A Role of Defensins in the Pathogenesis of Respiratory Diseases

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Published inJapanese Journal of Clinical Chemistry Vol. 32; no. 3; pp. 240 - 244
Main Authors Matsukura, Shigeru, Arimura, Yasuji, Nakazato, Masamitsu, Ashitani, Jun-ichi
Format Journal Article
LanguageJapanese
Published Japan Society of Clinical Chemistry 2003
一般社団法人 日本臨床化学会
Online AccessGet full text
ISSN0370-5633
2187-4077
DOI10.14921/jscc1971b.32.3_240

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Author Ashitani, Jun-ichi
Nakazato, Masamitsu
Matsukura, Shigeru
Arimura, Yasuji
Author_FL 中里 雅光
芦谷 淳一
有村 保次
松倉 茂
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  fullname: Matsukura, Shigeru
  organization: Kishiwada City Hospital
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  organization: Third Department of Internal Medicine, Miyazaki Medical College
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  fullname: Nakazato, Masamitsu
  organization: Third Department of Internal Medicine, Miyazaki Medical College
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  fullname: Ashitani, Jun-ichi
  organization: Third Department of Internal Medicine, Miyazaki Medical College
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DocumentTitleAlternate 呼吸器疾患におけるデフエンシン
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References 19) Garcia JR, Jaumann F, Schulz S, Krause A, Rodriguez- Jimenez FJ, Forssmann U, Adermann K, Kluver E, Vogelmeier C, Becker D, Hedrich R, Forssmann WG, Bals R: Identification of a novel, multifunctional β-defensin (human β-defensin 3) with specific antimicrobial activity, Cell Tissue Res, 306: 257-264, 2001.
9) Hiratsuka T, Nakazato M, Ihi T, Minematsu T, Chino N, Nakanishi T, Shimizu A, Kangawa K, Matsukura S: Structural analysis of human β-defensin 1 and its significance in urinary tract infection, Nephron, 85 34-40, 2000.
11) Lehrer RI, Lichtenstein AK, Ganz T: Defensins: antimicrobial and cytotoxic peptides of mammalian cells, Annu Rev Immunol, 11: 105-128, 1993.
2) Selsted ME, Szklarek D, Lehrer RI: Purification and antimicrobial activity of antimicrobial peptides of rabbit granulocytes, Infect Immun, 45: 150-154, 1984.
3) Yamashita T, Saito K: Purification, primary structure, and biological activity of guinea pig neutrophil cationic peptides, Infect Immun, 57: 2405-2409, 1989.
6) Diamond G, Russell JP, Bevins CL: Inducible expression of an antibiotic peptide gene in lipopolysaccharide-challenged tracheal epithelial cells, Proc Natl Acad Sci USA, 93: 5156-5160, 1996.
20) Garcia JR, Krause A, Schulz S, Rodriguez Jimenez FJ, Kluver E, Adermann K, Forssmann U, Frimpong- Boateng A, Bals R, Forssmann WG: Human β-defensin 4: a novel inducible peptide with a specific salt-sensitive spectrum of antimicrobial activity, FASEB J, 15: 1819-1821, 2001.
10) Hiratsuka T, Nakazato M, Date Y, Ashitani J, Minematsu T, Chino N, Matsukura S: Identification of human β-defensin-2 in respiratory tract and plasma and its increase in bacterial pneumonia, Biochem Biophys Res Commun, 249: 943-947, 1998.
13) Ashitani J, Mukae H, Hiratsuka T, Nakazato M, Kumamoto K, Matsukura S: Elevated levels of adefensins in plasma and BAL fluid of patients with active pulmonary tuberculosis, Chest, 121: 519-526, 2002.
7) Harder J, Bartels J, Christophers E, Schroder JM: A peptide antibiotic from human skin [letter], Nature, 387: 861, 1997.
21) Van Wetering S, Mannesse-Lazeroms SP, Van Sterkenburg MA, Daha MR, Dijkman JH, Hiemstra PS: Effect of defensins on interleukin-8 synthesis in airway epithelial cells, Am J Physiol, 272: L888-896, 1997.
16) Ashitani J, Mukae H, Hiratsuka T, Nakazato M, Kumamoto K, Matsukura S: Plasma and BAL fluid concentrations of antimicrobial peptides in patients with Mycobacterium avium-intracellulare infection, Chest, 119: 1131-1137, 2001.
5) Stolzenberg ED, Anderson GM, Ackermann MR, Whitlock RH, Zasloff M: Epithelial antibiotic induced in states of disease, Proc Natl Acad Sci USA, 94: 8686-8690, 1997.
1) Lehrer RI, Daher K, Ganz T, Selsted ME: Direct inactivation of viruses by MCP-1 and MCP-2, nat-ural peptide antibiotics from rabbit leukocytes, J Virol, 54: 467-472, 1985.
