 26：719-728, 2022. 120） Ferri EP, Gallo C de B, Abboud CS, et al: Efficacy of photobiomodulation on oral lichen planus: a protocol study for a double-blind, randomised controlled clinical trial. BMJ Open 8：e024083, 2018. 47） Arduino PG, Carbone M, Della Ferrera F, et al: Pimecrolimus vs. tacrolimus for the topical treatment of unresponsive oral erosive lichen planus: a 8 week randomized double-blind controlled study. Journal of the European Academy of Dermatology and Venereology: JEADV 28：475-482, 2014. 30） Shipley CA and Spivakovsky S: Tacrolimus or clobetasol for treatment of oral lichen planus. Evidence-based Dentistry 17：16, 2016. 80） Hu J-Y, Zhang J, Ma J-Z, et al: MicroRNA-155-IFN-γ Feedback loop in CD4（＋）T Cells of erosive type oral lichen planus. Scientific Reports 5：16935, 2015. 145） Abdolsamadi H, Rafieian N, Goodarzi MT, et al: Levels of salivary antioxidant vitamins and lipid peroxidation in patients with oral lichen planus and healthy individuals. Chonnam Medical Journal 50：58-62, 2014. 70） Cafaro A, Arduino PG, Massolini G, et al: Clinical evaluation of the efficiency of low-level laser therapy for oral lichen planus: a prospective case series. Lasers in Medical Science 29：185-190, 2014. 109） Gobbo M, Rupel K, Zoi V, et al: Scoring systems for Oral Lichen Planus used by differently experienced raters. Medicina Oral, Patologia Oral y Cirugia Cucal 22：e562-e571, 2017. 50） Su Z, Hu J, Cheng B, et al: Efficacy and safety of topical administration of tacrolimus in oral lichen planus: An updated systematic review and meta-analysis of randomized controlled trials. Journal of Oral Pathology ＆ Medicine 51：63-73, 2022. 115） Matsumoto K, Matsuo K, Yatagai N, et al: Clinical evaluation of co（2） laser vaporization therapy for oral lichen planus: a single-arm intervention study. |
| References_xml | – reference: 82） Lv KJ, Chen TC, Wang GH, et al: Clinical safety and efficacy of curcumin use for oral lichen planus: a systematic review. The Journal of Dermatological Treatment 30：605-611, 2019. – reference: 165） Solimani F, Meier K and Ghoreschi K: Emerging topical and systemic JAK inhibitors in dermatology. Frontiers in Immunology 10：2847, 2019. – reference: 28） Al-Janaby H, El-Sakka H, Masood M, et al: Xerostomia and salivary gland hypofunction in patients with oral lichen planus before and after treatment with topical corticosteroids. The Open Dentistry Journal 11：155-163, 2017. – reference: 168） El-Howati A, Thornhill MH, Colley HE, et al: Immune mechanisms in oral lichen planus. Oral Diseases 29：1400-1415, 2023. – reference: 44） Liu C, Xie B, Yang Y, et al: Efficacy of intralesional betamethasone for erosive oral lichen planus and evaluation of recurrence: a randomized, controlled trial. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 116：584-590, 2013. – reference: 88） Goel S, Marwah A, Kaushik S, et al: Role of serum interleukin-6 in deciding therapy for multidrug resistant oral lichen planus. Journal of Clinical and Experimental Dentistry 7：e477-e482, 2015. – reference: 114） Stępień K, Żabska E, Rahnama-Hezavah M, et al: Lichen Planus Activity and Damage Index （LiPADI）-Creation of the Questionnaire. Journal of Clinical Medicine 11, 2021. – reference: 81） Jimson S, Balachader N, Anita N, et al: Immunologically mediated oral diseases. Journal of Pharmacy ＆ Bioallied Sciences 7：S209-S212, 2015. – reference: 6） Sridharan K and Sivaramakrishnan G: Interventions for oral lichen planus: A systematic review and network meta-analysis of randomized clinical trials. Australian Dental Journal 66：295-303, 2021. – reference: 116） Manczyk B, Gołda J, Biniak A, et al: Evaluation of depression, anxiety and stress levels in patients with oral lichen planus. Journal of Oral Science 61：391-397, 2019. – reference: 179） Lingam HT, Swetha P and Manyam R: Immunohistochemical evaluation of survivin in oral lichen planus and oral squamous cell carcinoma―a retrospective study. Medicine and Pharmacy Reports 94：341-347, 2021. – reference: 17） Rodriguez-Archilla A and Fernandez-Torralbo S: Candida species colonization in oral lichen planus: a meta-analysis. International Journal of Health Sciences 16：58-63, 2022. – reference: 170） Li L, Cong B, Yu X, et al: The expression of membrane-bound complement regulatory proteins CD46, CD55 and CD59 in oral lichen planus. Archives of Oral Biology 124：105064, 2021. – reference: 8） Albaghli F, Zhou Y, Hsu C-C, et al: The effect of plaque control in the treatment of oral lichen planus with gingival manifestations: a systematic review. Community Dental Health 38：112-118, 2021. – reference: 49） Polizzi A, Santonocito S, Lo Giudice A, et al: Analysis of the response to two pharmacological protocols in patients with oral lichen planus: A randomized clinical trial. Oral Diseases 29：755-763, 2023. – reference: 146） Nagao T, Warnakulasuriya S, Ikeda N, et al: Serum antioxidant micronutrient levels in oral lichen planus. Journal of Oral Pathology ＆ Medicine 30：264-267, 2001. – reference: 115） Matsumoto K, Matsuo K, Yatagai N, et al: Clinical evaluation of co（2） laser vaporization therapy for oral lichen planus: a single-arm intervention study. Photobiomodulation, Photomedicine, and Laser Surgery 37：175-181, 2019. – reference: 122） Cosgarea R, Pollmann R, Sharif J, et al: Photodynamic therapy in oral lichen planus: A prospective case-controlled pilot study. Scientific Reports 10：1667, 2020. – reference: 172） Metwaly H, Ebrahem MA-M and Saku T: Vascular endothelial growth factor （VEGF） and inducible nitric oxide synthase （iNOS） in oral lichen planus: An immunohistochemical study for the correlation between vascular and inflammatory reactions. Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 26：390-396, 2014. – reference: 50） Su Z, Hu J, Cheng B, et al: Efficacy and safety of topical administration of tacrolimus in oral lichen planus: An updated systematic review and meta-analysis of randomized controlled trials. Journal of Oral Pathology ＆ Medicine 51：63-73, 2022. – reference: 59） 栗原清佳，塚本 光，塩竈素直，他：難治性口腔扁平苔癬に対するフコイダンの治療効果に関する検討．日本統合医療学会誌 5：73-77，2012. – reference: 92） Yeshurun A, Bergman R, Bathish N, et al: Hydroxychloroquine sulphate therapy of erosive oral lichen planus. The Australasian Journal of Dermatology 60：e109-e112, 2019. – reference: 136） Muramatsu K, Nishie W, Natsuga K, et al: Two cases of erosive oral lichen planus with autoantibodies to desmoglein 3. The Journal of Dermatology 43：1350-1353, 2016. – reference: 3） 太田耕司，鳴瀬貴子，島末 洋，他：口腔扁平苔癬130例の臨床的検討．日本口腔診断学会雑誌 30：151-156，2017. – reference: 134） 横澤 茂：口腔扁平苔癬患者における末梢血リンパ球サブセットとサイトカイン．日本口腔診断学会雑誌 22：206-213，2009. – reference: 123） 大林由美子，三宅 実，南 佑子，他：口腔扁平苔癬に対するマレイン酸イルソグラジンの治療効果の検討．日本口腔科学会雑誌 62：181-186，2013. – reference: 155） Siponen M, Bitu CC, Al-Samadi A, et al: Cathepsin K expression is increased in oral lichen planus. Journal of Oral Pathology ＆ Medicine 45：758-765, 2016. – reference: 167） Vered M, Fürth E, Shalev Y, et al: Inflammatory cells of immunosuppressive phenotypes in oral lichen planus have a proinflammatory pattern of expression and are associated with clinical parameters. Clinical Oral Investigations 17：1365-1373, 2013. – reference: 72） Lu SY, Chang TF and Lin CJ: Treatment effectiveness of levamisole plus prednisolone on oral lichen planus patients with emphasis on levamisole-induced agranulocytosis or pancytopenia. Journal of the Formosan Medical Association 118：1193-1201, 2019. – reference: 5） 大田原宏美，神部芳則，篠崎泰久，他：口腔扁平苔癬の臨床型分類に関する検討．日本口腔内科学会雑誌 22：8-12，2016. – reference: 100） You Y, Huang X, Chen Y, et al: Efficacy and safety of traditional Chinese medicine for erosive oral lichen planus: A protocol for systematic review and meta analysis. Medicine 99：e23375, 2020. – reference: 149） Eita AAB, Zaki AM and Mahmoud SA: Serum 8-isoprostane levels in patients with resistant oral lichen planus before and after treatment with lycopene: a randomized clinical trial. BMC Oral Health 21：343, 2021. – reference: 30） Shipley CA and Spivakovsky S: Tacrolimus or clobetasol for treatment of oral lichen planus. Evidence-based Dentistry 17：16, 2016. – reference: 105） Lavaee F and Shadmanpour M: Comparison of the effect of photodynamic therapy and topical corticosteroid on oral lichen planus lesions. Oral Diseases 25：1954-1963, 2019. – reference: 132） Ferri EP, Cunha KRL, Abboud CS, et al: Photobiomodulation is effective in oral lichen planus: a randomized, controlled, double-blind study. Oral Diseases 27：1205-1216, 2021. – reference: 34） Gonzalez-Moles MA, Bravo M, Gonzalez-Ruiz L, et al: Outcomes of oral lichen planus and oral lichenoid lesions treated with topical corticosteroid. Oral Diseases 24：573-579, 2018. – reference: 177） 太田尚克：口腔扁平苔癬の悪性化に関する免疫組織学的検討．歯学研究科（口腔医学専攻）甲第13054号. – reference: 173） 三田村治郎，神部芳則，野口忠秀，他：口腔扁平苔癬におけるuPA，uPAR，MMPs（MMP-2，MMP-3，MMP-9）発現の免疫組織化学的検討．日本口腔粘膜学会雑誌 15：9-14，2009. – reference: 76） 佐藤田鶴子，吉成伯夫，宗村 治，他：口腔粘膜疾患に対する半夏瀉心湯の使用経験．歯科薬物療法 4：1-10，1985. – reference: 68） Elshenawy HM, Eldin AM and Abdelmonem MA: Clinical Assessment of the Efficiency of Low Level Laser Therapy in the Treatment of Oral Lichen Planus. Macedonian Journal of Medical Sciences 3：717-721, 2015. – reference: 24） 乾 明成，伊藤良平，石崎 博，他：最近10年間の口腔扁平苔癬80例に関する臨床的観察．有病者歯科医療 25：354-358，2016. – reference: 21） Park SY, Lee HJ, Kim SH, et al: Factors affecting treatment outcomes in patients with oral lichen planus lesions: a retrospective study of 113 cases. Journal of Periodontal ＆ Implant science 48：213-223, 2018. – reference: 31） Jurczyszyn K, Trzeciakowski W, Kozakiewicz M, et al: Fractal Dimension and texture analysis of lesion autofluorescence in the evaluation of oral lichen planus treatment effectiveness. Materials （Basel, Switzerland） 14, 2021. – reference: 139） Mozaffari HR, Sharifi R and Sadeghi M: Interleukin-6 levels in the serum and saliva of patients with oral lichen planus compared with healthy controls: a meta-analysis study. Central-European Journal of Immunology 43：103-108, 2018. – reference: 130） Gupta A, Mohan RPS, Gupta S, et al: Roles of serum uric acid, prolactin levels, and psychosocial factors in oral lichen planus. Journal of Oral Science 59：139-146, 2017. – reference: 71） 青木実紀，神部芳則，大多和薫：口腔扁平苔癬のびらん病変に対するアルゴンプラズマ凝固療法．