肝微細構造の定量的観察-正常ヒト肝,急性肝炎,慢性肝炎および肝硬変について
正常ヒト肝楔状生検11例,針生検5例,急性肝炎11例,慢性肝炎15例,肝硬変7例でBachの方法で核の直径,電子顕微鏡的に杉岡らの方法でミトコンドリアの体積,長径,短径,細胞質との体積比,数,Tomkeieffらの方法で小胞体の表面積を測定した.核は肝硬変で正常ヒト肝に比し大きい傾向がみられた.ミトコンドリアは楔状生検で針生検より小さい傾向がみられ,急性肝炎でも針生検に比して小さく,数の多い傾向がみられ,肝硬変では明らかに大きく,数は減少していた.粗面小胞体は楔状生検で針生検より減少し,滑面小胞体は急性肝炎,肝硬変で針生検より減少していた.正常肝での差は部位による血液供給の差によると思われ,急...
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| Published in | 肝臓 Vol. 19; no. 5; pp. 421 - 429 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Japanese |
| Published |
一般社団法人 日本肝臓学会
01.05.1978
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0451-4203 1881-3593 |
| DOI | 10.2957/kanzo.19.421 |
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| Abstract | 正常ヒト肝楔状生検11例,針生検5例,急性肝炎11例,慢性肝炎15例,肝硬変7例でBachの方法で核の直径,電子顕微鏡的に杉岡らの方法でミトコンドリアの体積,長径,短径,細胞質との体積比,数,Tomkeieffらの方法で小胞体の表面積を測定した.核は肝硬変で正常ヒト肝に比し大きい傾向がみられた.ミトコンドリアは楔状生検で針生検より小さい傾向がみられ,急性肝炎でも針生検に比して小さく,数の多い傾向がみられ,肝硬変では明らかに大きく,数は減少していた.粗面小胞体は楔状生検で針生検より減少し,滑面小胞体は急性肝炎,肝硬変で針生検より減少していた.正常肝での差は部位による血液供給の差によると思われ,急性肝炎では回復期に生検が行なわれたための変化と思われた.慢性肝炎では正常肝と差がなく,肝機能検査異常は機能の差によると思われ,肝硬変ではDisse腔の変化により酸素や栄養素の不足による変化や加齢による変化と思われた. |
|---|---|
| AbstractList | 正常ヒト肝楔状生検11例,針生検5例,急性肝炎11例,慢性肝炎15例,肝硬変7例でBachの方法で核の直径,電子顕微鏡的に杉岡らの方法でミトコンドリアの体積,長径,短径,細胞質との体積比,数,Tomkeieffらの方法で小胞体の表面積を測定した.核は肝硬変で正常ヒト肝に比し大きい傾向がみられた.ミトコンドリアは楔状生検で針生検より小さい傾向がみられ,急性肝炎でも針生検に比して小さく,数の多い傾向がみられ,肝硬変では明らかに大きく,数は減少していた.粗面小胞体は楔状生検で針生検より減少し,滑面小胞体は急性肝炎,肝硬変で針生検より減少していた.正常肝での差は部位による血液供給の差によると思われ,急性肝炎では回復期に生検が行なわれたための変化と思われた.慢性肝炎では正常肝と差がなく,肝機能検査異常は機能の差によると思われ,肝硬変ではDisse腔の変化により酸素や栄養素の不足による変化や加齢による変化と思われた. |
| Author | 杉本, 立甫 |
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| Copyright | 社団法人 日本肝臓学会 |
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| References | 6) Wills, E.J.: Acute infective hepatitis: Fine structural and cytochemical alterations in human liver. Arch. Path., 86: 184, 1968. 27) Ranek, L.: Quantitation of size and composition of liver cell nuclei in acute viral hepatitis. In THE LIVER Quantitative Aspects of Structure and Function, ed. Paumgartner, G. and Preisig, R.S. Karger, Basel, Munchen, Paris, London, New York, Sydney, 1973, p.62-68. 17) 松田芳郎,池上文詔他:肝疾患と小胞体機能,肝臓,15: 721, 1974. 20) Weibel, E.R. & Knight, B.W.: A morphometric study on the thickness of the pulmonary air-blood barrier. J. Cell Biol., 21: 367, 1964. 1) Ma, M.H. & Biempica, L.: The normal human liver cell; Cytochemical and ultrastructural studies. Amer. J. Path., 62: 353, 1971. 10) Schaffner, F.: Intralobular changes in hepatocytes and the electron microscopic mesenchymal response in acute hepatitis. Medicine, 45: 547, 1966. 23) Weibel, E.R. & Gomez, D.M.: A principle for counting tissue structures on random sections. J. Appl. Physiol., 17: 343, 1963. 11) Tanikawa, K.: Ultrastructural aspects of the liver and its disorder. Igaku Shoin, Tokyo, 1968. 3) Novikoff, A.B. & Essner, E.: The liver cell: Some new approaches to its study. Amer. J. Med., 29: 102, 1960. 9) Gerlach, U., Manitz, G.: FeinStrukturuntersuchungen bei aktiver chronischer Hepatitis unter besonderer Berucksichtigung des Mesenchyms. Acta HepatoSplenol., 16: 90, 1969. 8) 鵜沼直雄:肝の微細構造,最新医学,28: 432, 1973. 15) Loud, A.V.: A quantitative stereological description of the ultrastructure of normal rat liver parenchymal cells. J. Cell Biol., 37: 27, 1968. 26) Hennig, A.: Bestimmug der oberflache beliebig geformeter Korper mit besonderer Anwendung auf Korperhaufen in mikroskopischen Bereich. Mikroskopie, 11: 1, 1956. 12) Pavel, S.C., Bonaparte, H.: Ultrastructural aspects of the liver in the viral hepatitis. Digestion, 2: 221, 1969. 