Caffeine combination chemotherapy for oral squamous cell carcinoma
Caffeine is known of inhibit DNA repair of cancer cells. The anticancer effects of caffeine increase when it is used in combination with anticarcinogenic agents. We examined the clinical and side effects of treating oral squamous cell carcinoma with intravenous (IV) drips of cisplatin (CDDP), etopos...
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| Published in | Japanese Journal of Chemotherapy Vol. 49; no. 3; pp. 162 - 165 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
Japanese Society of Chemotherapy
2001
公益社団法人 日本化学療法学会 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1340-7007 1884-5886 |
| DOI | 10.11250/chemotherapy1995.49.162 |
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| Abstract | Caffeine is known of inhibit DNA repair of cancer cells. The anticancer effects of caffeine increase when it is used in combination with anticarcinogenic agents. We examined the clinical and side effects of treating oral squamous cell carcinoma with intravenous (IV) drips of cisplatin (CDDP), etoposide (VP-16), bleomycin hydrochloride (BLM), and caffeine as a neoadjuvant. CDDP (25mg) was infused by IV for 2 hours, VP-16 (100mg) 1 hour, and BLM (20mg) 16 hours. Caffeine (1, 000mg) was them infused by IV for 18 hours. Subjects were 17 patients with oral squamous cell carcinoma, of these 14 underwent post treatment surgery, and cancer regression was seen in 8 of the 14 (57%). Side effects in the 17 patients were appetite loss (53%), leukopenia (47%), and nausea (29%). Insomnia did not occur. Other side effects were fever (2 cases), paleness (1 case), lip erosion (1 case) and skin eruption (1 case). This regimen has proven useful in treatment, but further work is necessary to determine the most efficacious doses. |
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| AbstractList | Caffeine is known of inhibit DNA repair of cancer cells. The anticancer effects of caffeine increase when it is used in combination with anticarcinogenic agents. We examined the clinical and side effects of treating oral squamous cell carcinoma with intravenous (IV) drips of cisplatin (CDDP), etoposide (VP-16), bleomycin hydrochloride (BLM), and caffeine as a neoadjuvant. CDDP (25mg) was infused by IV for 2 hours, VP-16 (100mg) 1 hour, and BLM (20mg) 16 hours. Caffeine (1, 000mg) was them infused by IV for 18 hours. Subjects were 17 patients with oral squamous cell carcinoma, of these 14 underwent post treatment surgery, and cancer regression was seen in 8 of the 14 (57%). Side effects in the 17 patients were appetite loss (53%), leukopenia (47%), and nausea (29%). Insomnia did not occur. Other side effects were fever (2 cases), paleness (1 case), lip erosion (1 case) and skin eruption (1 case). This regimen has proven useful in treatment, but further work is necessary to determine the most efficacious doses. Caffeine is known of inhibit DNA repair of cancer cells. The anticancer effects of caffeine increase when it is used in combination with anticarcinogenic agents. We examined the clinical and side effects of treating