Comparative Study on the Carcinogenicity of 1-Nitropyrene and Benzo (a) pyrene to the Lung of Syrian Golden Hamsters Induced by Intermittent Intratracheal Instlliations

• Published in: Journal of Japan Society of Air Pollution Vol. 22; no. 1; pp. 29 - 35
• Main Authors: YAMAMOTO, Akiyo, ISHINISHI, Noboru, HISANAGA, Akira, KITAMORI, Shigeji, INAMASU, Takeo
• Format: Journal Article
• Language: English
• Published: Japan Society for Atmospheric Environment 1987; 公益社団法人 大気環境学会
• Subjects: 1-nitropyrene; air pollutant; animal experiment; benzo (a) pyrene; carcinogenicity; intratracheal instillation; lung cancer
• ISSN: 0386-7064; 2186-3695
• DOI: 10.11298/taiki1978.22.29

1-nitropyrene (1-NP), which has recently been considered to be one of the important environmental mutagens among air pollutants, and benzo (a) pyrene (B (a) P), a well known environmental carcinogen, were intratracheally instilled into male Syrian golden hamsters once a week for 15 weeks. The total dosage was 30 mg. At the same time, a further control group received only phosphate buffer solution. During the total life span, tumor incidence rates in the 1-NP and B (a) P groups were 10% and 86%, respectively, but no tumor developed in the control group. The incidence rates of lung tumors in the 1-NP and B (a) P groups were significantly different, but not in the 1-NP and control groups. These results show that the carcinogenicity of B (a) P to the lung of Syrian golden hamsters should be considered more seriously than that of 1-NP.