カルボプラチンをベースとした肺がん化学療法に対するアプレピタントの制吐効果

「緒言」がん化学療法による悪心・嘔吐（chemotherapy induced nausea and vomiting：CINV）は, 患者にとって最も苦痛な副作用の一つであり, 患者quality of life（QOL）を低下させる. また, CINVにより治療強度が低下することは, 抗腫瘍効果を弱めることにも繋がる. 従って, CINVを制御することは, がん化学療法を継続するうえで必要不可欠である. すでに米国臨床腫瘍学会（ASCO）やNational Comprehensive Cancer Network（NCCN）から, CINVを予防するための制吐療法ガイドラインが作成され1～...

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Published in医療薬学 Vol. 38; no. 3; pp. 196 - 203
Main Authors 光家, 勉, 樹下, 成徳, 山中, 晃, 富田, 国男
Format Journal Article
LanguageJapanese
Published 一般社団法人日本医療薬学会 2012
日本医療薬学会
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ISSN1346-342X
1882-1499
DOI10.5649/jjphcs.38.196

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Abstract 「緒言」がん化学療法による悪心・嘔吐（chemotherapy induced nausea and vomiting：CINV）は, 患者にとって最も苦痛な副作用の一つであり, 患者quality of life（QOL）を低下させる. また, CINVにより治療強度が低下することは, 抗腫瘍効果を弱めることにも繋がる. 従って, CINVを制御することは, がん化学療法を継続するうえで必要不可欠である. すでに米国臨床腫瘍学会（ASCO）やNational Comprehensive Cancer Network（NCCN）から, CINVを予防するための制吐療法ガイドラインが作成され1～2）, 2010年5月には日本癌治療学会から, 制吐薬適正使用ガイドラインが発刊された3）. これらのガイドラインでは, CINVを発症させないことが目的となっており, 催吐性リスク分類に基づいた悪心・嘔吐予防をするように推奨されている.
AbstractList 「緒言」がん化学療法による悪心・嘔吐（chemotherapy induced nausea and vomiting：CINV）は, 患者にとって最も苦痛な副作用の一つであり, 患者quality of life（QOL）を低下させる. また, CINVにより治療強度が低下することは, 抗腫瘍効果を弱めることにも繋がる. 従って, CINVを制御することは, がん化学療法を継続するうえで必要不可欠である. すでに米国臨床腫瘍学会（ASCO）やNational Comprehensive Cancer Network（NCCN）から, CINVを予防するための制吐療法ガイドラインが作成され1～2）, 2010年5月には日本癌治療学会から, 制吐薬適正使用ガイドラインが発刊された3）. これらのガイドラインでは, CINVを発症させないことが目的となっており, 催吐性リスク分類に基づいた悪心・嘔吐予防をするように推奨されている.
Author 樹下, 成徳
富田, 国男
山中, 晃
光家, 勉
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References 1)Kris MG, Hesketh PJ, Somerfield MR, Feyer P, Clark-Snow R, MKoeller J, Morrow GR, Chinnery LW, Chesney MJ, Gralla RJ, Grunberg SM, American Society of Clinical Oncology Guideline for Antiemetics in Oncology: Update 2006, J Clin Oncol, 2006, 24, 2932-2937.
3)日本癌治療学会編：“制吐薬適正使用ガイドライン”, 第1版, 金原出版, 東京, 2010, pp.1-85.
4)Hesketh PJ, Grunberg SM, Gralla RJ, Warr DG, Roila F, de Wit R, Chawla SP, Carides AD, Ianus J, Elmer ME, Evans JK, Beck K, Reines S, Horgan KJ, The Oral Neurokinin-1 Antagonist Aprepitant for the Prevention of Chemotherapy-Induced Nausea and Vomiting: A Multinational, Randomized, Double-Blind, Placebo-Controlled Trial in Patients Receiving High-Dose Cisplatin-The Aprepitant Protocol 052 Study Group, J Clin Oncol, 2003, 21, 4112-4119.
5)Takahashi T, Hoshi E, Takagi M, Katsumata N, Kawahara M, Eguchi K, Multicenter, phaseⅡ, placebo-controlled, double-blind, randomized study of aprepitant in Japanese patients receiving high-dose cisplatin, Cancer Science, 2010, 11, 2455-2461.
10)Levine ME, Gillis MG, Koch SY, Voss AC, Stern RM, Koch KL, Protein and Ginger for the Treatment of Chemotherapy-Induced Delayed Nausea, J Alternative and Complementary Medicine, 2008, 14, 545-551.
2)National Comprehensive Cancer Network, NCCN Clinical Practice Guidelines in Oncology: Antiemesis, v4, 2009.
7)Hesketh PJ, Kris MG, Grunberg SM, Beck T, Hainsworth JD, Harker G, Aapro MS, Gandara D, Lindley CM, Proposal for Classifying the Acute Emetogenicity of Cancer Chemotherapy, J Clin Oncol, 1997, 15, 103-109.
8)Saito M, Aogi K, Sekine I, Yoshizawa H, Yanagita Y, Sakai H, Inoue K, Kitagawa C, Ogura T, Mitsuhashi S, Palonosetron plus dexamethasone versus granisetron plus dexamethasone for prevention of nausea and vomiting during chemotherapy: a double-blind, double-dummy, randmised, comparative phaseⅢ trial, Lancet Oncology, 2009, 2, 115-124.
