再発乳癌における骨単独転移症例の検討
乳癌治療後の初再発部位として骨転移は頻度が高いが骨単独転移症例に関しての報告は多くはない．1993年から2012年5月まで，当院にて初回治療された再発乳癌727例のうち骨単独再発例は110例（15.1％）であった．そのうち，検討可能な76例を対象とし，ホルモン受容体発現の有無との関係および，骨再発後に起こってくる他臓器転移について着目し臨床的特徴を後向きに検討した．骨単独再発症例は69.7％がER陽性であった．骨転移までの期間がER陽性，陰性例ではそれぞれ50.9±30.9カ月，19±42.9カ月，その後に他臓器へ転移を認めるまでの期間（中央値）はER陽性，陰性例でそれぞれ29.6カ月，19....
Saved in:
| Published in | 日本臨床外科学会雑誌 Vol. 75; no. 6; pp. 1484 - 1490 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
日本臨床外科学会
2014
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 1345-2843 1882-5133 |
| DOI | 10.3919/jjsa.75.1484 |
Cover
| Abstract | 乳癌治療後の初再発部位として骨転移は頻度が高いが骨単独転移症例に関しての報告は多くはない．1993年から2012年5月まで，当院にて初回治療された再発乳癌727例のうち骨単独再発例は110例（15.1％）であった．そのうち，検討可能な76例を対象とし，ホルモン受容体発現の有無との関係および，骨再発後に起こってくる他臓器転移について着目し臨床的特徴を後向きに検討した．骨単独再発症例は69.7％がER陽性であった．骨転移までの期間がER陽性，陰性例ではそれぞれ50.9±30.9カ月，19±42.9カ月，その後に他臓器へ転移を認めるまでの期間（中央値）はER陽性，陰性例でそれぞれ29.6カ月，19.8カ月でER陰性例では短く，また生存期間もER陰性例で短い傾向にあった．ER陰性，手術から骨転移までの期間が短いおよび肝転移がみられた症例が骨転移後の予後が不良であると考えられた． |
|---|---|
| AbstractList | 乳癌治療後の初再発部位として骨転移は頻度が高いが骨単独転移症例に関しての報告は多くはない．1993年から2012年5月まで，当院にて初回治療された再発乳癌727例のうち骨単独再発例は110例（15.1％）であった．そのうち，検討可能な76例を対象とし，ホルモン受容体発現の有無との関係および，骨再発後に起こってくる他臓器転移について着目し臨床的特徴を後向きに検討した．骨単独再発症例は69.7％がER陽性であった．骨転移までの期間がER陽性，陰性例ではそれぞれ50.9±30.9カ月，19±42.9カ月，その後に他臓器へ転移を認めるまでの期間（中央値）はER陽性，陰性例でそれぞれ29.6カ月，19.8カ月でER陰性例では短く，また生存期間もER陰性例で短い傾向にあった．ER陰性，手術から骨転移までの期間が短いおよび肝転移がみられた症例が骨転移後の予後が不良であると考えられた． |
| Author | 廣利, 浩一 吉田, 佐智子 前川, 陽子 高尾, 信太郎 三木, 万由子 |
| Author_xml | – sequence: 1 fullname: 前川, 陽子 organization: 兵庫県立がんセンター乳腺外科 – sequence: 1 fullname: 三木, 万由子 organization: 兵庫県立がんセンター乳腺外科 – sequence: 1 fullname: 廣利, 浩一 organization: 兵庫県立がんセンター乳腺外科 – sequence: 1 fullname: 高尾, 信太郎 organization: 兵庫県立がんセンター乳腺外科 – sequence: 1 fullname: 吉田, 佐智子 organization: 兵庫県立がんセンター乳腺外科 |
| BookMark | eNo9T8tKw0AAXKSCtfbmbyTuZp85iRRfUPCi52V3s9GEWiXpxWM8KFgreNKCJxEsKl48acGfSWvqX5igOIeZYQYGZhHUukddC8Aygi72kb8Sx6lyOXUREWQO1JEQnkMRxrXSY0IdTxC8AJppGmkIvRIU0jpg07NBMfyYvL8Vw8s8e86zizy7zk_730-j6eC26L_MxvfF47i4OZ989vPs9evhbja6WgLzoeqktvmnDbC3sb7b2nLaO5vbrbW2E3uEQwdrHUCkCVWcCK2E0UyHmCuhCLZQh8T4VgccGw4FNExQnzEj_DLFjAUI4gZY_d2N057at_I4iQ5VciJV0otMx8rqtORUsoqq5_-NOVCJjBX-AXMGZuY |
| ContentType | Journal Article |
| Copyright | 2014 日本臨床外科学会 |
| Copyright_xml | – notice: 2014 日本臨床外科学会 |
| DOI | 10.3919/jjsa.75.1484 |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| EISSN | 1882-5133 |
| EndPage | 1490 |
| ExternalDocumentID | article_jjsa_75_6_75_1484_article_char_ja |
| GroupedDBID | 123 2WC ALMA_UNASSIGNED_HOLDINGS CS3 JSF KQ8 RJT |
