The Clinical Utility of Asbestos Body Counts in Bronchoalveolar Lavage Fluid
To assess the clinical utility of measuring the number of asbestos bodies (AB) present in bronchoalveolar lavage fluid (BALF), we counted the number of AB in BALF from 119 subjects using light microscopy. The results were analyzed according to occupational histories, radiological findings of asbesto...
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| Published in | Nihon Kyōbu Shikkan Gakkai zasshi Vol. 35; no. 11; pp. 1196 - 1204 |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
Japan
The Japanese Respiratory Society
01.11.1997
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0301-1542 1883-471X |
| DOI | 10.11389/jjrs1963.35.1196 |
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| Abstract | To assess the clinical utility of measuring the number of asbestos bodies (AB) present in bronchoalveolar lavage fluid (BALF), we counted the number of AB in BALF from 119 subjects using light microscopy. The results were analyzed according to occupational histories, radiological findings of asbestos-induced lung and pleural changes, and asbestos-related diseases. The 94 subjects in group 1 had a history of dust exposure, whereas group 2 subjects (n=25) had no dust exposure. Group 1 was subdivided into subjects with obvious exposure to asbestos (group 1A, n=61), and subjects with no known exposure to asbestos (group 1B, n=33). The distribution of AB counts per ml of BALF (means±SEM) differed significantly between groups 1 and 2 (38.8±17.4 vs 0.06±0.04, p<0.0001). The AB counts were significantly different between groups 1A and 1B (57.9±26.6 vs 3.4±1.2, p=0.01). Subject, exposed to dust who had radiological evidence of pleural thickening had significantly higher AB counts than subjects in whom pleural thickening was absent (66.0±31.1 vs 5.1±4.2, p=0.03). In group 1, the BALF was positive for AB in 7 of 14 patients with pulmonary fibrosis, 4 of 5 patients with lung cancer, all 6 patients with malignant mesothelioma, and all 4 patients with benign asbestos pleural effusion. We conclude that AB counts in BALF are useful for evaluating both the history of asbestos exposure in a population exposed to dust, as well as patients having asbestos-related diseases. |
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| AbstractList | To assess the clinical utility of measuring the number of asbestos bodies (AB) present in bronchoalveolar lavage fluid (BALF), we counted the number of AB in BALF from 119 subjects using light microscopy. The results were analyzed according to occupational histories, radiological findings of asbestos-induced lung and pleural changes, and asbestos-related diseases. The 94 subjects in group 1 had a history of dust exposure, whereas group 2 subjects (n = 25) had no dust exposure. Group 1 was subdivided into subjects with obvious exposure to asbestos (group 1A, n = 61), and subjects with no known exposure to asbestos (group 1B, n = 33). The distribution of AB counts per ml of BALF (means +/- SEM) differed significantly between groups 1 and 2 (38.8 +/- 17.4 vs 0.06 +/- 0.04, p < 0.0001). The AB counts were significantly different between groups 1A and 1B (57.9 +/- 26.6 vs 3.4 +/- 1.2, p = 0.01). Subject, exposed to dust who had radiological evidence of pleural thickening had significantly higher AB counts than subjects in whom pleural thickening was absent (66.0 +/- 31.1 vs 5.1 +/- 4.2, p = 0.03). In group 1, the BALF was positive for AB in 7 of 14 patients with pulmonary fibrosis, 4 of 5 patients with lung cancer, all 6 patients with malignant mesothelioma, and all 4 patients with benign asbestos pleural effusion. We conclude that AB counts in BALF are useful for evaluating both the history of asbestos exposure in a population exposed to dust, as well as patients having asbestos-related diseases.To assess the clinical utility of measuring the number of asbestos bodies (AB) present in bronchoalveolar lavage fluid (BALF), we counted the number of AB in BALF from 119 subjects using light microscopy. The results were analyzed according to occupational histories, radiological findings of asbestos-induced lung and pleural changes, and asbestos-related diseases. The 94 subjects in group 1 had a history of dust exposure, whereas group 2 subjects (n = 25) had no dust exposure. Group 1 was subdivided into subjects with obvious exposure to asbestos (group 1A, n = 61), and subjects with no known exposure to asbestos (group 1B, n = 33). The distribution of AB counts per ml of BALF (means +/- SEM) differed significantly between groups 1 and 2 (38.8 +/- 17.4 vs 0.06 +/- 0.04, p < 0.0001). The AB counts were significantly different between groups 1A and 1B (57.9 +/- 26.6 vs 3.4 +/- 1.2, p = 0.01). Subject, exposed to dust who had radiological evidence of pleural thickening had significantly higher AB counts than subjects in whom pleural thickening was absent (66.0 +/- 31.1 vs 5.1 +/- 4.2, p = 0.03). In group 1, the BALF was positive for AB in 7 of 14 patients with pulmonary fibrosis, 4 of 5 patients with lung cancer, all 6 patients with malignant mesothelioma, and all 4 patients with benign asbestos pleural effusion. We conclude that AB counts in BALF are useful for evaluating both the history of asbestos exposure in a population exposed to dust, as well as patients having asbestos-related diseases. To assess the clinical utility of measuring the number of asbestos bodies (AB) present in bronchoalveolar lavage fluid (BALF), we counted the number of AB in BALF from 119 subjects using light microscopy. The results were analyzed according to occupational histories, radiological findings of asbestos-induced lung and pleural changes, and asbestos-related diseases. The 94 subjects in group 1 had a history of dust exposure, whereas group 2 subjects (n=25) had no dust exposure. Group 1 was subdivided into subjects with obvious exposure to asbestos (group 1A, n=61), and subjects with no known exposure to asbestos (group 1B, n=33). The distribution of AB counts per ml of BALF (means±SEM) differed significantly between groups 1 and 2 (38.8±17.4 vs 0.06±0.04, p<0.0001). The AB counts were significantly different between groups 1A and 1B (57.9±26.6 vs 3.4±1.2, p=0.01). Subject, exposed to dust who had radiological evidence of pleural thickening had significantly higher AB counts than subjects in whom pleural thickening was absent (66.0±31.1 vs 5.1±4.2, p=0.03). In group 1, the BALF was positive for AB in 7 of 14 patients with pulmonary fibrosis, 4 of 5 patients with lung cancer, all 6 patients with malignant mesothelioma, and all 4 patients with benign asbestos pleural effusion. We conclude that AB counts in BALF are useful for evaluating both the history of asbestos exposure in a population exposed to dust, as well as patients having asbestos-related diseases. To assess the clinical utility of measuring the number of asbestos bodies (AB) present in bronchoalveolar lavage fluid (BALF), we counted the number of AB in BALF from 119 subjects using light microscopy. The results were analyzed according to occupational histories, radiological findings of asbestos-induced lung and pleural changes, and asbestos-related diseases. The 94 subjects in group 1 had a history of dust exposure, whereas group 2 subjects (n = 25) had no dust exposure. Group 1 was subdivided into subjects with obvious exposure to asbestos (group 1A, n = 61), and subjects with no known exposure to asbestos (group 1B, n = 33). The distribution of AB counts per ml of BALF (means +/- SEM) differed significantly between groups 1 and 2 (38.8 +/- 17.4 vs 0.06 +/- 0.04, p < 0.0001). The AB counts were significantly different between groups 1A and 1B (57.9 +/- 26.6 vs 3.4 +/- 1.2, p = 0.01). Subject, exposed to dust who had radiological evidence of pleural thickening had significantly higher AB counts than subjects in whom pleural thickening was absent (66.0 +/- 31.1 vs 5.1 +/- 4.2, p = 0.03). In group 1, the BALF was positive for AB in 7 of 14 patients with pulmonary fibrosis, 4 of 5 patients with lung cancer, all 6 patients with malignant mesothelioma, and all 4 patients with benign asbestos pleural effusion. We conclude that AB counts in BALF are useful for evaluating both the history of asbestos exposure in a population exposed to dust, as well as patients having asbestos-related diseases. |
