当施設における NIPRO 左心補助人工心臓の臨床成績
補助人工心臓 (VAD) は末期心不全に対する外科治療として有効とされ，心臓移植までのブリッジやdestination therapy として使用されている．しかしながら，日本では極端なドナー不足や VAD の使用制限などの臓器移植システムに問題がある．最近まで認可がおりていたのは体外式補助人工心臓 (NIPRO VAD) のみであった．本研究では，NIPRO VAD を用いた左室補助人工心臓 (LVAD) の結果を報告する．2006 年から 2009 年までに 8 例に NIPRO 型 LVAD が植え込まれた．急性心筋梗塞による心原性ショックに対する LVAD の治療成績は不良であったが，...
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| Published in | 日大医学雑誌 Vol. 70; no. 5; pp. 230 - 236 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
日本大学医学会
01.10.2011
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0029-0424 1884-0779 |
| DOI | 10.4264/numa.70.230 |
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| Abstract | 補助人工心臓 (VAD) は末期心不全に対する外科治療として有効とされ，心臓移植までのブリッジやdestination therapy として使用されている．しかしながら，日本では極端なドナー不足や VAD の使用制限などの臓器移植システムに問題がある．最近まで認可がおりていたのは体外式補助人工心臓 (NIPRO VAD) のみであった．本研究では，NIPRO VAD を用いた左室補助人工心臓 (LVAD) の結果を報告する．2006 年から 2009 年までに 8 例に NIPRO 型 LVAD が植え込まれた．急性心筋梗塞による心原性ショックに対する LVAD の治療成績は不良であったが，劇症型心筋炎や心臓移植までの橋渡し治療として，LVAD 治療は有効であった． |
|---|---|
| AbstractList | 補助人工心臓 (VAD) は末期心不全に対する外科治療として有効とされ，心臓移植までのブリッジやdestination therapy として使用されている．しかしながら，日本では極端なドナー不足や VAD の使用制限などの臓器移植システムに問題がある．最近まで認可がおりていたのは体外式補助人工心臓 (NIPRO VAD) のみであった．本研究では，NIPRO VAD を用いた左室補助人工心臓 (LVAD) の結果を報告する．2006 年から 2009 年までに 8 例に NIPRO 型 LVAD が植え込まれた．急性心筋梗塞による心原性ショックに対する LVAD の治療成績は不良であったが，劇症型心筋炎や心臓移植までの橋渡し治療として，LVAD 治療は有効であった． |
| Author | 中田, 中金一 笠巻, 祐二 木村, 玄 中井, 俊子 国本, 聡 瀬在, 明 瀬在, 幸安 畑, 博明 塩野, 元美 新野, 哲也 秦, 光賢 和久井, 真司 飯田, 充 平山, 篤志 宇野澤, 聡 高山, 忠輝 吉武, 勇 |
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| References | 25) Morshuis M, El-Banayosy A, Arusoglu L, et al. European experience of DuraHeart magnetically levitated centrifugal left ventricular assist system. Eur J Cardio-thorac Surg 2009; 35: 1020-1028. 4) Sezai A, Minami K, El-Banayosy A, et al. Heart Replacement Artificial Heart 7. Mechanical Circulatory support with Abiomed BVS 5000 and BioMedicus BP-80 for postcardio-tomy cardiogenic shock. In: Akutsu T and Koyanagi H., editor. Heart replacement Artificial Heart 7. UK: Isis Medical Media, 2001; 445-448. 22) El-Banayosy A, Arusoglu L, Kizner L, et al. Preliminary experience with the LionHeart left ventricular assist device in patients with end-stage heart failure. Ann Thorac Surg 2003; 75: 1469-1475. 6) Sezai A, Arusoglu L, MinamiK, et al. Implantation of biventricular assist devices for chronic heart transplantation rejection. Ann Thorac Surg 2002; 74: 609-611. 14) Unosawa S, Hata M, Sezai A, et al. Successful management of fulminant myocarditis with left ventricular assist device: report of a severe case. Ann Thorac Cardiovasc Surg 2010; 16: 48-51. 16) Minami, El-Banayosy A, Sezai A, et al. Morbidity and outcome after mechanical ventricular support using Thoratec, Novacor, and HeartMate for bridging to heart transplantation. Artificial Organs 2000; 24: 421-426. 5) Sezai A, Shiono M, Nakata K, et al. The possibility of a Veno-arterial bypass system using the Abiomed BVS 5000. Artificial Organs 2006; 30: 74-77. 13) Chen YS, Yu HY, Huang SC, et al. Experience and result of extracorporeal membrane oxygenation in treating fulminant myocarditis with shock: what mechanical support should be considered first? J Heart Lung Transplant 2005; 24: 81-87. 7) Rose EA, Gelijins AC, Moskowittz AJ, et al. Randomized evaluation of mechanical assistance for the treatment of congestive heart failure (REMATCH) study group. Long-term mechanical left ventricular assistance foe end-stage heart failure. N Eng j Med 2001; 345: 1435-1443. 19) Boyle AJ, Ascheim DD, Russo MJ, et al. Clinical outcomes for continuous-flow left ventricular assist device patients stratified by pre-operative INTERMACS classification. J Heart Lung Transplant 2011; 30: 402-407. 1) 瀬在 明，南 和友．末期心不全に対する外科治療と日本の現状．日大医学雑誌，2002; 61: 391-395. 10) 瀬在 明，南 和友．海外渡航移植と臓器移植法改正について．綜合臨床，2006; 55: 2106-2110. 21) Noon GP, Morley DL, Irwin S, Clinical experience with the MicroMed DeBakey ventricular assist device. Ann Thorac Surg 2001; 71 (3 Suppl): S133-138. 18) Kirkilin JK, Naftel DC, Kormos RL, et al. Second INTERMACS annual report: more than 1,000 primary left ventricular assist device implants. J Heart Lung Transplant 2010; 29: 1-10. 