bone morphogenetic protein(BMP)サイトカインファミリーの卵胞発育に与える影響について
卵子の発育および成熟には、それを内在する卵胞の良好な発育が必要不可欠である。特に初期卵胞はFSH受容体を有していないため、良好な初期卵胞発育のためにはゴナドトロピンよりも、卵巣局所因子が重要であることが考えられる。卵巣局所因子のうち、特にTGF-βsuperfamily に属するbone morphogenetic protein(BMP)サイトカインがこれまで良く研究されてきた。本稿では卵巣におけるBMPサイトカインについて、我々の行ってきた研究も含め紹介する。...
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| Published in | Reproductive Immunology and Biology Vol. 32; pp. 7 - 12 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
日本生殖免疫学会
2017
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1881-607X 1881-7211 |
| DOI | 10.3192/jsirib.32.7 |
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| Abstract | 卵子の発育および成熟には、それを内在する卵胞の良好な発育が必要不可欠である。特に初期卵胞はFSH受容体を有していないため、良好な初期卵胞発育のためにはゴナドトロピンよりも、卵巣局所因子が重要であることが考えられる。卵巣局所因子のうち、特にTGF-βsuperfamily に属するbone morphogenetic protein(BMP)サイトカインがこれまで良く研究されてきた。本稿では卵巣におけるBMPサイトカインについて、我々の行ってきた研究も含め紹介する。 |
|---|---|
| AbstractList | 卵子の発育および成熟には、それを内在する卵胞の良好な発育が必要不可欠である。特に初期卵胞はFSH受容体を有していないため、良好な初期卵胞発育のためにはゴナドトロピンよりも、卵巣局所因子が重要であることが考えられる。卵巣局所因子のうち、特にTGF-βsuperfamily に属するbone morphogenetic protein(BMP)サイトカインがこれまで良く研究されてきた。本稿では卵巣におけるBMPサイトカインについて、我々の行ってきた研究も含め紹介する。 |
| Author | 吉野, 修 秋山, 育美 大須賀, 穣 齋藤, 滋 |
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| References | 11) Akiyama I, Yoshino O, Osuga Y, Shi J, Hirota Y, Hirata T, Harada M, Koga K, Fujimoto A, Yano T, Taketani Y: The localization and regulation of proprotein convertase subtilisin/kexin (PCSK) 6 in human ovary. Am J Reprod Immunol 2012;68:491-498. 2) Groome NP, Illingworth PJ, O'Brien M, Pai R, Rodger FE, Mather JP, McNeilly AS: Measurement of dimeric inhibin B throughout the human menstrual cycle. J Clin Endocrinol Metab 1996;81:1401-1405. 1) Urist MR: Bone: formation by autoinduction. Science 1965;150:893-899. 16) de Sousa Lopes SM, Roelen BA, Monteiro RM, Emmens R, Lin HY, Li E, Lawson KA, Mummery CL: BMP signaling mediated by ALK2 in the visceral endoderm is necessary for the generation of primordial germ cells in the mouse embryo. Genes Dev 2004;18:1838-1849. 4) Dong J, Albertini DF, Nishimori K, Kumar TR, Lu N, Matzuk MM: Growth differentiation factor-9 is required during early ovarian folliculogenesis. Nature 1996;383:531-535. 25) Yoshino O, McMahon HE, Sharma S, Shimasaki S: A unique preovulatory expression pattern plays a key role in the physiological functions of BMP-15 in the mouse. Proc Natl Acad Sci U S A 2006;103:10678-10683. 10) Hashimoto O, Moore RK, Shimasaki S: Posttranslational processing of mouse and human BMP-15: potential implication in the determination of ovulation quota. Proc Natl Acad Sci U S A 2005;102:5426-5431. 14) Ying Y, Liu XM, Marble A, Lawson KA, Zhao GQ: Requirement of Bmp8b for the generation of primordial germ cells in the mouse. Mol Endocrinol 2000;14:1053-1063. 