上唇粘膜部に発生した腺房細胞癌の2例
Acinic cell carcinoma (ACC) usually arises in the parotid gland and rarely occurs in the minor salivary glands. In particular, ACC of the upper lip is extremely rare, and the incidence is 0.94% of all minor salivary gland tumors. ACC of the lips is rare. We report two cases of ACC involving the uppe...
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| Published in | 日本口腔外科学会雑誌 Vol. 58; no. 9; pp. 526 - 530 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
社団法人 日本口腔外科学会
20.09.2012
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0021-5163 2186-1579 |
| DOI | 10.5794/jjoms.58.526 |
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| Abstract | Acinic cell carcinoma (ACC) usually arises in the parotid gland and rarely occurs in the minor salivary glands. In particular, ACC of the upper lip is extremely rare, and the incidence is 0.94% of all minor salivary gland tumors. ACC of the lips is rare. We report two cases of ACC involving the upper lips. The first patient was a 42-year-old woman with a 7 × 10 mm painless granulomatous mass in the upper lip. As a result of biopsy following a clinical diagnosis of inflammatory granuloma, the lesion was diagnosed as ACC. The lesion was excised surgically. The second patient was a 69-year-old man with an 18 × 30 mm painless mass in the upper lip. The clinical diagnosis was a low grade malignant tumor of the minor salivary glands, and the lesion was excised surgically. The pathological diagnosis of the tumor was ACC. The first case was characterized by solid / lobular and microcystic growth of intercalated ductal and vacuolated cells, whereas the second case showed a mixture of papillary-cystic and solid/lobular growth patterns of acinar and vascuolated cell types. Neither case has shown any evidence of recurrence or metastasis 4 years and 3 years after surgery, respectively. |
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| AbstractList | Acinic cell carcinoma (ACC) usually arises in the parotid gland and rarely occurs in the minor salivary glands. In particular, ACC of the upper lip is extremely rare, and the incidence is 0.94% of all minor salivary gland tumors. ACC of the lips is rare. We report two cases of ACC involving the upper lips. The first patient was a 42-year-old woman with a 7 × 10 mm painless granulomatous mass in the upper lip. As a result of biopsy following a clinical diagnosis of inflammatory granuloma, the lesion was diagnosed as ACC. The lesion was excised surgically. The second patient was a 69-year-old man with an 18 × 30 mm painless mass in the upper lip. The clinical diagnosis was a low grade malignant tumor of the minor salivary glands, and the lesion was excised surgically. The pathological diagnosis of the tumor was ACC. The first case was characterized by solid / lobular and microcystic growth of intercalated ductal and vacuolated cells, whereas the second case showed a mixture of papillary-cystic and solid/lobular growth patterns of acinar and vascuolated cell types. Neither case has shown any evidence of recurrence or metastasis 4 years and 3 years after surgery, respectively. |
| Author | 宮脇, 昭彦 中村, 典史 久米, 健一 比地岡, 浩志 仙波, 伊知郎 石田, 喬之 |
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| References | 5) Nakamura N, Kawano S, et al : An alternative method for vermillion reconstruction after resection of hemangioma of the lip. J oral Maxillofac Surg 63: 1239-1243, 2005. 9) 宮内美和，井垣浩一，他：有茎性腫瘤を呈したまれな臼後部腺房細胞癌の1例．日口外誌 47: 607-610, 2001. 12) 星 秀樹，松尾伸一，他：小唾液腺腫瘍の臨床病理学的検討．Jpn J Oral Diag / Oral Med 19: 374-382, 2006. 1) 高木 實 編：口腔病理アトラス．第4刷，文光堂，東京，2004，293-294頁，301頁 4) 田野智之，伊賀弘起，他：頰粘膜部に発生した乳頭状嚢胞型腺房細胞癌の1例．日口外誌 53: 238-242, 2007. 13) 森 裕介，青木隆幸，他：頰粘膜に発生した小嚢胞型腺房細胞癌の1例．日口外誌 50: 668-671, 2004. 17) Amos B, Phillip, WM, et al : Relative frequency of intra-oral minor salivary gland tumors: a study of 380 cases from northern California and comparison to reports from other parts of the world. J Oral Pathol Med 36: 207-214, 2007. 10) 渚 紀子，木村吉宏，他：下唇に発生した小嚢胞型腺房細胞癌の1例．日口診誌 22: 33-36, 2009. 24) 日本唾液腺学会編：唾液腺腫瘍アトラス．第1版，金原出版，東京，2005，82頁 3) 辻端亜紀彦，小田惠夫，他：上唇小唾液腺に発生した腺房細胞癌の1例．診断病理 21: 210-212, 2004. 20) Chengyan C, Guangjie Z, et al : Carcinoma of the minor salivary glands: results of surgery and combined therapy. J Oral Maxillofac Surg 54: 448-453, 1996. 7) 上田倫弘，山下徹郎，他：蝶形骨洞にも病変を認めた軟口蓋再発腺房細胞癌の1例．日口診誌 21: 253-257, 2008. 