Evaluation of Hypo-irritancy and Hypo-allergenicity in Cosmetic Products for Scalp

• Published in: Skin research Vol. 38; no. 4; pp. 448 - 456
• Main Author: SUGAI, Tetsuro
• Format: Journal Article
• Language: English; Japanese
• Published: Meeting of Osaka Dermatological Association 1996; 日本皮膚科学会大阪地方会
• Subjects: contact urticaria; cosmetic products for scalp; scarifications 20 minutes' patch test; scarifications 48 hours' patch test; skin safety; 乱切20分間パッチテスト; 乱切48時間パッチテスト; 接触蕁麻疹; 皮膚安全性; 頭皮用製品
• ISSN: 0018-1390; 1884-541X
• DOI: 10.11340/skinresearch1959.38.448

An attempt to evaluate the skin safety of three cosmetic products for scalp, that is, scalp lotion S, scalp lotion W and scalp essence, and their eight herb ingredients was made in 30 healthy adult female volunteers. Scarifications 20 minutes' patch test for contact urticaria reactions, scarifications 48 hours' prophetic patch test and photopatch test for irritant reactions as well as photourticarial and phototoxic reactions, and diagnostic patch test 2 weeks later for contact sensitivity were performed. Skin irritation index of the three cosmetic products for scalp was 10.0, 6.7 and 5.0 with scarifications prophetic patch test, while it was 1.7, 0.0 and 1.7 with simple prophetic patch test, respectively. Thus, they are judged as permissible to eczematous scalp and as safe to healthy scal. In scarifications 20 minutes' patch testing, however, contact urticaria was seen in a subject out of the 30 (3.3%), though contact urticaria index was 6.7, 8.3 and 8.3. Therefore, it will be necessary to warn the possibility to induce contact urticaria.