室温機械灌流保存法の現状と今後
近年, 機械灌流保存が冷却保存よりも有益であることが明らかになってきた. 冷温によって引き起こされる保存傷害は, 不十分な細胞代謝機能やエネルギー貯蔵の枯渇, 冷却による直接的な有害効果を引き起こす. 常温機械灌流法(NMP)は, 移植片機能の維持と回復, および生存率の評価に役立つ. しかし, 高レベルの酸素を必要とするため, 微小血管障害や細菌増殖のリスクを高める可能性のある血液製剤が使用される. それゆえ, 常温機械灌流法は依然として困難な問題である. 一方, 20°C-25°C付近の室温機械灌流法(SNMP)は, NMPに比べて必要な酸素レベルが低くなる. ここでは, SNMPの現状と...
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| Published in | Organ Biology Vol. 29; no. 1; pp. 13 - 20 |
|---|---|
| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
一般社団法人 日本臓器保存生物医学会
2022
日本臓器保存生物医学会 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1340-5152 2188-0204 |
| DOI | 10.11378/organbio.29.13 |
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| Abstract | 近年, 機械灌流保存が冷却保存よりも有益であることが明らかになってきた. 冷温によって引き起こされる保存傷害は, 不十分な細胞代謝機能やエネルギー貯蔵の枯渇, 冷却による直接的な有害効果を引き起こす. 常温機械灌流法(NMP)は, 移植片機能の維持と回復, および生存率の評価に役立つ. しかし, 高レベルの酸素を必要とするため, 微小血管障害や細菌増殖のリスクを高める可能性のある血液製剤が使用される. それゆえ, 常温機械灌流法は依然として困難な問題である. 一方, 20°C-25°C付近の室温機械灌流法(SNMP)は, NMPに比べて必要な酸素レベルが低くなる. ここでは, SNMPの現状と将来について説明する. |
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| AbstractList | 近年, 機械灌流保存が冷却保存よりも有益であることが明らかになってきた. 冷温によって引き起こされる保存傷害は, 不十分な細胞代謝機能やエネルギー貯蔵の枯渇, 冷却による直接的な有害効果を引き起こす. 常温機械灌流法(NMP)は, 移植片機能の維持と回復, および生存率の評価に役立つ. しかし, 高レベルの酸素を必要とするため, 微小血管障害や細菌増殖のリスクを高める可能性のある血液製剤が使用される. それゆえ, 常温機械灌流法は依然として困難な問題である. 一方, 20°C-25°C付近の室温機械灌流法(SNMP)は, NMPに比べて必要な酸素レベルが低くなる. ここでは, SNMPの現状と将来について説明する. 「要旨」近年, 機械灌流保存が冷却保存よりも有益であることが明らかになってきた. 冷温によって引き起こされる保存傷害は, 不十分な細胞代謝機能やエネルギー貯蔵の枯渇, 冷却による直接的な有害効果を引き起こす. 常温機械灌流法(NMP)は, 移植片機能の維持と回復, および生存率の評価に役立つ. しかし, 高レベルの酸素を必要とするため, 微小血管障害や細菌増殖のリスクを高める可能性のある血液製剤が使用される. それゆえ, 常温機械灌流法は依然として困難な問題である. 一方, 20℃-25℃付近の室温機械灌流法(SNMP)は, NMPに比べて必要な酸素レベルが低くなる. ここでは,SNMPの現状と将来について説明する. |
| Author | 髙橋, 裕之 今井, 浩二 石井, 大介 大谷, 将秀 萩原, 正弘 松野, 直徒 寺口, 博也 岩田, 浩義 鳥海, 飛鳥 横尾, 英樹 小原, 弘道 |
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| References | 4) Reddy S, Greenwood J, Maniakin N, Bhattacharjya S, Zilvetti M, Brockmann J, et al. Non-heart-beating donor porcine livers: the adverse effect of cooling. Liver Transpl. 2005 Jan; 11 (1): 35-8. 3) de Rougemont O, Breitenstein S, Leskosek B, Weber A, Graf R, Clavien PA, et al. One hour hypothermic oxygenated perfusion (HOPE) protects nonviable liver allografts donated after cardiac death. Ann Surg. 2009 May; 8 (5): 674-84. 20) Shonaka T, Matsuno N, Obara H, Yoshikawa R, Nishikawa Y, Ishihara Y, et al Impact of human-derived hemoglobin based oxygen vesicles as a machine perfusion solution for liver donation after cardiac death in a pig model. PLoS One. 2019 Dec; 14 (12): e0226183. 7) Kato A, Singh S, McLeish KR, Edwards MJ, Lentsch AB. Mechanisms of hypothermic protection against ischemic liver injury in mice. Am J Physiol Gastrointest Liver Physiol. 2002 Apr; 282 (4): G608-16. 15) Watanabe R, Kimura M, Matsuno N, Shigeta T, Hsu HC, Muto M, et al. Significant effect of initial flush out solution with use of CPD for DCD liver transplantation. Low Temperature Medicine. 2012; 38 (2): 47. 