BASIC AND CLINICAL STUDIES ON CS-807

Basic and clinical studies were performed on CS-807, a newly developed cephalosporin for oral use. The MICs of R-3763 for 285 strains of 17 species of clinical isolates were compared with those of AMPC, AMPC-CVA and CCL. The antibacterial activity of R-3763 against S. aureus was as high as that of C...

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Published inCHEMOTHERAPY Vol. 36; no. Supplement1; pp. 395 - 403
Main Authors KOIDE, JUN, TOHGOH, TOSHITO, AMAGAI, RIEKO, TOYODA, TAKEO, OKUI, SHINJI, HOMMA, SATOKI, FUJITA, TAKANORI, KAWAI, MIEKO, ABE, TOHRU, TAKASHI, KOHTAROH, KURISHIMA, SETSUKO, YUHARA, TAKAMICHI, FUKUI, TOSHIO, KATSU, MASATAKA, MIZUKOSHI, KAZUO
Format Journal Article
LanguageEnglish
Japanese
Published Japanese Society of Chemotherapy 1988
公益社団法人 日本化学療法学会
Online AccessGet full text
ISSN0009-3165
1884-5894
DOI10.11250/chemotherapy1953.36.Supplement1_395

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Abstract Basic and clinical studies were performed on CS-807, a newly developed cephalosporin for oral use. The MICs of R-3763 for 285 strains of 17 species of clinical isolates were compared with those of AMPC, AMPC-CVA and CCL. The antibacterial activity of R-3763 against S. aureus was as high as that of CCL and those of S. pneumoniae and S. pyogenes were comparable to those of AMPC and AMPC-CVA and higher than that of CCL. Against all gram-negative bacilli studied, antibacterial activity of R-3763 was the highest. In the clinical studies, a daily dose of 200-400mg of CS-807 administered b.i.d.was given orally for 7-23 days to 18 patients including 16 cases with respiratory tract infections and 2 cases with urinary tract infections. The clinical efficacy rate was 88.2% on 17 patients excluding 1 case who took CS-807 only 1 day because of vertigo. As side-effects, vertigo was observed in 1 case as stated above. BR>As abnormal laboratory findings related to CS-807, slightly elevated s-GOT, s-GPT and s-Al-P were observed in 1 case and basophilia was observed in 1 case. In conclusion, CS-807 is an effective antibiotic in the treatment of respiratory tract infections.
AbstractList Basic and clinical studies were performed on CS-807, a newly developed cephalosporin for oral use.The MICs of R-3763 for 285 strains of 17 species of clinical isolates were compared with those of AMPC, AMPC-CVA and CCL. The antibacterial activity of R-3763 against S. aureus was as high as that of CCL and those of S. pneumoniae and S. pyogenes were comparable to those of AMPC and AMPC-CVA and higher than that of CCL. Against all gram-negative bacilli studied, antibacterial activity of R-3763 was the highest.In the clinical studies, a daily dose of 200-400mg of CS-807 administered b.i.d.was given orally for 7-23 days to 18 patients including 16 cases with respiratory tract infections and 2 cases with urinary tract infections.The clinical efficacy rate was 88.2% on 17 patients excluding 1 case who took CS-807 only 1 day because of vertigo.As side-effects, vertigo was observed in 1 case as stated above. BR>As abnormal laboratory findings related to CS-807, slightly elevated s-GOT, s-GPT and s-Al-P were observed in 1 case and basophilia was observed in 1 case.In conclusion, CS-807 is an effective antibiotic in the treatment of respiratory tract infections. 新しく開発された経口用セファロスポリン剤であるCS-807について基礎的, 臨床的検討を行った。当院の臨床分離菌, 17菌種, 285株についてのMICを他の経口抗生剤amoxicillin (AMPC), clavulanic acidとamoxicillinの合剤 (AMPC-CVA), cefaclor (CCL) と比較検討した。本剤はグラム陽性球菌, 特にS. pneumoniae, S. pyogenes等に対し極めて優れたMICを示し, S. aureusなどの他のグラム陽性球菌でも良好な抗菌力を示した。グラム陰性菌ではいずれも本剤が他の3剤よりも優れ, 特にP.mirabilis, インドール陽性ProteusであるP. vulgaaris, P. rettgeri, さらにH. influenzae, N. gonorrhoeaeではこの傾向が顕著であった。臨床的には呼吸器感染症16例 (化膿性扁桃炎1例, 急性気管支炎5例, 肺炎3例, 慢性気管支炎3例, 慢性疾患の2次感染4例), 尿路感染症2例の計18例に本剤を1回100～200mg, 1日2回, 7～23日間食後経口投与したところ, 臨床効果は著効1例, 有効14例, 無効2例, 不明1例であった。副作用はめまい1例, 臨床検査値異常はGOT, GPT, Al-Pが同時に上昇したもの1例, また好塩基球増多1例を認めた。
Basic and clinical studies were performed on CS-807, a newly developed cephalosporin for oral use. The MICs of R-3763 for 285 strains of 17 species of clinical isolates were compared with those of AMPC, AMPC-CVA and CCL. The antibacterial activity of R-3763 against S. aureus was as high as that of CCL and those of S. pneumoniae and S. pyogenes were comparable to those of AMPC and AMPC-CVA and higher than that of CCL. Against all gram-negative bacilli studied, antibacterial activity of R-3763 was the highest. In the clinical studies, a daily dose of 200-400mg of CS-807 administered b.i.d.was given orally for 7-23 days to 18 patients including 16 cases with respiratory tract infections and 2 cases with urinary tract infections. The clinical efficacy rate was 88.2% on 17 patients excluding 1 case who took CS-807 only 1 day because of vertigo. As side-effects, vertigo was observed in 1 case as stated above. BR>As abnormal laboratory findings related to CS-807, slightly elevated s-GOT, s-GPT and s-Al-P were observed in 1 case and basophilia was observed in 1 case. In conclusion, CS-807 is an effective antibiotic in the treatment of respiratory tract infections.
Author FUJITA, TAKANORI
KATSU, MASATAKA
KAWAI, MIEKO
TOYODA, TAKEO
AMAGAI, RIEKO
MIZUKOSHI, KAZUO
TAKASHI, KOHTAROH
TOHGOH, TOSHITO
HOMMA, SATOKI
FUKUI, TOSHIO
OKUI, SHINJI
KOIDE, JUN
ABE, TOHRU
KURISHIMA, SETSUKO
YUHARA, TAKAMICHI
Author_FL 本間 聡起
水越 和夫
河合 美枝子
登田 丈夫
福井 俊夫
勝 正孝
天貝 理恵子
湯原 孝典
隆 孝太郎
安倍 達
小出 純
栗島 節子
東郷 利人
奥井 津二
藤田 享宣
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公益社団法人 日本化学療法学会
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References 1) 第35回日本化学療法学会総会, 新薬シンポジウムII, CS-807, 1987, 盛岡
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