18) Wang D, Li Y, et al : Intraoral minor salivary gland tumors in a Chinese population : A retrospective study on 737 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 104: 94-100, 2007. 11) 川野慎太郎，大部一成，他：唾液腺腫瘍151例の臨床統計的検討．日口外誌 52: 393-400, 2006. 22) 白砂兼光，古郷幹彦編：口腔外科学．第3版，医歯薬出版，東京，2010，384，423頁 2) Barnes L, Eveson JW, et al : Pathology & Genetics Head and Neck tumours WHO classification Head and Neck Tumours 216-218, 2005. 14) Hiroshi T, Shuichi F, et al : Intraoral salivary gland tumors: A demographic and histologic study of 200 cases. Tohoku J Exp 16: 111-128, 1990. 21) Jessica E, Omlie BA, et al : Acinic cell carcinoma of minor salivary glands. J Oral Maxillofac Surg 68: 2053-2057, 2010. 6) 河原 康，小澤総喜，他：舌下腺原発の腺房細胞癌の1例．口腔腫瘍 19: 133-138, 2007. 8) 浜尾 綾，岡田宗久，他：頰粘膜部に発生した濾胞型腺房細胞癌の1例．日口外誌 49: 578-581, 2003. 19) Copelli C, Bianchi B, et al : Malignant tumors of intraoral minor salivary glands. Oral Oncol 44: 658-663, 2008. 15) Ito FA, Ito K, et al : Salivary gland tumors in a Brazilian population: A retrospective study of 496 cases. Int J Oral Maxillofac Surg 34: 533-536, 2005. 16) Toida M, Shimokawa K, et al : Intraoral minor salivary gland tumors : A clinicopathological study of 82 cases. Int J Oral Maxillofac Surg 34: 528-532, 2005. 23) Suzzi M Vacchi, Alessi AC, et al : Prognostic relevance of cell proliferation in major salivary gland carcinoma. Act Otorhinolaryncol Ital 25: 161-168, 2005. |
| References_xml | – reference: 21) Jessica E, Omlie BA, et al : Acinic cell carcinoma of minor salivary glands. J Oral Maxillofac Surg 68: 2053-2057, 2010. – reference: 23) Suzzi M Vacchi, Alessi AC, et al : Prognostic relevance of cell proliferation in major salivary gland carcinoma. Act Otorhinolaryncol Ital 25: 161-168, 2005. – reference: 16) Toida M, Shimokawa K, et al : Intraoral minor salivary gland tumors : A clinicopathological study of 82 cases. Int J Oral Maxillofac Surg 34: 528-532, 2005. – reference: 24) 日本唾液腺学会編：唾液腺腫瘍アトラス．第1版，金原出版，東京，2005，82頁． – reference: 11) 川野慎太郎，大部一成，他：唾液腺腫瘍151例の臨床統計的検討．日口外誌 52: 393-400, 2006. – reference: 4) 田野智之，伊賀弘起，他：頰粘膜部に発生した乳頭状嚢胞型腺房細胞癌の1例．日口外誌 53: 238-242, 2007. – reference: 8) 浜尾 綾，岡田宗久，他：頰粘膜部に発生した濾胞型腺房細胞癌の1例．日口外誌 49: 578-581, 2003. – reference: 17) Amos B, Phillip, WM, et al : Relative frequency of intra-oral minor salivary gland tumors: a study of 380 cases from northern California and comparison to reports from other parts of the world. J Oral Pathol Med 36: 207-214, 2007. – reference: 2) Barnes L, Eveson JW, et al : Pathology & Genetics Head and Neck tumours WHO classification Head and Neck Tumours 216-218, 2005. – reference: 6) 河原 康，小澤総喜，他：舌下腺原発の腺房細胞癌の1例．口腔腫瘍 19: 133-138, 2007. – reference: 20) Chengyan C, Guangjie Z, et al : Carcinoma of the minor salivary glands: results of surgery and combined therapy. J Oral Maxillofac Surg 54: 448-453, 1996. – reference: 1) 高木 實 編：口腔病理アトラス．第4刷，文光堂，東京，2004，293-294頁，301頁． – reference: 10) 渚 紀子，木村吉宏，他：下唇に発生した小嚢胞型腺房細胞癌の1例．日口診誌 22: 33-36, 2009. – reference: 18) Wang D, Li Y, et al : Intraoral minor salivary gland tumors in a Chinese population : A retrospective study on 737 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 104: 94-100, 2007. – reference: 14) Hiroshi T, Shuichi F, et al : Intraoral salivary gland tumors: A demographic and histologic study of 200 cases. Tohoku J Exp 16: 111-128, 1990. – reference: 5) Nakamura N, Kawano S, et al : An alternative method for vermillion reconstruction after resection of hemangioma of the lip. J oral Maxillofac Surg 63: 1239-1243, 2005. – reference: 15) Ito FA, Ito K, et al : Salivary gland tumors in a Brazilian population: A retrospective study of 496 cases. Int J Oral Maxillofac Surg 34: 533-536, 2005. – reference: 22) 白砂兼光，古郷幹彦編：口腔外科学．第3版，医歯薬出版，東京，2010，384，423頁． – reference: 9) 宮内美和，井垣浩一，他：有茎性腫瘤を呈したまれな臼後部腺房細胞癌の1例．日口外誌 47: 607-610, 2001. – reference: 3) 辻端亜紀彦，小田惠夫，他：上唇小唾液腺に発生した腺房細胞癌の1例．診断病理 21: 210-212, 2004. – reference: 12) 星 秀樹，松尾伸一，他：小唾液腺腫瘍の臨床病理学的検討．Jpn J Oral Diag / Oral Med 19: 374-382, 2006. – reference: 19) Copelli C, Bianchi B, et al : Malignant tumors of intraoral minor salivary glands. Oral Oncol 44: 658-663, 2008. – reference: 7) 上田倫弘，山下徹郎，他：蝶形骨洞にも病変を認めた軟口蓋再発腺房細胞癌の1例．日口診誌 21: 253-257, 2008. – reference: 13) 森 裕介，青木隆幸，他：頰粘膜に発生した小嚢胞型腺房細胞癌の1例．日口外誌 50: 668-671, 2004. |
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| Title | 上唇粘膜部に発生した腺房細胞癌の2例 |
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