| ID | FETCH-LOGICAL-j2470-3bbd01b45a748ba8cb6bf37a8a43e0bf4c9ebd73c7080c685966c89c9e366d103 |
| ISSN | 1345-2843 |
| IngestDate | Wed Sep 03 06:28:50 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | false |
| IsScholarly | true |
| Issue | 6 |
| Language | Japanese |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-j2470-3bbd01b45a748ba8cb6bf37a8a43e0bf4c9ebd73c7080c685966c89c9e366d103 |
| OpenAccessLink | https://www.jstage.jst.go.jp/article/jjsa/75/6/75_1484/_article/-char/ja |
| PageCount | 7 |
| ParticipantIDs | jstage_primary_article_jjsa_75_6_75_1484_article_char_ja |
| PublicationCentury | 2000 |
| PublicationDate | 20140000 |
| PublicationDateYYYYMMDD | 2014-01-01 |
| PublicationDate_xml | – year: 2014 text: 20140000 |
| PublicationDecade | 2010 |
| PublicationTitle | 日本臨床外科学会雑誌 |
| PublicationTitleAlternate | 日臨外会誌 |
| PublicationYear | 2014 |
| Publisher | 日本臨床外科学会 |
| Publisher_xml | – name: 日本臨床外科学会 |
| References | 18) Hortobagyi GN : Treatment of breast cancer. N Engl J Med 1998 ; 339 : 974-984 5) Solomayer EF, Diel IJ, Meyberg GC, et al : Metastatic breast cancer : clinical course, prognosis and therapy related to the first site of metastasis. Breast Cancer Res Treat 2000 ; 59 : 271-278 17) Boissier S, Magnetto S, Frappart L, et al : Bisphosphonates inhibit prostate and breast carcinoma cell adhesion to unmineralized and mineralized bone extracellular matrices. Cancer Res 1997 ; 57 : 3890-3894 10) 高橋弘昌，高橋将人，田口和則他:乳癌の再発後生存期間に影響する因子の検討．日臨外会誌 2002;63:2875-2882 8) Hess KR, Pusztai L, Buzdar AU, et al : Estrogen receptors and distinct patterns of breast cancer relapse. Breast Cancer Res Treat 2003 ; 78 : 105-118 4) Saphner T, Tormet DC, Gray R : Annual hazard rates of recurrence for breast cancer after primary therapy. J Clin Oncol 1996 ; 14 : 2738-2746 12) Coleman RE, Smith P, Rubens RD : Clinical course and prognostic factors following bone recurrence from breast cancer. Br J Cancer 1998 ; 77 : 336-340 16) Gnant M, Mlineritsch B, Stoeger H, et al : Adjuvant endocrine therapy plus zoledronic acid in premenopausal women with early-stage breast cancer : 62-month follow-up from the ABCSG-12 randomised trial. Lancet Oncol 2011 ; 12 : 631-641 9) Kim RS, Avivar-Valderas A, Estrada Y, et al : Dormancy signatures and metastasis in estrogen receptor positive and negative breast cancer. PLoS One 2012 : 7 : e35569. doi : 10. 