日本口腔粘膜学会雑誌 10：1-5，2004. – reference: 156） Siponen M, Kauppila JH, Soini Y, et al: TLR4 and TLR9 are induced in oral lichen planus. Journal of Oral Pathology ＆ Medicine 41：741-747, 2012. – reference: 153） Tvarijonaviciute A, Aznar-Cayuela C, Rubio CP, et al: Salivary antioxidant status in patients with oral lichen planus: correlation with clinical signs and evolution during treatment with chamaemelum nobile. BioMed Research International 2018：5187549, 2018. – reference: 142） Jana A, Thomas J and Ghosh P: Erosive oral lichen planus inflicts higher cellular stress than reticular type. Journal of Oral and Maxillofacial Pathology 25：279-285, 2021. – reference: 55） Goel S and Khurana N: Effects of Mycophenolate Mofetil, Methotrexate and Pimecrolimus on cdk4 and p16 in Erosive Oral Lichen Planus. Indian Journal of Dermatology 66：490-495, 2021. – reference: 135） Liu J, Shi Q, Yang S, et al: The relationship between levels of salivary and serum interleukin-6 and oral lichen planus: A systematic review and meta-analysis. Journal of the American Dental Association 148：743-749. e9, 2017. – reference: 137） Thongprasom K, Prapinjumrune C, Kanjanabuch P, et al: Correlation of serum ANA and direct immunofluorescence studies in elderly Thai patients with red and white oral lesions. Journal of Oral Pathology ＆ Medicine 45：797-802, 2016. – reference: 1） 小宮山一雄，伊東大典，神部芳則，他：口腔扁平苔癬全国調査に基づいた病態解析および診断基準・治療指針の提案．日本口腔内科学会雑誌 21：49-57，2015. – reference: 109） Gobbo M, Rupel K, Zoi V, et al: Scoring systems for Oral Lichen Planus used by differently experienced raters. Medicina Oral, Patologia Oral y Cirugia Cucal 22：e562-e571, 2017. – reference: 133） Ohno S, Tateishi Y, Tatemoto Y, et al: Enhanced expression of Toll-like receptor 2 in lesional tissues and peripheral blood monocytes of patients with oral lichen planus. The Journal of Dermatology 38：335-344, 2011. – reference: 125） Shiva A, Arab S, Mousavi SJ, et al: Serum and salivary level of nitric oxide （nox） and crp in oral lichen planus （olp） patients. Journal of Dentistry （Shiraz, Iran） 21：6-11, 2020. – reference: 138） Oberti L, Alberta L, Massimo P, et al: Clinical management of oral lichen planus: a systematic review. Mini Reviews in Medicinal Chemistry 19：1049-1059, 2019. – reference: 176） Noguchi T, Jinbu Y, Mitamura J, et al: Immunohistochemical Study on SOD in Oral Lichen Planus. Journal of Japanese Society for Oral Mucous Membrane 11：48-53, 2005. – reference: 128） Deganello A, Paderno A, Morello R, et al: Diagnostic Accuracy of Narrow Band Imaging in Patients with Oral Lichen Planus: A Prospective Study. The Laryngoscope 131：E1156-E1161, 2021. – reference: 46） Resende JPM, Chaves M das GAM, et al: Oral lichen planus treated with tacrolimus 0.1％. International Journal of Clinical and Experimental Medicine 6：917-921, 2013. – reference: 163） Xie S, Ding L, Xiong Z, et al: Implications of Th1 and Th17 cells in pathogenesis of oral lichen planus. Journal of Huazhong University of Science and Technology Medical sciences 32：451-457, 2012. – reference: 51） Sun S-L, Liu J-J, Zhong B, et al: Topical calcineurin inhibitors in the treatment of oral lichen planus: a systematic review and meta-analysis. The British Journal of Dermatology 181：1166-1176, 2019. – reference: 13） De Porras-Carrique T, González-Moles MÁ, Warnakulasuriya S，et al: Depression, anxiety, and stress in oral lichen planus: a systematic review and meta-analysis. Clinical Oral Investigations 26：1391-1408, 2022. – reference: 73） Hashimoto T, Fukuda A, Himejima A, et al: Ten cases of severe oral lichen planus showing granular C3 deposition in oral mucosal basement membrane zone. European Journal of Dermatology: EJD 25：539-547, 2015. – reference: 161） Piccinni M-P, Lombardelli L, Logiodice F, et al: Potential pathogenetic role of Th17, Th0, and Th2 cells in erosive and reticular oral lichen planus. Oral Diseases 20：212-218, 2014. – reference: 124） Jalenques I, Lauron S, Almon S, et al: Prevalence and Odds of Signs of Depression and Anxiety in Patients with Lichen Planus: Systematic Review and Meta-analyses. Acta Dermato-Venereologica 100：adv00330, 2020. – reference: 23） Bakhshi M, Gholami S, Mahboubi A, et al: Combination Therapy with 1％ nanocurcumin gel and 0.1％ triamcinolone acetonide mouth rinse for oral lichen planus: a randomized double-blind placebo controlled clinical trial. Dermatology Research and Practice 2020 4298193, 2020. – reference: 37） Sivaraman S, Santham K, Nelson A, et al: A randomized triple-blind clinical trial to compare the effectiveness of topical triamcinolone acetonate （0.1％）, clobetasol propionate （0.05％）, and tacrolimus orabase （0.03％） in the management of oral lichen planus. Journal of Pharmacy ＆ Bioallied Sciences 8：S86-S89, 2016. – reference: 15） 大野清二，北村直也，笹部衣里，他：慢性C型肝炎患者に生じた口腔扁平苔癬の臨床的検討．日本口腔内科学会雑誌 27：52-58，2021. – reference: 64） 松本耕祐，榎本由依，小野真嵩，他：口腔扁平苔癬に対する炭酸ガスレーザー蒸散療法の臨床評価に関する前向き研究．