Vincristine によるラット胎仔の口蓋裂発生に関する走査電子顕微鏡的および光学顕微鏡的観察
口蓋裂の発生機序解明を目的として,妊娠8日12時間のWistar系ラットにvincristine 0.2mg/kgを単一腹腔内投与し,胎齢14日18時間から19日0時間まで6時間ごとの胎仔二次口蓋の走査電顕的および光顕的観察を行い,非投与群の正常胎仔と比較して次のごとき結果を得た. 1)胎齢16目12時間から19日0時間にいたるvincristine投与群生存胎仔の45.5%に口蓋裂が発生した.その多くは正中顔面裂を合併するもので,その他の口蓋裂でも外形異常とくに頭部異常を伴っていることが多かった. 2)投与群の口蓋裂胎仔では口蓋板の著しい低形成,口蓋板の水平転位不全ないし遅延,癒合不全などが...
Saved in:
| Published in | 日本口蓋裂学会雑誌 Vol. 17; no. 3; pp. 201 - 226 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Japanese |
| Published |
一般社団法人 日本口蓋裂学会
1992
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0386-5185 2186-5701 |
| DOI | 10.11224/cleftpalate1976.17.3_201 |
Cover
| Abstract | 口蓋裂の発生機序解明を目的として,妊娠8日12時間のWistar系ラットにvincristine 0.2mg/kgを単一腹腔内投与し,胎齢14日18時間から19日0時間まで6時間ごとの胎仔二次口蓋の走査電顕的および光顕的観察を行い,非投与群の正常胎仔と比較して次のごとき結果を得た. 1)胎齢16目12時間から19日0時間にいたるvincristine投与群生存胎仔の45.5%に口蓋裂が発生した.その多くは正中顔面裂を合併するもので,その他の口蓋裂でも外形異常とくに頭部異常を伴っていることが多かった. 2)投与群の口蓋裂胎仔では口蓋板の著しい低形成,口蓋板の水平転位不全ないし遅延,癒合不全などがみられた. 3)投与群で水平転位不全を示した胎仔には下顎の低形成を伴うものがあった.また,癒合不全による口蓋裂胎仔の口蓋板内側縁上皮細胞には分化遅延を示す所見が認められた. 4)投与群では蝶筋陥凹やJacobson器官の低形成ないし無形成が観察された. 5)vincristineによる口蓋裂の発生には上記のごとき変化が関与するが,とくに顔面正中部の低形成ないし欠損,鼻上顎体の形成不全に起因することが多いものと考えられた. |
|---|---|
| AbstractList | 口蓋裂の発生機序解明を目的として,妊娠8日12時間のWistar系ラットにvincristine 0.2mg/kgを単一腹腔内投与し,胎齢14日18時間から19日0時間まで6時間ごとの胎仔二次口蓋の走査電顕的および光顕的観察を行い,非投与群の正常胎仔と比較して次のごとき結果を得た. 1)胎齢16目12時間から19日0時間にいたるvincristine投与群生存胎仔の45.5%に口蓋裂が発生した.その多くは正中顔面裂を合併するもので,その他の口蓋裂でも外形異常とくに頭部異常を伴っていることが多かった. 2)投与群の口蓋裂胎仔では口蓋板の著しい低形成,口蓋板の水平転位不全ないし遅延,癒合不全などがみられた. 3)投与群で水平転位不全を示した胎仔には下顎の低形成を伴うものがあった.また,癒合不全による口蓋裂胎仔の口蓋板内側縁上皮細胞には分化遅延を示す所見が認められた. 4)投与群では蝶筋陥凹やJacobson器官の低形成ないし無形成が観察された. 5)vincristineによる口蓋裂の発生には上記のごとき変化が関与するが,とくに顔面正中部の低形成ないし欠損,鼻上顎体の形成不全に起因することが多いものと考えられた. |
| Author | 重松, 司朗 |
| Author_xml | – sequence: 1 fullname: 重松, 司朗 organization: 東京歯科大学大学院歯学研究科口腔外科学第2講座 |
| BookMark | eNpdkE9LAkEYxocwyMzvUB9Am3ln3XGPIf0RhC7VdZl2Z2vFLHb3Ep3WLbCEDLLAOogJQoQWSJeEvsy0uX6LlIKiy_M-8P54Dr95FCsflgVCSwSnCQFQlo2SsLwjXuKeIBpT04SlqQ6YzKA4kKyayjBMYiiO6bSTbGYOJV23iDGmQFUGNI5Oduyy4diuZ5fFovSfZKUqKzUZPMogkEE1Ci4_hg3p98N6J7quRZ3KqPk2arQm5Pj2QfrNCRy9vny2huP7Ydi7Grdvwvf-uN4e3Z1K_2K65g_Cs_Ow1_37irqD8Lm1gGYtXnJF8ucm0Pba6lZuI1XYXM_nVgqpIhDKU6BZAExTTANTZjCsgmUAUKpZmlAUAMtUQDVNlhGCalQDvIs1SpkwTMvkqmXQBMp_7xZdj-8J_cixD7hzrHPHsycG9X8WdcJ0Oo2JyF9mnzt6kdMvNpeaXg |
| ContentType | Journal Article |
| Copyright | 一般社団法人 日本口蓋裂学会 |
| Copyright_xml | – notice: 一般社団法人 日本口蓋裂学会 |
| DOI | 10.11224/cleftpalate1976.17.3_201 |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| EISSN | 2186-5701 |
| EndPage | 226 |
| ExternalDocumentID | article_cleftpalate1976_17_3_17_201_article_char_ja |
| GroupedDBID | ALMA_UNASSIGNED_HOLDINGS JSP KQ8 RJT |
| ID | FETCH-LOGICAL-j213a-29f22794dc037c7062fc22339f9e4422fd426dd75ee393920b09337ecdfda6fc3 |
| ISSN | 0386-5185 |
| IngestDate | Wed Sep 03 06:07:26 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | false |
| IsScholarly | false |
| Issue | 3 |
| Language | Japanese |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-j213a-29f22794dc037c7062fc22339f9e4422fd426dd75ee393920b09337ecdfda6fc3 |
| OpenAccessLink | https://www.jstage.jst.go.jp/article/cleftpalate1976/17/3/17_201/_article/-char/ja |
