大豆ペプチドは末梢白血球,情動ホルモン,脳表層血流変動と連携して若年成人健常者に対して調節的に作用する
大豆は 5000 年もの昔から,東洋の諸国を中心に食用に供されてきた.それ故,生体に及ぼす作用についても多くの研究が進められている.多くの有用性が示される一方で,女性ホルモンと類似構造を有することにより,性周期への影響が副作用として指摘されている.そこで,我々は良質の蛋白源としてのメリットを生かしながら低分子化大豆ペプチドを調製し,新しい機能性の研究を行うことを目的とした. 乾燥大豆ペプチド 8 gr を毎日 1 回,1 週間経口摂取し,摂取前後で採血し,生体への影響を検証した.その結果,投与前における白血球の数値には正常範囲ながらも個体差が認められた.個体差の内,投与前に高値であった場合は低...
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Published in | 日本補完代替医療学会誌 Vol. 8; no. 2; pp. 75 - 83 |
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Main Authors | , , , |
Format | Journal Article |
Language | Japanese |
Published |
日本補完代替医療学会
2011
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Subjects | |
Online Access | Get full text |
ISSN | 1348-7922 1348-7930 |
DOI | 10.1625/jcam.8.75 |
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Abstract | 大豆は 5000 年もの昔から,東洋の諸国を中心に食用に供されてきた.それ故,生体に及ぼす作用についても多くの研究が進められている.多くの有用性が示される一方で,女性ホルモンと類似構造を有することにより,性周期への影響が副作用として指摘されている.そこで,我々は良質の蛋白源としてのメリットを生かしながら低分子化大豆ペプチドを調製し,新しい機能性の研究を行うことを目的とした. 乾燥大豆ペプチド 8 gr を毎日 1 回,1 週間経口摂取し,摂取前後で採血し,生体への影響を検証した.その結果,投与前における白血球の数値には正常範囲ながらも個体差が認められた.個体差の内,投与前に高値であった場合は低下し,一方,低値の場合は増加を示し,調整作用が認められた.また,その変化率は投与前の数値に依存した逆相関を示した.さらに,大豆蛋白と大豆ペプチドそれにプラセボをダブルブラインド・クロスオーバーの手法で比較すると,この効果は大豆ペプチド,大豆蛋白の順で作用が弱まり,プラセボでは作用は認めなかった. この低分子化製剤は白血球亜群の調節並びに,リンパ球亜群に対しても調節作用を示した.CD 陽性細胞群の中では特に CD11 と CD56 陽性細胞に対して増加的な作用を示し,CD19 細胞は逆に減少を示した. 一方各種ホルモン検査では,アドレナリンの平均値はペプチドの投与で低下し,ドーパミンは逆に増加を示した. また,白血球,情動ホルモン,脳表層血流の変化がそれぞれ関連していることも明らかになった. |
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AbstractList | 大豆は 5000 年もの昔から,東洋の諸国を中心に食用に供されてきた.それ故,生体に及ぼす作用についても多くの研究が進められている.多くの有用性が示される一方で,女性ホルモンと類似構造を有することにより,性周期への影響が副作用として指摘されている.そこで,我々は良質の蛋白源としてのメリットを生かしながら低分子化大豆ペプチドを調製し,新しい機能性の研究を行うことを目的とした. 乾燥大豆ペプチド 8 gr を毎日 1 回,1 週間経口摂取し,摂取前後で採血し,生体への影響を検証した.その結果,投与前における白血球の数値には正常範囲ながらも個体差が認められた.個体差の内,投与前に高値であった場合は低下し,一方,低値の場合は増加を示し,調整作用が認められた.また,その変化率は投与前の数値に依存した逆相関を示した.さらに,大豆蛋白と大豆ペプチドそれにプラセボをダブルブラインド・クロスオーバーの手法で比較すると,この効果は大豆ペプチド,大豆蛋白の順で作用が弱まり,プラセボでは作用は認めなかった. この低分子化製剤は白血球亜群の調節並びに,リンパ球亜群に対しても調節作用を示した.CD 陽性細胞群の中では特に CD11 と CD56 陽性細胞に対して増加的な作用を示し,CD19 細胞は逆に減少を示した. 一方各種ホルモン検査では,アドレナリンの平均値はペプチドの投与で低下し,ドーパミンは逆に増加を示した. また,白血球,情動ホルモン,脳表層血流の変化がそれぞれ関連していることも明らかになった. |
Author | Wenhan, WAN 山口, 宣夫 竹井, 孝文 内川, 久美子 |
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References | 17) Hobbs MV, Ernst DN. T cell differentiation and cytokine expression in late life. Dev Comp Immunol 1997; 21: 461–470. 12) Munk A, Guyre PM, Holbrook NJ. Physiological functions of glucocorticoids in stress and their relation to actions. Endocrine pharmacological Rev 1984; 5: 25–44. 14) Adlercreutz H, Mazur W. Phyto-oestrogens and western diseases. Ann Med 1997; 2: 95–120. 25) Ammon C, Meyer SP, Schwarzfischer L, et al. Comparative analysis of integrin expression on monocyte-derived macrophages and monocyte-derived dendritic cells. Immunology 2000; 100: 364–369. 11) Mejia ED, Lumen BOD. Soybean bioactive peptides: A new horizon in preventing chronic diseases. Sex Reprod Menopause 2006; 4: 91–95. 24) Hobbs MV, Ernst DN. T cell differentiation and cytokine expression in late life. Dev Comp Immunol 1997; 21: 461–470. 