2)機能性消化管障害の基礎―病因に迫る研究の現状

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Published in日本内科学会雑誌 Vol. 99; no. 9; pp. 2128 - 2133
Main Authors 浅川, 明弘, 乾, 明夫
Format Journal Article
LanguageJapanese
Published 一般社団法人 日本内科学会 2010
Subjects
Online AccessGet full text
ISSN0021-5384
1883-2083
DOI10.2169/naika.99.2128

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Author 乾, 明夫
浅川, 明弘
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  organization: 鹿児島大学大学院社会・行動医学講座心身内科学分野
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References 12) Adam B, et al: Mechanisms of disease: genetics of functional gastrointestinal disorders-searching the genes that matter. Nat Clin Prac Gastroenterol Hepatol 4 (2): 102-110, 2007.
21) Vijay-Kumar M, et al: Metabolic syndrome and altered gut microbiota in mice lacking toll-like receptor 5. Science 328 (5975): 228-231.
15) Feinle-Bisset C, Horowitz M: Dietary factors in functional dyspepsia. Neurogastroenterol Motil 18: 608-618, 2006.
14) Bisschops R, Tack J: Dysaccomodation of the stomach: therapeutic nirvana? Neurogastroenterol Motil 19: 85-93, 2007.
19) Ringel Y: New directions in brain imaging research in functional gastrointestinal disorders. Dig Dis 24: 278-285, 2006.
8) Talley NJ, Choung RS: Whither dyspepsia? A historical perspective of functional dyspepsia, and concepts of pathogenesis and therapy in 2009. J Gastroenterol Hepatol 24 (3 Suppl): S20-S28, 2009.
10) Anand P, et al: Peripheral and central mechanisms of visceral sensitization in man. Neurogastroenterol Motil 19 (1 Suppl): 29-46, 2007.
3) Jones MP, et al: Brain-gut connections in functional GI disorders: anatomic and physiologic relationships. Neurogastroenterol Motil 18: 91-103, 2006.
9) Geeraerts B, Tack J: Functional dyspepsia: past, present, and future. J Gastroenterol 43: 251-255, 2008.
20) Mayer EA, Collins SM: Evolving pathophysiologic models of functional gastrointestinal disorders. Gastorenterology 122: 2032-2048, 2002.
11) Mayer EA, et al: Review article: modulation of the brain-gut axis as a therapeutic approach in gastrointestinal disease. Aliment Pharmacol Therap 24: 919-933, 2006.
22) Marx J: Cellular warriors at the battle of the bulge. Science 299 (5608): 846-849, 2003.
13) Jones MP, et al: Functional gastrointestinal disorders: an update for the psychiatrist. Psychosomatic 48 (2): 93-102, 2007.
1) Drossman DA: The functional gastrointestinal disorders and the Rome III process. Gastroenterology 130: 1377-1390, 2006.
16) Chen C, et al: Ghrelin gene products and the regulation of food intake and gut motility. Pharmacol Rev 61: 430-481, 2009.
5) De Giorgio R, et al: Novel therapeutic targets for enteric nervous system disorders. Trends Pharmacol Sci 28 (9): 473-481, 2007.
18) Bingel U, Tracey I: Imaging CNS modulation of pain in humans. Physiology 23: 371-380, 2008.
7) Mimidis K, Tack J: Pathogenesis of dyspepsia. Dig Dis 26: 194-202, 2008.
2) Sanger GJ, Alpers DH: Development of drugs for gastrointestinal motor disorders: translating science to clinical need. Neurogastroenterol Motil 20: 177-184, 2008.
17) Camilleri M: Novel pharmacology: asimadoline, a κ-opioid agonist, and visceral sensation. Neurogastroenterol Motil 20: 971-979, 2008.
6) Holtmann G, Gapasin J: Failed therapy and directions for the future in dyspepsia. Dig Dis 26: 218-224, 2008.
4) Tack J: Prokinetics and fundic relaxants in upper functional GI disorders. Curr Opin Pharmacol 8: 690-696, 2008.