14) Singh PK, Jia HP, Wiles K, Hesselberth J, Lui L, Conway BA, Greenberg EP, Valore EV, Welsh MJ, Ganz T, Tack BF, McCray PB Jr: Production of β-defensins by human airway epithelia, Proc Natl Acad Sci USA, 95: 14961-14966, 1998.
15) Mukae H, Ihiboshi H, Nakazato M, Hiratsuka T, Tokojima M, Abe K, Ashitani J, Kadota J, Matsukura S, Kohno S: Raised plasma concentrations of α-defensins in patients with idiopathic pulmonary fibrosis, Thorax, 57: 623-628, 2001.
4) Nakazato M, Shiomi K, Date Y, Matsukura S, Kangawa K, Minamino N, Matsuo H: Isolation and sequence determination of 6- and 8-kDa precursors of human neutrophil peptides from bone marrow, plasma and peripheral blood neutrophils, Biochem Biophys Res Commun, 211: 1053-1062, 1995.
8) Shiomi K, Nakazato M, Ihi T, Kangawa K, Matsuo H, Matsukura S: Establishment of radioimmunoassay for human neutrophil peptides and their increases in plasma and neutrophil in infection, Biochem Biophys Res Commun, 195: 1336-1344, 1993.
12) Ihi T, Nakazato M, Mukae H, Matsukura S: Elevated concentrations of human neutrophil peptides in plasma, blood, and body fluids from patients with infections, Clin Infect Dis, 25: 1134-1140, 1997.
18) Ashitani J, Nakazato M, Mukae H, Taniguchi H, Date Y, Matsukura S: Recombinant granulocyte colony-stimulating factor induces production of human neutrophil peptides in lung cancer patients with neutropenia, Regul Pept, 95: 87-92, 2000.
17) Ashitani J, Mukae H, Nakazato M, Ihi T, Mashimoto H, Kadota J, Kohno S, Matsukura S: Elevated concentrations of defensins in bronchoalveolar lavage fluid in diffuse panbronchiolitis, Eur Respir J, 11: 104-111, 1998.
22) Biragyn A, Ruffini PA, Leifer CA, Klyushnenkova E, Shakhov A, Chertov O, Shirakawa AK, Farber JM, Segal DM, Oppenheim JJ, Kwak LW: Toll-like receptor 4-dependent activation of dendritic cells by β-defensin 2, Science, 298: 1025-1029, 2002.
23) Zhang L, Yu W, He T, Yu J, Caffrey RE, Dalmasso EA, Fu S, Pham T, Mei J, Ho JJ, Zhang W, Lopez P, Ho DD: Contribution of human α-defensin 1, 2, and 3 to the antiHIV-1 activity of CD8 antiviral factor, Science, 298: 995-1000, 2002.
References_xml – reference: 7) Harder J, Bartels J, Christophers E, Schroder JM: A peptide antibiotic from human skin [letter], Nature, 387: 861, 1997.
– reference: 10) Hiratsuka T, Nakazato M, Date Y, Ashitani J, Minematsu T, Chino N, Matsukura S: Identification of human β-defensin-2 in respiratory tract and plasma and its increase in bacterial pneumonia, Biochem Biophys Res Commun, 249: 943-947, 1998.
– reference: 3) Yamashita T, Saito K: Purification, primary structure, and biological activity of guinea pig neutrophil cationic peptides, Infect Immun, 57: 2405-2409, 1989.
– reference: 11) Lehrer RI, Lichtenstein AK, Ganz T: Defensins: antimicrobial and cytotoxic peptides of mammalian cells, Annu Rev Immunol, 11: 105-128, 1993.
– reference: 4) Nakazato M, Shiomi K, Date Y, Matsukura S, Kangawa K, Minamino N, Matsuo H: Isolation and sequence determination of 6- and 8-kDa precursors of human neutrophil peptides from bone marrow, plasma and peripheral blood neutrophils, Biochem Biophys Res Commun, 211: 1053-1062, 1995.
– reference: 20) Garcia JR, Krause A, Schulz S, Rodriguez Jimenez FJ, Kluver E, Adermann K, Forssmann U, Frimpong- Boateng A, Bals R, Forssmann WG: Human β-defensin 4: a novel inducible peptide with a specific salt-sensitive spectrum of antimicrobial activity, FASEB J, 15: 1819-1821, 2001.
– reference: 21) Van Wetering S, Mannesse-Lazeroms SP, Van Sterkenburg MA, Daha MR, Dijkman JH, Hiemstra PS: Effect of defensins on interleukin-8 synthesis in airway epithelial cells, Am J Physiol, 272: L888-896, 1997.