| Author | Akabane, Hisamasa Takagiwa, Jun Miura, Hirotaro Shimizu, Takashi Takayama, Shigemitsu Takabe, Kazuhiko Hirayama, Minoru Nakayama, Morito Aida, Shinsuke Tsukada, Yoshikazu |
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| References | 7) Epler GR, McLoud TC, Gaensler EA: Prevalence and incidence of benign asbestos pleural effusion in a working population. JAMA 1982; 247: 617-622. 16) Xaubet A, Rodriguez-Roisin R, Bombi JA, et al: Correlation of bronchoalveolar lavage and clinical and functional findings in asbestosis. Am Rev Respir Dis 1986; 133: 848-854. 21) Hillerdal G: Pleural plaques and risk for bronchial carcinoma and mesothelioma. Chest 1994; 105: 144-150. 15) Teschler H, Friedrichs KH, Hoheisel GB, et al: Asbestos fibers in bronchoalveolar lavage and lung tissue of former asbestos workers. Am J Respir Crit Care Med 1994; 149: 641-645. 11) Smith MJ, Naylor B: A method of extracting ferruginous bodies: their formation and clinical significance. Am J Clin Pathol 1972; 58: 250-254. 13) Schwartz DA, Galvin JR, Burmeister LF, et al: The clinical utility and reliability of asbestos bodies in bronchoalveolar fluid. Am Rev Respir Dis 1991; 144: 684-688. 19) Gaensler EA, Jederlinic PJ, Churg A: Idiopathic pulmonary fibrosis in asbestos-exposed workers. Am Rev Respir Dis 1991; 144: 689-696. 18) 岸本卓巳, 佐藤利雄: 胸部X線上胸膜プラーク所見のみを認める症例の気管支肺胞洗浄液の免疫能に関する検討. 日胸疾会誌 1991; 29: 1017-1021. 1) Epler GR, Fitz Gerald MX, Gaensler EA, et al: Asbestos-related disease from household exposure. Respiration 1980; 39: 229-240. 17) Gellert AR, Kitajewska JY, Uthayakumar S, et al: Asbestos fibers in bronchoalveolar lavage fluid from asbestos workers: examination by electron microscopy. Br J Ind Med 1986; 43: 170-176. 2) Inase N, Takayama S, Nakayama M, et al: Pleural mesothelioma after neighborhood exposure to asbestos during childhood. Jpn J Med 1991; 30: 343-345. 8) 大八木重郎, 鏡森定信, 戸田弘一: 石綿暴露の指標とされる胸膜肥厚頻度の比較研究. 産業医学 1981; 23: 366-376. 3) Roggli VL, Pratt PC, Brody AR: Analysis of tissue mineral fiber content. In: Roggli VL, Greenberg SD, Pratt PC, eds, Pathology of asbestos-associated diseases, Little, Brown and Company, Boston 1992; 299-345. 10) Staples CA, Gamus G, Ray CS, et al: High resolution computed tomography and lung function in asbestosexposed workers with normal chest radiographs. Am Rev Respir Dis 1989; 139: 1502-1508. 20) Weiss W: Asbestos-related pleural plaques and lung cancer. Chest 1993; 103: 1854-1859. 12) Churg A, Warnock ML: Correlation of quantitative asbestos body counts and occupation in urban patients. Arch Pathol Lab Med 1977; 101: 629-634. 6) Sebastien P, Armstrong B, Monchaux G, et al: Asbestos bodies in bronchoalveolar lavage fluid and in lung parenchyma. Am Rev Respir Dis 1988; 137: 75-78. 9) Webb WR, Muller NL, Naidich DP: HRCT of the normal and abnormal pleura. In: Webb WR, Muller NL, Naidich DP, eds. High-resolution CT of the lung, Raven Press, New York 1992; 134-144. 14) Teschler H, Konietzko N, Schoenfeld B, et al: Distribution of asbestos bodies in the human lung as determined by bronchoalveolar lavage. Am Rev Respir Dis 1993; 147: 1211-1215. 4) De Vuyst P, Jedwab J, Dumortier P, et al: Asbestos bodies in bronchoalveolar lavage. Am Rev Respir Dis 1982; 126: 972-976. 5) De Vuyst P, Dumortier P, Moulin E, et al: Diagnostic value of asbestos bodies in bronchoalveolar lavage fluid. Am Rev Respir Dis 1987; 136: 1219-1224. |