日本レーザー歯学会誌 26：124-129，2015. – reference: 62） Bakhtiari S, Toosi P, Dolati F, et al: Evaluation of Salivary Secretor Status of Blood Group Antigens in Patients with Oral Lichen Planus. Medical Principles and Practice 25：266-269, 2016. – reference: 20） Mansourian A, Agha-Hosseini F, Kazemi HH, et al: Salivary oxidative stress in oral lichen planus treated with triamcinolone mouthrinse. Dental Research Journal 14：104-110, 2017. – reference: 39） Rogulj AA, Z Alajbeg I, Brailo V, et al: Topical NAVS naphthalan for the treatment of oral lichen planus and recurrent aphthous stomatitis: a double blind, randomized, parallel group study. PloS One 16：e0249862, 2021. – reference: 144） Gholizadeh N and Sheykhbahaei N: Micronutrients profile in oral lichen planus: a review literature. Biological Trace Element Research 199：912-924, 2021. – reference: 102） Kia SJ, Basirat M, Mortezaie T, et al: Comparison of oral Nano-Curcumin with oral prednisolone on oral lichen planus: a randomized double-blinded clinical trial. BMC Complementary Medicine and Therapies 20：328, 2020. – reference: 54） Sotoodian B, Lo J and Lin A: Efficacy of Topical Calcineurin Inhibitors in Oral Lichen Planus. Journal of Cutaneous Medicine and Surgery 19：539-545, 2015. – reference: 22） Monshi B, Ellersdorfer C, Edelmayer M, et al: Topical cyclosporine in oral lichen planus-a series of 21 open-label, biphasic, single-patient observations. Journal of Clinical Medicine 10, 2021. – reference: 56） Loré B, Saraceno R, Poladas G, et al: Oral lichen planus: therapy and phenotype. Giornale italiano di dermatologia e venereologia: organo ufficiale, Societa italiana di dermatologia e sifilografia 153：459-463, 2018. – reference: 83） Nosratzehi T, Arbabi-Kalati F, Hamishehkar H, et al: Comparison of the effects of curcumin mucoadhesive paste and local corticosteroid on the treatment of erosive oral lichen planus lesions. Journal of the National Medical Association 110：92-97, 2018. – reference: 85） Ali S and Wahbi W: The efficacy of aloe vera in management of oral lichen planus: a systematic review and meta-analysis. Oral Diseases 23：913-918, 2017. – reference: 61） Joshy A, Doggalli N, Patil K, et al: To evaluate the efficacy of topical propolis in the management of symptomatic oral lichen planus: a randomized controlled trial. Contemporary Clinical Dentistry 9：65-71, 2018. – reference: 7） 井川 健：重症扁平苔癬診療ガイドライン（案）．重症型扁平苔癬の病態解析及び診断基準・治療指針の確立 平成25年度研究報告書 9-40，2014. – reference: 111） Amirchaghmaghi M, Delavarian Z, Iranshahi M, et al: A randomized placebo-controlled double blind clinical trial of quercetin for treatment of oral lichen planus. Journal of Dental Research, Dental Clinics, Dental crospects 9：23-28, 2015. – reference: 89） Wee JS, Shirlaw PJ, Challacombe SJ, et al: Efficacy of mycophenolate mofetil in severe mucocutaneous lichen planus: a retrospective review of 10 patients. The British Journal of Dermatology 167：36-43, 2012. – reference: 126） Kozakai A, Ono K, Nomura T, et al: Usefulness of objective evaluations by fluorescence visualization device for differentiating between superficial oral squamous cell carcinoma and oral lichen planus. Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 32：26-32, 2020. – reference: 180） Farah CS, Fox S, Shearston K, et al: Lichenoid dysplasia is not a distinct pathological entity. Oral Oncology 119：105362, 2021. – reference: 162） Lu R, Zeng X, Han Q, et al: Overexpression and selectively regulatory roles of IL-23/IL-17 axis in the lesions of oral lichen planus. Mediators of Inflammation 2014：701094, 2014. – reference: 178） de Sousa FACG, ParadellaTC, Carvalho YR, et al: Immunohistochemical expression of PCNA, p53, bax and bcl-2 in oral lichen planus and epithelial dysplasia. Journal of Oral Science 51：117-121, 2009. – reference: 4） Mankapure PK, Humbe JG, Mandale MS, et al: Clinical profile of 108 cases of oral lichen planus. Journal of Oral Science 58：43-47, 2016. – reference: 16） Casparis S, Borm JM, Tektas S, et al: Oral lichen planus （OLP）, oral lichenoid lesions （OLL）, oral dysplasia, and oral cancer: retrospective analysis of clinicopathological data from 2002-2011. Oral and Maxillofacial Surgery 19：149-156, 2015. – reference: 43） Lee YC, Lee JS, Jung AR, et al: Factors Affecting the Result of Intralesional Corticosteroid Injection in Patients With Oral Lichen Planus. Clinical and Experimental Otorhinolaryngology 11：205-209, 2018. – reference: 120） Ferri EP, Gallo C de B, Abboud CS, et al: Efficacy of photobiomodulation on oral lichen planus: a protocol study for a double-blind, randomised controlled clinical trial. BMJ Open 8：e024083, 2018. – reference: 25） Wang B, Fan J, Wang L, et al: Photobiomodulation therapy/photodynamic therapy versus steroid therapy for oral lichen planus: a systematic review and meta-analysis. Photobiomodulation, Photomedicine, and Laser Surgery 39：145-154, 2021. – reference: 58） Fu J, Zhu X, Dan H, et al: Amlexanox is as effective as dexamethasone in topical treatment of erosive oral lichen planus: a short-term pilot study. Oral surgery, Oral Medicine, Oral Pathology and Oral Radiology 113：638-643, 2012. – reference: 93） Rivas-Tolosa N, Requena C, Llombart B, et al: Antimalarial drugs for the treatment of oral erosive lichen planus. Dermatology （Basel, Switzerland） 232：86-90, 2016. – reference: 94） Raj SC, Baral D, Garhnayak L, et al: Hydroxychloroquine- a new treatment option for erosive oral lichen planus. Indian