19) Ogura-Nose S, Yoshino O, Osuga Y, Shi J, Hiroi H, Yano T, Taketani Y: Anti-Mullerian hormone (AMH) is induced by bone morphogenetic protein (BMP) cytokines in human granulosa cells. Eur J Obstet Gynecol Reprod Biol 2012;164:44-7 20) Ogura-Nose S, Yoshino O, Akiyama I, Hirota Y, Hirata T, Harada M, Hiroi H, Koga K, Saito S, Osuga Y, Fujii T: Serum concentration of bone morphogenetic proteins (BMPs) is not linked toserum anti-mullerian hormone (AMH) level Integrative Molecular Medicine 2011; 1: 26-28 22) Makinoda S, Hirosaki N, Waseda T, Tomizawa H, Fujii R: Granulocyte colony-stimulating factor (G-CSF) in the mechanism of human ovulation and its clinical usefulness. Curr Med Chem 2008;15:604-613. 6) Shimasaki S, Moore RK, Otsuka F, Erickson GF: The bone morphogenetic protein system in mammalian reproduction. Endocr Rev 2004;25:72-101. 18) Tremblay KD, Dunn NR, Robertson EJ: Mouse embryos lacking Smad1 signals display defects in extra-embryonic tissues and germ cell formation. Development 2001;128:3609-3621. 21) Akiyama I, Yoshino O, Osuga Y, Shi J, Harada M, Koga K, Hirota Y, Hirata T, Fujii T, Saito S, Kozuma S: Bone morphogenetic protein 7 increased vascular endothelial growth factor (VEGF)-a expression in human granulosa cells and VEGF receptor expression in endothelial cells. Reprod Sci 2014;21:477-482. 5) Dube JL, Wang P, Elvin J, Lyons KM, Celeste AJ, Matzuk MM: The bone morphogenetic protein 15 gene is X-linked and expressed in oocytes. Mol Endocrinol 1998;12:1809-1817. 3) Shimasaki S, Zachow RJ, Li D, Kim H, Iemura S, Ueno N, Sampath K, Chang RJ, Erickson GF: A functional bone morphogenetic protein system in the ovary. Proc Natl Acad Sci U S A 1999;96:7282-7287. 13) Lawson KA, Dunn NR, Roelen BA, Zeinstra LM, Davis AM, Wright CV, Korving JP, Hogan BL: Bmp4 is required for the generation of primordial germ cells in the mouse embryo. Genes Dev 1999;13:424-436. 9) Shi J, Yoshino O, Osuga Y, Koga K, Hirota Y, Nose E, Nishii O, Yano T, Taketani Y: Bone morphogenetic protein-2 (BMP-2) increases gene expression of FSH receptor and aromatase and decreases gene expression of LH receptor and StAR in human granulosa cells. Am J Reprod Immunol 2011;65:421-427. 7) Shi J, Yoshino O, Osuga Y, Nishii O, Yano T, Taketani Y: Bone morphogenetic protein 7 (BMP-7) increases the expression of follicle-stimulating hormone (FSH) receptor in human granulosa cells. Fertil Steril 2010;93:1273-1279. 17) Chang H, Matzuk MM: Smad5 is required for mouse primordial germ cell development. Mech Dev 2001;104:61-67. 12) Miyazawa K, Shinozaki M, Hara T, Furuya T, Miyazono K: Two major Smad pathways in TGF-beta superfamily signalling. Genes Cells 2002;7:1191-1204. 8) Shi J, Yoshino O, Osuga Y, Koga K, Hirota Y, Hirata T, Yano T, Nishii O, Taketani Y: Bone morphogenetic protein-6 stimulates gene expression of follicle-stimulating hormone receptor, inhibin/activin beta subunits, and anti-Mullerian hormone in human granulosa cells. Fertil Steril 2009;92:1794-1798. 24) Akiyama I, Yoshino O, Osuga Y, Shi J, Takamura M, Harada M, Koga K, Hirota Y, Hirata T, Fujii T, Saito S, Kozuma S: The role of bone morphogenetic protein 6 in accumulation and regulation of neutrophils in the human ovary. Reprod Sci 2014;21:772-777. 23) Sugiura K, Su YQ, Eppig JJ: Does Bone Morphogenetic Protein 6 (BMP6) Affect Female Fertility in the Mouse? Biol Reprod 2010. 15) Ying Y, Zhao GQ: Cooperation of endoderm-derived BMP2 and extraembryonic ectoderm-derived BMP4 in primordial germ cell generation in the mouse. Dev Biol 2001;232:484-492. |