16) Hsu HC, Matsuno N, Machida N, Enosawa S. Improved Recovery of Hepatocytes Isolated From Warm Ischemic Rat Liver by Citrate Phosphate Dextrose (CPD)-Supplemented Euro-Collins solution. Cell Med. 2013 May; 5 (2-3): 97-101. 6) Vairetti M, Ferrigno A, Carlucci F, Tabucchi A, Rizzo V, Boncompagni E, et al. Subnormothermic machine perfusion protects steatotic livers against preservation injury: a potential for donor pool increase? Liver Transpl. 2009 Jan; 15 (1): 20-9. 11) Ferrigno A, Rizzo V, Boncompagni E, Bianchi A, Gringeri E, Neri D, et al. Machine perfusion at 20°C reduces preservation damage to livers from non-heart beating donors. Cryobiology. 2011 Apr; 62 (2); 152-8. 17) Sakai H. Overview of Potential Clinical Applications of Hemoglobin Vesicles (HbV) as Artificial Red Cells, Evidenced by Preclinical Studies of the Academic Research Consortium. J Funct Biomater. 2017 Mar; 8 (1):10. 1) Moers C, Smits JM, Maathuis MH, Treckmann J, van Gelder F, Napieralski BP, et al. Machine perfusion or cold storage in deceased-donor kidney transplantation. N Engl J Med. 2009 Jan 1;360 (1): 7-19. 14) Kakizaki Y, Miyagi S, Shimizu K, Miyazawa K, Nakanishi W, Tokodai K, et al. The Effects of Short-term Subnormothermic Perfusion After Cold Preservation on Liver Grafts From Donors After Circulatory Death: An Ex Vivo Rat Model. Transplantation. 2018 Apr; 102 (4): e147-e154. 27) Hoyer DP, Mathé Z, Gallinat A, Canbay AC, Treckmann JW, Rauen U, et al. Controlled Oxygenated Rewarming of Cold Stored Livers Prior to Transplantation: First Clinical Application of a New Concept. Transplantation. 2016 Jan; 100 (1): 147-52. 5) Olschewski P, Gass P, Ariyakhagorn V, Jasse K, Hunold G, Menzel M, et al. The influence of storage temperature during machine perfusion on preservation quality of marginal donor livers. Cryobiology. 2010 Jun; 60 (3): 347-43. 23) Westerkamp AC, Mahboub P, Meyer SL, Hottenrott M, Ottens PJ, Wiersema-Buist J, et al. End-ischemic machine perfusion reduces bile duct injury in donation after circulatory death rat donor livers independent of the machine perfusion temperature. Liver Transpl. 2015 Oct; 21 (10): 1300-11. 18) Sakai H, Sou K, Tsuchida E. Hemoglobin-vesicles as an artificial oxygen carrier. Methods Enzymol. 2009; 465: 363-84. 10) Berardo C, Di Pasqua LG, Siciliano V, Rizzo V, Richelmi P, Ferrigno A, et al. Machine Perfusion at 20°C Prevents Ischemic Injury and Reduces Hypoxia-Inducible Factor-1α Expression During Rat Liver Preservation. Ann Transplant. 2017 Sep; 22: 581-589. 12) Fontes P, Lopez R, van der Plaats A, Vodovotz Y, Minervini M, Scott V, et al. Liver preservation with machine perfusion and a newly developed cell-free oxygen carrier solution under subnormothermic conditions. Am J Transplanta. 2015 Feb; 15 (2): 381-94. 19) Shonaka T, Matsuno N, Obara H, Yoshikawa R, Nishikawa Y, Gouchi M, et al. Application of Perfusate With Human-Derived Oxygen Carrier Solution Under Subnormothermic Machine Perfusion for Donation After Cardiac Death Liver Grafts in Pigs. Transplant Proc. 2018 Nov; 50 (9): 2821-2825. 