3．腎硬化症
腎硬化症，あるいは高血圧性腎障害による透析導入患者数が増加しており，腎硬化症の発症予防，進行阻止が急務とされる．しかし，病理学的には“細動脈の硬化性変化による腎障害”と定義される腎硬化症と高血圧の関係は実ははっきりしておらず，またagingとの線引き，粥状動脈硬化による虚血性腎症との鑑別など多くの問題が未解決のままである．今後日本人における大規模かつ長期の観察研究を行う必要がある．...
Saved in:
| Published in | 日本内科学会雑誌 Vol. 102; no. 5; pp. 1180 - 1189 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | Japanese |
| Published |
一般社団法人 日本内科学会
2013
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0021-5384 1883-2083 |
| DOI | 10.2169/naika.102.1180 |
Cover
| Abstract | 腎硬化症，あるいは高血圧性腎障害による透析導入患者数が増加しており，腎硬化症の発症予防，進行阻止が急務とされる．しかし，病理学的には“細動脈の硬化性変化による腎障害”と定義される腎硬化症と高血圧の関係は実ははっきりしておらず，またagingとの線引き，粥状動脈硬化による虚血性腎症との鑑別など多くの問題が未解決のままである．今後日本人における大規模かつ長期の観察研究を行う必要がある． |
|---|---|
| AbstractList | 腎硬化症，あるいは高血圧性腎障害による透析導入患者数が増加しており，腎硬化症の発症予防，進行阻止が急務とされる．しかし，病理学的には“細動脈の硬化性変化による腎障害”と定義される腎硬化症と高血圧の関係は実ははっきりしておらず，またagingとの線引き，粥状動脈硬化による虚血性腎症との鑑別など多くの問題が未解決のままである．今後日本人における大規模かつ長期の観察研究を行う必要がある． |
| Author | 白石, 直樹 冨田, 公夫 |
| Author_xml | – sequence: 1 fullname: 冨田, 公夫 organization: 熊本大学大学院生命科学研究部腎臓内科学 – sequence: 1 fullname: 白石, 直樹 organization: 熊本大学大学院生命科学研究部腎臓内科学 |
| BookMark | eNo9z71KA0EUBeBBIrjGgJVvMeu9c2d2ZksN_kEgTayHO8uM7hpX2U3jA4iNpNTa3kfwdSR2voIaxeac4sCBb1sM2ps2CrGHkCssyv2W6yvOEVSO6GBDZOgcSQWOBiIDUCgNOb0lRn1fB9BUGIekM7FLn2_Lj_vl6uX1_fFp9fywIzYTz_s4-uuhOD8-mo1P5WR6cjY-mMhGqQIkoavQhsTBxcLoUhsNkcFERghEDqyJlmJIVRlY2-BQI9gUFCQm5kRDcfj72_QLvoj-tquvubvz3C3qah79GuS_Qd6s84f1P1aX3PmG6QudKkyE |
| ContentType | Journal Article |
| Copyright | 2013 一般社団法人 日本内科学会 |
| Copyright_xml | – notice: 2013 一般社団法人 日本内科学会 |
| DOI | 10.2169/naika.102.1180 |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1883-2083 |
| EndPage | 1189 |
| ExternalDocumentID | article_naika_102_5_102_1180_article_char_ja |
| GroupedDBID | ALMA_UNASSIGNED_HOLDINGS DIK F5P JSF OK1 RJT |
| ID | FETCH-LOGICAL-j2260-318c17bfab8e65494540ea05ea10b338075e73ebfc9ba47b814107fb20fa3aaf3 |
| ISSN | 0021-5384 |
| IngestDate | Wed Sep 03 06:30:13 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | false |
| IsScholarly | true |
| Issue | 5 |
| Language | Japanese |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-j2260-318c17bfab8e65494540ea05ea10b338075e73ebfc9ba47b814107fb20fa3aaf3 |
| OpenAccessLink | https://www.jstage.jst.go.jp/article/naika/102/5/102_1180/_article/-char/ja |
| PageCount | 10 |
| ParticipantIDs | jstage_primary_article_naika_102_5_102_1180_article_char_ja |
| PublicationCentury | 2000 |
| PublicationDate | 20130000 |
| PublicationDateYYYYMMDD | 2013-01-01 |
| PublicationDate_xml | – year: 2013 text: 20130000 |
| PublicationDecade | 2010 |
| PublicationTitle | 日本内科学会雑誌 |
| PublicationTitleAlternate | 日内会誌 |
| PublicationYear | 2013 |
| Publisher | 一般社団法人 日本内科学会 |
| Publisher_xml | – name: 一般社団法人 日本内科学会 |
