早朝頭痛を認めた片頭痛患者における閉塞性睡眠時無呼吸症候群の検討

早朝に頭痛が集中している片頭痛患者を臨床において経験することがある.慶應義塾大学病院神経内科頭痛外来を通院している片頭痛患者のうち,頭痛ダイアリーや問診上,早朝頭痛が目立った8例について,特徴および閉塞性睡眠時無呼吸症候群 (OSAS)との関連を検討した.8例中7例においてOSAS (6例が軽症,1例が中等症)を認めた.Apnea hypopnea indexと頭痛が早朝に生じる割合には正の相関傾向を示していた.OSASは片頭痛増悪因子となっている可能性もあり,早朝頭痛を認める片頭痛患者でOSAS合併例に対しての治療は今後の研究課題である....

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Published in日本頭痛学会誌 Vol. 48; no. 3; pp. 566 - 570
Main Authors 渡邊, 成美, 関口, 耕史, 中原, 仁, 渡辺, 理沙, 柴田, 護, 福永, 興壱, 臼田, 頌, 山澤, 稚子, 滝沢, 翼
Format Journal Article
LanguageJapanese
Published 一般社団法人 日本頭痛学会 2022
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ISSN1345-6547
2436-1577
DOI10.50860/jjho.48.3_566

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Abstract 早朝に頭痛が集中している片頭痛患者を臨床において経験することがある.慶應義塾大学病院神経内科頭痛外来を通院している片頭痛患者のうち,頭痛ダイアリーや問診上,早朝頭痛が目立った8例について,特徴および閉塞性睡眠時無呼吸症候群 (OSAS)との関連を検討した.8例中7例においてOSAS (6例が軽症,1例が中等症)を認めた.Apnea hypopnea indexと頭痛が早朝に生じる割合には正の相関傾向を示していた.OSASは片頭痛増悪因子となっている可能性もあり,早朝頭痛を認める片頭痛患者でOSAS合併例に対しての治療は今後の研究課題である.
AbstractList 早朝に頭痛が集中している片頭痛患者を臨床において経験することがある.慶應義塾大学病院神経内科頭痛外来を通院している片頭痛患者のうち,頭痛ダイアリーや問診上,早朝頭痛が目立った8例について,特徴および閉塞性睡眠時無呼吸症候群 (OSAS)との関連を検討した.8例中7例においてOSAS (6例が軽症,1例が中等症)を認めた.Apnea hypopnea indexと頭痛が早朝に生じる割合には正の相関傾向を示していた.OSASは片頭痛増悪因子となっている可能性もあり,早朝頭痛を認める片頭痛患者でOSAS合併例に対しての治療は今後の研究課題である.
Author 関口, 耕史
渡辺, 理沙
山澤, 稚子
滝沢, 翼
臼田, 頌
福永, 興壱
中原, 仁
渡邊, 成美
柴田, 護
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References 2) Karthik N, Sinha S, Taly AB, et al : Alteration in polysomnographic profile in ‘migraine without aura’ compared to healthy controls. Sleep Med 14 : 211―214, 2013
16) Idiman F, Oztura I, Baklan B, et al : Headache in sleep apnea syndrome. Headache 44 : 603―606, 2004
17) Kallweit U, Hidalgo H, Uhl V, et al : Continuous positive airway pressure therapy is effective for migraines in sleep apnea syndrome. Neurology 76 : 1189―1191, 2011
11) Sateia MJ : International classification of sleep disorders-third edition: highlights and modifications. Chest 146 : 1387―1394, 2014
12) Kelman L, Rains JC : Headache and sleep: examination of sleep patterns and complaints in a large clinical sample of migraineurs. Headache 45 : 904―910, 2005
4) 睡眠時無呼吸症候群 (SAS) の診療ガイドライン作成委員会 : 睡眠時無呼吸症候群 (SAS) の診療ガイドライン2020.南江堂,東京,2020 p2―3
14) Chen PK, Fuh JL, Lane HY, et al : Morning headache in habitual snorers: frequency, characteristics, predictors and impacts. Cephalalgia 31 : 829―836, 2011
3) Harnod T, Wang YC, Kao CH : Association of Migraine and Sleep-Related Breathing Disorder: A Population-Based Cohort Study. Medicine (Baltimore) 94 : e1506, 2015
15) Kristiansen HA, Kvaerner KJ, Akre H, et al : Migraine and sleep apnea in the general population. J Headache Pain 12 : 55―61, 2011
5) Fava C, Dorigoni S, Dalle Vedove F, et al : Effect of CPAP on blood pressure in patients with OSA/hypopnea a systematic review and meta-analysis. Chest 145 : 762―771, 2014
21) Ohayon MM : Prevalence and risk factors of morning headaches in the general population. Arch Intern Med 164 : 97―102, 2004
