口腔内空気分析による歯周病原性細菌レベルの評価
口腔内空気の分析により歯周組織の状態と歯周ポケット内歯周病原性細菌レベルの予測が可能か検討した。 被験者 30 名の口腔内空気または揮発性硫黄化合物(VSC)濃度を電子嗅覚装置(electronic nose)，ガスクロマトグラフィー(GC)および官能試験で分析した。また，歯周病の臨床パラメーターを測定し，刺激唾液中，舌苔および，歯肉縁下プラーク中の歯周病原性細菌数(P. gingivalis, A. actinomycetemcomitans, T. forsythia, P. intermedia, T. denticola)をリアルタイム PCR で算定した。その結果， 1.口腔内の最深...
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| Published in | 日本歯周病学会会誌 Vol. 56; no. 4; pp. 379 - 389 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
特定非営利活動法人 日本歯周病学会
2015
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0385-0110 1880-408X |
| DOI | 10.2329/perio.56.379 |
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| Abstract | 口腔内空気の分析により歯周組織の状態と歯周ポケット内歯周病原性細菌レベルの予測が可能か検討した。 被験者 30 名の口腔内空気または揮発性硫黄化合物(VSC)濃度を電子嗅覚装置(electronic nose)，ガスクロマトグラフィー(GC)および官能試験で分析した。また，歯周病の臨床パラメーターを測定し，刺激唾液中，舌苔および，歯肉縁下プラーク中の歯周病原性細菌数(P. gingivalis, A. actinomycetemcomitans, T. forsythia, P. intermedia, T. denticola)をリアルタイム PCR で算定した。その結果， 1.口腔内の最深 PD 値は官能試験値，Electronic nose total mode および CH3SH/H2S 比と有意な正の相関を示した。 2.Electronic nose total mode と CH3SH/H2S 比の 2 種の測定値と歯肉縁下プラーク中の 5 種の歯周病原性細菌総数との間に有意な相関が認められた(調整済み R2＝0.690，p＜0.027)。また，歯肉縁下プラーク中の 5 種の歯周病原性細菌総数の予測値と実測値においても有意な正の相関が認められた(R2＝0.447，p＜0.001)。 以上から，口腔内空気の分析測定により歯周組織の状態や歯肉縁下プラーク中の歯周病原性細菌レベルを判定できる可能性が示唆された。 日本歯周病学会会誌（日歯周誌）56(4)：379-389，2014 |
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| AbstractList | 口腔内空気の分析により歯周組織の状態と歯周ポケット内歯周病原性細菌レベルの予測が可能か検討した。 被験者 30 名の口腔内空気または揮発性硫黄化合物(VSC)濃度を電子嗅覚装置(electronic nose)，ガスクロマトグラフィー(GC)および官能試験で分析した。また，歯周病の臨床パラメーターを測定し，刺激唾液中，舌苔および，歯肉縁下プラーク中の歯周病原性細菌数(P. gingivalis, A. actinomycetemcomitans, T. forsythia, P. intermedia, T. denticola)をリアルタイム PCR で算定した。その結果， 1.口腔内の最深 PD 値は官能試験値，Electronic nose total mode および CH3SH/H2S 比と有意な正の相関を示した。 2.Electronic nose total mode と CH3SH/H2S 比の 2 種の測定値と歯肉縁下プラーク中の 5 種の歯周病原性細菌総数との間に有意な相関が認められた(調整済み R2＝0.690，p＜0.027)。また，歯肉縁下プラーク中の 5 種の歯周病原性細菌総数の予測値と実測値においても有意な正の相関が認められた(R2＝0.447，p＜0.001)。 以上から，口腔内空気の分析測定により歯周組織の状態や歯肉縁下プラーク中の歯周病原性細菌レベルを判定できる可能性が示唆された。 日本歯周病学会会誌（日歯周誌）56(4)：379-389，2014 |
| Author | 花田, 信弘 沼部, 幸博 鴨井, 久一 新井, 貴子 今井, 奬 |
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| References | 5)Loesche WJ,Kazor C：Microbiology and treatment of halitosis. Periodontology 2000, 28：256-279, 2002. 17)Murata T, Rahardjo A, Fujiyama Y, Yamaga T. Hanada M, Yaegaki K, Miyazaki H：Development of a Compact and Simple Gas Chromatography for Oral Malodor Measurement. J Periodontol, 77：1142-1147, 2006. 3)Goldberg S, Kozlovsky A, Gordon D, Gelernter I,Sintov A, Rosenberg M：Cadaverine as a putative component of oral malodor. Journal of Dental Research, 73：1168-1172, 1994. 24)Kita J, Yoshihiro Aoyama Y, Kinoshita M, Nakano H,Akamaru H, Ohkubo K, Tanabe S, Oda R, Kawamoto K：Development of an Odor Discrimination System. Shimadzu Review, 59：77-85, 2002 15)Reingewirtz Y, Girault O, Reingewirtz N, Senger B,Tenenbaum H：Mechanical effects and volatile sulfur compounds reducing effects of chewing gums：comparison between test and a control group. Quintessence International, 30：319-323, 1999. 