| References | 2) Wehrmann M, Bohle A: The long-term prognosis of benign nephrosclerosis accompanied by focal glomerulosclerosis and renal cortical interstitial fibrosis, designated so-called decompensated benign nephrosclerosis by Fahr, Bohle and Ratscheck. Pathol Res Pract 194: 571-576, 1998. 12) Darmady EM, et al: The parameters of the ageing kidney. J Pathol 109: 195-207, 1973. 14) Freedman BI, et al: The link between hypertension and nephrosclerosis. Am J Kidney Dis 25: 207-221, 1995. 15) Hoy WE, et al: Nephron number, glomerular volume, renal disease and hypertension. Curr Opin Nephrol Hypertens 17: 258-265, 2008. 16) Lerman LO, et al: Mechanisms of tissue injury in renal artery stenosis: ischemia and beyond. Prog Cardiovasc Dis 52: 196-203, 2009. 5) Schlessinger SD, et al: Clinical documentation of end-stage renal disease due to hypertension. Am J Kidney Dis 23: 655-660, 1994. 13) Imai E, et al: Slower decline of glomerular filtration rate in the Japanese general population: a longitudinal 10-year follow-up study. Hypertens Res 31: 433-441, 2008. 3) Tomson CR, et al: Does treated essential hypertension result in renal impairment? A cohort study. J Hum Hypertens 5: 189-192, 1991. 9) Hsu CY, et al: Elevated blood pressure and risk of end-stage renal disease in subjects without baseline kidney disease. Arch Intern Med 165: 923-928, 2005. 10) Ito S, et al: Strain vessel hypothesis: a viewpoint for linkage of albuminuria and cerebro-cardiovascular risk. Hypertens Res 32: 115-121, 2009. 17) Keddis MT, et al: Ischaemic nephropathy secondary to atherosclerotic renal artery stenosis: clinical and histopathological correlates. Nephrol Dial Transplant 25: 3615-3622, 2010. 19) Takebayashi S, et al: Benign nephrosclerosis: incidence, morphology and prognosis. Clin Nephrol 55: 349-356, 2001. 1) White KE, et al: Prevalence of atubular glomeruli in type 2 diabetic patients with nephropathy. Nephrol Dial Transplant 23: 3539-3545, 2008. 11) Ninomiya T, et al: Prehypertension increases the risk for renal arteriosclerosis in autopsies: the Hisayama Study. J Am Soc Nephrol 18: 2135-2142, 2007. 4) Hsu CY: Does treatment of non-malignant hypertension reduce the incidence of renal dysfunction? A meta-analysis of 10 randomised, controlled trials. J Hum Hypertens 15: 99-106, 2001. 6) Zarif L, et al: Inaccuracy of clinical phenotyping parameters for hypertensive nephrosclerosis. Nephrol Dial Transplant 15: 1801-1807, 2000. 8) Chang J, et al: Loss of GSTM1, a NRF2 Target, is associated with accelerated progression of hypertensive kidney disease in the African American Study of Kidney Disease (AASK). Am J Physiol Renal Physiol 2012. 7) Murea M, Freedman BI: Essential hypertension and risk of nephropathy: a reappraisal. Curr Opin Nephrol Hypertens 19: 235-241, 2010. 18) Zucchelli P, Zuccalà A: Recent data on hypertension and progressive renal disease. J Hum Hypertens 10: 679-682, 1996. |