– reference: 14) Singh PK, Jia HP, Wiles K, Hesselberth J, Lui L, Conway BA, Greenberg EP, Valore EV, Welsh MJ, Ganz T, Tack BF, McCray PB Jr: Production of β-defensins by human airway epithelia, Proc Natl Acad Sci USA, 95: 14961-14966, 1998.
– reference: 17) Ashitani J, Mukae H, Nakazato M, Ihi T, Mashimoto H, Kadota J, Kohno S, Matsukura S: Elevated concentrations of defensins in bronchoalveolar lavage fluid in diffuse panbronchiolitis, Eur Respir J, 11: 104-111, 1998.
– reference: 22) Biragyn A, Ruffini PA, Leifer CA, Klyushnenkova E, Shakhov A, Chertov O, Shirakawa AK, Farber JM, Segal DM, Oppenheim JJ, Kwak LW: Toll-like receptor 4-dependent activation of dendritic cells by β-defensin 2, Science, 298: 1025-1029, 2002.
– reference: 15) Mukae H, Ihiboshi H, Nakazato M, Hiratsuka T, Tokojima M, Abe K, Ashitani J, Kadota J, Matsukura S, Kohno S: Raised plasma concentrations of α-defensins in patients with idiopathic pulmonary fibrosis, Thorax, 57: 623-628, 2001.
– reference: 18) Ashitani J, Nakazato M, Mukae H, Taniguchi H, Date Y, Matsukura S: Recombinant granulocyte colony-stimulating factor induces production of human neutrophil peptides in lung cancer patients with neutropenia, Regul Pept, 95: 87-92, 2000.
– reference: 6) Diamond G, Russell JP, Bevins CL: Inducible expression of an antibiotic peptide gene in lipopolysaccharide-challenged tracheal epithelial cells, Proc Natl Acad Sci USA, 93: 5156-5160, 1996.
– reference: 8) Shiomi K, Nakazato M, Ihi T, Kangawa K, Matsuo H, Matsukura S: Establishment of radioimmunoassay for human neutrophil peptides and their increases in plasma and neutrophil in infection, Biochem Biophys Res Commun, 195: 1336-1344, 1993.
– reference: 16) Ashitani J, Mukae H, Hiratsuka T, Nakazato M, Kumamoto K, Matsukura S: Plasma and BAL fluid concentrations of antimicrobial peptides in patients with Mycobacterium avium-intracellulare infection, Chest, 119: 1131-1137, 2001.
– reference: 9) Hiratsuka T, Nakazato M, Ihi T, Minematsu T, Chino N, Nakanishi T, Shimizu A, Kangawa K, Matsukura S: Structural analysis of human β-defensin 1 and its significance in urinary tract infection, Nephron, 85 34-40, 2000.
– reference: 13) Ashitani J, Mukae H, Hiratsuka T, Nakazato M, Kumamoto K, Matsukura S: Elevated levels of adefensins in plasma and BAL fluid of patients with active pulmonary tuberculosis, Chest, 121: 519-526, 2002.
– reference: 23) Zhang L, Yu W, He T, Yu J, Caffrey RE, Dalmasso EA, Fu S, Pham T, Mei J, Ho JJ, Zhang W, Lopez P, Ho DD: Contribution of human α-defensin 1, 2, and 3 to the antiHIV-1 activity of CD8 antiviral factor, Science, 298: 995-1000, 2002.
– reference: 19) Garcia JR, Jaumann F, Schulz S, Krause A, Rodriguez- Jimenez FJ, Forssmann U, Adermann K, Kluver E, Vogelmeier C, Becker D, Hedrich R, Forssmann WG, Bals R: Identification of a novel, multifunctional β-defensin (human β-defensin 3) with specific antimicrobial activity, Cell Tissue Res, 306: 257-264, 2001.
– reference: 1) Lehrer RI, Daher K, Ganz T, Selsted ME: Direct inactivation of viruses by MCP-1 and MCP-2, nat-ural peptide antibiotics from rabbit leukocytes, J Virol, 54: 467-472, 1985.
– reference: 12) Ihi T, Nakazato M, Mukae H, Matsukura S: Elevated concentrations of human neutrophil peptides in plasma, blood, and body fluids from patients with infections, Clin Infect Dis, 25: 1134-1140, 1997.
– reference: 2) Selsted ME, Szklarek D, Lehrer RI: Purification and antimicrobial activity of antimicrobial peptides of rabbit granulocytes, Infect Immun, 45: 150-154, 1984.
– reference: 5) Stolzenberg ED, Anderson GM, Ackermann MR, Whitlock RH, Zasloff M: Epithelial antibiotic induced in states of disease, Proc Natl Acad Sci USA, 94: 8686-8690, 1997.
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