| PageCount | 26 |
| ParticipantIDs | jstage_primary_article_cleftpalate1976_17_3_17_201_article_char_ja |
| PublicationCentury | 1900 |
| PublicationDate | 1992 |
| PublicationDateYYYYMMDD | 1992-01-01 |
| PublicationDate_xml | – year: 1992 text: 1992 |
| PublicationDecade | 1990 |
| PublicationTitle | 日本口蓋裂学会雑誌 |
| PublicationTitleAlternate | 日口蓋誌 |
| PublicationYear | 1992 |
| Publisher | 一般社団法人 日本口蓋裂学会 |
| Publisher_xml | – name: 一般社団法人 日本口蓋裂学会 |
| References | 49)久保和子: ラット二次口蓋突起のin vitroにおける癒合過程とその過程に及ぼす風疹ウイルスならびにその変種株の影響. 阪大歯学誌, 24: 137-156, 1979. 55) Trasler, D. G., Walker, B. E. and Fraser, F. C.: Congenital malformations produced by am niotic-sac puncture. Science, 124: 439-440, 1956. 40) Shapiro, B. L. and Sweney, L.: Electron microscopic and histochemical examination of oral epithelial-mesenchymal interaction(programed cell death). J. Dent. Res., 48: 652-660, 1969. 1) Fuchs, H.: Untersuchungen über Ontogenie und Phylogonie der Gaumenbildungen bei der Wirbeltieren. Erste Mitteilung, Z. f. Morph. u. Anthrop., Bd, 10, 1907. 38) Green, R. M. and Kochhar, D. M.: Palatal closure in the mouse as demonstrated in f rozen sections. Am. J. Anat., 137: 477-482, 1973. 74) DeMyer, W.: Cleft lip and jaw induced in fetal rats by vincristine. Arch. Anat. Histol. Em bryol., 48: 180-186, 1965. 6) Inoue, M.: Die Entwickelung des sekunda ren Gaumens einiger Saugetiere mit beson d erer Berucksichtigung der Bildungsvorgange am Gesic h te und des Umlagerungsprozesses der Ga u menplatten. Anat., 46: 1-164, 1912. 15) Babiarz, B. S., Allenspach, A. L. and Zim merman, E. F.: Ultrastructural evidence of c ontractile systems in mouse palates prior to ro tation. Dev. Biol., 47: 32-44, 1975. 59) Green, R. M. and Kochhar, D. M.: Special relations in the oral cavity of cortisone-treated mouse fetuses during the time of secondary palate closure. Teratology, 8: 153-162, 1972. 17) Hassel, J. R. and Orkin, R. W.: Synthesis and distribution of collagen in the rat palate during shelf elevation. Dev. Biol., 49: 80-88, 1976. 7) Inoue, M.: Ober den Mec hanismus der Umlagerung der Gaumenplatten. Verh. D. Anat. Gesellsch., 39: 59-61, 1930. 50)丹京子, 高島庸一郎: 発生過程における形態形成病態生理, 11: 897-905, 1987. 2) Dursy, F.: Zur Entwickelungsgeschichte des Kopfes des Menschen und der höeren Wirbeltiere. 99, Verlag der H. Lauppschen Buchhadlung, Tubingen, 1869. 18) Lessard, J. L., Wee, A. L. and Zimmerman, E. F.: Presence of contractile proteins in mouse foetal palate prior to shelf elevation. Telatology, 9: 113-126, 1974. 31) Hart, J. C., Smiley, G. R. and Dixon, A. D.: Sagittal growth trends of the craniofacial complex during formation of the secondary palate in mice. Teratology, 6: 43-50, 1972. 45) Green, R. M. and Garbarino, M. P.: Role of cyclic AMP, prostaglandins, and catecholamines during normal palate development. Curr. Top. Dev. Biol., 19: 65-79, 1984. 10) Pratt, R. M., Goggins, J. R., Wilk, A. L., et al: Acid mucopolysaccharide synthesis in the secondary palate of the developing rat at the time of rotation and fusion. Dev. Biol., 32: 230 -237, 1973. 32) Humphrey, T.: The relation between human fetal mouth opening reflexes and closure of the palate. Am. J. Anat., 125: 317-344, 1969. 