舌に発生した血管肉腫の1例
Angiosarcoma is a malignant tumor originating from vascular endothelial cells. It is extremely rare in the oral cavity. We described a case of angiosarcoma of the tongue. A 79-year-old woman presented with a tumor located on the left lateral edge of tongue that measured 11 × 10 × 3mm. The tumor was...
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| Published in | 日本口腔外科学会雑誌 Vol. 68; no. 3; pp. 150 - 154 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
公益社団法人 日本口腔外科学会
20.03.2022
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0021-5163 2186-1579 |
| DOI | 10.5794/jjoms.68.150 |
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| Abstract | Angiosarcoma is a malignant tumor originating from vascular endothelial cells. It is extremely rare in the oral cavity. We described a case of angiosarcoma of the tongue. A 79-year-old woman presented with a tumor located on the left lateral edge of tongue that measured 11 × 10 × 3mm. The tumor was soft and dark red. A biopsy specimen revealed a vascular malignant tumor. She underwent for radical surgical excision under general anesthesia. Thus, the histopathological diagnosis of the tumor was angiosarcoma. Immunohistochemically it was confirmed with analysis of the specimen revealed positive staining for CD31 antibody. Although postoperative adjuvant therapy was required, the patient denied any treatments because of her advanced age. No recurrence or metastasis has been observed 4 years after surgery. This patient needs to be followed up carefully. |
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| AbstractList | Angiosarcoma is a malignant tumor originating from vascular endothelial cells. It is extremely rare in the oral cavity. We described a case of angiosarcoma of the tongue. A 79-year-old woman presented with a tumor located on the left lateral edge of tongue that measured 11 × 10 × 3mm. The tumor was soft and dark red. A biopsy specimen revealed a vascular malignant tumor. She underwent for radical surgical excision under general anesthesia. Thus, the histopathological diagnosis of the tumor was angiosarcoma. Immunohistochemically it was confirmed with analysis of the specimen revealed positive staining for CD31 antibody. Although postoperative adjuvant therapy was required, the patient denied any treatments because of her advanced age. No recurrence or metastasis has been observed 4 years after surgery. This patient needs to be followed up carefully. |
| Author | 竹川, 政範 谷野, 美智枝 吉田, 将亜 矢島, 優己 荒井, 五織 佐藤, 栄晃 |
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| References | 18) 桂 資泰， 内藤愼二， 他：出血性ショックを来した上歯肉血管肉腫の1例．頭頸部外 26: 413-418, 2017. 2) Rao KK, Kumer HN, et al : Primaryhemangiosarcoma of the tongue. Lyposarcoma. Int J Oral Maxillofac Surg 15: 489-491, 1986. 19) 長谷川正午， 木村将士， 他：十二指腸への遠隔転移を認めた上顎歯肉血管肉腫の1例．日口外誌 60: 7-11, 2014. 9) Tabata M, Sugihara K, et al : Angiosarcoma of the toungue : Report of a case with immunohistochemical findings. J Oral Pathol Med 28: 92-95, 1999. 7) Frick WG, McDaniel RK, et al : Angiosarcoma of Toungue : report of a case. J Oral Maxillofac Surg 46: 496-498, 1988. 11) Olson MT, Puttgen KB, et al : Angiosarcoma arising from the toungue of an 11-year-old girl with xeroderma pigmentousum. Head Neck Pathol 6: 255-257, 2012. 