長期経過観察し得た囊胞様X線透過像を伴った下顎骨骨性異形成症の1例
We report a case of osseous dysplasia associated with a radiolucent cyst-like bone cavity in the molar region of the mandible. A 46-year-old Japanese woman visited our hospital because of a pain on the right side of the mandible. A bone biopsy of the lesion revealed osseous dysplasia. The cyst-like...
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| Published in | 日本口腔外科学会雑誌 Vol. 64; no. 5; pp. 259 - 264 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
社団法人 日本口腔外科学会
20.05.2018
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0021-5163 2186-1579 |
| DOI | 10.5794/jjoms.64.259 |
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| Abstract | We report a case of osseous dysplasia associated with a radiolucent cyst-like bone cavity in the molar region of the mandible. A 46-year-old Japanese woman visited our hospital because of a pain on the right side of the mandible. A bone biopsy of the lesion revealed osseous dysplasia. The cyst-like bone cavity lesion contained serous content. Branches of inferior alveolar nerve were observed, whereas no epithelial structure was found on the wall of the cavity. The radiopaque lesion was solid and contained fibrous bone, therefor we did not consider surgical intervention of this lesion. However, we considered surgical treatment for the cyst-like lesion by filling the bone cavity with platelet-rich plasma to stimulate bone healing. We concomitantly performed an apicoectomy for the involved teeth in the bone cavity. After a long-term follow-up (10 years), ossification was observed in the bone cavity in the molar region with no signs of recurrence, and the osseous dysplasia lesion in the premolar region was stable without showing signs of growth. |
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| AbstractList | We report a case of osseous dysplasia associated with a radiolucent cyst-like bone cavity in the molar region of the mandible. A 46-year-old Japanese woman visited our hospital because of a pain on the right side of the mandible. A bone biopsy of the lesion revealed osseous dysplasia. The cyst-like bone cavity lesion contained serous content. Branches of inferior alveolar nerve were observed, whereas no epithelial structure was found on the wall of the cavity. The radiopaque lesion was solid and contained fibrous bone, therefor we did not consider surgical intervention of this lesion. However, we considered surgical treatment for the cyst-like lesion by filling the bone cavity with platelet-rich plasma to stimulate bone healing. We concomitantly performed an apicoectomy for the involved teeth in the bone cavity. After a long-term follow-up (10 years), ossification was observed in the bone cavity in the molar region with no signs of recurrence, and the osseous dysplasia lesion in the premolar region was stable without showing signs of growth. |
| Author | 川又, 均 博多, 研文 泉, さや香 小宮山, 雄介 和久井, 崇大 内田, 大亮 |
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| References | 23) Agata CB, Tomasz B, et al : Improved treatment of mandibular odontogenic cysts with platelet-rich gel. Oral Surg Oral Pathol Oral Radiol Endod 105: 423-429, 2008. 10) Melrose RJ, Abrams AM, et al : Florid osseous dysplasia: A clinic-pathological study of thirty-four cases. Oral Surg Oral Med Oral Pathol 41: 62-82, 1976. 9) Musella AE and Slater LJ : Familial florid osseous dysplasia: A case report. J Oral Maxillofac Surg 47: 636-640, 1989. 18) Regard JB, Malhotra D, et al : Activation of hedgehog signaling by loss of GNAS causes heterotopic ossification. Nat Med 19: 1505-1512, 2013. 16) Saito Y, Hoshina Y, et al : Simple bone cyst. A clinical and histopathologic study of fifteen cases. Oral Surg Oral Med Oral Pathol 74: 487-491, 1992. 13) 東川晃一郎， 重石英生， 他：囊胞様のX線透過像を示したセメント質骨異形成症の1例．日口外誌 51: 184-187, 2005. 2) Mohamed F, Altini M, et al : Cemento-osseous dysplasia with associated simple bone cysts: J Oral Maxillofac Surg 63: 1549-54, 2005. 8) Waldron CA : Fibro-osseous lesions of the jaws. J Oral Maxillofac Surg 51: 828-835, 1993. 1) Eversole R, Su L, et al : Benign fibro-osseous lesions of the craniofacial complex. A review. Head Neck Pathol 2: 177-202, 2008. 4) 成田真人， 大平貴士， 他：長期経過観察をし得た骨性異形成症の1例．歯科学報 111: 163-169, 2011. 20) Maiorana C, Sommariva L, et al : Maxillary sinus augmentation with anoroganic bovine bone and autologous platelet-rich plasma: preliminary clinical and histologic evaluations. Int J Restorative Dent 23: 227-235, 2003. 5) Noura A, Alsufyani, et al : Osseous (Cemento-osseous) dysplasia of the jaws: clinical and radiographical analysis. J Can Dent Assoc 77: b70, 2011. 11) 木村俊介， 足立守安， 他：単純性骨囊胞を伴い上下顎に多発した骨性異形成症の1例．日口診誌 27: 285-289, 2014. 