成人における脂肪組織インスリン抵抗性およびアディポカインと肝臓の脂肪蓄積との関連 ―横断研究
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| Published in | 健康支援 Vol. 27; no. 1; pp. 1 - 9 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | Japanese |
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日本健康支援学会
2025
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1345-0174 2758-3449 |
| DOI | 10.57438/jshp.20240724_1 |
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| Author | 藤田, 英二 中垣内, 真樹 内田, 遼太 沼尾, 成晴 引地, 優人 |
|---|---|
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| GrantInformation | 宮崎県児湯郡木城町/鹿屋体育大学受託研究 鹿屋体育大学令和５年度重点プロジェクト事業 |
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| References | 13） Adams-Huet B, Devaraj S, Siegel D, Siegel D, Jialal I.: Increased adipose tissue insulin resistance in metabolic syndrome: relationship to circulating adipokines. Metab Syndr Relat Disord, 2014; 12:503-507. DOI: 10.1089/met.2014.0092 ６） Saladin R, De Vos P, Guerre-Millo M, et al.: Transient increase in obese gene expression after food intake or insulin administration. Nature, 1995; 377:527-529. DOI: 10.1038/377527a0 23） Kim JY, Bacha F, Tfayli H, Michaliszyn SF, Yousuf S, Arslanian S.: Adipose tissue insulin resistance in youth on the spectrum from normal weight to obese and from normal glucose tolerance to impaired glucose tolerance to type 2 diabetes. Diabetes Care, 2019; 42:265-272. DOI: 10.2337/dc18-1178 ３） Delarue J, Magnan C.: Free fatty acids and insulin resistance. Curr Opin Clin Nutr Metab Care, 2007; 10:142-148. DOI: 10.1097/MCO.0b013e328042ba90 １） Feng G, Valenti L, Wong VW, et al.: Recompensation in cirrhosis: unravelling the evolving natural history of nonalcoholic fatty liver disease. Nat Rev Gastroenterol Hepatol, 2024; 21:46-56. DOI: 10.1038/s41575-023-00846-4 ７） Pajvani UB, Du X, Combs TP, et al.: Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications for metabolic regulation and bioactivity. J Biol Chem, 2003; 278: 9073-9085. DOI: 10.1074/jbc.M207198200 ８） Mohlig M, Wegewitz U, Osterhoff M, et al.: Insulin decreases human adiponectin plasma levels. Horm Metab Res, 2002; 34:655-658. DOI: 10.1055/s-2002-38248 16） Lee JJ, Britton KA, Pedley A, et al.: Adipose tissue depots and their cross-sectional associations with circulating biomarkers of metabolic regulation. Journal of the American Heart Association, 2016: 5. DOI: 10.1161/JAHA.115.002936 ２） Yki-Jarvinen H.: Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome. The lancet Diabetes & endocrinology, 2014; 2:901-910. DOI: 10.1016/S2213-8587(14)70032-4 10） Hosooka T, Hosokawa Y, Matsugi K, et al.: The PDK1-FoxO1 signaling in adipocytes controls systemic insulin sensitivity through the 5-lipoxygenase-leukotriene B（4） axis. Proc Natl Acad Sci U S A, 2020; 117:11674-11684. DOI: 10.1073/pnas.1921015117 15） Fischer J, Volzke H, Kassubek J, et al.: Associations of a panel of adipokines with fat deposits and metabolic phenotypes in a general population. Obesity, 2020; 28:1550-1559. DOI: 10.1002/oby.22871 18） Sondergaard E, Espinosa De Ycaza AE, Morgan-Bathke M, et al.: How to measure adipose tissue insulin sensitivity. J Clin Endocrinol Metab, 2017; 102:1193-1199. DOI: 10.1210/jc.2017-00047 20） Bosquet A, Guaita-Esteruelas S, et al.: Exogenous FABP4 induces endoplasmic reticulum stress in HepG2 liver cells. Atherosclerosis, 2016; 249:191-199. DOI: 10.1016/j.atherosclerosis.2016.04.012 ５） Gastaldelli A, Harrison SA, Belfort-Aguilar R, et al.: Importance of changes in adipose tissue insulin resistance to histological response during thiazolidinedione treatment of patients with nonalcoholic steatohepatitis. Hepatology, 2009; 50:1087-1093. DOI: 10.1002/hep.23116 17） Tanaka M, Takahashi S, Higashiura Y, et al.: Circulating level of fatty acid-binding protein 4 is an independent predictor of metabolic dysfunction-associated fatty liver disease in middle-aged and elderly individuals. Journal of diabetes investigation, 2021; 13: 878-888. DOI: 10.1111/jdi.13735 12） Zhang K, Pan H, Wang L, Yang H, Zhu H, Gong F.: Adipose tissue insulin resistance is closely associated with metabolic syndrome in northern