日本語話者における発達性読み書き障害児の脳形態の特徴
本研究では, 十分な検討がなされていない日本語話者の発達性読み書き障害 (Developmental Dyslexia: ディスレクシア) 児の脳形態の特徴を, 定型発達児と比較することで明らかにすることを目的とした。ディスレクシア児 22 名, 定型発達児 49 名 (7～14 歳) の男児を対象とした。読み成績と認知機能検査によりディスレクシア児と定型発達児をスクリーニングした。磁気共鳴画像 (MRI) 装置により, 参加者の脳の高解像度 T1 強調画像を撮像し, 局所灰白質・白質容量を算出した。灰白質容量には定型発達とディスレクシアに差はなかった。白質容量は定型発達のほうが小脳と皮質をつ...
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| Published in | 高次脳機能研究 （旧 失語症研究） Vol. 38; no. 3; pp. 272 - 276 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
一般社団法人 日本高次脳機能障害学会
30.09.2018
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1348-4818 1880-6554 |
| DOI | 10.2496/hbfr.38.272 |
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| Abstract | 本研究では, 十分な検討がなされていない日本語話者の発達性読み書き障害 (Developmental Dyslexia: ディスレクシア) 児の脳形態の特徴を, 定型発達児と比較することで明らかにすることを目的とした。ディスレクシア児 22 名, 定型発達児 49 名 (7～14 歳) の男児を対象とした。読み成績と認知機能検査によりディスレクシア児と定型発達児をスクリーニングした。磁気共鳴画像 (MRI) 装置により, 参加者の脳の高解像度 T1 強調画像を撮像し, 局所灰白質・白質容量を算出した。灰白質容量には定型発達とディスレクシアに差はなかった。白質容量は定型発達のほうが小脳と皮質をつなぐ広い領域で有意に大きかった。本研究で明らかになった小脳と皮質の神経連絡の問題が, 日本語話者における発達性ディスレクシアの原因の 1 つである可能性が推察された。 |
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| AbstractList | 本研究では, 十分な検討がなされていない日本語話者の発達性読み書き障害 (Developmental Dyslexia: ディスレクシア) 児の脳形態の特徴を, 定型発達児と比較することで明らかにすることを目的とした。ディスレクシア児 22 名, 定型発達児 49 名 (7～14 歳) の男児を対象とした。読み成績と認知機能検査によりディスレクシア児と定型発達児をスクリーニングした。磁気共鳴画像 (MRI) 装置により, 参加者の脳の高解像度 T1 強調画像を撮像し, 局所灰白質・白質容量を算出した。灰白質容量には定型発達とディスレクシアに差はなかった。白質容量は定型発達のほうが小脳と皮質をつなぐ広い領域で有意に大きかった。本研究で明らかになった小脳と皮質の神経連絡の問題が, 日本語話者における発達性ディスレクシアの原因の 1 つである可能性が推察された。 |
| Author | 樋口, 大樹 宇野, 彰 橋本, 照男 瀧, 靖之 川島, 隆太 |
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| Copyright | 2018 一般社団法人 日本高次脳機能障害学会 |
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| References | 24) Vandermosten, M., Hoeft, F. & Norton, E. S.: Integrating MRI brain imaging studies of pre-reading children with current theories of developmental dyslexia ; A review and quantitative meta-analysis. Curr. Opin. Behav. Sci., 10: 155-161, 2016. 8 ) Mariën, P., Ackermann, H., Adamaszek, M., et al.: Consensus paper ; Language and the cerebellum ; an ongoing enigma. Cerebellum, 13: 386-410, 2014. 14) Ronconi, L., Casartelli, L., Carna, S., et al.: When one is Enough ; Impaired Multisensory Integration in Cerebellar Agenesis. Cereb. Cortex, 27: 2041-2051, 2017. 23) Vandermosten, M., Boets, B., Wouters, J., et al.: A qualitative and quantitative review of diffusion tensor imaging studies in reading and dyslexia. Neurosci. Biobehav. Rev., 36: 1532-1552, 2012. 3 ) Drake, W. E.: Clinical and pathological findings in a child with a developmental learning disability. J. Learn. Disabil., 1: 486-502, 1968. 5 ) Hier, D. B., LeMay, M., Rosenberger, P. B., et al.: Developmental dyslexia. Evidence for a subgroup with a reversal of cerebral asymmetry. Archi. Neurol., 35: 90-92, 1978. 7 ) Krafnick, A. J., Flowers, D. L., Luetje, M. M., et al.: An investigation into the origin of anatomical differences in dyslexia. J. Neurosci., 34: 901-908, 2014. 9 ) Mascheretti, S., De Luca, A., Trezzi, V., et al.: Neurogenetics of developmental dyslexia ; from genes to behavior through brain neuroimaging and cognitive and sensorial mechanisms. Transl. Psychiatry, 7: e987, 2017. 1 ) Ailion, A. S., King, T. Z., Wang, L., et al.: Cerebellar Atrophy in Adult Survivors of Childhood Cerebellar Tumor. J. Int. Neuropsychol. Soc., 22: 501-511, 2016. 