Bacteriological and clinical studies on cefluprenam in the field of surgery

• Published in: Japanese Journal of Chemotherapy Vol. 43; no. Supplement4; pp. 170 - 173
• Main Authors: Shinagawa, Nagao, Mizuno, Akira, Hisada, Masazumi, Yura, Jiro, Ishikawa, Shu, Mashita, Keiji
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 1995; 公益社団法人 日本化学療法学会
• Subjects: cefluprenam; セフェム系抗生物質; 外科的感染症; 抗菌力; 胆汁中移行
• ISSN: 1340-7007; 1884-5886
• DOI: 10.11250/chemotherapy1995.43.Supplement4_170

We performed bacteriological and clinical studies on cefluprenam, a new parenteral cephalosporin antibiotic, in the field of surgery to determine its antibacterial activity and clinical efficacy.The results were as follows: (1) Antibacterial activity: The MIC50/MIC90 values (μg/ml) of cefluprenam against surgical lesion isolates of Staphylococcus aureus, Escherichia coil, Klebsiella pneumoniae, and Pseudomonas aeruginosa were 25/50, ≤0.2≤0.2, ≤0.2≤0.2, 1.56/12.5, respectively. (2) Transport to bile: After intravenous administration of cefluprenam (1 g) to 2 subjects, its maximum concentration in bile was 22.0μg/ml and 6.35μg/ml. (3) Clinical efficacy: In 5 patients with surgical infections treated with cefluprenam, the response was excellent in 1 patient, good in 2 and fair in 1.In the bacteriological study, the causative pathogens were isolated from 3 patients and eradicated in 2, replaced in 1, and unknown in 2 cases.Neither subjective nor objective side effects were observed.Abnormal laboratory test findings were observed in 1 case with elevated GOT, GPT and ALP.