大動脈瘤の分子病態

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Published inShinzo Vol. 41; no. 5; pp. 499 - 504
Main Authors 青木, 浩樹, 吉村, 耕一, 松崎, 益徳
Format Journal Article
LanguageJapanese
Published 公益財団法人 日本心臓財団 2009
Japan Heart Foundation
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ISSN0586-4488
2186-3016
DOI10.11281/shinzo.41.499

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Author 松崎, 益徳
吉村, 耕一
青木, 浩樹
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  fullname: 松崎, 益徳
  organization: 山口大学医学部分子脈管病態学
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References 13) Pyo R, Lee JK, Shipley JM, et al: Targeted gene disruption of matrix metalloproteinase-9(gelatinase B) suppresses development of experimental abdominal aortic aneurysms. J Clin Invest 2000; 105: 1641-1649
17) Petrinec D, Liao S, Holmes DR, et al: Doxycycline inhibition of aneurysmal degeneration in an elastase-induced rat model of abdominal aortic aneurysm: preservation of aortic elastin associated with suppressed production of 92 kD gelatinase. J Vasc Surg 1996; 23: 336-346
24) Nakashima H, Aoki M, Miyake T, et al: Inhibition of experimental abdominal aortic aneurysm in the rat by use of decoy oligodeoxynucleotides suppressing activity of nuclear factor kappaB and ets transcription factors. Circulation 2004; 109: 132-138
1) Hingorani A, Ascher E, Scheinman M, et al: The effect of tumor necrosis factor binding protein and interleukin-1 receptor antagonist on the development of abdominal aortic aneurysms in a rat model. J Vasc Surg 1998; 28: 522-526
2) Xiong W, Zhao Y, Prall A, et al: Key roles of CD4+ T cells and IFN-gamma in the development of abdominal aortic aneurysms in a murine model. J Immunol 2004; 72: 2607-2612
10) Thomas M, Gavrila D, McCormick ML, et al: Deletion of p47phox attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice. Circulation 2006; 114: 404-413
11) Gavrila D, Li WG, McCormick ML, et al: Vitamin E inhibits abdominal aortic aneurysm formation in angiotensin II-infused apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 2005; 25: 1671-1677
20) Huffman MD, Curci JA, Moore G, et al: Functional importance of connective tissue repair during the development of experimental abdominal aortic aneurysms. Surgery 2000; 128: 429-438
14) Longo GM, Xiong W, Greiner TC, et al: Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysms. J Clin Invest 2002; 110: 625-632
23) Isenburg JC, Simionescu DT, Starcher BC, Vyavahare NR: Elastin stabilization for treatment of abdominal aortic aneurysms. Circulation 2007; 115: 1729-1737
3) Shimizu K, Shichiri M, Libby P, et al: Th2-predominant inflammation and blockade of IFN-gamma signaling induce aneurysms in allografted aortas. J Clin Invest 2004; 114: 300-308
9) Zhao L, Moos MP, Grbner R, et al: The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm. Nat Med 2004; 10: 966-973
18) Baxter BT, Pearce WH, Waltke EA, et al: Prolonged administration of doxycycline in patients with small asymptomatic abdominal aortic aneurysms: report of a prospective (Phase II) multicenter study. J Vasc Surg 2002; 36: 1-12
12) Törnwall ME, Virtamo J, Haukka JK, et al: Alpha-tocopherol (vitamin E) and beta-carotene supplementation does not affect the risk for large abdominal aortic aneurysm in a controlled trial. Atherosclerosis 2001; 157: 167-173
22) Yoshimura K, Aoki H, Ikeda Y, et al: Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase. Nat Med 2005; 11: 1330-1338
25) Parodi FE, Mao D, Ennis TL, et al: Suppression of experimental abdominal aortic aneurysms in mice by treatment with pyrrolidine dithiocarbamate, an antioxidant inhibitor of nuclear factor-kappaB. J Vasc Surg 2005; 41: 479-489
5) Habashi JP, Judge DP, Holm TM, et al: Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. Science 2006; 312: 117-121