2) Ma, M.H., Goldfisher, S.: Morphology of the normal liver cell. In Progress in Liver Diseases, ed. H. Popper and F. Schaffner, Vol. 4. Grune & Stratton, New York, London, 1970, p.1-17. 18) Sugioka, G., Porta, E.A.: Early changes in livers of rats fed choline deficient diets at four levels of protein. Amer. J. Path., 57: 431, 1969. 25) Tomkeieff, S.I.: Liver intercepts, areas and volumes. Nature, 155: 24, 1945. 28) 鵜沼直雄:肝の形態学,臨床肝臓病学,上田英雄,武内重五郎,1版,南江堂,東京,京都,1976, p.9. 16) Porta, E.A., Sugioka, G.: Quantitative morphologic changes in hepatocytic mitochondria and smooth endoplasmic reticulum of rats in acute and chronic alcoholism. Acta Gastroent. Latinoamer., 1: 63, 1969. 4) Popper, H.: Electron microscopy in the diagnosis of liver disease. In the Liver, ed. Read, A.E. Butterworths, London, 1967, p.47-54. 13) 鵜沼直雄,斎藤昌三:肝硬変の電子顕微鏡的研究,肝臓,7: 36, 1966. 22) Chalkey, H.W.: Method for the quantitative morphologic analysis of tissues. J. Nat. Cancer Inst., 4: 47, 1953. 19) Rohr, H., Luthy, J.: A new supplement to the study of human liver biopsy specimens. In progress in liver diseases, ed. Popper, H. and Schaffner, F., vol. 5 Grune & Stratton, New York, London, 1976, p.24-34. 14) Phillips, M. & Steiner, J.W.: Electron microscopy of liver cells in cirrhosis nodules. Amer. J. Path., 46: 985, 1965. 7) Biava, C.G. & Muklova-Montiel, M.: Electron microscopic observations on councilman-like acidophilic bodies and other forms of acidophlic changes in human liver cells. Amer. J. Path., 46: 775, 1965. 29) Schaffner, F. & Popper, H.: Capillarization of hepatic sinusoids in man. Gastroenterology, 44: 239, 1963. 21) Bach, G.: Bestimmung der Hanfigkeitsverteilung der Radien kugelformiger Partikel aus den Haufigkeiten ihrer Schnittkreise in zufalligen Schnitten der Dicke δ. Z. Wiss. Mikrosk., 66: 193, 1964. 5) Schersten, T.: Metabolic differences between hepatitis and cholestasis in human liver. In Progress in Liver Diseases, ed. Popper, H. and Schaffner, F. Vol. 4. Grune & Stratton, New York, London, 1970, p.133-150. 30) Schaffner, F.: The structural basis of altered hepatic function in viral hepatitis. Amer. J. Med., 49: 658, 1970. 24) DeHoff, R.T. & Rhines, F.N.: Determination of number of particles per unit volume from measurement made on random plane sections: The general cylinder and ellipsoid. Trans. AIME, 221: 975, 1961. |
| References_xml | – reference: 3) Novikoff, A.B. & Essner, E.: The liver cell: Some new approaches to its study. Amer. J. Med., 29: 102, 1960. – reference: 10) Schaffner, F.: Intralobular changes in hepatocytes and the electron microscopic mesenchymal response in acute hepatitis. Medicine, 45: 547, 1966. – reference: 19) Rohr, H., Luthy, J.: A new supplement to the study of human liver biopsy specimens. In progress in liver diseases, ed. Popper, H. and Schaffner, F., vol. 5 Grune & Stratton, New York, London, 1976, p.24-34. – reference: 18) Sugioka, G., Porta, E.A.: Early changes in livers of rats fed choline deficient diets at four levels of protein. Amer. J. Path., 57: 431, 1969. – reference: 17) 松田芳郎,池上文詔他:肝疾患と小胞体機能,肝臓,15: 721, 1974. – reference: 16) Porta, E.A., Sugioka, G.: Quantitative morphologic changes in hepatocytic mitochondria and smooth endoplasmic reticulum of rats in acute and chronic alcoholism. Acta Gastroent. Latinoamer., 1: 63, 1969. – reference: 5) Schersten, T.: Metabolic differences between hepatitis and cholestasis in human liver. In Progress in Liver Diseases, ed. Popper, H. and Schaffner, F. Vol. 4. Grune & Stratton, New York, London, 