23)Hayashida A, Imai S, Hanada N, Hoshi K, Uematsu H：Relationships between breath odors and odor emission sources in the elderly investigated using the electronic nose. Jpn J Gerodont, 20：3-9, 2005. 18)Ryan M A, Homer M L, Buehler M G, Manatt K S,Zee F, and Graf J. Monitoring the air quality in a closed chamber using an electronic nose 27th International Conference on Environment system 7：14-17, 1997. 16)Yaegaki K. Appendix 3：Current and future semiconductor-based bad breath detectors Bad breath Research Perspectives, 2nd edition,Tel-Aviv, Ramot Publishing, Tel Aviv University,1997, 225-231. 4)Amano A, Yoshida Y, Oho T, Koga T：Minitoring ammonia to assess halitosis. Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology, 94：692-696, 2002. 27)Yaegaki K, Sanada K：Volatile sulfur compounds in mouth air from clinically healthy subjects and patients with periodontal disease. J Periodontal Res,27：233-238, 1992. 20)Tanaka M, Anguri H, Nonaka A, Kataoka K, Nagata H, Kita J, Shizukuishi S：Clinical assessment of oral malodor by the electronic nose system. J Dental Res,83：317-321, 2004. 11)Persson S, Edlund M B, Claesson R, Carlsson J：The formation of hydrogen sulfide and methyl-mercap tan by oral bacteria. Oral Microbiol Immun, 5：195-201,1990. 21)Miyazaki H, Arao M, Okamura K, Kawaguchi Y,Toyofuku A, Hoshi K, Yaegaki K：Tentative classification of halitosis and its treatment needs. Niigata Dent J, 29：11-15, 1999. 22)Murata T, Yamaga T, Iida T, Miyazaki H, Yaegaki K：Classification and examination of halitosis. Int Dent J, 52：181-186, 2002. 9)Kleinberg I, Westbay G：Oral malodor Crit. Rev. Oral Biol. Med, 1：247-259, 1990. 10)Persson S, Claesson R, Carlsson J：The capacity of subgingival microbiotas to produce volatile sulphur compounds in human serum. Oral Microbiol Immun,4：169-172, 1989. 29)Do Nascimento C, Sato S, Mardegan Issa J P, Edson Santos Barbosa R, Ferreira De Albuquerque, Junior R：DNA checkerboard method for bacterial detection of microbiota from teeth and tongue biofilms. A preliminary study. Minerva stomatol, 57：561-7,2008. 6)Tonzetich J：Direct gas chromatographic analysis of sulphur compounds in mouth air in man. Archives of Oral Biology, 16：587-597, 1971. 28)Kazor C E, Mitchell P M, Lee A M, Stokes L N,Loesche WJ,Dewhirst F E, Paster BJ：Diversity of bacterial populations on the tongue dorsa of patients with halitosis and healthy patients, J Clinical Microbiol, 41：558-563, 2003. 12)Hartley M G, El-Maaytah M A, McKenzie C,Greenman J：The tongue microbiota of low odour and malodorous individuals. Microb Ecol Health Dis,9：215-223,1996. 26)Kojima K：Clinical studies on coated tongue. J Oral Maxillofac Surg, 31：1659-1676, 1985. 13)Pham TA, Ueno M, Zaitsu T, Takehara S, Shinada K,Lam PH, Kawaguchi Y：Clinical trial of oral malodor treatment in patients with periodontal diseases. J Periodontal Res, 46：722-9, 2011. 7)Van den Velde S, van Steenberghe D, Van Hee P,Quirynen M：Detection of odorous compounds in breath. Journal of Dental Research, 88：285-289,2009. 2)Van den Broek, Annemiek M W T, Louw Feenstra,Cees de Baat：A review of the current literature on aetiology and measurement methods of halitosis. Journal of Dentistry, 35：627-635, 2007. 