17) Bianco P, Riminucci M, et al : Mutations of the GNAS1 gene, stromal cell dysfunction, and osteomalacic changes in non---McCune---Albright fibrous dysplasia of bone. J Bone Miner Res 15: 120-128, 2000. 19) Marx RE, Carlson ER, et al : Platelet-rich plasma: Growth factor enhancement for bone grafts. Oral Surg Oral Pathol Oral Radiol Endod 85: 638-646, 1998. 22) Rubina A and Ramon G : A review of platelet-rich plasma: history, biopsy, mechanism of action, and classifyion. Skin Appendage Disord 4: 18-24, 2018. 21) Thorn JJ, SorensenH, et al : Autologous fibrin glue with growth factors in reconstructive maxillofacial surgery. Int J Oral Maxillofac Surg. 33: 95-100, 2004. 7) 武田泰典， 福田容子：歯原性間葉性腫瘍 (その１) ．病理と臨 20: 1169-1174, 2002. 14) 田中健雄， 佐藤 徹， 他：セメント質骨異形成症の臨床的，病理学的検討．口科誌 54: 247-252, 2005. 12) 笠原和恵， 山本栄治， 他：顎骨に生じた骨性異形成症の臨床的検討．北海道歯誌 28: 76-82, 2007 6) 大倉一徳：顎骨に生じた限局性セメント質骨異形成症の臨床病理組織学的研究．口腔病会誌 68: 99-110, 2001. 3) Barnes L, Eveson JW, et al : World Health Organization classification of tumours. Pathology and genetics of head and neck tumours. IARC Press, Lyon, 2005, p319. 15) Horner K and Forman GH : Atypical simple bone cysts of the jaws. Ⅱ : a possible association with benign fibro-osseous (cemental) lesions of the jaws. Clin Radiol 39: 59-63, 1988. |
| References_xml | – reference: 8) Waldron CA : Fibro-osseous lesions of the jaws. J Oral Maxillofac Surg 51: 828-835, 1993. – reference: 5) Noura A, Alsufyani, et al : Osseous (Cemento-osseous) dysplasia of the jaws: clinical and radiographical analysis. J Can Dent Assoc 77: b70, 2011. – reference: 21) Thorn JJ, SorensenH, et al : Autologous fibrin glue with growth factors in reconstructive maxillofacial surgery. Int J Oral Maxillofac Surg. 33: 95-100, 2004. – reference: 12) 笠原和恵， 山本栄治， 他：顎骨に生じた骨性異形成症の臨床的検討．北海道歯誌 28: 76-82, 2007． – reference: 1) Eversole R, Su L, et al : Benign fibro-osseous lesions of the craniofacial complex. A review. Head Neck Pathol 2: 177-202, 2008. – reference: 9) Musella AE and Slater LJ : Familial florid osseous dysplasia: A case report. J Oral Maxillofac Surg 47: 636-640, 1989. – reference: 10) Melrose RJ, Abrams AM, et al : Florid osseous dysplasia: A clinic-pathological study of thirty-four cases. Oral Surg Oral Med Oral Pathol 41: 62-82, 1976. – reference: 13) 東川晃一郎， 重石英生， 他：囊胞様のX線透過像を示したセメント質骨異形成症の1例．日口外誌 51: 184-187, 2005. – reference: 3) Barnes L, Eveson JW, et al : World Health Organization classification of tumours. Pathology and genetics of head and neck tumours. IARC Press, Lyon, 2005, p319. – reference: 14) 田中健雄， 佐藤 徹， 他：セメント質骨異形成症の臨床的，病理学的検討．口科誌 54: 247-252, 2005. – reference: 18) Regard JB, Malhotra D, et al : Activation of hedgehog signaling by loss of GNAS causes heterotopic ossification. Nat Med 19: 1505-1512, 2013. – reference: 11) 木村俊介， 足立守安， 他：単純性骨囊胞を伴い上下顎に多発した骨性異形成症の1例．日口診誌 27: 285-289, 2014. – reference: 15) Horner K and Forman GH : Atypical simple bone cysts of the jaws. Ⅱ : a possible association with benign fibro-osseous (cemental) lesions of the jaws. Clin Radiol 39: 59-63, 1988. – reference: 17) Bianco P, Riminucci M, et al : Mutations of the GNAS1 gene, stromal cell dysfunction, and osteomalacic changes in non---McCune---Albright fibrous dysplasia of bone. J Bone Miner Res 15: 120-128, 2000. – reference: 22) Rubina A and Ramon G : A review of platelet-rich plasma: history, biopsy, mechanism of action, and classifyion. Skin Appendage Disord 4: 18-24, 2018. – reference: 7) 武田泰典， 福田容子：歯原性間葉性腫瘍 (その１) ．病理と臨 20: 1169-1174, 2002. – reference: 16) Saito Y, Hoshina Y, et al : Simple bone cyst. A clinical and histopathologic study of fifteen cases. Oral Surg Oral Med Oral Pathol 74: 487-491, 1992. – reference: 19) Marx RE, Carlson ER, et al : Platelet-rich plasma: Growth factor enhancement for bone grafts. Oral Surg Oral Pathol Oral Radiol Endod 85: 638-646, 1998. – reference: 6) 大倉一徳：顎骨に生じた限局性セメント質骨異形成症の臨床病理組織学的研究．口腔病会誌 68: 99-110, 2001. – reference: 20) Maiorana C, Sommariva L, et al : Maxillary sinus augmentation with anoroganic bovine bone and autologous platelet-rich plasma: preliminary clinical and histologic evaluations. Int J Restorative Dent 23: 227-235, 2003. – reference: 4) 成田真人， 大平貴士， 他：長期経過観察をし得た骨性異形成症の1例．歯科学報 111: 163-169, 2011. – reference: 2) Mohamed F, Altini M, et al : Cemento-osseous dysplasia with associated simple bone cysts: J Oral Maxillofac Surg 63: 1549-54, 2005. – reference: 23) Agata CB, Tomasz B, et al : Improved treatment of mandibular odontogenic cysts with platelet-rich gel. Oral Surg Oral Pathol Oral Radiol Endod 105: 423-429, 2008. |
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| Title | 長期経過観察し得た囊胞様X線透過像を伴った下顎骨骨性異形成症の1例 |
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