1970, p.133-150. – reference: 11) Tanikawa, K.: Ultrastructural aspects of the liver and its disorder. Igaku Shoin, Tokyo, 1968. – reference: 4) Popper, H.: Electron microscopy in the diagnosis of liver disease. In the Liver, ed. Read, A.E. Butterworths, London, 1967, p.47-54. – reference: 26) Hennig, A.: Bestimmug der oberflache beliebig geformeter Korper mit besonderer Anwendung auf Korperhaufen in mikroskopischen Bereich. Mikroskopie, 11: 1, 1956. – reference: 24) DeHoff, R.T. & Rhines, F.N.: Determination of number of particles per unit volume from measurement made on random plane sections: The general cylinder and ellipsoid. Trans. AIME, 221: 975, 1961. – reference: 6) Wills, E.J.: Acute infective hepatitis: Fine structural and cytochemical alterations in human liver. Arch. Path., 86: 184, 1968. – reference: 8) 鵜沼直雄:肝の微細構造,最新医学,28: 432, 1973. – reference: 2) Ma, M.H., Goldfisher, S.: Morphology of the normal liver cell. In Progress in Liver Diseases, ed. H. Popper and F. Schaffner, Vol. 4. Grune & Stratton, New York, London, 1970, p.1-17. – reference: 7) Biava, C.G. & Muklova-Montiel, M.: Electron microscopic observations on councilman-like acidophilic bodies and other forms of acidophlic changes in human liver cells. Amer. J. Path., 46: 775, 1965. – reference: 22) Chalkey, H.W.: Method for the quantitative morphologic analysis of tissues. J. Nat. Cancer Inst., 4: 47, 1953. – reference: 15) Loud, A.V.: A quantitative stereological description of the ultrastructure of normal rat liver parenchymal cells. J. Cell Biol., 37: 27, 1968. – reference: 14) Phillips, M. & Steiner, J.W.: Electron microscopy of liver cells in cirrhosis nodules. Amer. J. Path., 46: 985, 1965. – reference: 20) Weibel, E.R. & Knight, B.W.: A morphometric study on the thickness of the pulmonary air-blood barrier. J. Cell Biol., 21: 367, 1964. – reference: 12) Pavel, S.C., Bonaparte, H.: Ultrastructural aspects of the liver in the viral hepatitis. Digestion, 2: 221, 1969. – reference: 28) 鵜沼直雄:肝の形態学,臨床肝臓病学,上田英雄,武内重五郎,1版,南江堂,東京,京都,1976, p.9. – reference: 23) Weibel, E.R. & Gomez, D.M.: A principle for counting tissue structures on random sections. J. Appl. Physiol., 17: 343, 1963. – reference: 21) Bach, G.: Bestimmung der Hanfigkeitsverteilung der Radien kugelformiger Partikel aus den Haufigkeiten ihrer Schnittkreise in zufalligen Schnitten der Dicke δ. Z. Wiss. Mikrosk., 66: 193, 1964. – reference: 1) Ma, M.H. & Biempica, L.: The normal human liver cell; Cytochemical and ultrastructural studies. Amer. J. Path., 62: 353, 1971. – reference: 27) Ranek, L.: Quantitation of size and composition of liver cell nuclei in acute viral hepatitis. In THE LIVER Quantitative Aspects of Structure and Function, ed. Paumgartner, G. and Preisig, R.S. Karger, Basel, Munchen, Paris, London, New York, Sydney, 1973, p.62-68. – reference: 25) Tomkeieff, S.I.: Liver intercepts, areas and volumes. Nature, 155: 24, 1945. – reference: 29) Schaffner, F. & Popper, H.: Capillarization of hepatic sinusoids in man. Gastroenterology, 44: 239, 1963. – reference: 30) Schaffner, F.: The structural basis of altered hepatic function in viral hepatitis. Amer. J. Med., 49: 658, 1970. – reference: 9) Gerlach, U., Manitz, G.: FeinStrukturuntersuchungen bei aktiver chronischer Hepatitis unter besonderer Berucksichtigung des Mesenchyms. Acta HepatoSplenol., 16: 90, 1969. – reference: 13) 鵜沼直雄,斎藤昌三:肝硬変の電子顕微鏡的研究,肝臓,7: 36, 1966. |
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| Title | 肝微細構造の定量的観察-正常ヒト肝,急性肝炎,慢性肝炎および肝硬変について |
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