高齢者の腰痛症におけるサルコペニア
「はじめに」 平成25年度厚生労働省から出された国民生活基礎調査によると, 自覚症状のあるもの(有訴者)の症状では男性では腰痛が人口千人あたり92.2人で, 平成22年に引き続き第一位, 女性でも肩こりに次いで118.2人と第二位である. また通院者率では腰痛症は男性で第4位, 女性で第2位であり, 国民の体の不調の訴えにおける腰痛の占める度合いは決して少なくない. 腰痛や腰椎の変性疾患のために移動能力が低下した高齢者は, 現在あるいは将来的に要介護となる危険性があり, ロコモティブシンドロームにおける重要な疾患に含まれる. 腰痛の原因として考えられるものに, 椎間板, 骨(椎体)椎間関節,...
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| Published in | PAIN RESEARCH Vol. 32; no. 1; pp. 13 - 18 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Japanese |
| Published |
日本疼痛学会
31.03.2017
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0915-8588 2187-4697 |
| DOI | 10.11154/pain.32.13 |
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| Abstract | 「はじめに」 平成25年度厚生労働省から出された国民生活基礎調査によると, 自覚症状のあるもの(有訴者)の症状では男性では腰痛が人口千人あたり92.2人で, 平成22年に引き続き第一位, 女性でも肩こりに次いで118.2人と第二位である. また通院者率では腰痛症は男性で第4位, 女性で第2位であり, 国民の体の不調の訴えにおける腰痛の占める度合いは決して少なくない. 腰痛や腰椎の変性疾患のために移動能力が低下した高齢者は, 現在あるいは将来的に要介護となる危険性があり, ロコモティブシンドロームにおける重要な疾患に含まれる. 腰痛の原因として考えられるものに, 椎間板, 骨(椎体)椎間関節, 神経などが考えられるが, 原因を特定することが難しいことから約85%は原因の特定できない非特異的腰痛と言われている. しかし近年, この85%という数値が一人歩きし, 「腰痛は原因不明の病」との誤解が少なからず広まっていることに対し, 腰痛の原因を医学的に追求する意義が高まっているのも事実である. |
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| AbstractList | 「はじめに」 平成25年度厚生労働省から出された国民生活基礎調査によると, 自覚症状のあるもの(有訴者)の症状では男性では腰痛が人口千人あたり92.2人で, 平成22年に引き続き第一位, 女性でも肩こりに次いで118.2人と第二位である. また通院者率では腰痛症は男性で第4位, 女性で第2位であり, 国民の体の不調の訴えにおける腰痛の占める度合いは決して少なくない. 腰痛や腰椎の変性疾患のために移動能力が低下した高齢者は, 現在あるいは将来的に要介護となる危険性があり, ロコモティブシンドロームにおける重要な疾患に含まれる. 腰痛の原因として考えられるものに, 椎間板, 骨(椎体)椎間関節, 神経などが考えられるが, 原因を特定することが難しいことから約85%は原因の特定できない非特異的腰痛と言われている. しかし近年, この85%という数値が一人歩きし, 「腰痛は原因不明の病」との誤解が少なからず広まっていることに対し, 腰痛の原因を医学的に追求する意義が高まっているのも事実である. |
| Author | 酒井, 義人 |
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| DOI | 10.11154/pain.32.13 |
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| References | 24) Visser, M., Pahor, M., Taaffe, D.R., Goodpaster, B.H., Simonsick, E.M., Newman, A.B., Nevitt, M., Harris, T.B., Relationship of interleukin–6 and tumor necrosis factor–alpha with muscle mass and muscle strength in the elderly men and women. The Health ABC Study, J. Gerontol. Med. Sci., 57A (2002) 326–332. 1) Al Faraj, S., Al Mutairi, K., Vitamin D deficiency and chronic low back pain in Saudi Arabia, Spine, 28 (2003) 177–179. 19) 酒井義人, 原田敦, 伊藤定之, 飛田哲朗, 伊藤研悠, 慢性腰痛症におけるサルコペニア, J. Spine Res., 7 (2016) 1019–1023. 2) Braumgartner, R.N., Koehler, K.M., Gallagher, D., Romero, L., Heymsfield, S.B., Ross, R.R., Garry, P.J., Lindeman, R.D., Epidemiology of sarcopenia among the elderly in New Mexico, Am. J. Epidemiol., 147 (1988) 755–763. 3) Cruz–Jentoft, A.J., Baeyens, J.P., Bauer, J.M., Boire, Y., Cederholm, T., Landi, F., Martin, F.C., Michel, J.P., Rolland, Y., Schneider, S.M.,Topinková, E., Vandewoude, M., Zamboni, M., European Working Group on Sarcopenia in Older People: Sarcopenia European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People, AgeAging 39 (2010) 412–423. 