6) Brooke BS, Habashi JP, Judge DP, et al: Angiotensin II blockade and aortic-root dilation in Marfan’s syndrome. N Engl J Med 2008; 358: 2787-2795
7) Hackam DG, Thiruchelvam D, Redelmeier DA: Angiotensin-converting enzyme inhibitors and aortic rupture: a population-based case-control study. Lancet 2006; 368: 659-665
21) Allaire E, Muscatelli-Groux B, Guinault AM, et al: Vascular smooth muscle cell endovascular therapy stabilizes already developed aneurysms in a model of aortic injury elicited by inflammation and proteolysis. Ann Surg 2004; 239: 417-427
27) Schouten O, van Laanen JH, Boersma E, et al: Statins are associated with a reduced infrarenal abdominal aortic aneurysm growth. Eur J Vasc Endovasc Surg 2006; 32: 21-26
26) Miyake T, Aoki M, Masaki H, et al: Regression of abdominal aortic aneurysms by simultaneous inhibition of nuclear factor kappaB and ets in a rabbit model. Circ Res 2007; 101: 1175-1184
15) Longo GM, Buda SJ, Fiotta N, et al: MMP-12 has a role in abdominal aortic aneurysms in mice. Surgery 2005; 137: 457-462
8) Miralles M, Wester W, Sicard GA, et al: Indomethacin inhibits expansion of experimental aortic aneurysms via inhibition of the cox2 isoform of cyclooxygenase. J Vasc Surg 1999; 29: 884-892
4) Ishibashi M, Egashira K, Zhao Q, et al: Bone marrow-derived monocyte chemoattractant protein-1 receptor CCR2 is critical in angiotensin II-induced acceleration of atherosclerosis and aneurysm formation in hypercholesterolemic mice. Arterioscler Thromb Vasc Biol 2004; 24: e174-148
16) Xiong W, Knispel R, MacTaggart J, et al: Membrane-type 1 matrix metalloproteinase regulates macrophage-dependent elastolytic activity and aneurysm formation in vivo. J Biol Chem 2009; 284: 1765-1771
19) Curci JA, Baxter BT, Thompson RW: Arterial Aneurysms: Etiologic Considerations.(ed.) Rutherford, R.B., Vascular Surgery, Philadelphia: Saunders; 2005. p.475-492
References_xml – reference: 25) Parodi FE, Mao D, Ennis TL, et al: Suppression of experimental abdominal aortic aneurysms in mice by treatment with pyrrolidine dithiocarbamate, an antioxidant inhibitor of nuclear factor-kappaB. J Vasc Surg 2005; 41: 479-489
– reference: 12) Törnwall ME, Virtamo J, Haukka JK, et al: Alpha-tocopherol (vitamin E) and beta-carotene supplementation does not affect the risk for large abdominal aortic aneurysm in a controlled trial. Atherosclerosis 2001; 157: 167-173
– reference: 22) Yoshimura K, Aoki H, Ikeda Y, et al: Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase. Nat Med 2005; 11: 1330-1338
– reference: 3) Shimizu K, Shichiri M, Libby P, et al: Th2-predominant inflammation and blockade of IFN-gamma signaling induce aneurysms in allografted aortas. J Clin Invest 2004; 114: 300-308
– reference: 14) Longo GM, Xiong W, Greiner TC, et al: Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysms. J Clin Invest 2002; 110: 625-632
– reference: 16) Xiong W, Knispel R, MacTaggart J, et al: Membrane-type 1 matrix metalloproteinase regulates macrophage-dependent elastolytic activity and aneurysm formation in vivo. J Biol Chem 2009; 284: 1765-1771
– reference: 6) Brooke BS, Habashi JP, Judge DP, et al: Angiotensin II blockade and aortic-root dilation in Marfan’s syndrome. N Engl J Med 2008; 358: 2787-2795
– reference: 27) Schouten O, van Laanen JH, Boersma E, et al: Statins are associated with a reduced infrarenal abdominal aortic aneurysm growth. Eur J Vasc Endovasc Surg 2006; 32: 21-26
– reference: 8) Miralles M, Wester W, Sicard GA, et al: Indomethacin inhibits expansion of experimental aortic aneurysms via inhibition of the cox2 isoform of cyclooxygenase. J Vasc Surg 1999; 29: 884-892