24) Sezai A. Major organ microcirculation during assisted circulation --comparison studies of pulsatile and nonpulsatile assisted circulations--. Ann Thorac Cardiovasc Surg 1996; 2: 215-223. 20) Pae WE, Connell JM, Adelowo A, et al. Does total implantability reduce infection with the use of a left ventricular assist device? the LionHeart experience in Europe. J Heart Lung Transplant 2007; 26: 219-229. 9) Shiono M and Sezai Y. Pneumatic ventricular assist device: Its problems and future trends. Ann Thorac Cardiovasc Surg 1995; 1: 885-891. 3) Shiono M, Noon GP, Nose Y. Ventricular assist device as a mechanical support for postcardiotomy failure and as a bridge to heart transplantation. In: Minami K., editor. Cardio-Thoracic Surgery: What's new in current practice. Amsterdam: Elsevier Science Publishers B.V, 1992; 197-204. 8) Sezai Y. The development and clinical application of the ventricular assist device in Japan. In: Sezai Y., editor. Artificial Heart. Philadelphia: Harcourt Brace Jovanovich Inc, 1992; 23-39. 2) Minami K, Arusoglu L, Sezai A, et al. Bridging to heart transplantation using paracorporeal and implantable ventricular assist devices. In: Akutsu T and Koyanagi H., editor. Heart replacement Artificial Heart 7. UK: Isis Medical Media, 2001; 179-184. 17) Kirkilin JK, Naftel DC, Kormos RL, et al. Third INTERMACS annual report: the evolution of destination therapy in the United States. J Heart Lung Transplant 2011; 30: 115-123. 11) Handry PJ, Masters RG, Mussivand TV, et al. Circulatory support for cardiogenic shock due to acute myocardial infarction: a Canadian experience. Can J Cardiol 1999; 15: 1090-1094. 15) Sezai A, Hata M, Niino T, et al. Mechanical circulatory support for fulminant myocarditis. Surg Today 2008; 38: 773-777. 26) Yoshitake I, El-Banayosy A, Yoda M, et al. First clinical application of the DuraHeart centrifugal ventricular assist device for a Japanese patient. Artificial Organs 2009; 33: 763-766. 23) Sezai A, Shiono M, Orime Y, et al. Major organ function under mechanical support: comparative studies of pulsatile and nonpulsatile circulation. Artificial Organs 1999; 23: 280-285. 27) Yamazaki K, Kihara S, Akimoto T, et al. EVAHEART: an implantable centrifugal blood pump for long-term circulatory support. Jpn J Thorac Surg 2002; 50: 461-465. 12) Aoyama N, Isumi T, Hiramori K, et al. Japanese investigators of fulminant myocarditis. National survey of fulminant myocarditis in Japan: Therapeutic guidelines and long-term prognosis of using percutaneous cardiopulmonary support for fulminant myocarditis (special report from a scientific committee). Circ J 2002; 66: 133-144. |
| References_xml | – reference: 17) Kirkilin JK, Naftel DC, Kormos RL, et al. Third INTERMACS annual report: the evolution of destination therapy in the United States. J Heart Lung Transplant 2011; 30: 115-123. – reference: 16) Minami, El-Banayosy A, Sezai A, et al. Morbidity and outcome after mechanical ventricular support using Thoratec, Novacor, and HeartMate for bridging to heart transplantation. Artificial Organs 2000; 24: 421-426. – reference: 2) Minami K, Arusoglu L, Sezai A, et al. Bridging to heart transplantation using paracorporeal and implantable ventricular assist devices. In: Akutsu T and Koyanagi H., editor. Heart replacement Artificial Heart 7. UK: Isis Medical Media, 2001; 179-184. – reference: 20) Pae WE, Connell JM, Adelowo A, et al. Does total implantability reduce infection with the use of a left ventricular assist device? the LionHeart experience in Europe. J Heart Lung Transplant 2007; 26: 219-229. – reference: 24) Sezai A. Major organ microcirculation during assisted circulation --comparison studies of pulsatile and nonpulsatile assisted circulations--. Ann Thorac Cardiovasc Surg 1996; 2: 215-223. – reference: 5) Sezai A, Shiono M, Nakata K, et al. The possibility of a Veno-arterial bypass system using the Abiomed BVS 5000. Artificial Organs 2006; 30: 74-77. – reference: 25) Morshuis M, El-Banayosy A, Arusoglu L, et al. European experience of DuraHeart magnetically levitated centrifugal left ventricular assist system. Eur J Cardio-thorac Surg 2009; 35: 1020-1028. – reference: 27) Yamazaki K, Kihara S, Akimoto T, et al. EVAHEART: an implantable centrifugal blood pump for long-term circulatory support. Jpn J Thorac Surg 2002; 