Journal of Dental Research 32：192-198, 2021. – reference: 154） Ghallab NA, Kasem RF, El-Ghani SFA, et al: Gene expression of miRNA-138 and cyclin D1 in oral lichen planus. Clinical Oral Investigations 21：2481-2491, 2017. – reference: 29） El Shenawy HM and Eldin AM: A comparative evaluation of low-level laser and topical steroid therapies for the treatment of erosive-atrophic lichen planus. Macedonian Journal of Medical Sciences 3：462-466, 2015. – reference: 86） Kalaskar AR, Bhowate RR, Kalaskar RR, et al: Efficacy of herbal interventions in oral lichen planus: a systematic review. Contemporary Clinical Dentistry 11：311-319, 2020. – reference: 164） Solimani F, Pollmann R, Schmidt T, et al: Therapeutic targeting of Th17/Tc17 cells leads to clinical improvement of lichen planus. Frontiers in Immunology 10：1808, 2019. – reference: 53） Vohra S, Singal A and Sharma SB: Clinical and serological efficacy of topical calcineurin inhibitors in oral lichen planus: a prospective randomized controlled trial. International Journal of Dermatology 55：101-105, 2016. – reference: 118） Sobral SS, da Silva Brandão EH, de Barros Gallo C, et al: Analysis of the psychopathological profile, quality of life, and cost-effectiveness of oral lichen planus patients treated with photobiomodulation. Clinical Oral Investigations 26：719-728, 2022. – reference: 140） Wang X-S, Sun Z, Liu L-W, et al: Potential metabolic biomarkers for early detection of oral lichen planus, a precancerous lesion. Frontiers in Pharmacology 11：603899, 2020. – reference: 80） Hu J-Y, Zhang J, Ma J-Z, et al: MicroRNA-155-IFN-γ Feedback loop in CD4（＋）T Cells of erosive type oral lichen planus. Scientific Reports 5：16935, 2015. – reference: 159） Pereira JS, Monteiro BV, Nonaka CF, et al: FoxP3（＋） T regulatory cells in oral lichen planus and its correlation with the distinct clinical appearance of the lesions. International Journal of Experimental Pathology 93：287-294, 2012. – reference: 38） Villa A, Sankar V, Bassani G, et al: Dexamethasone solution and dexamethasone in Mucolox for the treatment of oral lichen planus: a preliminary study. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 129：585-590, 2020. – reference: 147） Du J, Li R, Yu F, et al: Experimental study on 1,25（OH）（2） D（3） amelioration of oral lichen planus through regulating NF-κB signaling pathway. Oral Diseases 23：770-778, 2017. – reference: 174） Mitamura J, Onodera K and Ooya K: Histopathological and immunohistochemical study of oral lichen planus in the buccal mucosa: relationship between clinicopathological features and histometrical analysis. Oral Medicine ＆ Pathology 13：1-6, 2008. – reference: 175） Köse O, Lalli A, Kutulola AO, Odell EW, et al: Changes in the expression of stem cell markers in oral lichen planus and hyperkeratotic lesions. Journal of Oral Science 49：133-139, 2007. – reference: 77） 桑原 徹，廣安一彦，土川幸三：ステロイド含嗽無効口腔扁平苔癬に十全大補湯が奏効した1例．漢方医学 31：107-109，2007. – reference: 11） Romano F, Arduino PG, Maggiora M, et al: Effect of a structured plaque control on MMP-1 and MMP-9 crevicular levels in patients with desquamative gingivitis associated with oral lichen planus. Clinical Oral Investigations 23：2651-2658, 2019. – reference: 129） Kalkur C, Sattur AP and Guttal KS: Role of depression, anxiety and stress in patients with oral lichen planus: a pilot study. Indian Journal of Dermatology 60：445-449, 2015. – reference: 10） 村野 好，神部芳則，井上千恵子，他：口腔扁平苔癬（びらん型）に対する口腔衛生管理の実際．日本口腔内科学会雑誌 23：40-45，2017. – reference: 145） Abdolsamadi H, Rafieian N, Goodarzi MT, et al: Levels of salivary antioxidant vitamins and lipid peroxidation in patients with oral lichen planus and healthy individuals. Chonnam Medical Journal 50：58-62, 2014. – reference: 27） Kurt MH, Kolsuz ME and Eren H: Corticosteroid injection in treatment of persistent oral lichen planus: three cases. Dermatologic Therapy 32：e13015, 2019. – reference: 97） Delavarian Z, Javadzadeh-Bolouri A, Dalirsani Z, et al: The evaluation of psychiatric drug therapy on oral lichen planus patients with psychiatric disorders. Medicina Oral, Patologia Oral y Cirugia Bucal 15：e322-e327, 2010. – reference: 119） Yuwanati M, Gondivkar S, Sarode SC, et al: Impact of oral lichen planus on oral health-related quality of life: a systematic review and meta-analysis. Clinics and Practice 11：272-286, 2021. – reference: 127） 酒巻裕之，藤本陽子，武田祥人，他：接触粘膜拡大鏡視検査による口腔扁平苔癬ならびに口腔白板症の診断に関する研究．