7) Barbe F, Duran-Cantolla J, Sanchez-de-la-Torre M, et al : Effect of continuous positive airway pressure on the incidence of hypertension and cardiovascular events in nonsleepy patients with obstructive sleep apnea: a randomized controlled trial. JAMA 307 : 2161―2168, 2012
10) Headache Classification Committee of the International Headache Society (IHS) : The International Classification of Headache Disorders, 3rd edition. Cephalalgia 38 : 1―211, 2018
1) Vos T, Flaxman AD, Naghavi M, et al : Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990―2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380 : 2163―2196, 2012
13) Bigal ME, Lipton RB : What predicts the change from episodic to chronic migraine? Curr Opin Neurol 22 : 269―276, 2009
9) Barbe F, Duran-Cantolla J, Capote F, et al : Long-term effect of continuous positive airway pressure in hypertensive patients with sleep apnea. Am J Respir Crit Care Med 181 : 718―726, 2010
22) De Luca Canto G, Singh V, Conti P, et al : Association between sleep bruxism and psychosocial factors in children and adolescents: a systematic review. Clin Pediatr (Phila) 54 : 469―478, 2015
8) Martinez-Garcia MA, Capote F, Campos-Rodriguez F, et al : Effect of CPAP on blood pressure in patients with obstructive sleep apnea and resistant hypertension: the HIPARCO randomized clinical trial. JAMA 310 : 2407―2415, 2013
20) 渡邉悠児,鈴木圭輔,宮本雅之,ほか : 持続陽圧呼吸療法中の閉塞性睡眠時無呼吸症候群における一次性頭痛の合併頻度とその治療効果.神経治療学 33 : 560―565,2016
19) Johnson KG, Ziemba AM, Garb JL : Improvement in headaches with continuous positive airway pressure for obstructive sleep apnea: a retrospective analysis. Headache 53 : 333―343, 2013
18) Goksan B, Gunduz A, Karadeniz D, et al : Morning headache in sleep apnoea: clinical and polysomnographic evaluation and response to nasal continuous positive airway pressure. Cephalalgia 29 : 635―641, 2009
23) Tufik S, Santos-Silva R, Taddei JA, et al : Obstructive sleep apnea syndrome in the Sao Paulo Epidemiologic Sleep Study. Sleep Med 11 : 441―446, 2010
6) Weaver TE, Maislin G, Dinges DF, et al : Relationship between hours of CPAP use and achieving normal levels of sleepiness and daily functioning. Sleep 30 : 711―719, 2007
References_xml – reference: 14) Chen PK, Fuh JL, Lane HY, et al : Morning headache in habitual snorers: frequency, characteristics, predictors and impacts. Cephalalgia 31 : 829―836, 2011.
– reference: 2) Karthik N, Sinha S, Taly AB, et al : Alteration in polysomnographic profile in ‘migraine without aura’ compared to healthy controls. Sleep Med 14 : 211―214, 2013.
– reference: 12) Kelman L, Rains JC : Headache and sleep: examination of sleep patterns and complaints in a large clinical sample of migraineurs. Headache 45 : 904―910, 2005.
– reference: 9) Barbe F, Duran-Cantolla J, Capote F, et al : Long-term effect of continuous positive airway pressure in hypertensive patients with sleep apnea. Am J Respir Crit Care Med 181 : 718―726, 2010.