50: 461-465. – reference: 26) Yoshitake I, El-Banayosy A, Yoda M, et al. First clinical application of the DuraHeart centrifugal ventricular assist device for a Japanese patient. Artificial Organs 2009; 33: 763-766. – reference: 15) Sezai A, Hata M, Niino T, et al. Mechanical circulatory support for fulminant myocarditis. Surg Today 2008; 38: 773-777. – reference: 14) Unosawa S, Hata M, Sezai A, et al. Successful management of fulminant myocarditis with left ventricular assist device: report of a severe case. Ann Thorac Cardiovasc Surg 2010; 16: 48-51. – reference: 3) Shiono M, Noon GP, Nose Y. Ventricular assist device as a mechanical support for postcardiotomy failure and as a bridge to heart transplantation. In: Minami K., editor. Cardio-Thoracic Surgery: What's new in current practice. Amsterdam: Elsevier Science Publishers B.V, 1992; 197-204. – reference: 10) 瀬在 明，南 和友．海外渡航移植と臓器移植法改正について．綜合臨床，2006; 55: 2106-2110. – reference: 1) 瀬在 明，南 和友．末期心不全に対する外科治療と日本の現状．日大医学雑誌，2002; 61: 391-395. – reference: 8) Sezai Y. The development and clinical application of the ventricular assist device in Japan. In: Sezai Y., editor. Artificial Heart. Philadelphia: Harcourt Brace Jovanovich Inc, 1992; 23-39. – reference: 18) Kirkilin JK, Naftel DC, Kormos RL, et al. Second INTERMACS annual report: more than 1,000 primary left ventricular assist device implants. J Heart Lung Transplant 2010; 29: 1-10. – reference: 19) Boyle AJ, Ascheim DD, Russo MJ, et al. Clinical outcomes for continuous-flow left ventricular assist device patients stratified by pre-operative INTERMACS classification. J Heart Lung Transplant 2011; 30: 402-407. – reference: 7) Rose EA, Gelijins AC, Moskowittz AJ, et al. Randomized evaluation of mechanical assistance for the treatment of congestive heart failure (REMATCH) study group. Long-term mechanical left ventricular assistance foe end-stage heart failure. N Eng j Med 2001; 345: 1435-1443. – reference: 9) Shiono M and Sezai Y. Pneumatic ventricular assist device: Its problems and future trends. Ann Thorac Cardiovasc Surg 1995; 1: 885-891. – reference: 21) Noon GP, Morley DL, Irwin S, Clinical experience with the MicroMed DeBakey ventricular assist device. Ann Thorac Surg 2001; 71 (3 Suppl): S133-138. – reference: 13) Chen YS, Yu HY, Huang SC, et al. Experience and result of extracorporeal membrane oxygenation in treating fulminant myocarditis with shock: what mechanical support should be considered first? J Heart Lung Transplant 2005; 24: 81-87. – reference: 22) El-Banayosy A, Arusoglu L, Kizner L, et al. Preliminary experience with the LionHeart left ventricular assist device in patients with end-stage heart failure. Ann Thorac Surg 2003; 75: 1469-1475. – reference: 11) Handry PJ, Masters RG, Mussivand TV, et al. Circulatory support for cardiogenic shock due to acute myocardial infarction: a Canadian experience. Can J Cardiol 1999; 15: 1090-1094. – reference: 12) Aoyama N, Isumi T, Hiramori K, et al. Japanese investigators of fulminant myocarditis. National survey of fulminant myocarditis in Japan: Therapeutic guidelines and long-term prognosis of using percutaneous cardiopulmonary support for fulminant myocarditis (special report from a scientific committee). Circ J 2002; 66: 133-144. – reference: 4) Sezai A, Minami K, El-Banayosy A, et al. Heart Replacement Artificial Heart 7. Mechanical Circulatory support with Abiomed BVS 5000 and BioMedicus BP-80 for postcardio-tomy cardiogenic shock. In: Akutsu T and Koyanagi H., editor. Heart replacement Artificial Heart 7. UK: Isis Medical Media, 2001; 445-448. – reference: 23) Sezai A, Shiono M, Orime Y, et al. Major organ function under mechanical support: comparative studies of pulsatile and nonpulsatile circulation. Artificial Organs 1999; 23: 280-285. – reference: 6) Sezai A, Arusoglu L, MinamiK, et al. Implantation of biventricular assist devices for chronic heart transplantation rejection. Ann Thorac Surg 2002; 74: 609-611. |
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| Snippet | 補助人工心臓 (VAD) は末期心不全に対する外科治療として有効とされ，心臓移植までのブリッジやdestination therapy として使用されている．しかしながら，日本では極... |
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| Title | 当施設における NIPRO 左心補助人工心臓の臨床成績 |
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