抗コラプシン反応媒介タンパク質2抗体の腎臓癌細胞遊走抑制作用

Renal cell carcinoma (RCC) accounts for 2-3% of all malignancies. After surgical resection, approximately 40% of patients develop metastases. The 5-year survival probability for patients with metastatic renal cell carcinoma is less than 10% due to resistance to chemotherapy and radiation therapy. Th...

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Published in日本薬理学会年会要旨集 p. 2-P2-43
Main Authors 山本, 泰弘, 矢上, 達郎, 高馬, 宏美
Format Journal Article
LanguageJapanese
Published 公益社団法人 日本薬理学会 2021
Subjects
antibody
cancer
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ISSN2435-4953
DOI10.1254/jpssuppl.94.0_2-P2-43

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Abstract Renal cell carcinoma (RCC) accounts for 2-3% of all malignancies. After surgical resection, approximately 40% of patients develop metastases. The 5-year survival probability for patients with metastatic renal cell carcinoma is less than 10% due to resistance to chemotherapy and radiation therapy. Therefore, there is an urgent need to establish novel therapies for the treatment of metastatic RCC. It has been reported that collapsin response mediator protein (CRMP), a cytoplasmic protein involved in the formation of neuronal axons, also contributes to the progression of malignant tumors. In the present study, we evaluated the effects of anti-CRMP2 antibody on the migration of Caki-2 RCC cells. The treatment with anti-CRMP2 antibody decreased the migration of Caki-2 cells. Our present study proposes the therapeutic potential of CRMP inhibition for prevention of RCC metastasis.
AbstractList Renal cell carcinoma (RCC) accounts for 2-3% of all malignancies. After surgical resection, approximately 40% of patients develop metastases. The 5-year survival probability for patients with metastatic renal cell carcinoma is less than 10% due to resistance to chemotherapy and radiation therapy. Therefore, there is an urgent need to establish novel therapies for the treatment of metastatic RCC. It has been reported that collapsin response mediator protein (CRMP), a cytoplasmic protein involved in the formation of neuronal axons, also contributes to the progression of malignant tumors. In the present study, we evaluated the effects of anti-CRMP2 antibody on the migration of Caki-2 RCC cells. The treatment with anti-CRMP2 antibody decreased the migration of Caki-2 cells. Our present study proposes the therapeutic potential of CRMP inhibition for prevention of RCC metastasis.
Author 山本, 泰弘
高馬, 宏美
矢上, 達郎
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Snippet Renal cell carcinoma (RCC) accounts for 2-3% of all malignancies. After surgical resection, approximately 40% of patients develop metastases. The 5-year...
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SubjectTerms antibody
cancer
Title 抗コラプシン反応媒介タンパク質2抗体の腎臓癌細胞遊走抑制作用
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