C型肝炎ウイルス研究のこれまでと今後の課題
2020年のノーベル医学生理学賞はC型肝炎とその原因ウイルス発見，病態解明に貢献のあった3研究者に送られた．これら受賞対象研究を経て，C型肝炎ウイルス(HCV)のウイルス学的技術や実験手法は大きく改善され，その後効果的な抗ウイルス治療も確立され，まさにHCV研究は円熟期を迎えている．本総説では，これまでのHCV研究の流れをおさらいし，今後のHCV研究の課題に触れながら，私たちがおこなっているHCV培養系を利用した生理活性天然物探索研究を紹介する．...
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| Published in | ウイルス Vol. 70; no. 2; pp. 129 - 134 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Japanese |
| Published |
日本ウイルス学会
2020
|
| Online Access | Get full text |
| ISSN | 0042-6857 1884-3433 |
| DOI | 10.2222/jsv.70.129 |
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| Abstract | 2020年のノーベル医学生理学賞はC型肝炎とその原因ウイルス発見，病態解明に貢献のあった3研究者に送られた．これら受賞対象研究を経て，C型肝炎ウイルス(HCV)のウイルス学的技術や実験手法は大きく改善され，その後効果的な抗ウイルス治療も確立され，まさにHCV研究は円熟期を迎えている．本総説では，これまでのHCV研究の流れをおさらいし，今後のHCV研究の課題に触れながら，私たちがおこなっているHCV培養系を利用した生理活性天然物探索研究を紹介する． |
|---|---|
| AbstractList | 2020年のノーベル医学生理学賞はC型肝炎とその原因ウイルス発見，病態解明に貢献のあった3研究者に送られた．これら受賞対象研究を経て，C型肝炎ウイルス(HCV)のウイルス学的技術や実験手法は大きく改善され，その後効果的な抗ウイルス治療も確立され，まさにHCV研究は円熟期を迎えている．本総説では，これまでのHCV研究の流れをおさらいし，今後のHCV研究の課題に触れながら，私たちがおこなっているHCV培養系を利用した生理活性天然物探索研究を紹介する． |
| Author | 渡士, 幸一 |
| Author_xml | – sequence: 1 fullname: 渡士, 幸一 organization: 国立感染症研究所ウイルス第二部 |
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| DOI | 10.2222/jsv.70.129 |
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| References | 8）Pawlotsky JM. Interferon-Free Hepatitis C Virus Therapy. Cold Spring Harb Perspect Med 2020;10. 11）Kanda Y, Yamasaki Y, Shimura S, et al. MA026, an anti-hepatitis C virus compound, opens tight junctions of the epithelial cell membrane. J Antibiot (Tokyo) 2017;70:691-694. 12）Nakajima S, Watashi K, Ohashi H, et al. Fungus-Derived Neoechinulin B as a Novel Antagonist of Liver X Receptor, Identified by Chemical Genetics Using a Hepatitis C Virus Cell Culture System. J Virol 2016;90:9058-74. 5）Kolykhalov AA, Agapov EV, Blight KJ, et al. Transmission of hepatitis C by intrahepatic inoculation with transcribed RNA. Science 1997;277:570-4. 3）Kolykhalov AA, Feinstone SM, Rice CM. Identification of a highly conserved sequence element at the 3' terminus of hepatitis C virus genome RNA. J Virol 1996;70:3363-71. 6）Lohmann V, Korner F, Koch J, et al. Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line. Science 1999;285:110-3. 2）Alter HJ, Purcell RH, Shih JW, et al. Detection of antibody to hepatitis C virus in prospectively followed transfusion recipients with acute and chronic non-A, non-B hepatitis. N Engl J Med 1989;321:1494-500. 7）Wakita T, Pietschmann T, Kato T, et al. Production of infectious hepatitis C virus in tissue culture from a cloned viral genome. Nat Med 2005;11:791-6. 9）Shin EC, Han JW, Kang W, et al. The Beginning of Ending Hepatitis C Virus: A Summary of the 26th International Symposium on Hepatitis C Virus and Related Viruses. Viruses 2020;12. 13）Nakajima S, Watashi K, Kamisuki S, et al. Specific inhibition of hepatitis C virus entry into host hepatocytes by fungi-derived sulochrin and its derivatives. Biochem Biophys Res Commun 2013;440:515-20. 14）Nishikori S, Takemoto K, Kamisuki S, et al. Anti-hepatitis C Virus Natural Product from a Fungus, Penicillium herquei. J Nat Prod 2016;79:442-6. 1）Choo QL, Kuo G, Weiner AJ, et al. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science 1989;244:359-62. 4）Tanaka T, Kato N, Cho MJ, et al. Structure of the 3' terminus of the hepatitis C virus genome. J Virol 1996; 70:3307-12. 10）Shimura S, Ishima M, Nakajima S, et al. Total synthesis and anti-hepatitis C virus activity of MA026. J Am Chem Soc 2013;135:18949-56. 15）Watanabe R, Mizoguchi H, Oikawa H, et al. Stereo-controlled synthesis of functionalized tetrahydropyridines based on the cyanomethylation of 1,6-dihydropyridines and generation of anti-hepatitis C virus agents. Bioorg Med Chem 2017;25:2851-2855. |