13) Walker, B. E.: The association of mucopolysaccharides with morphogenesis of the palate and other structures in mouse embryos. J. Embryol. Exp. Morph., 9: 22-31, 1961. 75)村上氏廣, 玉置勝, 亀山義郎, 他: 胎生環境の研究: 異常胎生環境による実験的奇形の成立: vincristine がラット胚におよぼす催奇形作用(予報1). 環境医学研究所年報, 18: 195-201, 1966. 64) Shah, R. M., Wong, D. T. and Suen, R. S.: Ultrastructural and cytochemical observations on 5-fluorouracil-induced cleft palate development in hamster. Am. J. Anat., 170: 567-580, 1984. 78)礒谷精彦: Vincristineによる催奇形実験. -とくに顔面異常と脳異常との関係について-. 日口蓋誌, 10: 9-31, 1985. 39) Smiley, G. R. and Koch, W. E.: Fine structure of mouse secondary palate development in vitro. J. Dent. Res., 50: 1671-1677, 1971. 77) Sieber, S. M., Whang-Peng, J., Botkin, C., et al: Teratogenic and cytogenetic effects of some plant-derived antitumor agents (vincristine, colchicine, maytansine, VP-16-213 and VM-26) in mice. Teratology, 18: 31-48, 1978. 53) Zenk, W., Winkelmann, H. und Wagner, T.: Die teratogen beeinflusste Palatogenese bei der Uje: WIST-Ratte. 4. Mitteilung: Rasterelektro nemikroskopische Morphologie des E pithels wahrend der Bildung des sekundaren Gaumens. Zahn Mund Kieferheilkd, 77: 161-166, 1989. 16) Babiarz, B. S., Wee, E. L. and Zimmerman, E. F.: Palate morphogenesis. III. C hanges in cell shape and orientation during shelf elevation. Teratology, 20: 249-278, 1979. 68) Gilliam, D. M., Kotch, L. E., Dudek, B. C., et al: Ethanol teratogenesis in mice selected for differences in alcohol sencitivility. Alcohol, 5: 513-519, 1989. 30) Harris, J. W. S.: Growth changes in the cranial base and lower jaw during the closure of the secondary palate in two strains of rat. J. Anat., 95: 286, 1961. 48)米田俊之, 北村昌也, 綾真一郎, 他: 培養ヒト胎児口蓋細胞によるプロスタグランディンE2(PGE2)合成によるEpidermal Growth Factor(EGF)の促進作用. 歯基礎誌24: 40-44, 1982. 60)栗栖浩二郎, 佐々木茂, 大崎康吉, 他: マウス胎仔口蓋突起におけるcollagen合成に対する glucocorticoid の影響. 歯基礎誌, 241820-830, 1982. 21) Brinkley, L. L. and Morris, W. J.: The role of extracellular matrices in palatal shelf closure. Curr. Top. Dev. Biol., 19: 17-36, 1984. 79)北村信隆: Vincristineによる口唇裂の発生過程に関する走査電顕的および光顕的観察. 日口蓋誌, 13: 133-156, 1988. 29) Smiley, G. R.: A profile cephalometolic appraisal of normal growth parameters in embryonic mice. Anat. Rec., 157, 323, 1967. 3) His, W.: Beoba chtungen zur Geschichte der Nasen und Gaumenbildung beim menschlichen Embryo. Abb. Geb. Naturw., 27: 349-389, 1901. 28) Wragg, L. E., Klein, M., Steinvorth, G., et al: Facial growth accommodating secondary palate closure in rat and man. Arch. Oral Biol., 15: 705-719, 1970. 35) Walker, B. E.: Palatal morphogenesis in the rabbit. Arch. Oral Biol., 16: 275-286, 1971. 8) Lazzaro, C.: Sul m eccanismo di chiusura del palato secondario. Monit. Zool. Ital., 51: 249 -273, 1940. 19) Jelinek, R. and Dostal, M.: The role of mitotic activity in the formation of the secondaay palate. Acta chir. Plast., 15: 216-222, 1973. 34) Walker, B. E.: Correlation of embryonic movement with palatal closure in mice. Teratology, 2: 191-198, 1969. 