Chinese populations. Diabetes Metab Syndr Obes, 2021; 14:1117-1128. DOI: 10.2147/DMSO.S291350 21） Francisco V, Sanz MJ, Real JT, et al.: Adipokines in non-alcoholic fatty liver disease: Are we on the road toward new biomarkers and therapeutic targets? Biology（Basel）, 2022: 11. DOI: 10.3390/biology11081237 11） Semnani-Azad Z, Connelly PW, Bazinet RP, et al.: Adipose tissue insulin resistance is longitudinally associated with adipose tissue dysfunction, circulating lipids, and dysglycemia: The PROMISE Cohort. Diabetes Care, 2021; 44:1682-1691. DOI: 10.2337/dc20-1918 ４） Xu Y, Ma X, Pan X, He X, Wang Y, Bao Y.: Serum adipocyte fatty acid-binding protein levels: An indicator of non-alcoholic fatty liver disease in Chinese individuals. Liver Int, 2019; 39: 568-574. DOI: 10.1111/liv.14021 19） Bedogni G, Bellentani S, Miglioli L, Morgan-Bathke M, Jensen MD.: The Fatty Liver Index: a simple and accurate predictor of hepatic steatosis in the general population. BMC Gastroenterol, 2006; 6:33. DOI: 10.1186/1471-230X-6-33 24） Wei Y, Liu J, Wang G, Wang Y.: Sex differences in the association between adipose insulin resistance and non-alcoholic fatty liver disease in Chinese adults. Biol Sex Differ, 2023; 14:69. DOI: 10.1186/s13293-023-00549-0 ９） Mita T, Furuhashi M, Hiramitsu S, et al.: FABP4 is secreted from adipocytes by adenyl cyclase-PKA-and guanylyl cyclase-PKG-dependent lipolytic mechanisms. Obesity, 2015; 23:359-367. DOI: 10.1002/oby.20954 22） Hershkop K, Besor O, Santoro N, Pierpont B, Caprio S, Weiss R.: Adipose insulin resistance in obese adolescents across the spectrum of glucose tolerance. J Clin Endocrinol Metab, 2016; 101:2423-2431. DOI: 10.1210/jc.2016-1376 14） Chiriaco M, Nesti L, Flyvbjerg A, et al.: At any level of adiposity, relatively elevated leptin concentrations are associated with decreased insulin sensitivity. J Clin Endocrinol Metab, 2024; 109:461-470. DOI: 10.1210/clinem/dgad505 25） Li X, Liu J, Zhou B, et al.: Sex differences in the effect of testosterone on adipose tissue insulin resistance from overweight to obese adults. J Clin Endocrinol Metab, 2021; 106:2252-2263. DOI: 10.1210/clinem/dgab325 |
| References_xml | – reference: ９） Mita T, Furuhashi M, Hiramitsu S, et al.: FABP4 is secreted from adipocytes by adenyl cyclase-PKA-and guanylyl cyclase-PKG-dependent lipolytic mechanisms. Obesity, 2015; 23:359-367. DOI: 10.1002/oby.20954 – reference: 23） Kim JY, Bacha F, Tfayli H, Michaliszyn SF, Yousuf S, Arslanian S.: Adipose tissue insulin resistance in youth on the spectrum from normal weight to obese and from normal glucose tolerance to impaired glucose tolerance to type 2 diabetes. Diabetes Care, 2019; 42:265-272. DOI: 10.2337/dc18-1178 – reference: ８） Mohlig M, Wegewitz U, Osterhoff M, et al.: Insulin decreases human adiponectin plasma levels. Horm Metab Res, 2002; 34:655-658. DOI: 10.1055/s-2002-38248 – reference: 17） Tanaka M, Takahashi S, Higashiura Y, et al.: Circulating level of fatty acid-binding protein 4 is an independent predictor of metabolic dysfunction-associated fatty liver disease in middle-aged and elderly individuals. Journal of diabetes investigation, 2021; 13: 878-888. DOI: 10.1111/jdi.13735 – reference: ４） Xu Y, Ma X, Pan X, He X, Wang Y, Bao Y.: Serum adipocyte fatty acid-binding protein levels: An indicator of non-alcoholic fatty liver disease in Chinese individuals. Liver Int, 2019; 39: 568-574. DOI: 10.1111/liv.14021 – reference: １） Feng G, Valenti L, Wong VW, et al.: Recompensation in cirrhosis: unravelling the evolving natural history of nonalcoholic fatty liver disease. Nat Rev Gastroenterol Hepatol, 2024; 21:46-56. DOI: 10.1038/s41575-023-00846-4 – reference: ２） Yki-Jarvinen H.: Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome. The lancet Diabetes & endocrinology, 2014; 2:901-910. DOI: 10.1016/S2213-8587(14)70032-4 – reference: 19） Bedogni G, Bellentani S, Miglioli L, Morgan-Bathke M, Jensen MD.: The Fatty Liver Index: a simple and accurate predictor of hepatic steatosis in the general population. BMC Gastroenterol, 2006; 6:33. DOI: 10.1186/1471-230X-6-33 – reference: 11） Semnani-Azad Z, Connelly