BMY-28100 IN RESPIRATORY INFECTION
We studied the clinical efficacy, bacteriological effect and safety of a new antibiotic, BMY-28100, in respiratory infections. The efficacy of BMY-28100 was clinically evaluated in 18 cases of respiratory infection including 12 cases of acute bronchitis, 4 of bacterial pneumonia, and 2 of chronic re...
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| Published in | CHEMOTHERAPY Vol. 37; no. Supplement3; pp. 409 - 414 |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English Japanese |
| Published |
Japanese Society of Chemotherapy
1989
公益社団法人 日本化学療法学会 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0009-3165 1884-5894 |
| DOI | 10.11250/chemotherapy1953.37.Supplement3_409 |
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| Abstract | We studied the clinical efficacy, bacteriological effect and safety of a new antibiotic, BMY-28100, in respiratory infections. The efficacy of BMY-28100 was clinically evaluated in 18 cases of respiratory infection including 12 cases of acute bronchitis, 4 of bacterial pneumonia, and 2 of chronic respiratory failure with acute exacerbation by respiratory infection. The causative organisms were revealed in 14 cases: Haemophilus influenzae in 6, H, influenzae plus Streptococcus pneumaniae in 1, S. pneumoniae in 2, Pseudomonas aeruginosa in 2, Klebsiella pneumaniae in 2 and Xanthomonas maltophilia in 1. The clinical efficacy rate was 70.6% in all patients. As an adverse reaction, slight elevation of GOT and GPT was found in 2 cases. |
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| AbstractList | We studied the clinical efficacy, bacteriological effect and safety of a new antibiotic, BMY-28100, in respiratory infections. The efficacy of BMY-28100 was clinically evaluated in 18 cases of respiratory infection including 12 cases of acute bronchitis, 4 of bacterial pneumonia, and 2 of chronic respiratory failure with acute exacerbation by respiratory infection. The causative organisms were revealed in 14 cases: Haemophilus influenzae in 6, H, influenzae plus Streptococcus pneumaniae in 1, S. pneumoniae in 2, Pseudomonas aeruginosa in 2, Klebsiella pneumaniae in 2 and Xanthomonas maltophilia in 1. The clinical efficacy rate was 70.6% in all patients. As an adverse reaction, slight elevation of GOT and GPT was found in 2 cases. We studied the clinical efficacy, bacteriological effect and safety of a new antibiotic, BMY-28100, in respiratory infections.The efficacy of BMY-28100 was clinically evaluated in 18 cases of respiratory infection including 12 cases of acute bronchitis, 4 of bacterial pneumonia, and 2 of chronic respiratory failure with acute exacerbation by respiratory infection.The causative organisms were revealed in 14 cases: Haemophilus influenzae in 6, H, influenzae plus Streptococcus pneumaniae in 1, S. pneumoniae in 2, Pseudomonas aeruginosa in 2, Klebsiella pneumaniae in 2 and Xanthomonas maltophilia in 1. The clinical efficacy rate was 70.6% in all patients.As an adverse reaction, slight elevation of GOT and GPT was found in 2 cases. 呼吸器感染症18例にBMY-28100を投与し, その臨床的効果, 副作用について検討した。投与法は, 1回1カプセル (250mg) を1日2～4回内服し, 持続投与日数は5～19日間で, 総投与量は5～18gであった。対象症例は, 急性気管支炎12例, 細菌性肺炎4例, 慢性呼吸不全の感染による急性増悪2例であり, 全症例に基礎疾患として呼吸器疾患を有していたが, 18例中, 著効2例, 有効10例, やや有効5例, 判定不能1例と, 70.6%の有効率を得た。対象症例よりの検出菌は, Haemophilus influenzaeが6例, H. influenzaeとStreptococcus pneumoniaeが1例, S. pneumoniaeが2例, Klebsiella pmeumoniaeが2例, Pseudomonas aeruginosaが2例, Xanthomonas maltophiliaが1例の14例であり, それぞれ本剤の投与により, 除菌, もしくは菌の減少をみた。本症に対する副作用としては, 2例にGOT, GPTの軽度の上昇をみたのみで, 他に特記すべきものは認められなかった以上の所見より, 種々の呼吸器感染症に対しての本剤の有効性が示唆された。 |
