アドレノメデュリン-RAMP2システムは, 小胞体ストレス誘導性細胞死を抑制し,腎保護的に働く

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Published inJapanese Journal of Circulation Research Vol. 36; no. 3; pp. 89 - 93
Main Authors 楊, 磊, 新藤, 隆行, 桜井, 敬之, 鳥山, 佑一, 河手, 久香, 山内, 啓弘, 吉沢, 隆浩, 田中, 愛, 植竹, 龍一, 神吉, 昭子, 新藤, 優佳, 五十嵐, 恭子, 小山, 晃英, 家里, 康弘
Format Journal Article
LanguageJapanese
Published 日本心脈管作動物質学会 2013
Japanese Society for Circulation Research
Online AccessGet full text
ISSN0911-4637
2759-2286
DOI10.60370/jjcircres.36.3_89

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Author 鳥山, 佑一
山内, 啓弘
神吉, 昭子
田中, 愛
植竹, 龍一
桜井, 敬之
楊, 磊
河手, 久香
家里, 康弘
小山, 晃英
五十嵐, 恭子
新藤, 隆行
新藤, 優佳
吉沢, 隆浩
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  organization: 信州大学大学院医学系研究科循環病態学講座
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References Niu P,Shindo T,Iwata H,Iimuro S,Takeda N,Zhang Y,Ebihara A,Suematsu Y,Kangawa K,Hirata Y,Nagai R.Protective eff ects of endogenous adrenomedullin on cardiac hypertrophy,fi brosis,and renal damage.Circulation.2004;109:1789-1794
Yoshizawa T,Sakurai T,Kamiyoshi A,Ichikawa-Shindo Y,Kawate H,Iesato Y,Koyama T,Uetake R,Yang L, Yamauchi A,Tanaka M,Toriyama Y,Igarashi K,Nakada T,Kashihara T,Yamada M,Kawakami H,Nakanishi H,Taguchi R,Nakanishi T,Akazawa H,Shindo T.Novel regulation of cardiac metabolism and homeostasis by the adrenomedullin-receptor activity-modifying protein 2 system.Hypertension.2013;61:341-351
Ohse T,Inagi R,Tanaka T,Ota T,Miyata T,Kojima I, Ingelfinger JR,Ogawa S,Fujita T,Nangaku M.Albumin induces endoplasmic reticulum stress and apoptosis in renal proximal tubular cells.Kidney Int.2006;70:1447-1455
Schnedl WJ,Ferber S,Johnson JH,Newgard CB.Stz transport and cytotoxicity.Specific enhancement in glut2-expressing cells.Diabetes.1994;43:1326-1333
Kitamura K,Kangawa K,Kawamoto M,Ichiki Y,Nakamura S,Matsuo H,Eto T.Adrenomedullin:A novel hypotensive peptide isolated from human pheochromocytoma.BiochemBiophys Res ommun.1993;192:553-560
Ichikawa-Shindo Y,Sakurai T,Kamiyoshi A,Kawate H, Iinuma N,Yoshizawa T,Koyama T,Fukuchi J,Iimuro S,Moriyama N,Kawakami H,Murata T,Kangawa K,Nagai R,Shindo T.The gpcr modulator protein ramp2 is essential for angiogenesis and vascular integrity.J Clin Invest.2008;118:29-39
Shindo T,Kurihara Y,Nishimatsu H,Moriyama N,Kakoki M, Wang Y,Imai Y,Ebihara A,Kuwaki T,Ju KH,Minamino N, Kangawa K,Ishikawa T,Fukuda M,Akimoto Y,Kawakami H,Imai T,Morita H,Yazaki Y,Nagai R,Hirata Y,Kurihara H.Vascular abnormalities and elevated blood pressure in mice lacking adrenomedullin gene.Circulation.2001;104:1964-1971
Shimosawa T,Shibagaki Y,Ishibashi K,Kitamura K, Kangawa K,Kato S,Ando K,Fujita .Adrenomedullin,an endogenous peptide,counteracts cardiovascular damage. Circulation.2002;105:106-111