日本口腔粘膜学会雑誌 17：7-16，2011. – reference: 152） Lopez-Jornet P, Zavattaro E, Mozaffari HR, et al: Evaluation of the salivary level of cortisol in patients with oral lichen planus: a meta-analysis. Medicina （Kaunas, Lithuania） 55：2019. – reference: 166） Enomoto A, Sato E, Yasuda T, et al: Intraepithelial CD8＋ lymphocytes as a predictive diagnostic biomarker for the remission of oral lichen planus. Human Pathology 74：43-53, 2018. – reference: 12） Yousefi H and Abdollahi M: An Update on Drug-induced Oral Reactions. Journal of Pharmacy ＆ Pharmaceutical Sciences: A Publication of the Canadian Society for Pharmaceutical Sciences 21：171-183, 2018. – reference: 19） Amirchaghmaghi M, Hashemy SI, Alirezaei B, et al: Evaluation of plasma isoprostane in patients with oral lichen planus. Journal of Dentistry （Shiraz, Iran） 17：21-25, 2016. – reference: 101） He Y, Deng J, Zhao Y, et al: Efficacy evaluation of photodynamic therapy for oral lichen planus: a systematic review and meta-analysis. BMC Oral Health 20：302, 2020. – reference: 32） Zborowski J, Kida D, Szarwaryn A, et al: A comparison of clinical efficiency of photodynamic therapy and topical corticosteroid in treatment of oral lichen planus: a split-mouth randomised controlled study. Journal of Clinical Medicine 10, 2021. – reference: 36） Piñas L, García-García A, Pérez-Sayáns M, et al: The use of topical corticosteroides in the treatment of oral lichen planus in spain: a national survey. Medicina Oral, Patologia Oral y Cirugia Bucal 22：e264-e269, 2017. – reference: 42） Sonthalia S and Singal A: Comparative efficacy of tacrolimus 0.1％ ointment and clobetasol propionate 0.05％ ointment in oral lichen planus: a randomized double-blind trial. International Journal of Dermatology 51：1371-1378, 2012. – reference: 78） 村上幸生，香村亜希子，岡田知之，他：セファランチン®の投与によって改善した口腔扁平苔癬の1例．日本口腔診断学会雑誌 30：28-31，2017. – reference: 141） Wang F, Ke Y, Yang L, et al: Quercetin protects human oral keratinocytes from lipopolysaccharide-induced injury by downregulating microRNA-22. Human ＆ Experimental Toxicology 39：1310-1317, 2020. – reference: 160） Lei L, Zhan L, Tan W, et al: Foxp3 gene expression in oral lichen planus: a clinicopathological study. Molecular Medicine Reports 9：928-934, 2014. – reference: 99） Song X, Wu X, Wang C, et al: Treatment of Oral Lichen Planus With a Focus on Psychological Methods. Frontiers in Psychiatry 12：731093, 2021. – reference: 40） Gambino A, Cabras M, Cafaro A, et al: Preliminary evaluation of the utility of optical coherence tomography in detecting structural changes during photobiomodulation treatment in patients with atrophic-erosive oral lichen planus. Photodiagnosis and Photodynamic Therapy 34：102255, 2021. – reference: 75） Momota Y, Takano H, Kani K, et al: Oral Lichen Planus Well-Treated with Kampo Medicines: Two Case Reports. IOSR Journal of Medical Sciences 18：68-72, 2019. – reference: 79） 菅原由美子，神部芳則，笹野高嗣，他：口腔扁平苔癬に対するCepharanthineの臨床効果に関する後方視的多施設共同研究．日本口腔内科学会雑誌 22：59-67，2016. – reference: 110） Amirchaghmaghi M, Pakfetrat A, Delavarian Z, et al: Evaluation of the efficacy of curcumin in the treatment of oral lichen planus: a randomized controlled trial. Journal of Clinical and Diagnostic csearch 10：ZC134-ZC137, 2016. – reference: 69） Dillenburg CS, Martins MAT, Munerato MC, et al: Efficacy of laser phototherapy in comparison to topical clobetasol for the treatment of oral lichen planus: a randomized controlled trial. Journal of Biomedical Optics 19：68002, 2014. – reference: 65） Agha-Hosseini F, Moslemi E and Mirzaii-Dizgah I: Comparative evaluation of low-level laser and CO2 laser in treatment of patients with oral lichen planus. International Journal of Oral and Maxillofacial Surgery 41：1265-1269, 2012. – reference: 90） Chauhan P, De D, Handa S, et al: A prospective observational study to compare efficacy of topical triamcinolone acetonide 0.1％ oral paste, oral methotrexate, and a combination of topical triamcinolone acetonide 0.1％ and oral methotrexate in moderate to severe oral lichen planus. Dermatologic Therapy 31：2018. – reference: 113） de Carvalho MM, Hidalgo MAR, Scarel-Caminaga RM, et al: Photobiomodulation of gingival lesions resulting from autoimmune diseases: systematic review and meta-analysis. Clinical Oral Investigations 26：3949-3964, 2022. – reference: 35） Thomas AE, Varma B, Kurup S, et al: Evaluation of efficacy of 1％ curcuminoids as local application in management of oral lichen planus-interventional study. Journal of Clinical and Diagnostic Research 11：ZC89-ZC93, 2017. – reference: 2） Petruzzi M, Lucchese A, Lajolo C, et al: Topical retinoids in oral lichen planus treatment: an overview. Dermatology （Basel, Switzerland） 226：61-67, 2013. – reference: 48） 福永大二郎，吉川博政，吉田将律，他：口腔扁平苔癬に対するタクロリムスの使用に関する検討．有病者歯科医療 26：280-287，2017. – reference: 96） Bender A, Fix C, Eubel V, et al: Adjuvant high-dose intravenous immunoglobulins for recalcitrant erosive oral lichen planus: mixed clinical responses. European Journal of Dermatology 28：496-501, 2018. – reference: 26） Lodi G, Manfredi M, Mercadante V, et al: Interventions for treating oral lichen planus: corticosteroid therapies. The Cochrane Database of Systematic Reviews 2：CD001168, 2020. – reference: 131） Aminzadeh A, Jahanshahi G and Ahmadi M: A retrospective comparative study on clinico-pathologic features of oral lichen planus and oral lichenoid lesions. Dental Research Journal 10：168-172, 2013. – reference: 67） Othman NA, Shaker OG, Elshenawy HM, et al: The effect of diode laser and topical steroid on serum level of TNF-alpha in oral lichen planus patients. Journal of Clinical and Experimental Dentistry 8：e566-e570, 2016. – reference: 121） Alves MGO, do Carmo Carvalho BF, Balducci I, et al: Emotional assessment of patients with oral lichen planus. International Journal of Dermatology 54：29-32, 2015. – reference: 57） Sethi Ahuja U, Puri N, More CB, et al: Comparative evaluation of effectiveness of autologous platelet rich plasma and intralesional corticosteroids in the management of erosive oral Lichen planus- a clinical study. Journal of Oral Biology and Craniofacial Research 10：714-718, 2020. – reference: 151） Wu KM, Wang YP, Lin HP, et al: Modulation of serum smooth muscle antibody levels by levamisole treatment in patients with oral lichen planus. Journal of the Formosan Medical Association 112：352-357, 2013. – reference: 9） Sanadi RM, Khandekar PD, Chaudhari SR, et al: Association of periodontal disease with oral lichen planus: a systematic review and meta analysis. Journal of Oral and Maxillofacial Pathology: JOMFP 27：173-180, 2023. – reference: 74） 川又, 均，野村有希，山川賀子，他：Castleman病に伴う腫瘍随伴性天疱瘡の1例．