1371/journal. pone. 0035569 15) Eidtmann H, de Boer R, Bundred N, et al : Efficacy of zoledronic acid in postmenopausal women with early breast cancer receiving adjuvant letrozole : 36-month results of the ZO-FAST study. Ann Oncol 2010 ; 21 : 2188-2194 7) Lee SJ, Park S, Ahn HK, et al : Implications of bone-only metastases in breast cancer : favorable preference with excellent outcome of hormone receptor positive breast cancer. Cancer Res Treat 2011 ; 43 : 89-95 2) 神野浩光，麻賀創太，坂田道生他:乳癌の再発診療に関する最新のデーター．臨外 2007;62:127-136 6) Tokuhashi Y, Matsuzaki H, Oda H : Metastatic spinal cord compression : diagnosis and management of patients at risk of or with metastatic spinal cord compression. Spine (Phila Pa 1976) 2005 ; 30 : 2186-2191 14) Sung GA, Hak ML, Sang-Hoon C, et al : Prognostic factors for patients with bone-only metastasis in breast cancer. Yonsei Med J 2013 ; 54 : 1168-1177 11) Koizumi M, Yoshimoto M, Kasumi F, et al : Comparison between solitary and multiple skeletal metastatic lesions of breast cancer patients. Ann Oncol 2003 ; 14 : 1234-1240 13) Niikura N, Liu J, Hayashi N, et al : Retrospective analysis of antitumor effects of zoledronic acid in breast cancer patients with bone-only metastases. Cancer 2012 ; 118 : 2039-2047 3) Niikura N, Liu J, Hayashi N, et al : Treatment outcome and prognostic factors for patients with bone-only metastases of breast cancer. A single-institution retrospective analysis. Oncologist 2011 ; 16 : 155-164 1) Manders K, van de Poll-Franse LV, Creemers GJ, et al : Clinical management of women with metastatic breast cancer : a descriptive study according to age group. BMC Cancer 2006 ; 6 : 179 |
| References_xml | – reference: 18) Hortobagyi GN : Treatment of breast cancer. N Engl J Med 1998 ; 339 : 974-984 – reference: 11) Koizumi M, Yoshimoto M, Kasumi F, et al : Comparison between solitary and multiple skeletal metastatic lesions of breast cancer patients. Ann Oncol 2003 ; 14 : 1234-1240 – reference: 1) Manders K, van de Poll-Franse LV, Creemers GJ, et al : Clinical management of women with metastatic breast cancer : a descriptive study according to age group. BMC Cancer 2006 ; 6 : 179 – reference: 9) Kim RS, Avivar-Valderas A, Estrada Y, et al : Dormancy signatures and metastasis in estrogen receptor positive and negative breast cancer. PLoS One 2012 : 7 : e35569. doi : 10. 1371/journal. pone. 0035569 – reference: 14) Sung GA, Hak ML, Sang-Hoon C, et al : Prognostic factors for patients with bone-only metastasis in breast cancer. Yonsei Med J 2013 ; 54 : 1168-1177 – reference: 10) 高橋弘昌，高橋将人，田口和則他:乳癌の再発後生存期間に影響する因子の検討．