oral squamous cell carcinoma with intravenous (IV) drips of cisplatin (CDDP), etoposide (VP-16), bleomycin hydrochloride (BLM), and caffeine as a neoadjuvant. CDDP (25mg) was infused by IV for 2 hours, VP-16 (100mg) 1 hour, and BLM (20mg) 16 hours. Caffeine (1, 000mg) was them infused by IV for 18 hours. Subjects were 17 patients with oral squamous cell carcinoma, of these 14 underwent post treatment surgery, and cancer regression was seen in 8 of the 14 (57%). Side effects in the 17 patients were appetite loss (53%), leukopenia (47%), and nausea (29%). Insomnia did not occur. Other side effects were fever (2 cases), paleness (1 case), lip erosion (1 case) and skin eruption (1 case). This regimen has proven useful in treatment, but further work is necessary to determine the most efficacious doses. CaffeineはDNA修復阻害作用を有し, 抗癌薬との併用で抗腫瘍効果が増強することが知られている。われわれは口腔扁平上皮癌のneoadjuvant chemotherapyとしてcisplatin (CDDP), etoposide (VP-16), bleomycin (BLM) およびcaffeineの静脈内投与を施行し, 臨床効果および副作用について検討した。投与はCDDP (25mg/body) を2時間, VP-16 (100mg/body) を1時間およびBLM (20mg/body) を16時間かけて点滴静注し, その後, caffbine 1,000mg/bodyを18時間かけて点滴静注した。これを1週間に1回とし2クール行った。口腔扁平上皮癌症例17例に行い検討した結果, 評価可能14例中, completeresponse (CR) 0例, partial response (PR) 8例で奏効率は57.1%であった。副作用は食欲不振 (52.9%), 骨髄抑制 (47.0%), 悪心 (29.4%) で不眠を訴える症例はなかった。その他, 発熱, 顔面蒼白, 口唇ビラン, 皮疹が少数例に見られた。以上より, neoadjuvant chemotherapyとして有用性を認めたが, 今後, さらに至適投与量の検討が必要と思われた。 |
| Author | Yamazaki, Hiroshi Ohta, Yoshihide Kaneko, Akihiro Sasaki, Jiro Karakida, Kazunari Watanabe, Daisuke Aoki, Takayuki Tsukinoki, Keiichi |
| Author_FL | 渡辺 大介 青木 隆幸 槻木 忠一 佐々木 次郎 山崎 浩史 唐木田 一成 太田 嘉英 金子 明寛 |
| Author_FL_xml | – sequence: 1 fullname: 唐木田 一成 – sequence: 2 fullname: 太田 嘉英 – sequence: 3 fullname: 青木 隆幸 – sequence: 4 fullname: 渡辺 大介 – sequence: 5 fullname: 山崎 浩史 – sequence: 6 fullname: 金子 明寛 – sequence: 7 fullname: 佐々木 次郎 – sequence: 8 fullname: 槻木 忠一 |
| Author_xml | – sequence: 1 fullname: Aoki, Takayuki organization: Department of Oral surgery, Tokai University School of Medicine – sequence: 1 fullname: Yamazaki, Hiroshi organization: Department of Oral surgery, Tokai University School of Medicine – sequence: 1 fullname: Kaneko, Akihiro organization: Department of Oral surgery, Tokai University School of Medicine – sequence: 1 fullname: Tsukinoki, Keiichi organization: Department of Oral Pathology, Kanagawa Dental College – sequence: 1 fullname: Sasaki, Jiro organization: Department of Oral surgery, Tokai University School of Medicine – sequence: 1 fullname: Ohta, Yoshihide organization: Department of Oral surgery, Tokai University School of Medicine – sequence: 1 fullname: Watanabe, Daisuke organization: Department of Oral surgery, Tokai University School of Medicine – sequence: 1 fullname: Karakida, Kazunari organization: Department of Oral surgery, Tokai University School of Medicine |