28) Penel N, Bui BN, et al : Phase Ⅱ trial of weekly paclitaxel for unresectable angiosarcoma : the ANGIOTAX Sutudy. J Clin Ocol 26: 5269-5274, 2008. 20) Akrami M, Mohammadipour M, et al : Exsanguinating hemorrhage during open biopsy in a primary breast angiosarcoma : A Case Report. Iran J Med Sci 41: 154-156, 2016. 8) 小笠原健文， 白川正順， 他：良性の様相を呈した舌血管肉腫．日口外誌 41: 808-810, 1995. 5) Fanburg-Smith JC, Furlong MA, et al : Oral and salivary gland angiosarcoma : a clinicopathologic study of 29 caces. Mod Pathol 16: 263-271, 2003. 13) Nagata M, Yoshitake Y, et al : Angiosarcoma of the oral cavity : a clinicopathological study and a review of the literature．Int J Oral Maxillofac Surg 43: 917-923, 2014. 26) 増澤幹男：血管肉腫治療ガイドライン作成に向けて 北里大学病院皮膚科の頭部脈管肉腫治療方針と治療評価．Skin Cancer 24: 377-384, 2009. 22) Morgan MB, Swann M, et al : Cutaneous angiosarcoma：a case series with prognostic correlation. J Am Acad Dermatol 50: 867-874, 2004. 30) Tomita H, Koike Y, et al : Angiosarcoma of the scalp successfully treated with pazopanib. J Am Acad Dermatol 70: 19-21, 2014. 17) 小田義直， 青笹克之， 他：癌診療指針のための病理診断プラクティス 骨・軟部腫瘍 血管内皮腫．第一版， 中山書店， 293-295 頁， 2013. 27) 増澤幹男， 東 一紀， 他：r-IL2 が著効を示した悪性血管内皮細胞腫．日皮会誌 98: 367-369, 1988. 3) Crymes T, Taylor RG, et al : Angiosarcoma metastatic to the tongue : report of case. J Oral Surg 24: 63-66, 1966. 10) Yasumatsu R, Hirakawa N, et al : Postradiation angiosarcoma of the toungue. Eur Arch Otorhinolaryngol 257: 464-465, 2000. 15) Young RJ, Brown NJ, et al : Angiosarcoma. Lancet Oncol 11: 983-991, 2010. 23) 水上晶子， 田口理史， 他：血管肉腫：日本皮膚外科学会アンケート調査結果を中心に．Skin Cancer 24: 350-362, 2009. 24) Guadagnolo BA, Zagars GK, et al : Outcomes after definitive treatment for cutaneous angiosarcoma of the face and scalp. Head Neck 33: 661-667, 2011. 16) 清水源一郎， 村上栄一郎， 他：血管内皮肉腫と考えられる1例．診療 8: 1047-1051, 1955. 25) 緒方 大：最近のトピックス2017 Clinical Dermatology 2017皮膚疾患治療のポイント 血管肉腫に対する新たな治療選択肢 (解説/特集)．臨皮 71: 125-129, 2017. 6) Harter JH : Angiosarcoma of Toungue-Case Report. Laryngoscope 37: 869-871, 1927. 4) 増澤幹男， 竹中秀也， 他：頭部血管肉腫診療ガイドライン．日皮会誌 125: 1871-1888, 2015. 14) Pratik BP, Edward CK, et al : Angiosarcoma of the tongue : A case series and literature review. American Journal of Otolaryngology 38: 475-478, 2017. 29) The NCCN Guidelines for Soft Tissue Sarcoma. Available at : http://www.nccn.org/professionals/physician_gls/pdf/sarcoma.pdf. Accessed February 28, 2022. 1) Naka N, Ohsawa M, et al : Prognostic factors in angiosarcoma : a multivariate analysis of 55 caces. J Surg Oncol 61: 170-176, 1996. 21) 日本整形外科学会 骨・軟部腫瘍委員会：整形外科・病理 悪性軟部腫瘍取扱い規約．第3版， 金原出版， 141 頁， 2002. 12) Chadha VRD, Prasad B, et al : Angiosarcoma of the toungue : a cace report. Int J Otolaryngol Head Neck Surg 1: 51-52, 2012. |
| References_xml | – reference: 23) 水上晶子， 田口理史， 他：血管肉腫：日本皮膚外科学会アンケート調査結果を中心に．Skin Cancer 24: 350-362, 2009. – reference: 4) 増澤幹男， 竹中秀也， 他：頭部血管肉腫診療ガイドライン．日皮会誌 125: 1871-1888, 2015. – reference: 22) Morgan MB, Swann M, et al : Cutaneous angiosarcoma：a case series with prognostic correlation. J Am Acad Dermatol 50: 867-874, 2004. – reference: 19) 長谷川正午， 木村将士， 他：十二指腸への遠隔転移を認めた上顎歯肉血管肉腫の1例．