| References_xml | – reference: 4）Tanaka T, Kato N, Cho MJ, et al. Structure of the 3' terminus of the hepatitis C virus genome. J Virol 1996; 70:3307-12. – reference: 6）Lohmann V, Korner F, Koch J, et al. Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line. Science 1999;285:110-3. – reference: 14）Nishikori S, Takemoto K, Kamisuki S, et al. Anti-hepatitis C Virus Natural Product from a Fungus, Penicillium herquei. J Nat Prod 2016;79:442-6. – reference: 11）Kanda Y, Yamasaki Y, Shimura S, et al. MA026, an anti-hepatitis C virus compound, opens tight junctions of the epithelial cell membrane. J Antibiot (Tokyo) 2017;70:691-694. – reference: 8）Pawlotsky JM. Interferon-Free Hepatitis C Virus Therapy. Cold Spring Harb Perspect Med 2020;10. – reference: 13）Nakajima S, Watashi K, Kamisuki S, et al. Specific inhibition of hepatitis C virus entry into host hepatocytes by fungi-derived sulochrin and its derivatives. Biochem Biophys Res Commun 2013;440:515-20. – reference: 9）Shin EC, Han JW, Kang W, et al. The Beginning of Ending Hepatitis C Virus: A Summary of the 26th International Symposium on Hepatitis C Virus and Related Viruses. Viruses 2020;12. – reference: 2）Alter HJ, Purcell RH, Shih JW, et al. Detection of antibody to hepatitis C virus in prospectively followed transfusion recipients with acute and chronic non-A, non-B hepatitis. N Engl J Med 1989;321:1494-500. – reference: 3）Kolykhalov AA, Feinstone SM, Rice CM. Identification of a highly conserved sequence element at the 3' terminus of hepatitis C virus genome RNA. J Virol 1996;70:3363-71. – reference: 15）Watanabe R, Mizoguchi H, Oikawa H, et al. Stereo-controlled synthesis of functionalized tetrahydropyridines based on the cyanomethylation of 1,6-dihydropyridines and generation of anti-hepatitis C virus agents. Bioorg Med Chem 2017;25:2851-2855. – reference: 1）Choo QL, Kuo G, Weiner AJ, et al. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science 1989;244:359-62. – reference: 5）Kolykhalov AA, Agapov EV, Blight KJ, et al. Transmission of hepatitis C by intrahepatic inoculation with transcribed RNA. Science 1997;277:570-4. – reference: 12）Nakajima S, Watashi K, Ohashi H, et al. Fungus-Derived Neoechinulin B as a Novel Antagonist of Liver X Receptor, Identified by Chemical Genetics Using a Hepatitis C Virus Cell Culture System. J Virol 2016;90:9058-74. – reference: 10）Shimura S, Ishima M, Nakajima S, et al. Total synthesis and anti-hepatitis C virus activity of MA026. J Am Chem Soc 2013;135:18949-56. – reference: 7）Wakita T, Pietschmann T, Kato T, et al. Production of infectious hepatitis C virus in tissue culture from a cloned viral genome. Nat Med 2005;11:791-6. |
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| Title | C型肝炎ウイルス研究のこれまでと今後の課題 |
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