口腔苔癬様病変11例の臨床的・病理組織学的検討

Oral lichenoid lesion (OLL) is a lesion that causes cell-mediated immune tissue reactions, and is very similar to oral lichen planus (OLP). This disease can be distinguished from OLP when the cause is clear. OLL is often caused by dental metals, drugs and diseases such as graft-versus-host disease(G...

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Published in日本口腔外科学会雑誌 Vol. 69; no. 4; pp. 185 - 196
Main Authors 河野, 通良, 野村, 武史, 橋本, 和彦, 稲田, 潤一郎, 髙橋, 慎一, 松浦, 信幸, 秋山, 友理恵, 三邉, 正樹, 青木, 勇介, 森田, 奈那
Format Journal Article
LanguageJapanese
Published 公益社団法人 日本口腔外科学会 20.04.2023
Subjects
OLL-GVHDによる口腔苔癬様病変
口腔扁平苔癬
口腔苔癬様接触性病変
口腔苔癬様病変
口腔苔癬様薬物反応
Online AccessGet full text
ISSN0021-5163
2186-1579
DOI10.5794/jjoms.69.185

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Abstract Oral lichenoid lesion (OLL) is a lesion that causes cell-mediated immune tissue reactions, and is very similar to oral lichen planus (OLP). This disease can be distinguished from OLP when the cause is clear. OLL is often caused by dental metals, drugs and diseases such as graft-versus-host disease(GVHD). The clinical and histopathological differences between OLP and OLL are still under debate. In this study, the clinical and histopathological findings of 11 cases of OLL were retrospectively investigated.　The study included 11 patients who visited the outpatient clinic for oral mucosal diseases(joint outpatient clinic for oral surgery and dermatology) at the Tokyo Dental College Ichikawa General Hospital and were diagnosed with OLL in cooperation with dermatologists between April 2014 and March 2019. The patients included four males and seven females, with an average age of 56.9 years. Lesions were associated with drugs (4 cases), materials (3 cases), GVHD(2 cases), dental material(1 case) and hepatitis C (1 case). OLL lesions were in the buccal mucosa (9 cases), gingiva (8 cases), dorsum of the tongue(8 cases), lip(6 cases) and sublingual surface (6 cases). The clinical classifications were red type (6 cases) and white type(5 cases), with 6 cases including skin symptoms. Lesions were found in 4.7 sites on average.　Histopathological findings were consistent with OLP in 11 cases, and no findings characteristic of OLL were observed.　Immunohistochemical staining for p53 and Ki-67 (carcinogenesis markers) was performed; however, no epithelial positive cell overlay was observed in any of the cases.
AbstractList Oral lichenoid lesion (OLL) is a lesion that causes cell-mediated immune tissue reactions, and is very similar to oral lichen planus (OLP). This disease can be distinguished from OLP when the cause is clear. OLL is often caused by dental metals, drugs and diseases such as graft-versus-host disease(GVHD). The clinical and histopathological differences between OLP and OLL are still under debate. In this study, the clinical and histopathological findings of 11 cases of OLL were retrospectively investigated.　The study included 11 patients who visited the outpatient clinic for oral mucosal diseases(joint outpatient clinic for oral surgery and dermatology) at the Tokyo Dental College Ichikawa General Hospital and were diagnosed with OLL in cooperation with dermatologists between April 2014 and March 2019. The patients included four males and seven females, with an average age of 56.9 years. Lesions were associated with drugs (4 cases), materials (3 cases), GVHD(2 cases), dental material(1 case) and hepatitis C (1 case). OLL lesions were in the buccal mucosa (9 cases), gingiva (8 cases), dorsum of the tongue(8 cases), lip(6 cases) and sublingual surface (6 cases). The clinical classifications were red type (6 cases) and white type(5 cases), with 6 cases including skin symptoms. Lesions were found in 4.7 sites on average.　Histopathological findings were consistent with OLP in 11 cases, and no findings characteristic of OLL were observed.　Immunohistochemical staining for p53 and Ki-67 (carcinogenesis markers) was performed; however, no epithelial positive cell overlay was observed in any of the cases.