Imai Y,Shindo T,Maemura K,Sata M,Saito Y,Kurihara Y,Akishita M,Osuga J,Ishibashi S,Tobe K,Morita H,Oh-hashi Y,Suzuki T,Maekawa H,Kangawa K,Minamino N,Yazaki Y,Nagai R,Kurihara H.Resistance to neointimal hyperplasia and fatty streak formation in mice with adrenomedullin overexpression.Arterioscler Thromb Vasc Biol. 2002;22:1310-1315
McLatchie LM,Fraser NJ,Main MJ,Wise A,Brown J,Thompson N,Solari R,Lee MG,Foord SM.Ramps regulate the transport and ligand specifi city of the calcitonin-receptor-like receptor.Nature.1998;393:333-339
Szkudelski T.The mechanism of alloxan and streptozotocin action in b cells of the rat pancreas.Physiological research/Academia Scientiarum Bohemoslovaca.2001;50:537-546
Kawakami T,Inagi R,Wada T,Tanaka T,Fujita T,Nangaku M.Indoxyl sulfate inhibits proliferation of human proximal tubular cells via endoplasmic reticulum stress.Am J Physiol
Nishimatsu H,Hirata Y,Shindo T,Kurihara H,Kakoki M, Nagata D,Hayakawa H,Satonaka H,Sata M,Tojo A,Suzuki E,Kangawa K,Matsuo H,Kitamura T,Nagai R.Role of endogenous adrenomedullin in the regulation of vascular tone and ischemic renal injury:Studies on transgenic/knockout mice of adrenomedullin gene.Circ Res.2002;90:657-663
Kronenberg F.Emerging risk factors and markers of chronic kidney disease progression.Nat Rev Nephrol.2009;5:677-689
Koyama T,Ochoa-Callejero L,Sakurai T,Kamiyoshi A, Ichikawa-Shindo Y,Iinuma N,Arai T,Yoshizawa T,Iesato Y,Lei Y,Uetake R,Okimura A,Yamauchi A,Tanaka M, Igarashi K,Toriyama Y,Kawate H,Adams RH,Kawakami H,Mochizuki N,Martinez A,Shindo T.Vascular endothelialadrenomedullin-ramp2 system is essential for vascular integrity and organ homeostasis.Circulation.2013;127:842-853
References_xml – reference: Shindo T,Kurihara Y,Nishimatsu H,Moriyama N,Kakoki M, Wang Y,Imai Y,Ebihara A,Kuwaki T,Ju KH,Minamino N, Kangawa K,Ishikawa T,Fukuda M,Akimoto Y,Kawakami H,Imai T,Morita H,Yazaki Y,Nagai R,Hirata Y,Kurihara H.Vascular abnormalities and elevated blood pressure in mice lacking adrenomedullin gene.Circulation.2001;104:1964-1971
– reference: Schnedl WJ,Ferber S,Johnson JH,Newgard CB.Stz transport and cytotoxicity.Specific enhancement in glut2-expressing cells.Diabetes.1994;43:1326-1333
– reference: Szkudelski T.The mechanism of alloxan and streptozotocin action in b cells of the rat pancreas.Physiological research/Academia Scientiarum Bohemoslovaca.2001;50:537-546
– reference: Koyama T,Ochoa-Callejero L,Sakurai T,Kamiyoshi A, Ichikawa-Shindo Y,Iinuma N,Arai T,Yoshizawa T,Iesato Y,Lei Y,Uetake R,Okimura A,Yamauchi A,Tanaka M, Igarashi K,Toriyama Y,Kawate H,Adams RH,Kawakami H,Mochizuki N,Martinez A,Shindo T.Vascular endothelialadrenomedullin-ramp2 system is essential for vascular integrity and organ homeostasis.Circulation.2013;127:842-853