10) 厚生労働省, 世帯員の健康状況, 平成25年国民生活基礎調査の概況. (http: http://www.mhlw. go.jp/toukei/saikin/hw/k–tyosa/k–tyosa13/dl/04. pdf 9) Koca, I., Savas, E., Ozturk, Z.A., Boyaci, A., Tutoglu, A., Alkan, S., Yildiz, H., Kimyon, G., The evaluation in terms of sarcopenia of patients with fibromyagia syndrome, Wien Klin Wochenschr 2015; Jul 4. Epub ahead of print 11) Laurentani, F., Russo, C.R., Bandinelli, S., Bartali, B., Cavazzini, C., Di Iorio, A., Corsi, A.M., Rantanen, T., Guralnik, J.M., Ferrucci, L., Ageassociated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia, J. Appl. Physiol., 95 (2003) 1851–1860. 15) 日本整形外科学会, ロコモティブシンドロームの原因となる疾患. ロコモティブシンドローム診療ガイド2010, 文光堂, 2010, pp44‒50. 6) Handschin, C., Spiegelman, B.M., The role of exercise and PGC–1α in inflammation and chronic disease, Nature, 454 (2008) 463–469. 7) Hida, T., Ishiguro, N., Shimokata, H., Sakai, Y., Matsui, Y., Takemura, M., Terabe, Y., Harada, A., High prevalence of sarcopenia and reduced leg muscle mass in Japanese patients immediately after a hip fracture, Geriatr. Gerontol. Int., 13 (2013) 413–420. 23) Tsujinaka, T., Fujita, J., Ebisui, C., Yano, M., Kominami, E., Suzuki, K., Tanaka, K., Katsume, A., Ohsugi, Y., Shiozaki, H., Monden, M., Interleukin 6 receptor antibody inhibits muscle atrophy and modulates proteolytic systems in interleukin 6 transgenic mice, J. Clin. Invest., 97 (1996) 244–249. 22) Scott, D., Blizzard, L., Fell, J., Jones, G.,Prospective study of self–reported pain, radiographic osteoarthritis, sarcopenia progression, and falls risk in community–dwelling older adults, Arthritis Care Res., 64 (2012) 30–37. 16) Pojednic, R.M., Ceglia, L., The emerging biomolecular role of vitamin D in skeletal muscle, Exerc. Sport Sci. Rev., 42 (2014) 76–81. 17) Queiroz, B.Z., Pereira, D.S., Rosa, N.M., Lopes, R.A., Felício, D.C., Pereira, D.G., Dias, J.M., Dias, R.C., Pereira, L.S., Functional performance and plasma cytokine levels in elderly women with and without low back pain, J. Back Musculoskelet. Rehabil., 28 (2015) 343–349. 12) Lexell, J., Taylor, C.C., Sjöstrom, M., What is the cause of the ageing atrophy? Total number, size and proportion of different fiber types studied in whole vastus lateralis muscle from 15–to 83–years–old men, J. Neurosci., 84 (1988) 275–294. 14) Nagae, M., Hiraga, T., Wakabayashi, H., Wang, L., Iwata, K., Yoneda, T., Osteoclasts play a part in pain due to the inflammation adjacent to bone, Bone, 39 (2006) 1107–1115. 20) Salvioli, S., Capri, M., Valensin, S., Tieri, P., Monti, D., Ottaviani, E., Franceschi, C., Inflamm–aging, cytokines and aging: state of the art, new hypotheses in the role of mitochondria and new perspectives from systemic biology, Curr. Pharm. Des., 12 (2006) 3161–3171. 13) Lotfi, A., Abdel–Nasser, A.M., Hamdy, A., Omran, A.A., El–Rehany M.A., Hypovitaminosis D in female patients with chronic low back pain, Clin. Rheumatol., 26 (2007) 1895–1901. 18) Sainoh, T., Orita, S., Miyagi, M., Inoue, G., Kamoda, H., Ishikawa, T., Yamauchi, K., Suzuki, M., Sakuma, Y., Kubota, G., Oikawa, Y., Inage,K., Sato, J., Nakata, Y., Nakamura, J., Aoki, Y., Toyone, T., Takahashi, K., Ohtori, S., Single intradiscal aministration of the Tumor Necrosis Factor–Alpha Inhibitor, Etanercept, for patients with discogenic low back pain, Pain Med., 17 (2015) 40–45. 4) Deyo, R.A., Weinstein J.N., Low back pain, N. Engl. J. Med., 344 (2001) 363–370. 5) Haddad, F., Zaldivar, F., Cooper, D.M., Adams, G.R., IL–6–induced skeletal muscle atrophy, J. Appl. Physiol., 98 (2005) 911–917. 