Author 髙橋, 慎一
橋本, 和彦
秋山, 友理恵
稲田, 潤一郎
青木, 勇介
森田, 奈那
河野, 通良
野村, 武史
三邉, 正樹
松浦, 信幸
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References_xml – reference: 44) Mignogna MD, Fedele S, et al : Unexpected low incidence of oral lichen planus in an HCV hyperendemic area of southern Italy．Gastroenterology 121: 1528-1529, 2001.
– reference: 54) Mravak-Stipetić M, Lončar-Brzak B, et al : Clinicopathologic correlation of oral lichen planus and oral lichenoid lesions: A preliminary study．Sci World J 2014: 1-6, 2014.
– reference: 39) Tanaka Y, Kurosawa S, et al : Increased incidence of oral and gastrointestinal secondary cancer after allogeneic hematopoietic stem cell transplantation．Bone Marrow Transplant 52: 789-791, 2017.
– reference: 21) 医薬品インタビューフォーム 潰瘍性大腸炎治療剤 メサラジン注腸製剤1％ペンタサ® 注腸1g．2020．入手先 URL https://www.kyorin-pharm.co.jp/prodinfo/medicine/pdf/i_pentene.pdf 2022年6月8日参照
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– reference: 43) Henderson L, Muir M, et al : Oral health of patients with hepatitis C virus infection: a pilot study．Oral Dis 7: 271-275, 2001.
– reference: 24) Davies PT and Shadforth MF : Sulphasalazine induced oral lichen planus．Br Med J 288: 194, 1984.
– reference: 2) Schlosser BJ : Lichen planus and lichenoid reactions of the oral mucosa．Dermatol Ther 23: 251-267, 2010.
– reference: 23) Alstead EM, Wilson AG, et al : Lichen planus and mesalazine．J Clin Gastroenterol 13: 335-337, 1991.
– reference: 17) 檜垣裕子：苔癬型薬疹．池澤善郎， 相原道子， 編：薬疹のすべて−エキスパートにまなぶ診療のすべて．第1版， 南山堂， 東京， 2008, 213-216 頁．
– reference: 38) Atsuta Y, Suzuki R, et al : Continuing increased risk of oral/esophageal cancer after allogeneic hematopoietic stem cell transplantation in adults in association with chronic graft-versus-host disease．Ann Oncol 25: 435-441, 2014.
– reference: 41) Bagan JV, Ramon C, et al : Preliminary investigation of the association of oral lichen planus and hepatitis．Oral Surg Oral Med Oral Pathol Oral Radiol Endod 85: 532-536, 1998.
– reference: 25) Andrade P, Lopes S, et al : Oral Lichen Planus in IBD Patients: A Paradoxical Adverse Effect of Anti-TNF-α Therapy．Dig Dis Sci 60: 2746-2749, 2015.
– reference: 58) Acay RR, Felizzola CR, et al : Evaluation of proliferative potential in oral lichen planus and oral lichenoid lesions using immunohistochemical expression of p53 and Ki67．Oral Oncol 42: 475-480, 2006.
– reference: 29) 医薬品インタビューフォーム　気道粘液調整・粘膜正常化剤日本薬局方 L- カルボシステイン錠200mg・500mg. 2020．入手先 URL https://med.sawai.co.jp/file/pr22_99.pdf 2022年6月8日参照
– reference: 51) Müller S : Oral lichenoid lesions: distinguishing the benign from the deadly．Mod Pathol 30: 54-67, 2017.
– reference: 20) Ito H, Furuta S, et al : Pharmacokinetics and safety of single and multiple doses of Asacol tablets in Japanese healthy volunteers．Adv Ther 26: 749-761, 2009.
– reference: 18) 福田英嗣：苔癬型薬疹 今と昔．皮病診療 32: 563-569, 2010.
– reference: 34) 日本造血細胞移植学会ガイドライン委員会：造血細胞移植ガイドラインGVDH 第4版， 一般般社団法人 日本造血・免疫細胞療法学会ガイドライン一覧，7-8, 2018．https://www.jstct.or.jp/uploads/files/guideline/01_02_gvhd_ver04.pdf 2022年12月20日参照
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– reference: 11) Kragelund C, Hansen C, et al : Can the genotype or phenotype of two polymorphic drug metabolizing cytochrome P450-enzymes identify oral lichenoid drug eruptions? J Oral Pathol Med 39: 497-505, 2010.
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Snippet Oral lichenoid lesion (OLL) is a lesion that causes cell-mediated immune tissue reactions, and is very similar to oral lichen planus (OLP). This disease can be...
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SubjectTerms OLL-GVHDによる口腔苔癬様病変
口腔扁平苔癬
口腔苔癬様接触性病変
口腔苔癬様病変
口腔苔癬様薬物反応
Title 口腔苔癬様病変11例の臨床的・病理組織学的検討
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