毛孔性紅色丘疹を呈したGVHD
骨髄移植後約70日目に毛孔性の皮疹を呈し急性GVHDと診断した1例を報告した. GVHDにおける皮膚症状は他の臓器障害に先行することが多く, 早期診断に重要である. 薬疹・各種感染症等に加え, 骨髄移植前の大量放射線照射や化学療法による臓器の不可逆性変化 (RRT) との鑑別を要し, 表皮内のHLA-DR染色が重要と考える. また皮膚GVHDの1つの説として外毛根鞘の幹細胞がリンパ球の標的とする“幹細胞標的説”があり, 本症例も毛嚢部のリンパ球浸潤・液状変性を認めた. 毛孔性の皮疹を呈した皮膚GVHDの診断には毛孔部の組織学的変化とCDla・HLA-DR等の免疫組織染色が重要である....
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| Published in | Skin research Vol. 41; no. 4; pp. 429 - 433 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
日本皮膚科学会大阪地方会
1999
Meeting of Osaka Dermatological Association |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0018-1390 1884-541X |
| DOI | 10.11340/skinresearch1959.41.429 |
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| Abstract | 骨髄移植後約70日目に毛孔性の皮疹を呈し急性GVHDと診断した1例を報告した. GVHDにおける皮膚症状は他の臓器障害に先行することが多く, 早期診断に重要である. 薬疹・各種感染症等に加え, 骨髄移植前の大量放射線照射や化学療法による臓器の不可逆性変化 (RRT) との鑑別を要し, 表皮内のHLA-DR染色が重要と考える. また皮膚GVHDの1つの説として外毛根鞘の幹細胞がリンパ球の標的とする“幹細胞標的説”があり, 本症例も毛嚢部のリンパ球浸潤・液状変性を認めた. 毛孔性の皮疹を呈した皮膚GVHDの診断には毛孔部の組織学的変化とCDla・HLA-DR等の免疫組織染色が重要である. |
|---|---|
| AbstractList | GVHD is piercing as well as sometimes lethal. Active diagnosis of the change of the skin is very crucial since it often precedes damages of other organs. GVHD of the skin needs to be distinguished from damages caused by heavy irradiation and/or chemotherapy (regimen related toxicity: RRT), drug-eruptions and infections. Here we report a case of acute follicular GVHD revealed on 70 days after bone marrow transfer from HLA-identical sibling. Pathological changes of the epidermis were hardly notable in the very early phase when only follicular papules arose. Immunohistochemically, however, CDla+cells disappeared from the epidermis and HLA-DR expression was induced on the epidermal cells. Differential diagnosis with RRT and onset mechanisms of follicular GVHD were discussed.
骨髄移植後約70日目に毛孔性の皮疹を呈し急性GVHDと診断した1例を報告した. GVHDにおける皮膚症状は他の臓器障害に先行することが多く, 早期診断に重要である. 薬疹・各種感染症等に加え, 骨髄移植前の大量放射線照射や化学療法による臓器の不可逆性変化 (RRT) との鑑別を要し, 表皮内のHLA-DR染色が重要と考える. また皮膚GVHDの1つの説として外毛根鞘の幹細胞がリンパ球の標的とする“幹細胞標的説”があり, 本症例も毛嚢部のリンパ球浸潤・液状変性を認めた. 毛孔性の皮疹を呈した皮膚GVHDの診断には毛孔部の組織学的変化とCDla・HLA-DR等の免疫組織染色が重要である. 骨髄移植後約70日目に毛孔性の皮疹を呈し急性GVHDと診断した1例を報告した. GVHDにおける皮膚症状は他の臓器障害に先行することが多く, 早期診断に重要である. 薬疹・各種感染症等に加え, 骨髄移植前の大量放射線照射や化学療法による臓器の不可逆性変化 (RRT) との鑑別を要し, 表皮内のHLA-DR染色が重要と考える. また皮膚GVHDの1つの説として外毛根鞘の幹細胞がリンパ球の標的とする“幹細胞標的説”があり, 本症例も毛嚢部のリンパ球浸潤・液状変性を認めた. 毛孔性の皮疹を呈した皮膚GVHDの診断には毛孔部の組織学的変化とCDla・HLA-DR等の免疫組織染色が重要である. |
| Author | 小阪, 博 吉川, 邦彦 田所, 丈嗣 板見, 智 東山, 真里 種村, 篤 磯ノ上, 正明 |
| Author_FL | 板見 智 磯ノ上 正明 小阪 博 種村 篤 田所 丈嗣 吉川 邦彦 東山 真里 |
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| References | 3. 菊地新, 清水宏, 西川武二, 岡本真一郎, 池田康夫: 同種骨髄移植後急性皮膚GVHD: 自験23例の臨床的病理組織学的検討, 日皮会誌, 106: 285-291, 1996 13. Sprent J: T lymphocytes and the Thymus, Fundamental Immunology, Third, (Paul WE, Ed), Raven Press, Ltd, New York, 1993, 75-109 6. 菊地新, 西川武二, 岡本真一郎, 池田康夫: 同種骨髄移植後急性皮膚GVHD: 自験30例の免疫組織学的検討, 日皮会誌, 106: 1065-1070, 1996 8. 平林紀男, 伊藤雅文: 皮膚GVHDの病理, 病理と臨床, 15: 210-214, 1997 11. Sale GE: Are stem cells attacked in graft-versushost disease?, J Cutan Pathol, 18: 305-306, 1991 14. Miller JFAP, Kurts C, Allison J, Kosaka H, Carbone FR, Health WR: Induction of peripheral CD8+ T-cell tolerance by cross-presentation self antigens, Immunological Reviews, 165: 267-277, 1998 1. Rovelli A, Arrigo C, Nesi B et al: The role of thalidomide in the treatment of refractory chronic graft-versus-host disease following bone marrow transplantation in children, Bone Marrow Transplant, 21: 577-581, 1998 7. 