日本口腔外科学会雑誌 56：9-13，2010. – reference: 52） Bendas ER, Abdullah H, El-Komy MHM, et al: Hydroxychloroquine niosomes: a new trend in topical management of oral lichen planus. International Journal of Pharmaceutics 458：287-295, 2013. – reference: 95） Jeong SH, Na HS, Park SH, et al: Topical sulfasalazine for unresponsive oral lichen planus. Quintessence International （Berlin, Germany） 47：319-327, 2016. – reference: 14） Nosratzehi T: Oral lichen planus: an overview of potential risk factors, biomarkers and treatments. Asian Pacific Journal of Cancer Prevention 19：1161-1167, 2018. – reference: 103） Gabriella D, Klemens R, Xiao-Hui R-F, et al: Effect of personality traits on the oral health-related quality of life in patients with oral lichen planus undergoing treatment. Clinical Oral Investigations 25：2381-2389, 2021. – reference: 45） Ribero S, Stieger M, Quaglino P, et al: Efficacy of topical tacrolimus for oral lichen planus: real-life experience in a retrospective cohort of patients with a review of the literature. Journal of the European Academy of Dermatology and Venereology 29：1107-1113, 2015. – reference: 143） Rezazadeh F and Haghighat S: Serum vitamin profile in oral lichen planus patients in southwest of iran. BioMed Research International 2021：8627435, 2021. – reference: 98） Guarneri F, Guarneri C and Marini H: Oral lichen planus and neurogenic inflammation: new observations and therapeutic implications from four clinical cases. Dermatologic Therapy 27：206-210, 2014. – reference: 91） Lajevardi V, Ghodsi SZ, Hallaji Z, et al: Treatment of erosive oral lichen planus with methotrexate. Journal of the German Society of Dermatology 14：286-293, 2016. – reference: 171） Shimada K, Ochiai T, Shen F-C, et al: Phenotypic alteration of basal cells in oral lichen planus; switching keratin 19 and desmoglein 1 expression. Journal of Oral Science 60：507-513, 2018. – reference: 108） Nasr MM, Ebrahim HM, Khattab FM, et al: Bacillus Calmette-Guerin, polysaccharide nucleic acid in the treatment of cutaneous and oral lichen planus. Dermatologic Therapy 31：e12591, 2018. – reference: 112） 岩本 修，轟 圭太，青木修子，他：口腔粘膜疾患に対するオゾンナノバブル水の臨床効果―口腔扁平苔癬と口腔白板症への応用―．日本口腔診断学会誌 24：389-396，2011. – reference: 47） Arduino PG, Carbone M, Della Ferrera F, et al: Pimecrolimus vs. tacrolimus for the topical treatment of unresponsive oral erosive lichen planus: a 8 week randomized double-blind controlled study. Journal of the European Academy of Dermatology and Venereology: JEADV 28：475-482, 2014. – reference: 104） Suvarna C, Chaitanya NC, Ameer S, et al: A Comparative Evaluation on the Effect of Oral Zinc 50mg with or without 0.1％ Triamcinolone Orabase on Oral Lichen Planus. International Journal of Applied ＆ Basic Medical Research 10：54-58, 2020. – reference: 18） Vijayan AK, Muthukrishnan A, Velayudhannair V, et al: Expression of human papillomavirus 16 and 18 DNA in oral lichen planus using polymerase chain reaction. Journal of Oral and Maxillofacial Pathology 26：495-500, 2022. – reference: 169） Shan J, Li S, Wang C, et al: Expression and biological functions of the CCL5-CCR5 axis in oral lichen planus. Experimental Dermatology 28：816-821, 2019. – reference: 70） Cafaro A, Arduino PG, Massolini G, et al: Clinical evaluation of the efficiency of low-level laser therapy for oral lichen planus: a prospective case series. Lasers in Medical Science 29：185-190, 2014. – reference: 60） Lopez Jornet P and Aznar-Cayuela C: Efficacy of topical chamomile management vs. placebo in patients with oral lichen planus: a randomized double-blind study. Journal of the European Academy of Dermatology and Venereology 30：1783-1786, 2016. – reference: 63） Arcuri F, Stellin L, Gatti A, et al: Surgical approach to oral lichen planus by submucosal autologous fat grafting. The Journal of Craniofacial Surgery 24：e258-e260, 2013. – reference: 87） Buajeeb W, Kraivaphan P, Amornchat C, et al: Reduction of micronuclei in oral lichen planus supplemented with beta-carotene. Journal of Oral Science 50：461-467, 2008. – reference: 117） Lopez-Jornet P, Martinez-Canovas A and Pons-Fuster A: Salivary biomarkers of oxidative stress and quality of life in patients with oral lichen planus. Geriatrics ＆ Gerontology International 14：654-659, 2014. – reference: 150） Khattab FM and Said NM: Chitinase-3-like protein 1 （YKL-40）: novel biomarker of lichen planus. International