8) Ito, A., Kumamoto, E., Takeda, M., Shibata, K., Sagai, H., Yoshimura, M., Mechanisms for ovariectomy–induced hyperalgesia and its relief by calcitonin: Participation of 5–HT1A–like receptor on C–afferent terminals in substantia gelatinosa of the rat spinal cord, J. Neurosci., 20 (2000) 6302–6308. 21) Sanada, K., Miyachi, M., Tanimoto, M., Yamamoto, K., Murakami, H., Okumura, S., Gando, Y., Suzuki, K., Tabata, I., Higuchi, M., A cross–sectional study of sarcopenia in Japanese men and women: reference values and association with cardiovascular risk factors, Eur. J. App. Physiol., 110 (2010) 57–55. |
| References_xml | – reference: 18) Sainoh, T., Orita, S., Miyagi, M., Inoue, G., Kamoda, H., Ishikawa, T., Yamauchi, K., Suzuki, M., Sakuma, Y., Kubota, G., Oikawa, Y., Inage,K., Sato, J., Nakata, Y., Nakamura, J., Aoki, Y., Toyone, T., Takahashi, K., Ohtori, S., Single intradiscal aministration of the Tumor Necrosis Factor–Alpha Inhibitor, Etanercept, for patients with discogenic low back pain, Pain Med., 17 (2015) 40–45. – reference: 19) 酒井義人, 原田敦, 伊藤定之, 飛田哲朗, 伊藤研悠, 慢性腰痛症におけるサルコペニア, J. Spine Res., 7 (2016) 1019–1023. – reference: 10) 厚生労働省, 世帯員の健康状況, 平成25年国民生活基礎調査の概況. (http: http://www.mhlw. go.jp/toukei/saikin/hw/k–tyosa/k–tyosa13/dl/04. pdf) – reference: 14) Nagae, M., Hiraga, T., Wakabayashi, H., Wang, L., Iwata, K., Yoneda, T., Osteoclasts play a part in pain due to the inflammation adjacent to bone, Bone, 39 (2006) 1107–1115. – reference: 11) Laurentani, F., Russo, C.R., Bandinelli, S., Bartali, B., Cavazzini, C., Di Iorio, A., Corsi, A.M., Rantanen, T., Guralnik, J.M., Ferrucci, L., Ageassociated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia, J. Appl. Physiol., 95 (2003) 1851–1860. – reference: 13) Lotfi, A., Abdel–Nasser, A.M., Hamdy, A., Omran, A.A., El–Rehany M.A., Hypovitaminosis D in female patients with chronic low back pain, Clin. Rheumatol., 26 (2007) 1895–1901. – reference: 23) Tsujinaka, T., Fujita, J., Ebisui, C., Yano, M., Kominami, E., Suzuki, K., Tanaka, K., Katsume, A., Ohsugi, Y., Shiozaki, H., Monden, M., Interleukin 6 receptor antibody inhibits muscle atrophy and modulates proteolytic systems in interleukin 6 transgenic mice, J. Clin. Invest., 97 (1996) 244–249. – reference: 12) Lexell, J., Taylor, C.C., Sjöstrom, M., What is the cause of the ageing atrophy? Total number, size and proportion of different fiber types studied in whole vastus lateralis muscle from 15–to 83–years–old men, J. Neurosci., 84 (1988) 275–294. – reference: 20) Salvioli, S., Capri, M., Valensin, S., Tieri, P., Monti, D., Ottaviani, E., Franceschi, C., Inflamm–aging, cytokines and aging: state of the art, new hypotheses in the role of mitochondria and new perspectives from systemic biology, Curr. Pharm. Des., 12 (2006) 3161–3171. – reference: 15) 日本整形外科学会, ロコモティブシンドロームの原因となる疾患. ロコモティブシンドローム診療ガイド2010, 文光堂, 2010, pp44‒50. – reference: 21) Sanada, K., Miyachi, M., Tanimoto, M., Yamamoto, K., Murakami, H., Okumura, S., Gando, Y., Suzuki, K., Tabata, I., Higuchi, M., A cross–sectional study of sarcopenia in Japanese men and women: reference values and association with cardiovascular risk