– reference: Imai Y,Shindo T,Maemura K,Sata M,Saito Y,Kurihara Y,Akishita M,Osuga J,Ishibashi S,Tobe K,Morita H,Oh-hashi Y,Suzuki T,Maekawa H,Kangawa K,Minamino N,Yazaki Y,Nagai R,Kurihara H.Resistance to neointimal hyperplasia and fatty streak formation in mice with adrenomedullin overexpression.Arterioscler Thromb Vasc Biol. 2002;22:1310-1315
– reference: Kitamura K,Kangawa K,Kawamoto M,Ichiki Y,Nakamura S,Matsuo H,Eto T.Adrenomedullin:A novel hypotensive peptide isolated from human pheochromocytoma.BiochemBiophys Res ommun.1993;192:553-560
– reference: Ichikawa-Shindo Y,Sakurai T,Kamiyoshi A,Kawate H, Iinuma N,Yoshizawa T,Koyama T,Fukuchi J,Iimuro S,Moriyama N,Kawakami H,Murata T,Kangawa K,Nagai R,Shindo T.The gpcr modulator protein ramp2 is essential for angiogenesis and vascular integrity.J Clin Invest.2008;118:29-39
– reference: Shimosawa T,Shibagaki Y,Ishibashi K,Kitamura K, Kangawa K,Kato S,Ando K,Fujita .Adrenomedullin,an endogenous peptide,counteracts cardiovascular damage. Circulation.2002;105:106-111
– reference: McLatchie LM,Fraser NJ,Main MJ,Wise A,Brown J,Thompson N,Solari R,Lee MG,Foord SM.Ramps regulate the transport and ligand specifi city of the calcitonin-receptor-like receptor.Nature.1998;393:333-339
– reference: Nishimatsu H,Hirata Y,Shindo T,Kurihara H,Kakoki M, Nagata D,Hayakawa H,Satonaka H,Sata M,Tojo A,Suzuki E,Kangawa K,Matsuo H,Kitamura T,Nagai R.Role of endogenous adrenomedullin in the regulation of vascular tone and ischemic renal injury:Studies on transgenic/knockout mice of adrenomedullin gene.Circ Res.2002;90:657-663
– reference: Yoshizawa T,Sakurai T,Kamiyoshi A,Ichikawa-Shindo Y,Kawate H,Iesato Y,Koyama T,Uetake R,Yang L, Yamauchi A,Tanaka M,Toriyama Y,Igarashi K,Nakada T,Kashihara T,Yamada M,Kawakami H,Nakanishi H,Taguchi R,Nakanishi T,Akazawa H,Shindo T.Novel regulation of cardiac metabolism and homeostasis by the adrenomedullin-receptor activity-modifying protein 2 system.Hypertension.2013;61:341-351
– reference: Ohse T,Inagi R,Tanaka T,Ota T,Miyata T,Kojima I, Ingelfinger JR,Ogawa S,Fujita T,Nangaku M.Albumin induces endoplasmic reticulum stress and apoptosis in renal proximal tubular cells.Kidney Int.2006;70:1447-1455
– reference: Kawakami T,Inagi R,Wada T,Tanaka T,Fujita T,Nangaku M.Indoxyl sulfate inhibits proliferation of human proximal tubular cells via endoplasmic reticulum stress.Am J Physiol
– reference: Kronenberg F.Emerging risk factors and markers of chronic kidney disease progression.Nat Rev Nephrol.2009;5:677-689
– reference: Niu P,Shindo T,Iwata H,Iimuro S,Takeda N,Zhang Y,Ebihara A,Suematsu Y,Kangawa K,Hirata Y,Nagai R.Protective eff ects of endogenous adrenomedullin on cardiac hypertrophy,fi brosis,and renal damage.Circulation.2004;109:1789-1794
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Title アドレノメデュリン-RAMP2システムは, 小胞体ストレス誘導性細胞死を抑制し,腎保護的に働く
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