| References_xml | – reference: 24) Akiyama I, Yoshino O, Osuga Y, Shi J, Takamura M, Harada M, Koga K, Hirota Y, Hirata T, Fujii T, Saito S, Kozuma S: The role of bone morphogenetic protein 6 in accumulation and regulation of neutrophils in the human ovary. Reprod Sci 2014;21:772-777. – reference: 15) Ying Y, Zhao GQ: Cooperation of endoderm-derived BMP2 and extraembryonic ectoderm-derived BMP4 in primordial germ cell generation in the mouse. Dev Biol 2001;232:484-492. – reference: 1) Urist MR: Bone: formation by autoinduction. Science 1965;150:893-899. – reference: 16) de Sousa Lopes SM, Roelen BA, Monteiro RM, Emmens R, Lin HY, Li E, Lawson KA, Mummery CL: BMP signaling mediated by ALK2 in the visceral endoderm is necessary for the generation of primordial germ cells in the mouse embryo. Genes Dev 2004;18:1838-1849. – reference: 7) Shi J, Yoshino O, Osuga Y, Nishii O, Yano T, Taketani Y: Bone morphogenetic protein 7 (BMP-7) increases the expression of follicle-stimulating hormone (FSH) receptor in human granulosa cells. Fertil Steril 2010;93:1273-1279. – reference: 6) Shimasaki S, Moore RK, Otsuka F, Erickson GF: The bone morphogenetic protein system in mammalian reproduction. Endocr Rev 2004;25:72-101. – reference: 4) Dong J, Albertini DF, Nishimori K, Kumar TR, Lu N, Matzuk MM: Growth differentiation factor-9 is required during early ovarian folliculogenesis. Nature 1996;383:531-535. – reference: 20) Ogura-Nose S, Yoshino O, Akiyama I, Hirota Y, Hirata T, Harada M, Hiroi H, Koga K, Saito S, Osuga Y, Fujii T: Serum concentration of bone morphogenetic proteins (BMPs) is not linked toserum anti-mullerian hormone (AMH) level Integrative Molecular Medicine 2011; 1: 26-28 – reference: 11) Akiyama I, Yoshino O, Osuga Y, Shi J, Hirota Y, Hirata T, Harada M, Koga K, Fujimoto A, Yano T, Taketani Y: The localization and regulation of proprotein convertase subtilisin/kexin (PCSK) 6 in human ovary. Am J Reprod Immunol 2012;68:491-498. – reference: 12) Miyazawa K, Shinozaki M, Hara T, Furuya T, Miyazono K: Two major Smad pathways in TGF-beta superfamily signalling. Genes Cells 2002;7:1191-1204. – reference: 9) Shi J, Yoshino O, Osuga Y, Koga K, Hirota Y, Nose E, Nishii O, Yano T, Taketani Y: Bone morphogenetic protein-2 (BMP-2) increases gene expression of FSH receptor and aromatase and decreases gene expression of LH receptor and StAR in human granulosa cells. Am J Reprod Immunol 2011;65:421-427. – reference: 2) Groome NP, Illingworth PJ, O'Brien M, Pai R, Rodger FE, Mather JP, McNeilly AS: Measurement of dimeric inhibin B throughout the human menstrual cycle. J Clin Endocrinol Metab 1996;81:1401-1405. – reference: 23) Sugiura K, Su YQ, Eppig JJ: Does Bone Morphogenetic Protein 6 (BMP6) Affect Female