| References_xml | – reference: 3) Tomson CR, et al: Does treated essential hypertension result in renal impairment? A cohort study. J Hum Hypertens 5: 189-192, 1991. – reference: 15) Hoy WE, et al: Nephron number, glomerular volume, renal disease and hypertension. Curr Opin Nephrol Hypertens 17: 258-265, 2008. – reference: 6) Zarif L, et al: Inaccuracy of clinical phenotyping parameters for hypertensive nephrosclerosis. Nephrol Dial Transplant 15: 1801-1807, 2000. – reference: 11) Ninomiya T, et al: Prehypertension increases the risk for renal arteriosclerosis in autopsies: the Hisayama Study. J Am Soc Nephrol 18: 2135-2142, 2007. – reference: 14) Freedman BI, et al: The link between hypertension and nephrosclerosis. Am J Kidney Dis 25: 207-221, 1995. – reference: 2) Wehrmann M, Bohle A: The long-term prognosis of benign nephrosclerosis accompanied by focal glomerulosclerosis and renal cortical interstitial fibrosis, designated so-called decompensated benign nephrosclerosis by Fahr, Bohle and Ratscheck. Pathol Res Pract 194: 571-576, 1998. – reference: 16) Lerman LO, et al: Mechanisms of tissue injury in renal artery stenosis: ischemia and beyond. Prog Cardiovasc Dis 52: 196-203, 2009. – reference: 17) Keddis MT, et al: Ischaemic nephropathy secondary to atherosclerotic renal artery stenosis: clinical and histopathological correlates. Nephrol Dial Transplant 25: 3615-3622, 2010. – reference: 1) White KE, et al: Prevalence of atubular glomeruli in type 2 diabetic patients with nephropathy. Nephrol Dial Transplant 23: 3539-3545, 2008. – reference: 7) Murea M, Freedman BI: Essential hypertension and risk of nephropathy: a reappraisal. Curr Opin Nephrol Hypertens 19: 235-241, 2010. – reference: 19) Takebayashi S, et al: Benign nephrosclerosis: incidence, morphology and prognosis. Clin Nephrol 55: 349-356, 2001. – reference: 13) Imai E, et al: Slower decline of glomerular filtration rate in the Japanese general population: a longitudinal 10-year follow-up study. Hypertens Res 31: 433-441, 2008. – reference: 18) Zucchelli P, Zuccalà A: Recent data on hypertension and progressive renal disease. J Hum Hypertens 10: 679-682, 1996. – reference: 12) Darmady EM, et al: The parameters of the ageing kidney. J Pathol 109: 195-207, 1973. – reference: 5) Schlessinger SD, et al: Clinical documentation of end-stage renal disease due to hypertension. Am J Kidney Dis 23: 655-660, 1994. – reference: 4) Hsu CY: Does treatment of non-malignant hypertension reduce the incidence of renal dysfunction? A meta-analysis of 10 randomised, controlled trials. J Hum Hypertens 15: 99-106, 2001. – reference: 8) Chang J, et al: Loss of GSTM1, a NRF2 Target, is associated with accelerated progression of hypertensive kidney disease in the African American Study of Kidney Disease (AASK). Am J Physiol Renal Physiol 2012. – reference: 9) Hsu CY, et al: Elevated blood pressure and risk of end-stage renal disease in subjects without baseline kidney disease. Arch Intern Med 165: 923-928, 2005. – reference: 10) Ito S, et al: Strain vessel hypothesis: a viewpoint for linkage of albuminuria and cerebro-cardiovascular risk. Hypertens Res 32: 115-121, 2009. |