| Author | IKEDA, AKIHITO YOSHIDA, MINORU SENJU, SHOUJI TOYOSHIMA, HIDEO MIYAHARA, SATOKO ARITOMI, TAKAMICHI HAYASHI, TOKIKO SEKI, MASAHIKO YANO, ATSUSHI MAEDA, FUMIHIKO |
| Author_FL | 吉田 稔 池田 昭仁 豊島 秀夫 有冨 貴道 関 雅彦 千手 昭司 宮原 智子 前田 文彦 林 登喜子 矢野 淳 |
| Author_FL_xml | – sequence: 1 fullname: 吉田 稔 – sequence: 2 fullname: 宮原 智子 – sequence: 3 fullname: 関 雅彦 – sequence: 4 fullname: 有冨 貴道 – sequence: 5 fullname: 矢野 淳 – sequence: 6 fullname: 林 登喜子 – sequence: 7 fullname: 池田 昭仁 – sequence: 8 fullname: 千手 昭司 – sequence: 9 fullname: 豊島 秀夫 – sequence: 10 fullname: 前田 文彦 |
| Author_xml | – sequence: 1 fullname: MIYAHARA, SATOKO organization: Pulmonary Division, The Second Department of Internal Medicine, School of Medicine, Fukuoka University – sequence: 1 fullname: HAYASHI, TOKIKO organization: Pulmonary Division, The Second Department of Internal Medicine, School of Medicine, Fukuoka University – sequence: 1 fullname: MAEDA, FUMIHIKO organization: Nishifukuoka Hospital – sequence: 1 fullname: SEKI, MASAHIKO organization: Pulmonary Division, The Second Department of Internal Medicine, School of Medicine, Fukuoka University – sequence: 1 fullname: SENJU, SHOUJI organization: Pulmonary Division, The Second Department of Internal Medicine, School of Medicine, Fukuoka University – sequence: 1 fullname: YOSHIDA, MINORU organization: Pulmonary Division, The Second Department of Internal Medicine, School of Medicine, Fukuoka University – sequence: 1 fullname: TOYOSHIMA, HIDEO organization: Pulmonary Division, The Second Department of Internal Medicine, School of Medicine, Fukuoka University – sequence: 1 fullname: YANO, ATSUSHI organization: Pulmonary Division, The Second Department of Internal Medicine, School of Medicine, Fukuoka University – sequence: 1 fullname: ARITOMI, TAKAMICHI organization: Pulmonary Division, The Second Department of Internal Medicine, School of Medicine, Fukuoka University – sequence: 1 fullname: IKEDA, AKIHITO organization: Pulmonary Division, The Second Department of Internal Medicine, School of Medicine, Fukuoka University |
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| References | 2) ELIOPOULOS G M, REISZNER E, WENNERSTEN C, MOELLERING R C JR: In vitro activity of BMY-28100, a new oral cephalosporin. Antimicrobial Agents and Chemotherapy 31: 653-656, 1987 1) HIRAOKA M, MASUYOSHI S, TOMATSU K, INOUE M, MITSUHASHI S: In vitro activity and beta-lactamase stability of the oral cephalosporin BMY-28100. Eur. J. Clin. Microbiol. 6: 559-563, 1987 4) TOMATSU K, ANDO S, MASUYOSHI S, KONDO S, HIRANO M, MIYAKI T, KAWAGUCHI H In vitro and in vivo evaluations of BMY-28100, a new oral cephalosporin. The Journal of Antibiotics. 40: 1175-1183, 1987 3) CHIN N X, NEU H C: Comparative antibacterial activity of a new oral cephalosporin, BMY-28100. Antimicrobial Agents and Chemotherapy 31: 480-483, 1987 |
| References_xml | – reference: 4) TOMATSU K, ANDO S, MASUYOSHI S, KONDO S, HIRANO M, MIYAKI T, KAWAGUCHI H In vitro and in vivo evaluations of BMY-28100, a new oral cephalosporin. The Journal of Antibiotics. 40: 1175-1183, 1987 – reference: 2) ELIOPOULOS G M, REISZNER E, WENNERSTEN C, MOELLERING R C JR: In vitro activity of BMY-28100, a new oral cephalosporin. Antimicrobial Agents and Chemotherapy 31: 653-656, 1987 – reference: 1) HIRAOKA M, MASUYOSHI S, TOMATSU K, INOUE M, MITSUHASHI S: In vitro activity and beta-lactamase stability of the oral cephalosporin BMY-28100. Eur. J. Clin. Microbiol. 6: 559-563, 1987 – reference: 3) CHIN N X, NEU H C: Comparative antibacterial activity of a new oral cephalosporin, BMY-28100. Antimicrobial Agents and Chemotherapy 31: 480-483, 1987 |
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| Title | BMY-28100 IN RESPIRATORY INFECTION |
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