27) Feron DT, Locksley RM. The instructive role of innate immunity in the acquired immune response. Science 1996; 272: 50–54. 22) Yamauchi F, Suetsuna K. Immunological effects of dietary peptide derived from soybean protein. J Nurr Biochem 1993; 4: 45 & 457. 26) Dhodapkar KM, Kaufman JL, Ehlers M, et al. Selective blockade of inhibitory Fc γ receptor enables human dendritic cell maturation with Il-12p70 production and immunity to antibody-coated tumor cells. PNAS 2005; 102: 2910–2915. 7) Chen JR, Suetsuna K, Yamauchi F. Isolation and characterization of immunostimulative peptides from soybean. J Nutri Biochem 1995; 6: 310–313. 21) Kishino Y, Moriguchi S. The effects of soybean protein on cellular immunologic response. Nutr Sci Soy Prorein 1984; 5: 67–70. 6) Young VR. Soy protein in relation to human protein and amino acid nutrition. J Am Diet Assoc 1991; 91: 828–835. 28) Biron CA, Nguyen KB, Pien GC, et al. Natural killer cells in antiviral defense: function and regulation by innate cytokine. Ann Rev Immunol 1999; 17: 189–220. 16) Setchell KDR. Phytoestrogens: The biochemistry, physiology, and implications for human health of soy phytoestrogens. Am J Clin Nutr 1998; 68(suppl): 1333–1348S. 15) Hanson LN, Engelman HM, Alekel DL, et al. Efects of soy isofl avones and phytate on homocysteine, C-reactive protein, and iron status in postmenopausal women. Am J Clin Nutr 2006; 84: 774–780. 8) Xu L, Li HM, Huang YB, et al. Chem Res in Chin U 2006; 22: 205–208. 20) Malave I, Nemeth A, Pocino M. Changes in lymphocyte populations in protein-calorie-deficient mice. Cell Immunol 1980; 49: 235. 29) Abbas AK, Murphy KM, Sher A. Functional diversity of helper T lymphocytes. Nature 1996; 383: 787–793. 23) Chen JR, Swuetsuma K, Yamauchi F. Isolation and characterization of immunostimulative peptides from soybean. J Nutr Biochem 1995; 6: 310–313. 9) Tovar AR, Murguía F, Cruz C, et al. A soy protein diet alters hepatic lipid metabolism gene expression and reduces serum lipids and renal fibrogenic cytokines in rats with chronic nephritic syndrome. J Nutr 2002; 132: 2562–2569. 31) Abo T, Kumagai K. Studies of surface immunoglobulins on human B lymphocytes. III. Physiological variations of SIgt cells in peripheral blood. Clin Exp Immunol 1978; 33: 441–452. 2) Alzamora SM, Salvatori D, Tapia MS, et al. P. Novel functional foods from vegetable matrices impregnated with biologically active compounds. J F Eng 2005; 67: 205–214. 13) Nowakowska E, Chodera A, Kus K, et al. Reversal of stress-induced memory changes by moclobemide: the role of neurotransmitters. Polish Journal of Pharmacology 2001; 53: 227–233. 19) Marko MG, Ahmed T, Bunnell SC, et al. Age-associated decline in effective immune synapse formation of CD4T cells is reversed by vitamin E supplementation. J Immunol 2007; 178: 1443–1449. 30) Liu YJ, Kanzler H, Soumelis V, et al. Dendritic cell lineage, plasticity and cross-regulation. Nat Immunol 2001; 2: 585–589. 10) Kwon DY, Daily JW 3rd, Kim HJ, et al. Antidiabetic effects of fermented soybean products on type 2 diabetes. Nutri Res 2010; 30: 1–13. 5) Messina M. Soy, soy phytoestrogens (isoflavones), and breast cancer. Am J Clin Nutr 1999; 70: 574–575. 