PW, Bazinet RP, et al.: Adipose tissue insulin resistance is longitudinally associated with adipose tissue dysfunction, circulating lipids, and dysglycemia: The PROMISE Cohort. Diabetes Care, 2021; 44:1682-1691. DOI: 10.2337/dc20-1918 – reference: ７） Pajvani UB, Du X, Combs TP, et al.: Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications for metabolic regulation and bioactivity. J Biol Chem, 2003; 278: 9073-9085. DOI: 10.1074/jbc.M207198200 – reference: 10） Hosooka T, Hosokawa Y, Matsugi K, et al.: The PDK1-FoxO1 signaling in adipocytes controls systemic insulin sensitivity through the 5-lipoxygenase-leukotriene B（4） axis. Proc Natl Acad Sci U S A, 2020; 117:11674-11684. DOI: 10.1073/pnas.1921015117 – reference: 12） Zhang K, Pan H, Wang L, Yang H, Zhu H, Gong F.: Adipose tissue insulin resistance is closely associated with metabolic syndrome in northern Chinese populations. Diabetes Metab Syndr Obes, 2021; 14:1117-1128. DOI: 10.2147/DMSO.S291350 – reference: 14） Chiriaco M, Nesti L, Flyvbjerg A, et al.: At any level of adiposity, relatively elevated leptin concentrations are associated with decreased insulin sensitivity. J Clin Endocrinol Metab, 2024; 109:461-470. DOI: 10.1210/clinem/dgad505 – reference: ３） Delarue J, Magnan C.: Free fatty acids and insulin resistance. Curr Opin Clin Nutr Metab Care, 2007; 10:142-148. DOI: 10.1097/MCO.0b013e328042ba90 – reference: 16） Lee JJ, Britton KA, Pedley A, et al.: Adipose tissue depots and their cross-sectional associations with circulating biomarkers of metabolic regulation. Journal of the American Heart Association, 2016: 5. DOI: 10.1161/JAHA.115.002936 – reference: 22） Hershkop K, Besor O, Santoro N, Pierpont B, Caprio S, Weiss R.: Adipose insulin resistance in obese adolescents across the spectrum of glucose tolerance. J Clin Endocrinol Metab, 2016; 101:2423-2431. DOI: 10.1210/jc.2016-1376 – reference: 18） Sondergaard E, Espinosa De Ycaza AE, Morgan-Bathke M, et al.: How to measure adipose tissue insulin sensitivity. J Clin Endocrinol Metab, 2017; 102:1193-1199. DOI: 10.1210/jc.2017-00047 – reference: ５） Gastaldelli A, Harrison SA, Belfort-Aguilar R, et al.: Importance of changes in adipose tissue insulin resistance to histological response during thiazolidinedione treatment of patients with nonalcoholic steatohepatitis. Hepatology, 2009; 50:1087-1093. DOI: 10.1002/hep.23116 – reference: 24） Wei Y, Liu J, Wang G, Wang Y.: Sex differences in the association between adipose insulin resistance and non-alcoholic fatty liver disease in Chinese adults. Biol Sex Differ, 2023; 14:69. DOI: 10.1186/s13293-023-00549-0 – reference: ６） Saladin R, De Vos P, Guerre-Millo M, et al.: Transient increase in obese gene expression after food intake or insulin administration. Nature, 1995; 377:527-529. DOI: 10.1038/377527a0 – reference: 20） Bosquet A, Guaita-Esteruelas S, et al.: Exogenous FABP4 induces endoplasmic reticulum stress in HepG2 liver cells. Atherosclerosis, 2016; 249:191-199. DOI: 10.1016/j.atherosclerosis.2016.04.012 – reference: 21） Francisco V, Sanz MJ, Real JT, et al.: Adipokines in non-alcoholic fatty liver disease: Are we on the road toward new biomarkers and therapeutic targets? Biology（Basel）, 2022: 11. DOI: 10.3390/biology11081237 – reference: 15） Fischer J, Volzke H, Kassubek J, et al.: Associations of a panel of adipokines with fat deposits and metabolic phenotypes in a general population. Obesity, 2020; 28:1550-1559. DOI: 10.1002/oby.22871 – reference: 25） Li X, Liu J, Zhou B, et al.: Sex differences in the effect of testosterone on adipose tissue insulin resistance from overweight to obese adults. J Clin Endocrinol Metab, 2021; 106:2252-2263. DOI: 10.1210/clinem/dgab325 – reference: 13） Adams-Huet B, Devaraj S, Siegel D, Siegel D, Jialal I.: Increased adipose tissue insulin resistance in metabolic syndrome: relationship to circulating adipokines. Metab Syndr Relat Disord, 2014; 12:503-507. DOI: 10.1089/met.2014.0092 |
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| Title | 成人における脂肪組織インスリン抵抗性およびアディポカインと肝臓の脂肪蓄積との関連 ―横断研究 |
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