21) Iwata H, Toriumi A, Ishii D, Yamamoto A, Sato Y, Takahashi H, et al. Applicability of Hemoglobin Vesicles as Transplantable Liver Perfusion Preservation Solution. Artificial Blood. 2021 Sep; 29 (1): 43-49. 22) Spetzler VN, Goldaracena N, Echiverri J, Kaths JM, Louis KS, Adeyi OA, et al. Subnormothermic ex vivo liver perfusion is a safe alternative to cold static storage for preserving standard criteria grafts. Liver Transpl. 2016 Nov; 22 (1): 111-9. 25) Shigeta T, Matsuno N, Obara H, Kanazawa H, Tanaka H, Fukuda A, et al. Impact of rewarming preservation by continuous machine perfusion: improved post-transplant recovery in pigs. Transplant Proc. 2013 Jun; 45 (5): 1684-9. 26) Minor T, Efferz P, Fox M, Wohlschlaeger J, Lüer B. Controlled oxygenated rewarming of cold stored liver grafts by thermally graduated machine perfusion prior to reperfusion. Am J Transplant. 2013 Jun; 13 (6): 1450-60. 13) Kakizaki Y, Miyagi S, Shimizu K, Kumata H, Matsumura M, Miyazaki Y, et al. Effects of Subnormothermic Perfusion Before Transplantation for Liver Grafts from Donation After Cardiac Death: A Simplified Dripping Perfusion Methods in Pigs. Transplant Proc. 2018 Jun; 50 (5): 1538-1543. 8) Bruinsma BG, Yeh H, Ozer S, Martins PN, Farmer A, Wu W, et al. Subnormothermic machine perfusion for ex vivo preservation and recovery of the human liver for transplantation. Am J Transplant. 2014 Jun; 14 (6): 1400-9. 9) Tolboom H, Izamis ML, Sharma N, Milwid JM, Uygun B, Berthiaume F, et al. Subnormothermic machine perfusion at both 20°C and 30°C recovers ischemic rat livers for successful transplantation. J Surg Res. 2012 Jun; 175 (1): 149-56. 24) Obara H, Matsuno N, Shigeta T, Enosawa S, Hirano T, Mizunuma H. Rewarming Machine Perfusion System for Liver Transplantation. J Med Devices. 2013 Dec; 7 (4): 041011-7. 2) Guarrera JV, Henry SD, Samstein B, Odeh-Ramadan R, Kinkhabwala M, Goldstein MJ, et al. Hypothermic machine preservation in human liver transplantation: the first clinical series. Am J Transplant. 2010 Feb; 10 (2): 372-81. |
| References_xml | – reference: 6) Vairetti M, Ferrigno A, Carlucci F, Tabucchi A, Rizzo V, Boncompagni E, et al. Subnormothermic machine perfusion protects steatotic livers against preservation injury: a potential for donor pool increase? Liver Transpl. 2009 Jan; 15 (1): 20-9. – reference: 8) Bruinsma BG, Yeh H, Ozer S, Martins PN, Farmer A, Wu W, et al. Subnormothermic machine perfusion for ex vivo preservation and recovery of the human liver for transplantation. Am J Transplant. 2014 Jun; 14 (6): 1400-9. – reference: 4) Reddy S, Greenwood J, Maniakin N, Bhattacharjya S, Zilvetti M, Brockmann J, et al. Non-heart-beating donor porcine livers: the adverse effect of cooling. Liver Transpl. 2005 Jan; 11 (1): 35-8. – reference: 24) Obara H, Matsuno N, Shigeta T, Enosawa S, Hirano T, Mizunuma H. Rewarming Machine Perfusion System for Liver Transplantation. J Med Devices. 