Journal of Dermatology 58：993-996, 2019. – reference: 148） Wang J, Yang J, Wang C, et al: Systematic review and meta-analysis of oxidative stress and antioxidant markers in oral lichen planus. Oxidative Medicine and Cellular Longevity 2021：9914652, 2021. – reference: 158） Wang H, Bai J, Luo Z, et al: Overexpression and varied clinical significance of Th9 versus Th17 cells in distinct subtypes of oral lichen planus. Archives of Oral Biology 80：110-116, 2017. – reference: 84） Chainani-Wu N, Collins K and Silverman SJ: Use of curcuminoids in a cohort of patients with oral lichen planus, an autoimmune disease. Phytomedicine 19：418-423, 2012. – reference: 33） Hashem AS, Issrani R, Elsayed TEE, et al: Topical hyaluronic acid in the management of oral lichen planus: a comparative study. Journal of Investigative and Clinical Dentistry 10：e12385, 2019. – reference: 41） Said Z, Murdoch C, Hansen J, et al: Corticosteroid delivery using oral mucosa equivalents for the treatment of inflammatory mucosal diseases. European Journal of Oral Sciences 129：e12761, 2021. – reference: 66） Arora KS, Bansal R, Mohapatra S, et al: Prevention of malignant transformation of oral leukoplakia and oral lichen planus using laser: an observational study. Asian Pacific Journal of Cancer Prevention 19：3635-3641, 2018. – reference: 107） Rakesh N, Clint JB, Reddy SS, et al: Clinical evaluation of photodynamic therapy for the treatment of refractory oral Lichen planus―a case series. Photodiagnosis and Photodynamic Cherapy 24：280-285, 2018. – reference: 106） Sulewska M, Duraj E, Sobaniec S, et al: A clinical evaluation of efficacy of photodynamic therapy in treatment of reticular oral lichen planus: a case series. Photodiagnosis and Photodynamic Therapy 25：50-57, 2019. – reference: 157） Tao X, Xia J, Chen X, Wang H, et al: FOXP3 T regulatory cells in lesions of oral lichen planus correlated with disease activity. Oral Diseases 16：76-82, 2010. |
| SSID | ssj0003236731 ssib044495048 ssib012352363 |
| Score | 1.9248325 |
| Snippet | 本稿は，日本口腔内科学会OLP委員会内の第二期口腔扁平苔癬ワーキンググループが，公開されている論文（国際誌，国内誌）を基に，口腔扁平苔癬に対して，現在行われている... |
| SourceID | jstage |
| SourceType | Publisher |
| StartPage | 21 |
| SubjectTerms | 口腔扁平苔癬 慢性活動性 慢性非活動性 治療方法 治療評価 |
| Title | 口腔扁平苔癬の治療方法とその臨床評価に関する文献レビューとタスクフォースコンセンサス |
| URI | https://www.jstage.jst.go.jp/article/jjsom/29/2/29_21/_article/-char/ja |
| Volume | 29 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| ispartofPNX | 日本口腔内科学会雑誌, 2023, Vol.29(2), pp.21-35 |
| journalDatabaseRights | – providerCode: PRVAFT databaseName: Colorado Digital library customDbUrl: eissn: 2186-6155 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0003236731 issn: 2186-6147 databaseCode: KQ8 dateStart: 20120101 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrR1NaxNBdCn14kUUFb_pwTluTWZ2dmeOu8mGIigILfQWsptdMGArmoJ4EJIgRSt4sC304EFFaLFUMHioFf0xY9P4L3xvdifdth5q8bK8vK95895O5r1hZtaybgqeunHsMpvyZtOGDDy2BWWRLV3eTLigTlPfM3vnrjs149ye5bNj408Ku5YW2tFk_PSv50pOElXAQVzxlOw_RHakFBAAQ3zhCRGG57FiTEJORI34jISCCE6kQ0KXCAnpIZICSYKMFGiSR6QkfoWEDBn8EJkDSoIgJwmKGOmiIJIYkdwwixyQ1YI4aPY0CdryifAR40st5ZAgJH7ZMEMTEjX71OiRGqBoW9YoqAIzREVrBhIzpoIZzGB4DgSVg4ZBL2oGMJr9mhHnBiMPiheYA9NEDmRuOYThI6liTq_t97RtAFS02UfjAhgXYeijD97WAfKrxHe1rypE-tpFgSaBG8GfowVsrbiKgcVAAXsJR4bWAJ6vav-jqn1-HU-kAFDDHmh-V-9rKagFOU-HVNsrhFGLjXlFNnynqkdaBwF5qPV8ASk73a0H-_9yz_6UhR84syHhyyxMirjsMmYz5-arXPcLSx9mAi2kYtlFNocneReqepzkW4_nH0xSOWlEDtyano_JuuaqU1mn-lGuGwIeaqy3oLI6RT3IUXE7x73RTIQHyGnhYjrHgX-xUr5wgDkew4sP9cdOR13ODv-icbcKpkFi24Iyz2wR1Vnr9FnrTF5uTviZOeessVbjvPVs9_WH4fPlwYvO7nZ_uLS8t7apOluDLzt7a93B6vagv6I666rzFpDDxfXdby-HGyu_frxTnU-_V9-rzprqLg1WF_debanepuq9Ub2PqvcdRbo_VXdbdT-r3orqbiASf_ZVr6-6O_r5FTAXrJlaOF2ZsvPvsNgtCgWI3UhYkzlRLBKnARVZiaUpTSMmI5rytCGh716Zx01ZinG9gjm4UA1sHgQ9lrEQ7KI1Pjc_l1yyJni5SVnqOVAkJE4iyxETcVpqQJmXcC-KosuWl7mr_jC7bKd-3EBeObHkVes0DotsXfWaNd5-tJBch0qjHd3QL8Uf2aj8FA |
| linkProvider | Colorado Alliance of Research Libraries |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%E5%8F%A3%E8%85%94%E6%89%81%E5%B9%B3%E8%8B%94%E7%99%AC%E3%81%AE%E6%B2%BB%E7%99%82%E6%96%B9%E6%B3%95%E3%81%A8%E3%81%9D%E3%81%AE%E8%87%A8%E5%BA%8A%E8%A9%95%E4%BE%A1%E3%81%AB%E9%96%A2%E3%81%99%E3%82%8B%E6%96%87%E7%8C%AE%E3%83%AC%E3%83%93%E3%83%A5%E3%83%BC%E3%81%A8%E3%82%BF%E3%82%B9%E3%82%AF%E3%83%95%E3%82%A9%E3%83%BC%E3%82%B9%E3%82%B3%E3%83%B3%E3%82%BB%E3%83%B3%E3%82%B5%E3%82%B9&rft.jtitle=%E6%97%A5%E6%9C%AC%E5%8F%A3%E8%85%94%E5%86%85%E7%A7%91%E5%AD%A6%E4%BC%9A%E9%9B%91%E8%AA%8C&rft.au=%E6%9D%89%E7%94%B0%2C+%E5%A5%BD%E5%BD%A6&rft.au=%E7%99%BD%E7%9F%B3%2C+%E6%80%9C&rft.au=%E5%B7%9D%E5%8F%88%2C+%E5%9D%87&rft.au=%E5%89%8D%E7%94%B0%2C+%E5%88%9D%E5%BD%A6&rft.date=2023&rft.pub=%E6%97%A5%E6%9C%AC%E5%8F%A3%E8%85%94%E5%86%85%E7%A7%91%E5%AD%A6%E4%BC%9A&rft.issn=2186-6147&rft.eissn=2186-6155&rft.volume=29&rft.issue=2&rft.spage=21&rft.epage=35&rft_id=info:doi/10.6014%2Fjjsom.29.21&rft.externalDocID=article_jjsom_29_2_29_21_article_char_ja |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2186-6147&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2186-6147&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2186-6147&client=summon |