スニチニブ投与患者に発症した顎骨壊死の1例
Osteonecrosis of the jaw is one of the problematic side effects observed during administration of angiogenesis inhibitors in patients receiving treatment for cancer. We report a case of osteonecrosis of the jaw in a patient receiving sunitinib. The patient was a 72-year-old man who was referred to o...
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| Published in | 日本口腔外科学会雑誌 Vol. 64; no. 2; pp. 83 - 87 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
社団法人 日本口腔外科学会
20.02.2018
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0021-5163 2186-1579 |
| DOI | 10.5794/jjoms.64.83 |
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| Abstract | Osteonecrosis of the jaw is one of the problematic side effects observed during administration of angiogenesis inhibitors in patients receiving treatment for cancer. We report a case of osteonecrosis of the jaw in a patient receiving sunitinib. The patient was a 72-year-old man who was referred to our hospital because of exposed bone and contact pain of the tongue. After the clinical diagnosis of osteonecrosis of the jaw, observation and irrigation of the exposed bone were frequently performed. Four months later, the lesion healed. After 1 year, exposed bone was found in other sites ; however, it disappeared a month later. The present case suggests that the use of sunitinib can be associated with osteonecrosis of the jaw and indicates that invasive dental treatment and the status of the main disease should be considered when prescribing sunitinib, as is done when prescribing bisphosphonates or denosumab. |
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| AbstractList | Osteonecrosis of the jaw is one of the problematic side effects observed during administration of angiogenesis inhibitors in patients receiving treatment for cancer. We report a case of osteonecrosis of the jaw in a patient receiving sunitinib. The patient was a 72-year-old man who was referred to our hospital because of exposed bone and contact pain of the tongue. After the clinical diagnosis of osteonecrosis of the jaw, observation and irrigation of the exposed bone were frequently performed. Four months later, the lesion healed. After 1 year, exposed bone was found in other sites ; however, it disappeared a month later. The present case suggests that the use of sunitinib can be associated with osteonecrosis of the jaw and indicates that invasive dental treatment and the status of the main disease should be considered when prescribing sunitinib, as is done when prescribing bisphosphonates or denosumab. |
| Author | 古森, 孝英 古土井, 春吾 岸本, 恵実 明石, 昌也 岩田, 英治 鰐渕, 聡 |
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| References | 11) Bex A, Kroon BK, et al : Is there a role for neoadjuvant targeted therapy to downsize primary tumors for organ sparing strategies in renal cell carcinoma? Int J Surg Oncol 2012 : 250479, 2012. 1) Chaw LQ and Eckhardt SG : Sunitinib:from rational design to clinical efficacy. J Clin Oncol 25 : 884-896, 2007. 16) Liu Y, Berendsen AD, et al : Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation. J Clin Invest 122 : 3101-3113, 2012. 14) Serra E, Paolantonio M, et al : Bevacizumab-related Osteonecrosis of the jaw. Lnt J lmmunopathol Pharmacol 22 : 1121-1123, 2009. 4) Motzer RJ, Hutson TE, et al : Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med 356 : 115-124, 2007. 10) Migliorati CA， Casiglia J, et al : Managing the care of patients with bisphosphonate-associated osteonecrosis. JADA 136 : 1658-1668, 2005. 6) Oudard S, Beuselinck B, et al : Sunitinib for the treatment of metastatic renal cell carcinoma. Cancer Treat Rev 37: 178-184, 2011. 5) Ruggiero SL, Dodson TB, et al : American association of oral and maxillofacial surgeons : mediation-related osteonecrosis of the jaw -- 2014 up date. J Oral Maxillofac Surg 72 : 1938-1956, 2014. 9) Nicolatou-Galitis O, Migkou M, et al : Gingival bleeding and jaw bone necrosis in patients with metastatic renal cell carcinoma receiving sunitinib : report of 2 cases with clinical implications. Oral Surg Oral Med Oral Pathol Oral Radiol 113 : 234-238, 2012. 