25)Silness J,Löe H：Periodontal disease in pregnancy II. Correlation between oral hygiene and periodontal condition. Acta Odontologica Scandinavica, 22：121-135, 1964. 1)Phillips M, Herrera J, Krishnan S, Zain M, Greenberg J, Cataneo R N：Variation in volatile organic compounds in the breath of normal humans. The Journal of Chromatography B, 729：75-88, 1999. 8)Yaegaki K, Sanada K：Biochemical and clinical factors influencing oral malodor in periodontal patients. Journal of Periodontology, 63：783-789,1992. 14)Yaegaki K, Coil J M：Examination, Classification,and Treatment of Halitosis；Clinical Perspectives. J Can Dent Assoc, 66：257-61, 2000. 19)Persaud K, Dodd G：Analysis of discrimination mechanisms in the mammalian olfactory system using a model nose. Nature 299：352-355, 1982. |
| References_xml | – reference: 23)Hayashida A, Imai S, Hanada N, Hoshi K, Uematsu H：Relationships between breath odors and odor emission sources in the elderly investigated using the electronic nose. Jpn J Gerodont, 20：3-9, 2005. – reference: 10)Persson S, Claesson R, Carlsson J：The capacity of subgingival microbiotas to produce volatile sulphur compounds in human serum. Oral Microbiol Immun,4：169-172, 1989. – reference: 2)Van den Broek, Annemiek M W T, Louw Feenstra,Cees de Baat：A review of the current literature on aetiology and measurement methods of halitosis. Journal of Dentistry, 35：627-635, 2007. – reference: 9)Kleinberg I, Westbay G：Oral malodor Crit. Rev. Oral Biol. Med, 1：247-259, 1990. – reference: 1)Phillips M, Herrera J, Krishnan S, Zain M, Greenberg J, Cataneo R N：Variation in volatile organic compounds in the breath of normal humans. The Journal of Chromatography B, 729：75-88, 1999. – reference: 3)Goldberg S, Kozlovsky A, Gordon D, Gelernter I,Sintov A, Rosenberg M：Cadaverine as a putative component of oral malodor. Journal of Dental Research, 73：1168-1172, 1994. – reference: 12)Hartley M G, El-Maaytah M A, McKenzie C,Greenman J：The tongue microbiota of low odour and malodorous individuals. Microb Ecol Health Dis,9：215-223,1996. – reference: 27)Yaegaki K, Sanada K：Volatile sulfur compounds in mouth air from clinically healthy subjects and patients with periodontal disease. J Periodontal Res,27：233-238, 1992. – reference: 7)Van den Velde S, van Steenberghe D, Van Hee P,Quirynen M：Detection of odorous compounds in breath. Journal of Dental Research, 88：285-289,2009. – reference: 18)Ryan M A, Homer M L, Buehler M G, Manatt K S,Zee F, and Graf J. Monitoring the air quality in a closed chamber using an electronic nose 27th International Conference on Environment system 7：14-17, 1997. – reference: 20)Tanaka M, Anguri H, Nonaka A, Kataoka K, Nagata H, Kita J, Shizukuishi S：Clinical assessment of oral malodor by the electronic nose system. J Dental Res,83：317-321, 2004. – reference: 14)Yaegaki K, Coil J M：Examination, Classification,and Treatment of Halitosis；Clinical Perspectives. J Can Dent Assoc, 66：257-61, 2000. – reference: 25)Silness J,Löe H：Periodontal disease in pregnancy II. Correlation between oral hygiene and periodontal condition. Acta Odontologica Scandinavica, 22：121-135, 1964. – reference: 29)Do Nascimento C, Sato S, Mardegan Issa J P, Edson Santos Barbosa R, Ferreira De