3) Madureira AR, Tavares T, Gomes AM, et al. Physiological properties of bioactive peptides obtained from whey proteins. J Dairy Sci 2010; 93: 437–455. 18) Alvarez P, Alvarado C, Puerto M, et al. Improvement of leukocyte functions in prematurely aging mice after five weeks of diet supplementation with polyphenol-rich cereals. Nutr 2006; 22: 913–921. 1) Wei JT, Chiang BH. Bioactive peptide production by hydrolysis of porcine blood proteins in a continuous enzymatic membrane reactor. J Sci Food Agric 2009; 89: 372–378. 4) Erdmann K, Cheung BWY, Schroder H. The possible roles of food-derived bioactive peptides in reducing the risk of cardiovascular disease. Review article. J Nutri Biochem 2008; 19: 643–654. |
References_xml | – reference: 30) Liu YJ, Kanzler H, Soumelis V, et al. Dendritic cell lineage, plasticity and cross-regulation. Nat Immunol 2001; 2: 585–589. – reference: 11) Mejia ED, Lumen BOD. Soybean bioactive peptides: A new horizon in preventing chronic diseases. Sex Reprod Menopause 2006; 4: 91–95. – reference: 22) Yamauchi F, Suetsuna K. Immunological effects of dietary peptide derived from soybean protein. J Nurr Biochem 1993; 4: 45 & 457. – reference: 26) Dhodapkar KM, Kaufman JL, Ehlers M, et al. Selective blockade of inhibitory Fc γ receptor enables human dendritic cell maturation with Il-12p70 production and immunity to antibody-coated tumor cells. PNAS 2005; 102: 2910–2915. – reference: 5) Messina M. Soy, soy phytoestrogens (isoflavones), and breast cancer. Am J Clin Nutr 1999; 70: 574–575. – reference: 4) Erdmann K, Cheung BWY, Schroder H. The possible roles of food-derived bioactive peptides in reducing the risk of cardiovascular disease. Review article. J Nutri Biochem 2008; 19: 643–654. – reference: 12) Munk A, Guyre PM, Holbrook NJ. Physiological functions of glucocorticoids in stress and their relation to actions. Endocrine pharmacological Rev 1984; 5: 25–44. – reference: 20) Malave I, Nemeth A, Pocino M. Changes in lymphocyte populations in protein-calorie-deficient mice. Cell Immunol 1980; 49: 235. – reference: 29) Abbas AK, Murphy KM, Sher A. Functional diversity of helper T lymphocytes. Nature 1996; 383: 787–793. – reference: 7) Chen JR, Suetsuna K, Yamauchi F. Isolation and characterization of immunostimulative peptides from soybean. J Nutri Biochem 1995; 6: 310–313. – reference: 6) Young VR. Soy protein in relation to human protein and amino acid nutrition. J Am Diet Assoc 1991; 91: 828–835. – reference: 8) Xu L, Li HM, Huang YB, et al. Chem Res in Chin U 2006; 22: 205–208. – reference: 31) Abo T, Kumagai K. Studies of surface immunoglobulins on human B lymphocytes. III. Physiological variations of SIgt cells in peripheral blood. Clin Exp Immunol 1978; 33: 441–452. – reference: 25) Ammon C, Meyer SP, Schwarzfischer L, et al. Comparative analysis of integrin expression on monocyte-derived macrophages and monocyte-derived dendritic cells. Immunology 2000; 100: 364–369. – reference: 13) Nowakowska E, Chodera A, Kus K, et al. Reversal of stress-induced memory changes by moclobemide: the role of neurotransmitters. Polish