Basic and clinical studies on NM441

• Published in: Japanese Journal of Chemotherapy Vol. 44; no. Supplement1; pp. 289 - 294
• Main Authors: Sato, Yasunobu, Ishida, Yuichiro, Takahashi, Takayuki, Matsumoto, Fumio, Shimada, Jingoro, Sakurai, Iwao, Nakamura, Toru, Morita, Masayuki, Imai, Takeo
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 1996; 公益社団法人 日本化学療法学会
• Subjects: NM441; 抗菌力; 臨床効果
• ISSN: 1340-7007; 1884-5886
• DOI: 10.11250/chemotherapy1995.44.Supplement1_289

We investigated the antibacterial activities and clinical efficacy of NM441, a newly-developed quinolone antibiotic, and the following results were obtained. 1) Antibacterial activities The antibacterial activities of NM394 (active form of NM441) against 150 strains of 6 species were measured. MIC90s of NM394 against methicillin-susceptible Staphylococcus aureus (MSSA), methicillinresistant S. aureus (MRSA), Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis and Pseudomonas aeruginosa were 3.13, 6.25, 0.1, 0.2, 0.39 and 3.13μg/ml, respectively. 2) Clinical results Subjects in the clinical study were a total of 10 patients including 5 cases with bacterial pneumonia, 1 with acute bronchitis, 1 with chronic bronchitis, 1 with acute pharyngolaryngitis, 1 with tonsillitis and 1 with acute cystitis. The clinical response was good in 8 cases and fair in 1 of the 9 patients able to be evaluated, and the efficacy rate was 88.9%. In the bacteriological efficacy, S.aureus and α-Streptococcus were isolated from 2 patients with bacterial pneumonia, K.pneumoniae from 1 with acute bronchitis, S.aureus from 1 with chronic bronchitis, Streptococcus pyogenes from 1 with tonsillitis and E. coli from 1 with cystitis, and all isolated organisms were eradicated except S.aureus in bacterial pneumonia and unknown in tonsillitis. Subjective and objective side effects were observed eruption in a patient with tonsillitis, and blister with glossitis in a patient with acute cystitis. From the above results, NM441 showed a wide antibacterial spectrum and good clinical response, and it was considered a useful drug for use in internal medical infections.