筋生検で見出される Polyglucosan body と加齢
1歳より90歳におよぶ生検筋790について, 筋内神経の intraaxonal polyglucosan body の出現頻度および微細構造について検討し, 次の結果を得た. 1) 86筋でみられた神経枝のうち, 8筋に polyglucosan body をみとめた (9.3%). 2) 出現例の年齢はすべて54歳以上であった. 3) 原疾患は種々であった. 4) 筋病変は, 神経原性, 筋原性ともにみとめられた. 5) Polyglucosan body を示す神経枝の半数に脱髄や繊維化がみとめられた. 6) Polyglucosan body は, PAS陽性で糖質をふくみ, 電顕的に...
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| Published in | 日本老年医学会雑誌 Vol. 20; no. 4; pp. 330 - 334 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
一般社団法人 日本老年医学会
01.07.1983
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| Online Access | Get full text |
| ISSN | 0300-9173 |
| DOI | 10.3143/geriatrics.20.330 |
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| Abstract | 1歳より90歳におよぶ生検筋790について, 筋内神経の intraaxonal polyglucosan body の出現頻度および微細構造について検討し, 次の結果を得た. 1) 86筋でみられた神経枝のうち, 8筋に polyglucosan body をみとめた (9.3%). 2) 出現例の年齢はすべて54歳以上であった. 3) 原疾患は種々であった. 4) 筋病変は, 神経原性, 筋原性ともにみとめられた. 5) Polyglucosan body を示す神経枝の半数に脱髄や繊維化がみとめられた. 6) Polyglucosan body は, PAS陽性で糖質をふくみ, 電顕的には繊維状構造物で, corpora amylacea (アミロイド小体) と全く同様の性質をしめした. この病変は, 高齢者に非特異的にみいだされる軸索変性像の一つと考えられる. |
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| AbstractList | 1歳より90歳におよぶ生検筋790について, 筋内神経の intraaxonal polyglucosan body の出現頻度および微細構造について検討し, 次の結果を得た. 1) 86筋でみられた神経枝のうち, 8筋に polyglucosan body をみとめた (9.3%). 2) 出現例の年齢はすべて54歳以上であった. 3) 原疾患は種々であった. 4) 筋病変は, 神経原性, 筋原性ともにみとめられた. 5) Polyglucosan body を示す神経枝の半数に脱髄や繊維化がみとめられた. 6) Polyglucosan body は, PAS陽性で糖質をふくみ, 電顕的には繊維状構造物で, corpora amylacea (アミロイド小体) と全く同様の性質をしめした. この病変は, 高齢者に非特異的にみいだされる軸索変性像の一つと考えられる. |
| Author | 田渕, 正康 長沢, 治夫 斉藤, 光典 朝長, 正徳 |
| Author_xml | – sequence: 1 fullname: 田渕, 正康 organization: 現 兵庫県立姫路循環器センター – sequence: 1 fullname: 斉藤, 光典 organization: 東京都養育院附属病院神経内科 – sequence: 1 fullname: 長沢, 治夫 organization: 東京都養育院附属病院神経内科 – sequence: 1 fullname: 朝長, 正徳 organization: 東京都養育院附属病院神経内科 |
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| References | 11) Yagishita S, Itoh Y: Corpora amylacea in the peripheral nerve axons. Acta Neuropathol 37: 73-76, 1977. 4) Robitaille Y, Carpenter S, Karpati G, Dimauro S: A distinct form of adult polyglocosan body disease with massive involvement of central and peripheral neuronal processes and astrocytes. A report of four cases and a review of the occurrence of polyglucosan bodies in other conditions such as Lafora's disease and normal ageing. Brain 103: 315-336, 1980. 3) Carpenter S, Karpati G, Robitaille Y, Melmed C: Adult polyglucosan body axonopathy-distinct chronic neurological disease. 8th International Congress of Neuropathology, Washington, D.C., 1978. 1) Asbury AK, Johnson PC: Pathology of peripheral nerve. Saunders, 1979, 256-257. 5) Suzuki Y, Akiyama K, Suu S: Lafora-like inclusion bodies in the CNS of aged dogs. Acta Neuropathol 44: 217-222, 1978. 2) 斉藤光典, 朝長正徳, 松浦美喜雄: 末梢神経軸索内にみられた corpora amylacea. 神経内科 9: 297-301, 1978. 7) Palmucci L, Anzil AP, Luh S: Intra-astrocytic glycogen granules and corpora amylacea stain positively for polyglucosans: A cytochemical contribution on the fine structural polymorphism of particulate polysaccharides. Acta neuropathol 57: 99-102, 1982. 