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| References | 13) 山本裕司, 天野富薫, 今田敏夫, 他: 腹膜播種に対するcaffeine併用CDDP腹腔内投与に関する実験的研究. 癌と化学療法18: 1325-1831, 1991 10) Schlegel R, Pardee A B: Caffeine-induced uncoupling of mitosis from the completion of DNA replication in mammalian cells. Science 232: 1264-1266, 1986 5) Frei E: Clinical cancer research: An embattled Species. Cancer 50: 1979-1992, 1982 14) 漆崎一郎: 最新癌化学療法. p.167-175, メデイカルレビュー社, 1996 7) Chen G L, Yang L, Rowe T C, et al.: Nonintercalative antitumor drugs interfere with the greakage reunion reaction of mammalian DNA topoisomerase II. J biol chem 259: 13560-13566, 1984 3) 日本頭頸部腫瘍学会編: 臨床・病理頭頸部癌取り扱い規約. p.96-100, 金原出版, 東京, 1991 4) 日本癌治療学会臨床試験委員会編: 臨床試験実地ガイドライン. P.64-71, 金原出版, 東京, 1997 11) Lau C C, Pardee A B: Mechanism by which caffeine potentiates lethality of nitrogen mustard. Proc. Natl. Acad. Sci. USA 79: 2942-2946. 1982 2) 山本裕司, 須川嵩, 岡田賢三, 他: 胃癌腹膜播種性転移に対するシスプラチン・エトポシド・カフェインの腹腔内投与の検討. 日癌治29: 19-26, 1994 6) 上屋弘行: カフェインによる制癌剤の効果増強に関する研究. 金沢大十全医誌97: 543-556, 1988 8) Allen T E, Aliano N A, Cowan R J, et al.: Amplification of the anti-tumor activity of phleomycins and bleomycins in rats and mice by caffeine. Cancer Res. 45: 2516-2521, 1985 12) 富田勝郎, 土屋弘行, 佐々木琢磨: DNA repalr機構と抗癌剤耐性. 癌と化学療法16: 576-584, 1989 9) Fingert H J, Chang J D, Pardee A B: Cytotoxic, cell cycle, and chromosomal effects of methylxanthines in human tumor cells treated with alkylating agents. Cancer Res 46: 2463-2467, 1986 1) 石本二見男, 笠井健司: 臨床におけるカフェインの適用. 薬局42: 55-58, 1991 |
| References_xml | – reference: 4) 日本癌治療学会臨床試験委員会編: 臨床試験実地ガイドライン. P.64-71, 金原出版, 東京, 1997 – reference: 14) 漆崎一郎: 最新癌化学療法. p.167-175, メデイカルレビュー社, 1996 – reference: 5) Frei E: Clinical cancer research: An embattled Species. Cancer 50: 1979-1992, 1982 – reference: 7) Chen G L, Yang L, Rowe T C, et al.: Nonintercalative antitumor drugs interfere with the greakage reunion reaction of mammalian DNA topoisomerase II. J biol chem 259: 13560-13566, 1984 – reference: 6) 上屋弘行: カフェインによる制癌剤の効果増強に関する研究. 金沢大十全医誌97: 543-556, 1988 – reference: 11) Lau C C, Pardee A B: Mechanism by which caffeine potentiates lethality of nitrogen mustard. Proc. Natl. Acad. Sci. USA 79: 2942-2946. 1982 – reference: 2) 山本裕司, 須川嵩, 岡田賢三, 他: 胃癌腹膜播種性転移に対するシスプラチン・エトポシド・カフェインの腹腔内投与の検討. 日癌治29: 19-26, 1994 – reference: 9) Fingert H J, Chang J D, Pardee A B: Cytotoxic, cell cycle, and chromosomal effects of methylxanthines in human tumor cells treated with alkylating agents. Cancer Res 46: 2463-2467, 1986 – reference: 12) 富田勝郎, 土屋弘行, 佐々木琢磨: DNA repalr機構と抗癌剤耐性. 癌と化学療法16: 576-584, 1989 – reference: 1) 石本二見男, 笠井健司: 臨床におけるカフェインの適用. 薬局42: 55-58, 1991 – reference: 3) 日本頭頸部腫瘍学会編: 臨床・病理頭頸部癌取り扱い規約. p.96-100, 金原出版, 東京, 1991 – reference: 13) 山本裕司, 天野富薫, 今田敏夫, 他: 腹膜播種に対するcaffeine併用CDDP腹腔内投与に関する実験的研究. 癌と化学療法18: 1325-1831, 1991 – reference: 8) Allen T E, Aliano N A, Cowan R J, et al.: Amplification of the anti-tumor activity of phleomycins and bleomycins in rats and mice by caffeine. Cancer Res. 45: 2516-2521, 1985 – reference: 10) Schlegel R, Pardee A B: Caffeine-induced uncoupling of mitosis from the completion of DNA replication in mammalian cells. Science 232: 1264-1266, 1986 |
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| SubjectTerms | bleomycin caffeine cisplatin neoadjuvant chemotherapy 口腔扁平上皮癌 |
| Title | Caffeine combination chemotherapy for oral squamous cell carcinoma |
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