References_xml – reference: 13) Jones MP, et al: Functional gastrointestinal disorders: an update for the psychiatrist. Psychosomatic 48 (2): 93-102, 2007.
– reference: 2) Sanger GJ, Alpers DH: Development of drugs for gastrointestinal motor disorders: translating science to clinical need. Neurogastroenterol Motil 20: 177-184, 2008.
– reference: 17) Camilleri M: Novel pharmacology: asimadoline, a κ-opioid agonist, and visceral sensation. Neurogastroenterol Motil 20: 971-979, 2008.
– reference: 1) Drossman DA: The functional gastrointestinal disorders and the Rome III process. Gastroenterology 130: 1377-1390, 2006.
– reference: 5) De Giorgio R, et al: Novel therapeutic targets for enteric nervous system disorders. Trends Pharmacol Sci 28 (9): 473-481, 2007.
– reference: 3) Jones MP, et al: Brain-gut connections in functional GI disorders: anatomic and physiologic relationships. Neurogastroenterol Motil 18: 91-103, 2006.
– reference: 14) Bisschops R, Tack J: Dysaccomodation of the stomach: therapeutic nirvana? Neurogastroenterol Motil 19: 85-93, 2007.
– reference: 19) Ringel Y: New directions in brain imaging research in functional gastrointestinal disorders. Dig Dis 24: 278-285, 2006.
– reference: 9) Geeraerts B, Tack J: Functional dyspepsia: past, present, and future. J Gastroenterol 43: 251-255, 2008.
– reference: 10) Anand P, et al: Peripheral and central mechanisms of visceral sensitization in man. Neurogastroenterol Motil 19 (1 Suppl): 29-46, 2007.
– reference: 7) Mimidis K, Tack J: Pathogenesis of dyspepsia. Dig Dis 26: 194-202, 2008.
– reference: 6) Holtmann G, Gapasin J: Failed therapy and directions for the future in dyspepsia. Dig Dis 26: 218-224, 2008.
– reference: 20) Mayer EA, Collins SM: Evolving pathophysiologic models of functional gastrointestinal disorders. Gastorenterology 122: 2032-2048, 2002.
– reference: 8) Talley NJ, Choung RS: Whither dyspepsia? A historical perspective of functional dyspepsia, and concepts of pathogenesis and therapy in 2009. J Gastroenterol Hepatol 24 (3 Suppl): S20-S28, 2009.
– reference: 4) Tack J: Prokinetics and fundic relaxants in upper functional GI disorders. Curr Opin Pharmacol 8: 690-696, 2008.
– reference: 12) Adam B, et al: Mechanisms of disease: genetics of functional gastrointestinal disorders-searching the genes that matter. Nat Clin Prac Gastroenterol Hepatol 4 (2): 102-110, 2007.
– reference: 16) Chen C, et al: Ghrelin gene products and the regulation of food intake and gut motility. Pharmacol Rev 61: 430-481, 2009.
– reference: 21) Vijay-Kumar M, et al: Metabolic syndrome and altered gut microbiota in mice lacking toll-like receptor 5. Science 328 (5975): 228-231.
– reference: 15) Feinle-Bisset C, Horowitz M: Dietary factors in functional dyspepsia. Neurogastroenterol Motil 18: 608-618, 2006.
– reference: 11) Mayer EA, et al: Review article: modulation of the brain-gut axis as a therapeutic approach in gastrointestinal disease. Aliment Pharmacol Therap 24: 919-933, 2006.
– reference: 22) Marx J: Cellular warriors at the battle of the bulge. Science 299 (5608): 846-849, 2003.
– reference: 18) Bingel U, Tracey I: Imaging CNS modulation of pain in humans. Physiology 23: 371-380, 2008.
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SubjectTerms 内臓知覚過敏
機能性消化管障害
消化管運動
脳腸相関
Title 2)機能性消化管障害の基礎―病因に迫る研究の現状
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