日臨外会誌 2002;63:2875-2882 – reference: 7) Lee SJ, Park S, Ahn HK, et al : Implications of bone-only metastases in breast cancer : favorable preference with excellent outcome of hormone receptor positive breast cancer. Cancer Res Treat 2011 ; 43 : 89-95 – reference: 12) Coleman RE, Smith P, Rubens RD : Clinical course and prognostic factors following bone recurrence from breast cancer. Br J Cancer 1998 ; 77 : 336-340 – reference: 3) Niikura N, Liu J, Hayashi N, et al : Treatment outcome and prognostic factors for patients with bone-only metastases of breast cancer. A single-institution retrospective analysis. Oncologist 2011 ; 16 : 155-164 – reference: 8) Hess KR, Pusztai L, Buzdar AU, et al : Estrogen receptors and distinct patterns of breast cancer relapse. Breast Cancer Res Treat 2003 ; 78 : 105-118 – reference: 15) Eidtmann H, de Boer R, Bundred N, et al : Efficacy of zoledronic acid in postmenopausal women with early breast cancer receiving adjuvant letrozole : 36-month results of the ZO-FAST study. Ann Oncol 2010 ; 21 : 2188-2194 – reference: 16) Gnant M, Mlineritsch B, Stoeger H, et al : Adjuvant endocrine therapy plus zoledronic acid in premenopausal women with early-stage breast cancer : 62-month follow-up from the ABCSG-12 randomised trial. Lancet Oncol 2011 ; 12 : 631-641 – reference: 2) 神野浩光，麻賀創太，坂田道生他:乳癌の再発診療に関する最新のデーター．臨外 2007;62:127-136 – reference: 4) Saphner T, Tormet DC, Gray R : Annual hazard rates of recurrence for breast cancer after primary therapy. J Clin Oncol 1996 ; 14 : 2738-2746 – reference: 5) Solomayer EF, Diel IJ, Meyberg GC, et al : Metastatic breast cancer : clinical course, prognosis and therapy related to the first site of metastasis. Breast Cancer Res Treat 2000 ; 59 : 271-278 – reference: 17) Boissier S, Magnetto S, Frappart L, et al : Bisphosphonates inhibit prostate and breast carcinoma cell adhesion to unmineralized and mineralized bone extracellular matrices. Cancer Res 1997 ; 57 : 3890-3894 – reference: 13) Niikura N, Liu J, Hayashi N, et al : Retrospective analysis of antitumor effects of zoledronic acid in breast cancer patients with bone-only metastases. Cancer 2012 ; 118 : 2039-2047 – reference: 6) Tokuhashi Y, Matsuzaki H, Oda H : Metastatic spinal cord compression : diagnosis and management of patients at risk of or with metastatic spinal cord compression. Spine (Phila Pa 1976) 2005 ; 30 : 2186-2191 |
| SSID | ssib002222505 ssib029852155 ssib039893138 ssib043658141 ssib058493876 ssj0061900 ssib000940327 ssib002822084 ssib002484630 ssib002484631 |
| Score | 1.9639168 |
| Snippet | 乳癌治療後の初再発部位として骨転移は頻度が高いが骨単独転移症例に関しての報告は多くはない．1993年から2012年5月まで，当院にて初回治療された再発乳癌727例のうち骨... |
| SourceID | jstage |
| SourceType | Publisher |
| StartPage | 1484 |
| SubjectTerms | 再発乳癌 骨単独転移 |