日口外誌 60: 7-11, 2014. – reference: 2) Rao KK, Kumer HN, et al : Primaryhemangiosarcoma of the tongue. Lyposarcoma. Int J Oral Maxillofac Surg 15: 489-491, 1986. – reference: 10) Yasumatsu R, Hirakawa N, et al : Postradiation angiosarcoma of the toungue. Eur Arch Otorhinolaryngol 257: 464-465, 2000. – reference: 30) Tomita H, Koike Y, et al : Angiosarcoma of the scalp successfully treated with pazopanib. J Am Acad Dermatol 70: 19-21, 2014. – reference: 25) 緒方 大：最近のトピックス2017 Clinical Dermatology 2017皮膚疾患治療のポイント 血管肉腫に対する新たな治療選択肢 (解説/特集)．臨皮 71: 125-129, 2017. – reference: 1) Naka N, Ohsawa M, et al : Prognostic factors in angiosarcoma : a multivariate analysis of 55 caces. J Surg Oncol 61: 170-176, 1996. – reference: 13) Nagata M, Yoshitake Y, et al : Angiosarcoma of the oral cavity : a clinicopathological study and a review of the literature．Int J Oral Maxillofac Surg 43: 917-923, 2014. – reference: 21) 日本整形外科学会 骨・軟部腫瘍委員会：整形外科・病理 悪性軟部腫瘍取扱い規約．第3版， 金原出版， 141 頁， 2002. – reference: 20) Akrami M, Mohammadipour M, et al : Exsanguinating hemorrhage during open biopsy in a primary breast angiosarcoma : A Case Report. Iran J Med Sci 41: 154-156, 2016. – reference: 29) The NCCN Guidelines for Soft Tissue Sarcoma. Available at : http://www.nccn.org/professionals/physician_gls/pdf/sarcoma.pdf. Accessed February 28, 2022. – reference: 5) Fanburg-Smith JC, Furlong MA, et al : Oral and salivary gland angiosarcoma : a clinicopathologic study of 29 caces. Mod Pathol 16: 263-271, 2003. – reference: 16) 清水源一郎， 村上栄一郎， 他：血管内皮肉腫と考えられる1例．診療 8: 1047-1051, 1955. – reference: 18) 桂 資泰， 内藤愼二， 他：出血性ショックを来した上歯肉血管肉腫の1例．頭頸部外 26: 413-418, 2017. – reference: 28) Penel N, Bui BN, et al : Phase Ⅱ trial of weekly paclitaxel for unresectable angiosarcoma : the ANGIOTAX Sutudy. J Clin Ocol 26: 5269-5274, 2008. – reference: 24) Guadagnolo BA, Zagars GK, et al : Outcomes after definitive treatment for cutaneous angiosarcoma of the face and scalp. Head Neck 33: 661-667, 2011. – reference: 12) Chadha VRD, Prasad B, et al : Angiosarcoma of the toungue : a cace report. Int J Otolaryngol Head Neck Surg 1: 51-52, 2012. – reference: 17) 小田義直， 青笹克之， 他：癌診療指針のための病理診断プラクティス 骨・軟部腫瘍 血管内皮腫．第一版， 中山書店， 293-295 頁， 2013. – reference: 26) 増澤幹男：血管肉腫治療ガイドライン作成に向けて 北里大学病院皮膚科の頭部脈管肉腫治療方針と治療評価．Skin Cancer 24: 377-384, 2009. – reference: 14) Pratik BP, Edward CK, et al : Angiosarcoma of the tongue : A case series and literature review. American Journal of Otolaryngology 38: 475-478, 2017. – reference: 8) 小笠原健文， 白川正順， 他：良性の様相を呈した舌血管肉腫．日口外誌 41: 808-810, 1995. – reference: 27) 増澤幹男， 東 一紀， 他：r-IL2 が著効を示した悪性血管内皮細胞腫．日皮会誌 98: 367-369, 1988. – reference: 11) Olson MT, Puttgen KB, et al : Angiosarcoma arising from the toungue of an 11-year-old girl with xeroderma pigmentousum. Head Neck Pathol 6: 255-257, 2012. – reference: 9) Tabata M, Sugihara K, et al : Angiosarcoma of the toungue : Report of a case with immunohistochemical findings. J Oral Pathol Med 28: 92-95, 1999. – reference: 15) Young RJ, Brown NJ, et al : Angiosarcoma. Lancet Oncol 11: 983-991, 2010. – reference: 7) Frick WG, McDaniel RK, et al : Angiosarcoma of Toungue : report of a case. J Oral Maxillofac Surg 46: 496-498, 1988. – reference: 6) Harter JH : Angiosarcoma of Toungue-Case Report. Laryngoscope 37: 869-871, 1927. – reference: 3) Crymes T, Taylor RG, et al : Angiosarcoma metastatic to the tongue : report of case. J Oral Surg 24: 63-66, 1966. |
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| Title | 舌に発生した血管肉腫の1例 |
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