2013 Dec; 7 (4): 041011-7. – reference: 5) Olschewski P, Gass P, Ariyakhagorn V, Jasse K, Hunold G, Menzel M, et al. The influence of storage temperature during machine perfusion on preservation quality of marginal donor livers. Cryobiology. 2010 Jun; 60 (3): 347-43. – reference: 23) Westerkamp AC, Mahboub P, Meyer SL, Hottenrott M, Ottens PJ, Wiersema-Buist J, et al. End-ischemic machine perfusion reduces bile duct injury in donation after circulatory death rat donor livers independent of the machine perfusion temperature. Liver Transpl. 2015 Oct; 21 (10): 1300-11. – reference: 16) Hsu HC, Matsuno N, Machida N, Enosawa S. Improved Recovery of Hepatocytes Isolated From Warm Ischemic Rat Liver by Citrate Phosphate Dextrose (CPD)-Supplemented Euro-Collins solution. Cell Med. 2013 May; 5 (2-3): 97-101. – reference: 9) Tolboom H, Izamis ML, Sharma N, Milwid JM, Uygun B, Berthiaume F, et al. Subnormothermic machine perfusion at both 20°C and 30°C recovers ischemic rat livers for successful transplantation. J Surg Res. 2012 Jun; 175 (1): 149-56. – reference: 12) Fontes P, Lopez R, van der Plaats A, Vodovotz Y, Minervini M, Scott V, et al. Liver preservation with machine perfusion and a newly developed cell-free oxygen carrier solution under subnormothermic conditions. Am J Transplanta. 2015 Feb; 15 (2): 381-94. – reference: 17) Sakai H. Overview of Potential Clinical Applications of Hemoglobin Vesicles (HbV) as Artificial Red Cells, Evidenced by Preclinical Studies of the Academic Research Consortium. J Funct Biomater. 2017 Mar; 8 (1):10. – reference: 26) Minor T, Efferz P, Fox M, Wohlschlaeger J, Lüer B. Controlled oxygenated rewarming of cold stored liver grafts by thermally graduated machine perfusion prior to reperfusion. Am J Transplant. 2013 Jun; 13 (6): 1450-60. – reference: 15) Watanabe R, Kimura M, Matsuno N, Shigeta T, Hsu HC, Muto M, et al. Significant effect of initial flush out solution with use of CPD for DCD liver transplantation. Low Temperature Medicine. 2012; 38 (2): 47. – reference: 27) Hoyer DP, Mathé Z, Gallinat A, Canbay AC, Treckmann JW, Rauen U, et al. Controlled Oxygenated Rewarming of Cold Stored Livers Prior to Transplantation: First Clinical Application of a New Concept. Transplantation. 2016 Jan; 100 (1): 147-52. – reference: 11) Ferrigno A, Rizzo V, Boncompagni E, Bianchi A, Gringeri E, Neri D, et al. Machine perfusion at 20°C reduces preservation damage to livers from non-heart beating donors. Cryobiology. 2011 Apr; 62 (2); 152-8. – reference: 19) Shonaka T, Matsuno N, Obara H, Yoshikawa R, Nishikawa Y, Gouchi M, et al. Application of Perfusate With Human-Derived Oxygen Carrier Solution Under Subnormothermic Machine Perfusion for Donation After Cardiac Death Liver Grafts in Pigs. Transplant Proc. 2018 Nov; 50 (9): 2821-2825. – reference: 7) Kato A, Singh S, McLeish KR, Edwards MJ, Lentsch AB. Mechanisms of hypothermic protection against ischemic liver injury in mice. Am J Physiol Gastrointest Liver Physiol. 