8) Moore S, Peterson RG, Felten DK, O'Connor BL: Glycogen accumalation in tibial nerves of experimental diabetic and aging control rats. J Neurol Sci 52: 289-303, 1981. 10) Avervack P, Langevin H: Corpora amylacea of the lumbar spinal cord and peripheral nervous system. Arch Neurol 35: 95-96, 1978. 12) Fukuhara N: Intra-axonal corpora amylacea in the peripheral nerve seen in a healthy woman. J Neurol Sci 34: 423-426, 1977. 9) Powell HC, Ward HW, Garrett MS, Orloff MJ, Lampert PW: Glycogen accumulation in the nerves and kidney of chronically diabetic rats. a quantitative electron microscopic study. J Neuropath Exp Neurol 38: 114-127, 1979. 6) Suzuki Y, Kamiya S, Ohta K, Suu S: Laforalike bodies in a cat. Acta Neuropathol 48: 55-58, 1979. |
| References_xml | – reference: 12) Fukuhara N: Intra-axonal corpora amylacea in the peripheral nerve seen in a healthy woman. J Neurol Sci 34: 423-426, 1977. – reference: 1) Asbury AK, Johnson PC: Pathology of peripheral nerve. Saunders, 1979, 256-257. – reference: 8) Moore S, Peterson RG, Felten DK, O'Connor BL: Glycogen accumalation in tibial nerves of experimental diabetic and aging control rats. J Neurol Sci 52: 289-303, 1981. – reference: 7) Palmucci L, Anzil AP, Luh S: Intra-astrocytic glycogen granules and corpora amylacea stain positively for polyglucosans: A cytochemical contribution on the fine structural polymorphism of particulate polysaccharides. Acta neuropathol 57: 99-102, 1982. – reference: 3) Carpenter S, Karpati G, Robitaille Y, Melmed C: Adult polyglucosan body axonopathy-distinct chronic neurological disease. 8th International Congress of Neuropathology, Washington, D.C., 1978. – reference: 11) Yagishita S, Itoh Y: Corpora amylacea in the peripheral nerve axons. Acta Neuropathol 37: 73-76, 1977. – reference: 4) Robitaille Y, Carpenter S, Karpati G, Dimauro S: A distinct form of adult polyglocosan body disease with massive involvement of central and peripheral neuronal processes and astrocytes. A report of four cases and a review of the occurrence of polyglucosan bodies in other conditions such as Lafora's disease and normal ageing. Brain 103: 315-336, 1980. – reference: 5) Suzuki Y, Akiyama K, Suu S: Lafora-like inclusion bodies in the CNS of aged dogs. Acta Neuropathol 44: 217-222, 1978. – reference: 9) Powell HC, Ward HW, Garrett MS, Orloff MJ, Lampert PW: Glycogen accumulation in the nerves and kidney of chronically diabetic rats. a quantitative electron microscopic study. J Neuropath Exp Neurol 38: 114-127, 1979. – reference: 10) Avervack P, Langevin H: Corpora amylacea of the lumbar spinal cord and peripheral nervous system. Arch Neurol 35: 95-96, 1978. – reference: 2) 斉藤光典, 朝長正徳, 松浦美喜雄: 末梢神経軸索内にみられた corpora amylacea. 神経内科 9: 297-301, 1978. – reference: 6) Suzuki Y, Kamiya S, Ohta K, Suu S: Laforalike bodies in a cat. Acta Neuropathol 48: 55-58, 1979. |
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| Title | 筋生検で見出される Polyglucosan body と加齢 |
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