17) Snowling, M. J.: Phonemic deficits in developmental dyslexia. Psychol, Res., 43: 219-234, 1981. 10) Moberget, T., Andersson, S., Lundar, T., et al.: Longterm supratentorial brain structure and cognitive function following cerebellar tumour resections in childhood. Neuropsychologia, 69: 218-231, 2015. 18) Snowling, M. J.: Changing concepts of dyslexia ; nature, treatment and comorbidity. J. Child. Psychol. Psychiatry, 53: e1-3, 2012. 13) Ramus, F., Altarelli, I., Jednoróg, K., et al.: Neuroanatomy of developmental dyslexia ; Pitfalls and promise. Neurosci. Biobehav. Rev., 84: 434-452, 2018. 2 ) Bishop, D. V.: Cerebellar abnormalities in developmental dyslexia; cause, correlate or consequence ? Cortex, 38: 491-498, 2002. 11) Moll, K., Kunze, S., Neuhoff, N., et al.: Specific learning disorder ; prevalence and gender differences. PLoS One, 9: e103537, 2014. 4 ) Heim, S., Tschierse, J., Amunts, K., et al.: Cognitive subtypes of dyslexia. Acta. Neurobiol. Exp. (Wars) , 68: 73-82, 2008. 19) Stein, J.: The magnocellular theory of developmental dyslexia. Dyslexia, 7: 12-36, 2001. 15) Rumsey, J. M., Dorwart, R., Vermess, M., et al.: Magnetic resonance imaging of brain anatomy in severe developmental dyslexia. Archi. Neurol., 43: 1045-1046, 1986. 20) Stoodley, C. J. & Stein, J. F.: Cerebellar function in developmental dyslexia. Cerebellum, 12: 267-276, 2013. 6 ) Kita, Y., Yamamoto, H., Oba, K., et al.: Altered brain activity for phonological manipulation in dyslexic Japanese children. Brain, 136: 3696-3708, 2013. 12) Nicolson, R. I. & Fawcett, A. J.: Automaticity ; a new framework for dyslexia research ? Cognition, 35: 159-182, 1990. 21) Stoodley, C. J.: The Cerebellum and Neurodevelopmental Disorders. Cerebellum, 15: 34-37, 2016. 16) Seki, A., Koeda, T., Sugihara, S., et al.: A functional magnetic resonance imaging study during sentence reading in Japanese dyslexic children. Brain. Dev., 23: 312-316, 2001. 22) Uno, A., Wydell, T. N., Haruhara, N., et al.: Relationship between reading/writing skills and cognitive abilities among Japanese primary-school children ; normal readers versus poor readers (dyslexics) . Read. Writ., 22: 755-789, 2009. |
| References_xml | – reference: 5 ) Hier, D. B., LeMay, M., Rosenberger, P. B., et al.: Developmental dyslexia. Evidence for a subgroup with a reversal of cerebral asymmetry. Archi. Neurol., 35: 90-92, 1978. – reference: 8 ) Mariën, P., Ackermann, H., Adamaszek, M., et al.: Consensus paper ; Language and the cerebellum ; an ongoing enigma. Cerebellum, 13: 386-410, 2014. – reference: 12) Nicolson, R. I. & Fawcett, A. J.: Automaticity ; a new framework for dyslexia research ? Cognition, 35: 159-182, 1990. – reference: 18) Snowling, M. J.: Changing concepts of dyslexia ; nature, treatment and comorbidity. J. Child. Psychol. Psychiatry, 53: e1-3, 2012. – reference: 17) Snowling, M. J.: Phonemic deficits in developmental dyslexia. Psychol, Res., 43: 219-234, 1981. – reference: 9 ) Mascheretti, S., De Luca, A., Trezzi, V., et al.: Neurogenetics of developmental dyslexia ; from genes to behavior through brain neuroimaging and cognitive and sensorial mechanisms. Transl. Psychiatry, 7: e987, 2017. – reference: 4 ) Heim, S., Tschierse, J., Amunts, K., et al.: Cognitive subtypes of dyslexia. Acta. Neurobiol. Exp. (Wars) , 68: 73-82, 