– reference: 22) De Luca Canto G, Singh V, Conti P, et al : Association between sleep bruxism and psychosocial factors in children and adolescents: a systematic review. Clin Pediatr (Phila) 54 : 469―478, 2015.
– reference: 1) Vos T, Flaxman AD, Naghavi M, et al : Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990―2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380 : 2163―2196, 2012.
– reference: 21) Ohayon MM : Prevalence and risk factors of morning headaches in the general population. Arch Intern Med 164 : 97―102, 2004.
– reference: 8) Martinez-Garcia MA, Capote F, Campos-Rodriguez F, et al : Effect of CPAP on blood pressure in patients with obstructive sleep apnea and resistant hypertension: the HIPARCO randomized clinical trial. JAMA 310 : 2407―2415, 2013.
– reference: 10) Headache Classification Committee of the International Headache Society (IHS) : The International Classification of Headache Disorders, 3rd edition. Cephalalgia 38 : 1―211, 2018.
– reference: 18) Goksan B, Gunduz A, Karadeniz D, et al : Morning headache in sleep apnoea: clinical and polysomnographic evaluation and response to nasal continuous positive airway pressure. Cephalalgia 29 : 635―641, 2009.
– reference: 15) Kristiansen HA, Kvaerner KJ, Akre H, et al : Migraine and sleep apnea in the general population. J Headache Pain 12 : 55―61, 2011.
– reference: 4) 睡眠時無呼吸症候群 (SAS) の診療ガイドライン作成委員会 : 睡眠時無呼吸症候群 (SAS) の診療ガイドライン2020.南江堂,東京,2020 p2―3.
– reference: 3) Harnod T, Wang YC, Kao CH : Association of Migraine and Sleep-Related Breathing Disorder: A Population-Based Cohort Study. Medicine (Baltimore) 94 : e1506, 2015.
– reference: 17) Kallweit U, Hidalgo H, Uhl V, et al : Continuous positive airway pressure therapy is effective for migraines in sleep apnea syndrome. Neurology 76 : 1189―1191, 2011.
– reference: 19) Johnson KG, Ziemba AM, Garb JL : Improvement in headaches with continuous positive airway pressure for obstructive sleep apnea: a retrospective analysis. Headache 53 : 333―343, 2013.
– reference: 23) Tufik S, Santos-Silva R, Taddei JA, et al : Obstructive sleep apnea syndrome in the Sao Paulo Epidemiologic Sleep Study. Sleep Med 11 : 441―446, 2010.
– reference: 20) 渡邉悠児,鈴木圭輔,宮本雅之,ほか : 持続陽圧呼吸療法中の閉塞性睡眠時無呼吸症候群における一次性頭痛の合併頻度とその治療効果.神経治療学 33 : 560―565,2016.
– reference: 11) Sateia MJ : International classification of sleep disorders-third edition: highlights and modifications. Chest 146 : 1387―1394, 2014.
– reference: 16) Idiman F, Oztura I, Baklan B, et al : Headache in sleep apnea syndrome. Headache 44 : 603―606, 2004.
– reference: 7) Barbe F, Duran-Cantolla J, Sanchez-de-la-Torre M, et al : Effect of continuous positive airway pressure on the incidence of hypertension and cardiovascular events in nonsleepy patients with obstructive sleep apnea: a randomized controlled trial. JAMA 307 : 2161―2168, 2012.
– reference: 13) Bigal ME, Lipton RB : What predicts the change from episodic to chronic migraine? Curr Opin Neurol 22 : 269―276, 2009.
– reference: 5) Fava C, Dorigoni S, Dalle Vedove F, et al : Effect of CPAP on blood pressure in patients with OSA/hypopnea a systematic review and meta-analysis. Chest 145 : 762―771, 2014.
– reference: 6) Weaver TE, Maislin G, Dinges DF, et al : Relationship between hours of CPAP use and achieving normal levels of sleepiness and daily functioning. Sleep 30 : 711―719, 2007.
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SubjectTerms 早朝頭痛
片頭痛
睡眠時無呼吸症候群
Title 早朝頭痛を認めた片頭痛患者における閉塞性睡眠時無呼吸症候群の検討
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