| SSID | ssib043658134 ssj0066765 ssib002821954 ssib005879745 ssib007485360 ssib058493862 ssib000940260 ssib002484664 |
| Score | 1.9455576 |
| Snippet | 腎硬化症，あるいは高血圧性腎障害による透析導入患者数が増加しており，腎硬化症の発症予防，進行阻止が急務とされる．しかし，病理学的には“細動脈の硬化性変化による腎... |
| SourceID | jstage |
| SourceType | Publisher |
| StartPage | 1180 |
| SubjectTerms | 末期腎不全 腎硬化症 虚血性腎症 高血圧 |
| Title | 3．腎硬化症 |
| URI | https://www.jstage.jst.go.jp/article/naika/102/5/102_1180/_article/-char/ja |
| Volume | 102 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| ispartofPNX | 日本内科学会雑誌, 2013/05/10, Vol.102(5), pp.1180-1189 |
| journalDatabaseRights | – providerCode: PRVAFT databaseName: Colorado Digital library customDbUrl: eissn: 1883-2083 dateEnd: 99991231 omitProxy: true ssIdentifier: ssib007485360 issn: 0021-5384 databaseCode: KQ8 dateStart: 19130101 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3NaxQxFA9LBfHit2j9oAdzkqkz-Q6eMtspRaggtNDbkGwzhz2sItuLd_FSetSzd_8E_x2pN_8CwfeS2d1Z6MHWZRgymZeXeftC8kt4H4Q856HkHfyKY1jfC-E7W3g9EUVU6pgD3LCSoe_w_hu1dyheH8mj0ejPwGrpZB62Jx8v9Cu5ilahDvSKXrKX0OySKVRAGfQLd9Aw3P9Jx5w2u7QeU9PQxlAjU0FTV1E3pg08jqlVWGM17RecHofSRmGlk6kwXtArZIIcoEmFNW6HOuAgsBfraGOprdMrQ50D_gt99a2dSb0BeYm6S7WyZ-4EdfWKHsgsrXdSAYTgmV4j_1rgVwGv2g4PJbI3aRpA6YsMWmmg3Cb1oLGHusGugIfjyAPYWpmIHVwvrib1cGJnVQFzdz6biHkuNzD6WJnz5Cwn-5INRrUcTN0YC28AA-DRXrTEsEphhNYZOnhh3IvtVbu1sN39oGgTYQuErUx3JG8XL9Gzrp0CvL_GNAAltCl4O0DHVmDEtwGaMmvJAGC3XA2j-Umj7TB5gRaAxVbtBQe0Wa2iAQL0tNyoZbQ1tHbOCT_6_zLHOEWBX66LC2htCnuXhd1jgmIHt8nNfg-15bJ4d8ho6u-S6_u9lcg9cov__nH269PZ-bfvP0-_nH_9fJ8c7jYH472iz_xRTGE7kFz6J5UOnQ8mKikshomMvpTRV2XgmCNBRs1j6CY2eKGDQWtl3QVWdp573_EHZGP2bhYfkq2qM76K3GJiBCFsGTrmNfNcx6hY4OwReZVlad_n8C7tZTS3-V-tH5MbLGVXwRO9J2Rj_uEkPgWMOw_P0kj4C0eld7w |
| linkProvider | Colorado Alliance of Research Libraries |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=3%EF%BC%8E%E8%85%8E%E7%A1%AC%E5%8C%96%E7%97%87&rft.jtitle=%E6%97%A5%E6%9C%AC%E5%86%85%E7%A7%91%E5%AD%A6%E4%BC%9A%E9%9B%91%E8%AA%8C&rft.au=%E5%86%A8%E7%94%B0%2C+%E5%85%AC%E5%A4%AB&rft.au=%E7%99%BD%E7%9F%B3%2C+%E7%9B%B4%E6%A8%B9&rft.date=2013&rft.pub=%E4%B8%80%E8%88%AC%E7%A4%BE%E5%9B%A3%E6%B3%95%E4%BA%BA+%E6%97%A5%E6%9C%AC%E5%86%85%E7%A7%91%E5%AD%A6%E4%BC%9A&rft.issn=0021-5384&rft.eissn=1883-2083&rft.volume=102&rft.issue=5&rft.spage=1180&rft.epage=1189&rft_id=info:doi/10.2169%2Fnaika.102.1180&rft.externalDocID=article_naika_102_5_102_1180_article_char_ja |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0021-5384&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0021-5384&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0021-5384&client=summon |