Fertility in the Mouse? Biol Reprod 2010. – reference: 5) Dube JL, Wang P, Elvin J, Lyons KM, Celeste AJ, Matzuk MM: The bone morphogenetic protein 15 gene is X-linked and expressed in oocytes. Mol Endocrinol 1998;12:1809-1817. – reference: 10) Hashimoto O, Moore RK, Shimasaki S: Posttranslational processing of mouse and human BMP-15: potential implication in the determination of ovulation quota. Proc Natl Acad Sci U S A 2005;102:5426-5431. – reference: 25) Yoshino O, McMahon HE, Sharma S, Shimasaki S: A unique preovulatory expression pattern plays a key role in the physiological functions of BMP-15 in the mouse. Proc Natl Acad Sci U S A 2006;103:10678-10683. – reference: 14) Ying Y, Liu XM, Marble A, Lawson KA, Zhao GQ: Requirement of Bmp8b for the generation of primordial germ cells in the mouse. Mol Endocrinol 2000;14:1053-1063. – reference: 17) Chang H, Matzuk MM: Smad5 is required for mouse primordial germ cell development. Mech Dev 2001;104:61-67. – reference: 8) Shi J, Yoshino O, Osuga Y, Koga K, Hirota Y, Hirata T, Yano T, Nishii O, Taketani Y: Bone morphogenetic protein-6 stimulates gene expression of follicle-stimulating hormone receptor, inhibin/activin beta subunits, and anti-Mullerian hormone in human granulosa cells. Fertil Steril 2009;92:1794-1798. – reference: 21) Akiyama I, Yoshino O, Osuga Y, Shi J, Harada M, Koga K, Hirota Y, Hirata T, Fujii T, Saito S, Kozuma S: Bone morphogenetic protein 7 increased vascular endothelial growth factor (VEGF)-a expression in human granulosa cells and VEGF receptor expression in endothelial cells. Reprod Sci 2014;21:477-482. – reference: 3) Shimasaki S, Zachow RJ, Li D, Kim H, Iemura S, Ueno N, Sampath K, Chang RJ, Erickson GF: A functional bone morphogenetic protein system in the ovary. Proc Natl Acad Sci U S A 1999;96:7282-7287. – reference: 18) Tremblay KD, Dunn NR, Robertson EJ: Mouse embryos lacking Smad1 signals display defects in extra-embryonic tissues and germ cell formation. Development 2001;128:3609-3621. – reference: 22) Makinoda S, Hirosaki N, Waseda T, Tomizawa H, Fujii R: Granulocyte colony-stimulating factor (G-CSF) in the mechanism of human ovulation and its clinical usefulness. Curr Med Chem 2008;15:604-613. – reference: 13) Lawson KA, Dunn NR, Roelen BA, Zeinstra LM, Davis AM, Wright CV, Korving JP, Hogan BL: Bmp4 is required for the generation of primordial germ cells in the mouse embryo. Genes Dev 1999;13:424-436. – reference: 19) Ogura-Nose S, Yoshino O, Osuga Y, Shi J, Hiroi H, Yano T, Taketani Y: Anti-Mullerian hormone (AMH) is induced by bone morphogenetic protein (BMP) cytokines in human granulosa cells. Eur J Obstet Gynecol Reprod Biol 2012;164:44-7 |
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| Snippet | 卵子の発育および成熟には、それを内在する卵胞の良好な発育が必要不可欠である。特に初期卵胞はFSH受容体を有していないため、良好な初期卵胞発... |
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| SubjectTerms | BMPサイトカイン、卵胞発育、排卵、黄体化 |
| Title | bone morphogenetic protein(BMP)サイトカインファミリーの卵胞発育に与える影響について |
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