CLINICAL STUDIES OF CEFOXITIN IN THE FIELD OF OBSTETRICS AND GYNECOLOGY
Clinical studies were done on cefoxitin, a new cephamycin antibiotic, in the field of obstetrics and gynecology and the following results were obtained. The drug was absorbed rapidly and transferred well into umbilical cord blood and amniotic fluid. Cefotitin was administered intravenously at a dail...
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| Published in | CHEMOTHERAPY Vol. 26; no. Supplement1; pp. 468 - 475 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English Japanese |
| Published |
Japanese Society of Chemotherapy
1978
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| Online Access | Get full text |
| ISSN | 0009-3165 1884-5894 |
| DOI | 10.11250/chemotherapy1953.26.Supplement1_468 |
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| Abstract | Clinical studies were done on cefoxitin, a new cephamycin antibiotic, in the field of obstetrics and gynecology and the following results were obtained. The drug was absorbed rapidly and transferred well into umbilical cord blood and amniotic fluid. Cefotitin was administered intravenously at a daily dose of 4 g (2g b.i.d.) to 16 patients (2 with carbuncles and wound abscess, 12 with intrapelvic infections and 2 with urinary tract infections). The clinical response was good in 12 cases and failed in 4 cases with the efficacy rate being about 75%. No noteworthy side effects were noted with the drug. |
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| AbstractList | Clinical studies were done on cefoxitin, a new cephamycin antibiotic, in the field of obstetrics and gynecology and the following results were obtained. The drug was absorbed rapidly and transferred well into umbilical cord blood and amniotic fluid. Cefotitin was administered intravenously at a daily dose of 4 g (2g b.i.d.) to 16 patients (2 with carbuncles and wound abscess, 12 with intrapelvic infections and 2 with urinary tract infections). The clinical response was good in 12 cases and failed in 4 cases with the efficacy rate being about 75%. No noteworthy side effects were noted with the drug. |
| Author | NAKAYAMA, TETSUYA SAITO, HIROSHI UEHARA, KAZUHIRO KUNII, KATSUAKI CHO, NANKUN MIYAGAMI, JUNSHI Seo, FUMIHIRO SUGIZAKI, KENZO |
| Author_xml | – sequence: 1 fullname: SUGIZAKI, KENZO organization: Department of Obstetrics and Gynecology, School of Medicine, Showa University – sequence: 1 fullname: Seo, FUMIHIRO organization: Department of Obstetrics and Gynecology, School of Medicine, Showa University – sequence: 1 fullname: MIYAGAMI, JUNSHI organization: Department of Obstetrics and Gynecology, School of Medicine, Showa University – sequence: 1 fullname: KUNII, KATSUAKI organization: Kunii Hospital – sequence: 1 fullname: CHO, NANKUN organization: Department of Obstetrics and Gynecology, School of Medicine, Showa University – sequence: 1 fullname: UEHARA, KAZUHIRO organization: Department of Obstetrics and Gynecology, School of Medicine, Showa University – sequence: 1 fullname: NAKAYAMA, TETSUYA organization: Department of Obstetrics and Gynecology, School of Medicine, Showa University – sequence: 1 fullname: SAITO, HIROSHI organization: Department of Obstetrics and Gynecology, School of Medicine, Showa University |
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| References | 2) ONISHI, H. R.; D. R. DAOUST, S. B. ZIMMERMAN, D. HENDLIN & E. O. STAPLEY: Cefoxitin, a semisynthetic cephamycin antibiotic; resistance to β-lactam inactivation. Antimicr. Agents & Chemoth. 5 (1): 38-48, 1974 6) 第25回日本化学療法学会総会新薬シンポジウムIV, Cefoxitin, 1977 3) WALLICK, H. & D. HENDLIN Cefoxitin, a semisynthetic cephamycin antibiotic; susceptibility studies. Antimicr. Agents & Chemoth. 5 (1): 25-32, 1974 7) 張南薫, 斉藤静雄, 松崎浩, 藤山武久, 千坂正毅, 小森山義弘: 塵婦人科領域におけるCarfecillinに関する臨床的検討. Chemotherapy 23 (7): 2510-2517, 1975 8) 張南薫, 木村武彦, 大沼靖彦, 国井勝昭, 斉藤忠明, 高橋亨正, 藤山武久, 小森山数弘; 産婦人科領域におけるCeftezoleに関する臨床的検討. Chemotherapy 24 (4): 1149-1155, 1976 1) TALLY, F. P.; N. V. JACOBUS, J. G. BARTLETT & S.L. GORBACH: Susceptibility of anaerobes to cefoxitin and other cephalosporins. Antimicr. Agents & Chemoth. 7 (2): 128-132, 1975 4) ONISHI, H. R.; S. B. ZIMMERMAN & E. O. STAPLEY: Observations on the mode of action of cefoxitin. Ann. N. Y. Acad. Sci, 325: 406-425, 1974 |
| References_xml | – reference: 4) ONISHI, H. R.; S. B. ZIMMERMAN & E. O. STAPLEY: Observations on the mode of action of cefoxitin. Ann. N. Y. Acad. Sci, 325: 406-425, 1974 – reference: 3) WALLICK, H. & D. HENDLIN Cefoxitin, a semisynthetic cephamycin antibiotic; susceptibility studies. Antimicr. Agents & Chemoth. 5 (1): 25-32, 1974 – reference: 7) 張南薫, 斉藤静雄, 松崎浩, 藤山武久, 千坂正毅, 小森山義弘: 塵婦人科領域におけるCarfecillinに関する臨床的検討. Chemotherapy 23 (7): 2510-2517, 1975 – reference: 6) 第25回日本化学療法学会総会新薬シンポジウムIV, Cefoxitin, 1977 – reference: 1) TALLY, F. P.; N. V. JACOBUS, J. G. BARTLETT & S.L. GORBACH: Susceptibility of anaerobes to cefoxitin and other cephalosporins. Antimicr. Agents & Chemoth. 7 (2): 128-132, 1975 – reference: 2) ONISHI, H. R.; D. R. DAOUST, S. B. ZIMMERMAN, D. HENDLIN & E. O. STAPLEY: Cefoxitin, a semisynthetic cephamycin antibiotic; resistance to β-lactam inactivation. Antimicr. Agents & Chemoth. 5 (1): 38-48, 1974 – reference: 8) 張南薫, 木村武彦, 大沼靖彦, 国井勝昭, 斉藤忠明, 高橋亨正, 藤山武久, 小森山数弘; 産婦人科領域におけるCeftezoleに関する臨床的検討. Chemotherapy 24 (4): 1149-1155, 1976 |
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| Title | CLINICAL STUDIES OF CEFOXITIN IN THE FIELD OF OBSTETRICS AND GYNECOLOGY |
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