臨床病理学:健常犬のリンパ球幼若化反応におよぼす遺伝子組換え型ヒト顆粒球コロニー刺激因子の影響(短報)

健常犬のリンパ球数ならびにリンパ球幼若化反応におよぼす遺伝子組換え型ヒト顆粒球コロニー刺激因子(rhG−CSF)の影響を検討した.健常犬に2.5μg/kgの濃度でrhG−CSFを3日間皮下投与したところ,投与1日ならびに2日後の末梢血中リンパ球数は増加したが,3日目以降は処置前のレベルに復した.また,rhG−CSF投与によりPHA,Con A,PWMに対するリンパ球幼若化反応が処置前の2倍に増強した.以上の結果から,健常犬に投与されたrhG−CSFにはリンパ球機能を活性化する作用があると考えられた....

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Published inJournal of Veterinary Medical Science Vol. 62; no. 11; pp. 1205 - 1207
Main Authors 長谷川, 貴史, 猪俣, 生輝
Format Journal Article
LanguageEnglish
Published 公益社団法人 日本獣医学会 2000
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ISSN0916-7250
1347-7439
DOI10.1292/jvms.62.1205

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Abstract 健常犬のリンパ球数ならびにリンパ球幼若化反応におよぼす遺伝子組換え型ヒト顆粒球コロニー刺激因子(rhG−CSF)の影響を検討した.健常犬に2.5μg/kgの濃度でrhG−CSFを3日間皮下投与したところ,投与1日ならびに2日後の末梢血中リンパ球数は増加したが,3日目以降は処置前のレベルに復した.また,rhG−CSF投与によりPHA,Con A,PWMに対するリンパ球幼若化反応が処置前の2倍に増強した.以上の結果から,健常犬に投与されたrhG−CSFにはリンパ球機能を活性化する作用があると考えられた.
AbstractList 健常犬のリンパ球数ならびにリンパ球幼若化反応におよぼす遺伝子組換え型ヒト顆粒球コロニー刺激因子(rhG−CSF)の影響を検討した.健常犬に2.5μg/kgの濃度でrhG−CSFを3日間皮下投与したところ,投与1日ならびに2日後の末梢血中リンパ球数は増加したが,3日目以降は処置前のレベルに復した.また,rhG−CSF投与によりPHA,Con A,PWMに対するリンパ球幼若化反応が処置前の2倍に増強した.以上の結果から,健常犬に投与されたrhG−CSFにはリンパ球機能を活性化する作用があると考えられた.
Author 長谷川, 貴史
猪俣, 生輝
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– reference: 15. Weaver, C.H., Longin, K, Buckner, C.D. and Bensinger, W. 1994. Bone Marrow Transplant. 13: 411-415.
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– reference: 11. Ogilvie, G.K. and Moore, A.S. 1995. pp.142-147. In: Managing the Veterinary Cancer Patient, Veterinary Learning Systems, Trenton.
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– reference: 3 Gabrilove, J.L., Jakubowski, A.M.D., Scher, H., Stemberg, C., Wong, G., Grous, J., Yagoda, A., Fain, K., Moore, M.A.S., Clarkson, B., Oettgen, H.F., Alton, K., Welte, K. and Souza, L. 1988. New. Engl. J. Med. 318: 1414-1422.
– reference: 4. Harp, J.A., Kehrli, Jr.M.E., Hurley, D.J., Wilson, R.A. and Boone, T.C. 1991. Vet. Immunol. Immunopathol. 28: 29-35.
– reference: 1. Cassatela, M.A. 1995. Immunol. Today 16: 21-26.
– reference: 6. Henry, C.J., Buss, M.S. and Lothrop, C.D. Jr. 1998. Compend. Contin. Edu. Pract. Vet. 20: 728-735.
– reference: 8. Lieschke, G.J. and Burgess, A.W. 1992. New. Engl. J. Med. 327: 28-35.
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Title 臨床病理学:健常犬のリンパ球幼若化反応におよぼす遺伝子組換え型ヒト顆粒球コロニー刺激因子の影響(短報)
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