2002 Apr; 282 (4): G608-16. – reference: 13) Kakizaki Y, Miyagi S, Shimizu K, Kumata H, Matsumura M, Miyazaki Y, et al. Effects of Subnormothermic Perfusion Before Transplantation for Liver Grafts from Donation After Cardiac Death: A Simplified Dripping Perfusion Methods in Pigs. Transplant Proc. 2018 Jun; 50 (5): 1538-1543. – reference: 20) Shonaka T, Matsuno N, Obara H, Yoshikawa R, Nishikawa Y, Ishihara Y, et al Impact of human-derived hemoglobin based oxygen vesicles as a machine perfusion solution for liver donation after cardiac death in a pig model. PLoS One. 2019 Dec; 14 (12): e0226183. – reference: 3) de Rougemont O, Breitenstein S, Leskosek B, Weber A, Graf R, Clavien PA, et al. One hour hypothermic oxygenated perfusion (HOPE) protects nonviable liver allografts donated after cardiac death. Ann Surg. 2009 May; 8 (5): 674-84. – reference: 14) Kakizaki Y, Miyagi S, Shimizu K, Miyazawa K, Nakanishi W, Tokodai K, et al. The Effects of Short-term Subnormothermic Perfusion After Cold Preservation on Liver Grafts From Donors After Circulatory Death: An Ex Vivo Rat Model. Transplantation. 2018 Apr; 102 (4): e147-e154. – reference: 21) Iwata H, Toriumi A, Ishii D, Yamamoto A, Sato Y, Takahashi H, et al. Applicability of Hemoglobin Vesicles as Transplantable Liver Perfusion Preservation Solution. Artificial Blood. 2021 Sep; 29 (1): 43-49. – reference: 2) Guarrera JV, Henry SD, Samstein B, Odeh-Ramadan R, Kinkhabwala M, Goldstein MJ, et al. Hypothermic machine preservation in human liver transplantation: the first clinical series. Am J Transplant. 2010 Feb; 10 (2): 372-81. – reference: 10) Berardo C, Di Pasqua LG, Siciliano V, Rizzo V, Richelmi P, Ferrigno A, et al. Machine Perfusion at 20°C Prevents Ischemic Injury and Reduces Hypoxia-Inducible Factor-1α Expression During Rat Liver Preservation. Ann Transplant. 2017 Sep; 22: 581-589. – reference: 22) Spetzler VN, Goldaracena N, Echiverri J, Kaths JM, Louis KS, Adeyi OA, et al. Subnormothermic ex vivo liver perfusion is a safe alternative to cold static storage for preserving standard criteria grafts. Liver Transpl. 2016 Nov; 22 (1): 111-9. – reference: 1) Moers C, Smits JM, Maathuis MH, Treckmann J, van Gelder F, Napieralski BP, et al. Machine perfusion or cold storage in deceased-donor kidney transplantation. N Engl J Med. 2009 Jan 1;360 (1): 7-19. – reference: 18) Sakai H, Sou K, Tsuchida E. Hemoglobin-vesicles as an artificial oxygen carrier. Methods Enzymol. 2009; 465: 363-84. – reference: 25) Shigeta T, Matsuno N, Obara H, Kanazawa H, Tanaka H, Fukuda A, et al. Impact of rewarming preservation by continuous machine perfusion: improved post-transplant recovery in pigs. Transplant Proc. 2013 Jun; 45 (5): 1684-9. |
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| Snippet | 近年, 機械灌流保存が冷却保存よりも有益であることが明らかになってきた. 冷温によって引き起こされる保存傷害は, 不十分な細胞代謝機能やエネルギー貯蔵の枯渇, 冷... 「要旨」近年, 機械灌流保存が冷却保存よりも有益であることが明らかになってきた. 冷温によって引き起こされる保存傷害は, 不十分な細胞代謝機能やエネルギー貯蔵の枯渇, ... |
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| SubjectTerms | 人工赤血球 体外式膜型人工肺 室温機械灌流法 復温機械灌流法 臓器保存法 |
| Title | 室温機械灌流保存法の現状と今後 |
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