| Title | 再発乳癌における骨単独転移症例の検討 |
| URI | https://www.jstage.jst.go.jp/article/jjsa/75/6/75_1484/_article/-char/ja |
| Volume | 75 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| ispartofPNX | 日本臨床外科学会雑誌, 2014, Vol.75(6), pp.1484-1490 |
| journalDatabaseRights | – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 1882-5133 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0061900 issn: 1345-2843 databaseCode: KQ8 dateStart: 19980101 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV0_b9QwFI9KWVgQCBD_1QGPOZLYcezRuUtVIYGE1ErdojiXDDcUBNeF7RhA4igSE1RiQkhUgFiYoBIfgK9xLVe-Be_ZviaVbigVS_Ty7PfHz0n8e1Zse94trvt4fAP3pWCVzyoe-kWNv4lR3E-sqHVhTi25e4-vrLE76_H6wqlfrb-WNoe6Uz6Zu67kJL0KPOhXXCX7Dz17qBQYQEP_whV6GK7H6mOSxURwInokS4iUJFUkYyQFgjqO6JKMAlokKnWEUI6QoSEiIqBIEqWIEkZhj0iB4sBXIC5ICkSEHJUgjZqhNDG2MiNuTWQk40QxIo0UaBNZG_tiKQiq2BBdpxz0WLvgPPoWGw3cmUMngdMjihtzXSIVeitTUyTQbXE40WvclyYeoA-ke_gEmfoQk55TJYOmPqgUKOI8Era-5SampUCHcwRjExVqLIIX0gpyksZ44zS06kvsAWkbGmDYZoaWiQpdq5VpmqCzuLnJmLCZhv1fIWwNRZTFPoAH-_mvLA_zITyRpz1-2ZNn3HvaHoxCu03sDNhALhzMGzSpDHHP2cHgcdFJ4k4jdWQbcveQ51gtT-Kc4wXr5rMSXCaYDyBXOR3h3Bj-IHG_BfUlC2jUnjqIEH23oCIg4VYqa--PrLGOgmZNdSQFAM9mTTWVALzDZixhFKB12EB9wNmSCoTeFqWBg4HdQcBF2S6KwVjcbkcCgOkA0rTZL54Gda6e8866dHFJ2caf9xYGxQWP7z_bmm7_2Pv-bbr9cjL6PBm9mIxeT56O_3za2d96Ox1_Odh9P_24O33zfO_neDL6-vvDu4OdVxe9teVstbviu_NP_EHEEoBHWveDULO4SJjQhSg11zVNClEwWgW6ZqWs4FNLywTSvpKLWHJeCglcynk_DOglb3HjwUZ12VtiuhY1ZHalTAqGi_EDVvRLCWZ0qSFju-IJ28z8od3kJj92f189ueg17wy-RHZG87q3OHy0Wd0AjD_UN83D8xf96MDn |
| linkProvider | Colorado Alliance of Research Libraries |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%E5%86%8D%E7%99%BA%E4%B9%B3%E7%99%8C%E3%81%AB%E3%81%8A%E3%81%91%E3%82%8B%E9%AA%A8%E5%8D%98%E7%8B%AC%E8%BB%A2%E7%A7%BB%E7%97%87%E4%BE%8B%E3%81%AE%E6%A4%9C%E8%A8%8E&rft.jtitle=%E6%97%A5%E6%9C%AC%E8%87%A8%E5%BA%8A%E5%A4%96%E7%A7%91%E5%AD%A6%E4%BC%9A%E9%9B%91%E8%AA%8C&rft.au=%E5%89%8D%E5%B7%9D%2C+%E9%99%BD%E5%AD%90&rft.au=%E4%B8%89%E6%9C%A8%2C+%E4%B8%87%E7%94%B1%E5%AD%90&rft.au=%E5%BB%A3%E5%88%A9%2C+%E6%B5%A9%E4%B8%80&rft.au=%E9%AB%98%E5%B0%BE%2C+%E4%BF%A1%E5%A4%AA%E9%83%8E&rft.date=2014&rft.pub=%E6%97%A5%E6%9C%AC%E8%87%A8%E5%BA%8A%E5%A4%96%E7%A7%91%E5%AD%A6%E4%BC%9A&rft.issn=1345-2843&rft.eissn=1882-5133&rft.volume=75&rft.issue=6&rft.spage=1484&rft.epage=1490&rft_id=info:doi/10.3919%2Fjjsa.75.1484&rft.externalDocID=article_jjsa_75_6_75_1484_article_char_ja |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1345-2843&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1345-2843&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1345-2843&client=summon |