9)Lijun T, Jiangtao L, Xiuli L, Jie C, Zhijun Y, Huifen Y, Daxin Z, Clinical research of Olanzapine for prevention of chemotherapy-induced nausea and vomiting, Journal of Experimental & Clinical Cancer Research, 2009, 28, 131.
6)Rapoport BL, Jordan K, Boice JA, Taylor A, Brown C, Hardwick JS, Carides A, Webb T, Schmoll HJ, Aprepitant for the prevention of chemotherapy-induced nausea and vomiting associated with a broad range of moderately emetogenic chemotherapies and tumor types: a randomized, double-blind study, Support Care Cancer, 2010, 18, 423-431.
References_xml – reference: 5)Takahashi T, Hoshi E, Takagi M, Katsumata N, Kawahara M, Eguchi K, Multicenter, phaseⅡ, placebo-controlled, double-blind, randomized study of aprepitant in Japanese patients receiving high-dose cisplatin, Cancer Science, 2010, 11, 2455-2461.
– reference: 3)日本癌治療学会編：“制吐薬適正使用ガイドライン”, 第1版, 金原出版, 東京, 2010, pp.1-85.
– reference: 7)Hesketh PJ, Kris MG, Grunberg SM, Beck T, Hainsworth JD, Harker G, Aapro MS, Gandara D, Lindley CM, Proposal for Classifying the Acute Emetogenicity of Cancer Chemotherapy, J Clin Oncol, 1997, 15, 103-109.
– reference: 10)Levine ME, Gillis MG, Koch SY, Voss AC, Stern RM, Koch KL, Protein and Ginger for the Treatment of Chemotherapy-Induced Delayed Nausea, J Alternative and Complementary Medicine, 2008, 14, 545-551.
– reference: 1)Kris MG, Hesketh PJ, Somerfield MR, Feyer P, Clark-Snow R, MKoeller J, Morrow GR, Chinnery LW, Chesney MJ, Gralla RJ, Grunberg SM, American Society of Clinical Oncology Guideline for Antiemetics in Oncology: Update 2006, J Clin Oncol, 2006, 24, 2932-2937.
– reference: 4)Hesketh PJ, Grunberg SM, Gralla RJ, Warr DG, Roila F, de Wit R, Chawla SP, Carides AD, Ianus J, Elmer ME, Evans JK, Beck K, Reines S, Horgan KJ, The Oral Neurokinin-1 Antagonist Aprepitant for the Prevention of Chemotherapy-Induced Nausea and Vomiting: A Multinational, Randomized, Double-Blind, Placebo-Controlled Trial in Patients Receiving High-Dose Cisplatin-The Aprepitant Protocol 052 Study Group, J Clin Oncol, 2003, 21, 4112-4119.
– reference: 9)Lijun T, Jiangtao L, Xiuli L, Jie C, Zhijun Y, Huifen Y, Daxin Z, Clinical research of Olanzapine for prevention of chemotherapy-induced nausea and vomiting, Journal of Experimental & Clinical Cancer Research, 2009, 28, 131.
– reference: 2)National Comprehensive Cancer Network, NCCN Clinical Practice Guidelines in Oncology: Antiemesis, v4, 2009.
– reference: 6)Rapoport BL, Jordan K, Boice JA, Taylor A, Brown C, Hardwick JS, Carides A, Webb T, Schmoll HJ, Aprepitant for the prevention of chemotherapy-induced nausea and vomiting associated with a broad range of moderately emetogenic chemotherapies and tumor types: a randomized, double-blind study, Support Care Cancer, 2010, 18, 423-431.
– reference: 8)Saito M, Aogi K, Sekine I, Yoshizawa H, Yanagita Y, Sakai H, Inoue K, Kitagawa C, Ogura T, Mitsuhashi S, Palonosetron plus dexamethasone versus granisetron plus dexamethasone for prevention of nausea and vomiting during chemotherapy: a double-blind, double-dummy, randmised, comparative phaseⅢ trial, Lancet Oncology, 2009, 2, 115-124.
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Title カルボプラチンをベースとした肺がん化学療法に対するアプレピタントの制吐効果
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