| References_xml | – reference: 2) Inase N, Takayama S, Nakayama M, et al: Pleural mesothelioma after neighborhood exposure to asbestos during childhood. Jpn J Med 1991; 30: 343-345. – reference: 18) 岸本卓巳, 佐藤利雄: 胸部X線上胸膜プラーク所見のみを認める症例の気管支肺胞洗浄液の免疫能に関する検討. 日胸疾会誌 1991; 29: 1017-1021. – reference: 3) Roggli VL, Pratt PC, Brody AR: Analysis of tissue mineral fiber content. In: Roggli VL, Greenberg SD, Pratt PC, eds, Pathology of asbestos-associated diseases, Little, Brown and Company, Boston 1992; 299-345. – reference: 19) Gaensler EA, Jederlinic PJ, Churg A: Idiopathic pulmonary fibrosis in asbestos-exposed workers. Am Rev Respir Dis 1991; 144: 689-696. – reference: 17) Gellert AR, Kitajewska JY, Uthayakumar S, et al: Asbestos fibers in bronchoalveolar lavage fluid from asbestos workers: examination by electron microscopy. Br J Ind Med 1986; 43: 170-176. – reference: 8) 大八木重郎, 鏡森定信, 戸田弘一: 石綿暴露の指標とされる胸膜肥厚頻度の比較研究. 産業医学 1981; 23: 366-376. – reference: 10) Staples CA, Gamus G, Ray CS, et al: High resolution computed tomography and lung function in asbestosexposed workers with normal chest radiographs. Am Rev Respir Dis 1989; 139: 1502-1508. – reference: 5) De Vuyst P, Dumortier P, Moulin E, et al: Diagnostic value of asbestos bodies in bronchoalveolar lavage fluid. Am Rev Respir Dis 1987; 136: 1219-1224. – reference: 11) Smith MJ, Naylor B: A method of extracting ferruginous bodies: their formation and clinical significance. Am J Clin Pathol 1972; 58: 250-254. – reference: 12) Churg A, Warnock ML: Correlation of quantitative asbestos body counts and occupation in urban patients. Arch Pathol Lab Med 1977; 101: 629-634. – reference: 21) Hillerdal G: Pleural plaques and risk for bronchial carcinoma and mesothelioma. Chest 1994; 105: 144-150. – reference: 20) Weiss W: Asbestos-related pleural plaques and lung cancer. Chest 1993; 103: 1854-1859. – reference: 14) Teschler H, Konietzko N, Schoenfeld B, et al: Distribution of asbestos bodies in the human lung as determined by bronchoalveolar lavage. Am Rev Respir Dis 1993; 147: 1211-1215. – reference: 4) De Vuyst P, Jedwab J, Dumortier P, et al: Asbestos bodies in bronchoalveolar lavage. Am Rev Respir Dis 1982; 126: 972-976. – reference: 13) Schwartz DA, Galvin JR, Burmeister LF, et al: The clinical utility and reliability of asbestos bodies in bronchoalveolar fluid. Am Rev Respir Dis 1991; 144: 684-688. – reference: 15) Teschler H, Friedrichs KH, Hoheisel GB, et al: Asbestos fibers in bronchoalveolar lavage and lung tissue of former asbestos workers. Am J Respir Crit Care Med 1994; 149: 641-645. – reference: 1) Epler GR, Fitz Gerald MX, Gaensler EA, et al: Asbestos-related disease from household exposure. Respiration 1980; 39: 229-240. – reference: 7) Epler GR, McLoud TC, Gaensler EA: Prevalence and incidence of benign asbestos pleural effusion in a working population. JAMA 1982; 247: 617-622. – reference: 9) Webb WR, Muller NL, Naidich DP: HRCT of the normal and abnormal pleura. In: Webb WR, Muller NL, Naidich DP, eds. High-resolution CT of the lung, Raven Press, New York 1992; 134-144. – reference: 16) Xaubet A, Rodriguez-Roisin R, Bombi JA, et al: Correlation of bronchoalveolar lavage and clinical and functional findings in asbestosis. Am Rev Respir Dis 1986; 133: 848-854. – reference: 6) Sebastien P, Armstrong B, Monchaux G, et al: Asbestos bodies in bronchoalveolar lavage fluid and in lung parenchyma. Am Rev Respir Dis 1988; 137: 75-78. |
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| SubjectTerms | Adult Aged Aged, 80 and over Asbestos - adverse effects Asbestos - analysis Asbestosis Asbestosis - etiology Asbestosis - metabolism Benign asbestos pleural effusion Bronchoalveolar Lavage Fluid - chemistry Female Humans Lung cancer Lung Neoplasms - chemistry Lung Neoplasms - etiology Male Malignant pleural mesothelioma Mesothelioma - chemistry Mesothelioma - etiology Middle Aged Mineral Fibers - analysis Occupational Exposure - adverse effects Pleural Neoplasms - chemistry Pleural Neoplasms - etiology Pleural plaque |
| Title | The Clinical Utility of Asbestos Body Counts in Bronchoalveolar Lavage Fluid |
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