2008. – reference: 22) Uno, A., Wydell, T. N., Haruhara, N., et al.: Relationship between reading/writing skills and cognitive abilities among Japanese primary-school children ; normal readers versus poor readers (dyslexics) . Read. Writ., 22: 755-789, 2009. – reference: 6 ) Kita, Y., Yamamoto, H., Oba, K., et al.: Altered brain activity for phonological manipulation in dyslexic Japanese children. Brain, 136: 3696-3708, 2013. – reference: 13) Ramus, F., Altarelli, I., Jednoróg, K., et al.: Neuroanatomy of developmental dyslexia ; Pitfalls and promise. Neurosci. Biobehav. Rev., 84: 434-452, 2018. – reference: 23) Vandermosten, M., Boets, B., Wouters, J., et al.: A qualitative and quantitative review of diffusion tensor imaging studies in reading and dyslexia. Neurosci. Biobehav. Rev., 36: 1532-1552, 2012. – reference: 7 ) Krafnick, A. J., Flowers, D. L., Luetje, M. M., et al.: An investigation into the origin of anatomical differences in dyslexia. J. Neurosci., 34: 901-908, 2014. – reference: 16) Seki, A., Koeda, T., Sugihara, S., et al.: A functional magnetic resonance imaging study during sentence reading in Japanese dyslexic children. Brain. Dev., 23: 312-316, 2001. – reference: 1 ) Ailion, A. S., King, T. Z., Wang, L., et al.: Cerebellar Atrophy in Adult Survivors of Childhood Cerebellar Tumor. J. Int. Neuropsychol. Soc., 22: 501-511, 2016. – reference: 21) Stoodley, C. J.: The Cerebellum and Neurodevelopmental Disorders. Cerebellum, 15: 34-37, 2016. – reference: 24) Vandermosten, M., Hoeft, F. & Norton, E. S.: Integrating MRI brain imaging studies of pre-reading children with current theories of developmental dyslexia ; A review and quantitative meta-analysis. Curr. Opin. Behav. Sci., 10: 155-161, 2016. – reference: 10) Moberget, T., Andersson, S., Lundar, T., et al.: Longterm supratentorial brain structure and cognitive function following cerebellar tumour resections in childhood. Neuropsychologia, 69: 218-231, 2015. – reference: 3 ) Drake, W. E.: Clinical and pathological findings in a child with a developmental learning disability. J. Learn. Disabil., 1: 486-502, 1968. – reference: 11) Moll, K., Kunze, S., Neuhoff, N., et al.: Specific learning disorder ; prevalence and gender differences. PLoS One, 9: e103537, 2014. – reference: 15) Rumsey, J. M., Dorwart, R., Vermess, M., et al.: Magnetic resonance imaging of brain anatomy in severe developmental dyslexia. Archi. Neurol., 43: 1045-1046, 1986. – reference: 20) Stoodley, C. J. & Stein, J. F.: Cerebellar function in developmental dyslexia. Cerebellum, 12: 267-276, 2013. – reference: 14) Ronconi, L., Casartelli, L., Carna, S., et al.: When one is Enough ; Impaired Multisensory Integration in Cerebellar Agenesis. Cereb. Cortex, 27: 2041-2051, 2017. – reference: 19) Stein, J.: The magnocellular theory of developmental dyslexia. Dyslexia, 7: 12-36, 2001. – reference: 2 ) Bishop, D. V.: Cerebellar abnormalities in developmental dyslexia; cause, correlate or consequence ? Cortex, 38: 491-498, 2002. |
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| Snippet | 本研究では, 十分な検討がなされていない日本語話者の発達性読み書き障害 (Developmental Dyslexia: ディスレクシア) 児の脳形態の特徴を, 定型発達児と比較することで... |
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| SubjectTerms | 脳形態解析, 白質容量, 小脳 |
| Title | 日本語話者における発達性読み書き障害児の脳形態の特徴 |
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