factors, Eur. J. App. Physiol., 110 (2010) 57–55. – reference: 9) Koca, I., Savas, E., Ozturk, Z.A., Boyaci, A., Tutoglu, A., Alkan, S., Yildiz, H., Kimyon, G., The evaluation in terms of sarcopenia of patients with fibromyagia syndrome, Wien Klin Wochenschr 2015; Jul 4. Epub ahead of print – reference: 2) Braumgartner, R.N., Koehler, K.M., Gallagher, D., Romero, L., Heymsfield, S.B., Ross, R.R., Garry, P.J., Lindeman, R.D., Epidemiology of sarcopenia among the elderly in New Mexico, Am. J. Epidemiol., 147 (1988) 755–763. – reference: 3) Cruz–Jentoft, A.J., Baeyens, J.P., Bauer, J.M., Boire, Y., Cederholm, T., Landi, F., Martin, F.C., Michel, J.P., Rolland, Y., Schneider, S.M.,Topinková, E., Vandewoude, M., Zamboni, M., European Working Group on Sarcopenia in Older People: Sarcopenia European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People, AgeAging 39 (2010) 412–423. – reference: 17) Queiroz, B.Z., Pereira, D.S., Rosa, N.M., Lopes, R.A., Felício, D.C., Pereira, D.G., Dias, J.M., Dias, R.C., Pereira, L.S., Functional performance and plasma cytokine levels in elderly women with and without low back pain, J. Back Musculoskelet. Rehabil., 28 (2015) 343–349. – reference: 5) Haddad, F., Zaldivar, F., Cooper, D.M., Adams, G.R., IL–6–induced skeletal muscle atrophy, J. Appl. Physiol., 98 (2005) 911–917. – reference: 7) Hida, T., Ishiguro, N., Shimokata, H., Sakai, Y., Matsui, Y., Takemura, M., Terabe, Y., Harada, A., High prevalence of sarcopenia and reduced leg muscle mass in Japanese patients immediately after a hip fracture, Geriatr. Gerontol. Int., 13 (2013) 413–420. – reference: 6) Handschin, C., Spiegelman, B.M., The role of exercise and PGC–1α in inflammation and chronic disease, Nature, 454 (2008) 463–469. – reference: 16) Pojednic, R.M., Ceglia, L., The emerging biomolecular role of vitamin D in skeletal muscle, Exerc. Sport Sci. Rev., 42 (2014) 76–81. – reference: 1) Al Faraj, S., Al Mutairi, K., Vitamin D deficiency and chronic low back pain in Saudi Arabia, Spine, 28 (2003) 177–179. – reference: 4) Deyo, R.A., Weinstein J.N., Low back pain, N. Engl. J. Med., 344 (2001) 363–370. – reference: 8) Ito, A., Kumamoto, E., Takeda, M., Shibata, K., Sagai, H., Yoshimura, M., Mechanisms for ovariectomy–induced hyperalgesia and its relief by calcitonin: Participation of 5–HT1A–like receptor on C–afferent terminals in substantia gelatinosa of the rat spinal cord, J. Neurosci., 20 (2000) 6302–6308. – reference: 22) Scott, D., Blizzard, L., Fell, J., Jones, G.,Prospective study of self–reported pain, radiographic osteoarthritis, sarcopenia progression, and falls risk in community–dwelling older adults, Arthritis Care Res., 64 (2012) 30–37. – reference: 24) Visser, M., Pahor, M., Taaffe, D.R., Goodpaster, B.H., Simonsick, E.M., Newman, A.B., Nevitt, M., Harris, T.B., Relationship of interleukin–6 and tumor necrosis factor–alpha with muscle mass and muscle strength in the elderly men and women. The Health ABC Study, J. Gerontol. Med. Sci., 57A (2002) 326–332. |
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| SubjectTerms | Aging Elderly person Low back pain Sarcopenia |
| Title | 高齢者の腰痛症におけるサルコペニア |
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