13) Greuter S, Schmid F, et al : Bevacizumab-associated osteonecrosis of the jaw. Ann Oncol 19: 2091-2092, 2008. 15) Hu K and Olsen BR : Osteoblast-derived VEGF regulates osteoblast differentiation and bone formation during bone repair. J Clin Invest 126 : 509-526, 2016. 3) Raymond E, Dahan L, et al : Sunitinib malate for the treatment of pancreatic neuroendocrine tumors. N Engl J Med 364 : 501-513, 2011. 8) 増田 晃， 岡田浩司， 他：腎細胞癌に対する分子標的治療薬の副作用発現時期の後方視的調査．泌外29 : 1007-1012, 2016. 2) Demetri GD, van Oosterom AT, et al : Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumor after failure of imatinib: a randomized controlled trial. Lancet 368 : 1329-1338, 2006. 17) Kodama I, Niida S, et al : Estrogen regulates the production of VEGF for osteoclast formation and activity in op/op mice. J Bone Miner Res 19 : 200-206, 2004. 7) Patyna S, Laird AD, et al : SU14813 : a novel multiple receptor tyrosine kinase inhibitor with potent antiangiogenic and antitumor activity. Mol Cancer Ther 5 : 1774-1782, 2006. 12) Fleissig Y, Regev E, et al : Sunitinb related osteonecrosis of jaw : a case report. Oral Surg Oral Med Oral Pathol Oral Radiol 113 : e1, 2012. |
| References_xml | – reference: 1) Chaw LQ and Eckhardt SG : Sunitinib:from rational design to clinical efficacy. J Clin Oncol 25 : 884-896, 2007. – reference: 9) Nicolatou-Galitis O, Migkou M, et al : Gingival bleeding and jaw bone necrosis in patients with metastatic renal cell carcinoma receiving sunitinib : report of 2 cases with clinical implications. Oral Surg Oral Med Oral Pathol Oral Radiol 113 : 234-238, 2012. – reference: 17) Kodama I, Niida S, et al : Estrogen regulates the production of VEGF for osteoclast formation and activity in op/op mice. J Bone Miner Res 19 : 200-206, 2004. – reference: 5) Ruggiero SL, Dodson TB, et al : American association of oral and maxillofacial surgeons : mediation-related osteonecrosis of the jaw -- 2014 up date. J Oral Maxillofac Surg 72 : 1938-1956, 2014. – reference: 11) Bex A, Kroon BK, et al : Is there a role for neoadjuvant targeted therapy to downsize primary tumors for organ sparing strategies in renal cell carcinoma? Int J Surg Oncol 2012 : 250479, 2012. – reference: 13) Greuter S, Schmid F, et al : Bevacizumab-associated osteonecrosis of the jaw. Ann Oncol 19: 2091-2092, 2008. – reference: 10) Migliorati CA， Casiglia J, et al : Managing the care of patients with bisphosphonate-associated osteonecrosis. JADA 136 : 1658-1668, 2005. – reference: 6) Oudard S, Beuselinck B, et al : Sunitinib for the treatment of metastatic renal cell carcinoma. Cancer Treat Rev 37: 178-184, 2011. – reference: 3) Raymond E, Dahan L, et al : Sunitinib malate for the treatment of pancreatic neuroendocrine tumors. N Engl J Med 364 : 501-513, 2011. – reference: 14) Serra E, Paolantonio M, et al : Bevacizumab-related Osteonecrosis of the jaw. Lnt J lmmunopathol Pharmacol 22 : 1121-1123, 2009. – reference: 15) Hu K and Olsen BR : Osteoblast-derived VEGF regulates osteoblast differentiation and bone formation during bone repair. J Clin Invest 126 : 509-526, 2016. – reference: 2) Demetri GD, van Oosterom AT, et al : Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumor after failure of imatinib: a randomized controlled trial. Lancet 368 : 1329-1338, 2006. – reference: 4) Motzer RJ, Hutson TE, et al : Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med 356 : 115-124, 2007. – reference: 7) Patyna S, Laird AD, et al : SU14813 : a novel multiple receptor tyrosine kinase inhibitor with potent antiangiogenic and antitumor activity. Mol Cancer Ther 5 : 1774-1782, 2006. – reference: 16) Liu Y, Berendsen AD, et al : Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation. J Clin Invest 122 : 3101-3113, 2012. – reference: 12) Fleissig Y, Regev E, et al : Sunitinb related osteonecrosis of jaw : a case report. Oral Surg Oral Med Oral Pathol Oral Radiol 113 : e1, 2012. – reference: 8) 増田 晃， 岡田浩司， 他：腎細胞癌に対する分子標的治療薬の副作用発現時期の後方視的調査．泌外29 : 1007-1012, 2016. |
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| SubjectTerms | スニチニブ デノスマブ ビスフォスフォネート 血管新生阻害薬 顎骨壊死 |
| Title | スニチニブ投与患者に発症した顎骨壊死の1例 |
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