– reference: 2) Xiong W, Zhao Y, Prall A, et al: Key roles of CD4+ T cells and IFN-gamma in the development of abdominal aortic aneurysms in a murine model. J Immunol 2004; 72: 2607-2612
– reference: 5) Habashi JP, Judge DP, Holm TM, et al: Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. Science 2006; 312: 117-121
– reference: 7) Hackam DG, Thiruchelvam D, Redelmeier DA: Angiotensin-converting enzyme inhibitors and aortic rupture: a population-based case-control study. Lancet 2006; 368: 659-665
– reference: 4) Ishibashi M, Egashira K, Zhao Q, et al: Bone marrow-derived monocyte chemoattractant protein-1 receptor CCR2 is critical in angiotensin II-induced acceleration of atherosclerosis and aneurysm formation in hypercholesterolemic mice. Arterioscler Thromb Vasc Biol 2004; 24: e174-148
– reference: 24) Nakashima H, Aoki M, Miyake T, et al: Inhibition of experimental abdominal aortic aneurysm in the rat by use of decoy oligodeoxynucleotides suppressing activity of nuclear factor kappaB and ets transcription factors. Circulation 2004; 109: 132-138
– reference: 11) Gavrila D, Li WG, McCormick ML, et al: Vitamin E inhibits abdominal aortic aneurysm formation in angiotensin II-infused apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 2005; 25: 1671-1677
– reference: 1) Hingorani A, Ascher E, Scheinman M, et al: The effect of tumor necrosis factor binding protein and interleukin-1 receptor antagonist on the development of abdominal aortic aneurysms in a rat model. J Vasc Surg 1998; 28: 522-526
– reference: 15) Longo GM, Buda SJ, Fiotta N, et al: MMP-12 has a role in abdominal aortic aneurysms in mice. Surgery 2005; 137: 457-462
– reference: 17) Petrinec D, Liao S, Holmes DR, et al: Doxycycline inhibition of aneurysmal degeneration in an elastase-induced rat model of abdominal aortic aneurysm: preservation of aortic elastin associated with suppressed production of 92 kD gelatinase. J Vasc Surg 1996; 23: 336-346
– reference: 9) Zhao L, Moos MP, Grbner R, et al: The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm. Nat Med 2004; 10: 966-973
– reference: 18) Baxter BT, Pearce WH, Waltke EA, et al: Prolonged administration of doxycycline in patients with small asymptomatic abdominal aortic aneurysms: report of a prospective (Phase II) multicenter study. J Vasc Surg 2002; 36: 1-12
– reference: 21) Allaire E, Muscatelli-Groux B, Guinault AM, et al: Vascular smooth muscle cell endovascular therapy stabilizes already developed aneurysms in a model of aortic injury elicited by inflammation and proteolysis. Ann Surg 2004; 239: 417-427
– reference: 19) Curci JA, Baxter BT, Thompson RW: Arterial Aneurysms: Etiologic Considerations.(ed.) Rutherford, R.B., Vascular Surgery, Philadelphia: Saunders; 2005. p.475-492
– reference: 26) Miyake T, Aoki M, Masaki H, et al: Regression of abdominal aortic aneurysms by simultaneous inhibition of nuclear factor kappaB and ets in a rabbit model. Circ Res 2007; 101: 1175-1184
– reference: 20) Huffman MD, Curci JA, Moore G, et al: Functional importance of connective tissue repair during the development of experimental abdominal aortic aneurysms. Surgery 2000; 128: 429-438
– reference: 23) Isenburg JC, Simionescu DT, Starcher BC, Vyavahare NR: Elastin stabilization for treatment of abdominal aortic aneurysms. Circulation 2007; 115: 1729-1737
– reference: 10) Thomas M, Gavrila D, McCormick ML, et al: Deletion of p47phox attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice. Circulation 2006; 114: 404-413
– reference: 13) Pyo R, Lee JK, Shipley JM, et al: Targeted gene disruption of matrix metalloproteinase-9(gelatinase B) suppresses development of experimental abdominal aortic aneurysms. J Clin Invest 2000; 105: 1641-1649
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Title 大動脈瘤の分子病態
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