Albuquerque, Junior R：DNA checkerboard method for bacterial detection of microbiota from teeth and tongue biofilms. A preliminary study. Minerva stomatol, 57：561-7,2008. – reference: 6)Tonzetich J：Direct gas chromatographic analysis of sulphur compounds in mouth air in man. Archives of Oral Biology, 16：587-597, 1971. – reference: 11)Persson S, Edlund M B, Claesson R, Carlsson J：The formation of hydrogen sulfide and methyl-mercap tan by oral bacteria. Oral Microbiol Immun, 5：195-201,1990. – reference: 24)Kita J, Yoshihiro Aoyama Y, Kinoshita M, Nakano H,Akamaru H, Ohkubo K, Tanabe S, Oda R, Kawamoto K：Development of an Odor Discrimination System. Shimadzu Review, 59：77-85, 2002 – reference: 13)Pham TA, Ueno M, Zaitsu T, Takehara S, Shinada K,Lam PH, Kawaguchi Y：Clinical trial of oral malodor treatment in patients with periodontal diseases. J Periodontal Res, 46：722-9, 2011. – reference: 21)Miyazaki H, Arao M, Okamura K, Kawaguchi Y,Toyofuku A, Hoshi K, Yaegaki K：Tentative classification of halitosis and its treatment needs. Niigata Dent J, 29：11-15, 1999. – reference: 26)Kojima K：Clinical studies on coated tongue. J Oral Maxillofac Surg, 31：1659-1676, 1985. – reference: 5)Loesche WJ,Kazor C：Microbiology and treatment of halitosis. Periodontology 2000, 28：256-279, 2002. – reference: 28)Kazor C E, Mitchell P M, Lee A M, Stokes L N,Loesche WJ,Dewhirst F E, Paster BJ：Diversity of bacterial populations on the tongue dorsa of patients with halitosis and healthy patients, J Clinical Microbiol, 41：558-563, 2003. – reference: 19)Persaud K, Dodd G：Analysis of discrimination mechanisms in the mammalian olfactory system using a model nose. Nature 299：352-355, 1982. – reference: 22)Murata T, Yamaga T, Iida T, Miyazaki H, Yaegaki K：Classification and examination of halitosis. Int Dent J, 52：181-186, 2002. – reference: 16)Yaegaki K. Appendix 3：Current and future semiconductor-based bad breath detectors Bad breath Research Perspectives, 2nd edition,Tel-Aviv, Ramot Publishing, Tel Aviv University,1997, 225-231. – reference: 17)Murata T, Rahardjo A, Fujiyama Y, Yamaga T. Hanada M, Yaegaki K, Miyazaki H：Development of a Compact and Simple Gas Chromatography for Oral Malodor Measurement. J Periodontol, 77：1142-1147, 2006. – reference: 8)Yaegaki K, Sanada K：Biochemical and clinical factors influencing oral malodor in periodontal patients. Journal of Periodontology, 63：783-789,1992. – reference: 4)Amano A, Yoshida Y, Oho T, Koga T：Minitoring ammonia to assess halitosis. Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology, 94：692-696, 2002. – reference: 15)Reingewirtz Y, Girault O, Reingewirtz N, Senger B,Tenenbaum H：Mechanical effects and volatile sulfur compounds reducing effects of chewing gums：comparison between test and a control group. Quintessence International, 30：319-323, 1999. |
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| Snippet | 口腔内空気の分析により歯周組織の状態と歯周ポケット内歯周病原性細菌レベルの予測が可能か検討した。 被験者 30 名の口腔内空気または揮発性硫黄化合物(VSC)濃度を電子嗅... |
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| SubjectTerms | 口臭 揮発性硫化物 歯周病原性細菌 電子嗅覚装置 |
| Title | 口腔内空気分析による歯周病原性細菌レベルの評価 |
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