Journal of Pharmacology 2001; 53: 227–233. – reference: 9) Tovar AR, Murguía F, Cruz C, et al. A soy protein diet alters hepatic lipid metabolism gene expression and reduces serum lipids and renal fibrogenic cytokines in rats with chronic nephritic syndrome. J Nutr 2002; 132: 2562–2569. – reference: 10) Kwon DY, Daily JW 3rd, Kim HJ, et al. Antidiabetic effects of fermented soybean products on type 2 diabetes. Nutri Res 2010; 30: 1–13. – reference: 14) Adlercreutz H, Mazur W. Phyto-oestrogens and western diseases. Ann Med 1997; 2: 95–120. – reference: 23) Chen JR, Swuetsuma K, Yamauchi F. Isolation and characterization of immunostimulative peptides from soybean. J Nutr Biochem 1995; 6: 310–313. – reference: 28) Biron CA, Nguyen KB, Pien GC, et al. Natural killer cells in antiviral defense: function and regulation by innate cytokine. Ann Rev Immunol 1999; 17: 189–220. – reference: 27) Feron DT, Locksley RM. The instructive role of innate immunity in the acquired immune response. Science 1996; 272: 50–54. – reference: 2) Alzamora SM, Salvatori D, Tapia MS, et al. P. Novel functional foods from vegetable matrices impregnated with biologically active compounds. J F Eng 2005; 67: 205–214. – reference: 21) Kishino Y, Moriguchi S. The effects of soybean protein on cellular immunologic response. Nutr Sci Soy Prorein 1984; 5: 67–70. – reference: 3) Madureira AR, Tavares T, Gomes AM, et al. Physiological properties of bioactive peptides obtained from whey proteins. J Dairy Sci 2010; 93: 437–455. – reference: 18) Alvarez P, Alvarado C, Puerto M, et al. Improvement of leukocyte functions in prematurely aging mice after five weeks of diet supplementation with polyphenol-rich cereals. Nutr 2006; 22: 913–921. – reference: 1) Wei JT, Chiang BH. Bioactive peptide production by hydrolysis of porcine blood proteins in a continuous enzymatic membrane reactor. J Sci Food Agric 2009; 89: 372–378. – reference: 15) Hanson LN, Engelman HM, Alekel DL, et al. Efects of soy isofl avones and phytate on homocysteine, C-reactive protein, and iron status in postmenopausal women. Am J Clin Nutr 2006; 84: 774–780. – reference: 16) Setchell KDR. Phytoestrogens: The biochemistry, physiology, and implications for human health of soy phytoestrogens. Am J Clin Nutr 1998; 68(suppl): 1333–1348S. – reference: 17) Hobbs MV, Ernst DN. T cell differentiation and cytokine expression in late life. Dev Comp Immunol 1997; 21: 461–470. – reference: 24) Hobbs MV, Ernst DN. T cell differentiation and cytokine expression in late life. Dev Comp Immunol 1997; 21: 461–470. – reference: 19) Marko MG, Ahmed T, Bunnell SC, et al. Age-associated decline in effective immune synapse formation of CD4T cells is reversed by vitamin E supplementation. J Immunol 2007; 178: 1443–1449. |
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Snippet | 大豆は 5000 年もの昔から,東洋の諸国を中心に食用に供されてきた.それ故,生体に及ぼす作用についても多くの研究が進められている.多くの有用性が示される一方で,女... |
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SubjectTerms | 大豆ペプチド 情動ホルモン 白血球亜群比 白血球総数 脳表層血流 |
Title | 大豆ペプチドは末梢白血球,情動ホルモン,脳表層血流変動と連携して若年成人健常者に対して調節的に作用する |
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