平林紀男, 伊藤雅文: GVHDの今日的問題点一病理の視点, 病理と臨床, 15: 205-209, 1997 9. Lerner KG, Kao GF, Storb R, Buchner CD, Clift RA, Thomas ED: Histopathology of GVHR in human recipients on marrow from HLA-matched sibling donors, Transplant Proc, 6: 367-371, 1974 12. Health WR, Hurd ME, Carbone FR, Sherman LA: Peptide-dependent recognition of H-2Kb by alloreactive cytotoxic T lymphocytes, Nature (London), 341: 749-752, 1989 2. 田中敬子: 骨髄移植に伴う急性GVHDの診断と問題点, 西日皮膚, 55: 851-855, 1993 5. Bearman SI, Appelbaum FR, Buckner CD et al: Regimen-Related Toxicity In Patients Undergoing Bone Marrow Transplantation, J Crinical Oncology, 6: 1562-1568, 1988 10. Sale GE, Beauchamp M: Parafollicular hair bulge in human GVHD: a stem cell-rich primary target, Bone Marrow Transplant, 11: 223-225, 1993 4. Murphy GF, Lavker RM, Whitaker D, Korngold R: Cytotoxic folliculitis in GVHD. J Cutan Pathol, 18: 309-314, 1990 |
| References_xml | – reference: 6. 菊地新, 西川武二, 岡本真一郎, 池田康夫: 同種骨髄移植後急性皮膚GVHD: 自験30例の免疫組織学的検討, 日皮会誌, 106: 1065-1070, 1996 – reference: 12. Health WR, Hurd ME, Carbone FR, Sherman LA: Peptide-dependent recognition of H-2Kb by alloreactive cytotoxic T lymphocytes, Nature (London), 341: 749-752, 1989 – reference: 7. 平林紀男, 伊藤雅文: GVHDの今日的問題点一病理の視点, 病理と臨床, 15: 205-209, 1997 – reference: 2. 田中敬子: 骨髄移植に伴う急性GVHDの診断と問題点, 西日皮膚, 55: 851-855, 1993 – reference: 13. Sprent J: T lymphocytes and the Thymus, Fundamental Immunology, Third, (Paul WE, Ed), Raven Press, Ltd, New York, 1993, 75-109 – reference: 10. Sale GE, Beauchamp M: Parafollicular hair bulge in human GVHD: a stem cell-rich primary target, Bone Marrow Transplant, 11: 223-225, 1993 – reference: 8. 平林紀男, 伊藤雅文: 皮膚GVHDの病理, 病理と臨床, 15: 210-214, 1997 – reference: 11. Sale GE: Are stem cells attacked in graft-versushost disease?, J Cutan Pathol, 18: 305-306, 1991 – reference: 5. Bearman SI, Appelbaum FR, Buckner CD et al: Regimen-Related Toxicity In Patients Undergoing Bone Marrow Transplantation, J Crinical Oncology, 6: 1562-1568, 1988 – reference: 3. 菊地新, 清水宏, 西川武二, 岡本真一郎, 池田康夫: 同種骨髄移植後急性皮膚GVHD: 自験23例の臨床的病理組織学的検討, 日皮会誌, 106: 285-291, 1996 – reference: 4. Murphy GF, Lavker RM, Whitaker D, Korngold R: Cytotoxic folliculitis in GVHD. J Cutan Pathol, 18: 309-314, 1990 – reference: 1. Rovelli A, Arrigo C, Nesi B et al: The role of thalidomide in the treatment of refractory chronic graft-versus-host disease following bone marrow transplantation in children, Bone Marrow Transplant, 21: 577-581, 1998 – reference: 9. Lerner KG, Kao GF, Storb R, Buchner CD, Clift RA, Thomas ED: Histopathology of GVHR in human recipients on marrow from HLA-matched sibling donors, Transplant Proc, 6: 367-371, 1974 – reference: 14. Miller JFAP, Kurts C, Allison J, Kosaka H, Carbone FR, Health WR: Induction of peripheral CD8+ T-cell tolerance by cross-presentation self antigens, Immunological Reviews, 165: 267-277, 1998 |
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| Snippet | 骨髄移植後約70日目に毛孔性の皮疹を呈し急性GVHDと診断した1例を報告した. GVHDにおける皮膚症状は他の臓器障害に先行することが多く, 早期診断に重要である. 薬疹・各種... GVHD is piercing as well as sometimes lethal. Active diagnosis of the change of the skin is very crucial since it often precedes damages of other organs. GVHD... |
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| SubjectTerms | (RRT) regimen related toxicity follicular red papules GVHD the method of a stem cell-rich primary target 幹細胞傷害説 毛孔性紅色丘疹 |
| Title | 毛孔性紅色丘疹を呈したGVHD |
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