11) Pratt, R. M., Figueroa, A. A., Green, R. M., et al: Alterlations in macromolecular Synthesis related to abnormal palatal development. In Persaud, T. V. N. ed. Advances in the Study of Birth Defects, Vol. 3, Abnormal Embryogenesis, Cellular and Molecular Aspects. 161-176, M. T. P., Lancaster, 1979. 72) Pratt, R. M. and King, C. T. G.: Inhibitation of collagen crosslinkaging associated with 19-aminopropionitrileinduced cleft palate in the rat. Dev. Biol., 27: 322-328, 1972. 51) Sunk, K. K., Cook, C. S. and Webster, W. S.: Teratogens and craniofacial malformations: relationships to cell death. Dev., 103 (Suppl. )213-232,1988. 54)増山弥太郎: X線照射による口蓋裂の実験発生学的研究阪大歯学誌4: 847-870, 1959. 71) Katz, R. A.: Effect of diazepam on the embryonic development of the palate in the rat. J. Craniofac. Genet. Dev. Biol., 8: 155-166, 1988. 67) Abott, B. D. and Pratt, R. M.: Retinoids and epidermal growth factor alter embryonic mouse palatal epithelial and mesenchymal cell diffe rentiation in organ culture. J. Craniofac. Genet. Dev. Biol., 7: 219-240, 1987. 14) Pratt, R. M. and King, C. T. G.: Collagen synthesis in the secondary palate of the developing rat. Arch. Oral Biol., 16: 1181-1185, 1971. 27) Diewert, V. M.: Graphic reconstructions of craniofacial structures during secondary palat e development in rats. Teratology, 14: 291-314. 1976. 52)北野栄一郎: マウス口蓋の発生および生後発育過程における粘膜上皮表面の微細構造変化. 阪大歯学誌, 33: 27-53, 1987. 69) Bannigan, J. G., Cottell, D. C. and Morris, A.: Study of the mechanisms of BUdR -induced cleft palate in the mouse. Teratology, 42: 79-89, 1990. 66) Abott, B. D., Adamson, E. S. and Pratt, R. M.: Retinoic acid alters EGF receptor expre ssion during palatogenesis. Dev., 102: 853-867, 1988. 76)村上氏廣, 菅原勉, 棚瀬久雄, 他: 胎生環境の研究: 異常胎生環境による実験的奇形の成立: vincristine がラット胚におよぼす催奇形作用(予報2), 連続投与と単一投与の影響の相違. 環境医学研究所年報, 18: 201-204, 1966. 58) Walker, B. E. and Fraser, F. C.: The embryology of cortisone-induced cleft plate. J. Em bryol. Exp. Morph., 5: 201-209, 1957. 41) Smiley, G. R. and Koch, W. E.: An in vitro and in vivo study of single palatal processes. Anat. Res., 173: 405-416, 1972. 22) Bulleit, R. F. and Zimmerman, E. F.: The influence of the epithelium on palate shelf reorientation. J. Embryol. Exp. Morph., 88: 265-279, 1985. 26) Diewert, V. M.: A cephalometric study of orofacial structures during secondary palate closure in the rat. Arch. Oral Biol., 19: 303-315, 1974. 20) Brinkley, L. L. and Vickerman, M. M.: Elevation of lesioned palatal shelves in vitro. J. Embryol. Exp. Morph., 54: 229-240, 1979. 44) Smiley, G. R.: Fine structure of mouse embryonic palatal epithelium prior to and after midline fusion. Arch. Oral Biol., 15: 287-296, 1970. 62) Goldman, A. S.: Biochemical mechanism of glucocorticoid-and phenytoin-induced cleft palate. Curr. Top. Dev. Biol., 19: 217-237, 1984. 56) Schtipbach, P. M.: Experimental induction of an incomplete hard-palate cleft in the rat. Oral Surg., 55: 2-9, 1983. 9) Walke r, B. E. and Fraser, F. C.: Closure of the secondary palate in three strains of mice. J. Embryol. Exp. Morph., 4: 176-189, 1956. 73) Ferm, V. H.: Congenital malformations in hamster embryos after treatment with vinblastine and vincristine. Science, 141: 426, 1963. 37) Wragg, L. E., Diewert, V. M. and Klein, M.: Special relations in the oral cavity and the mechanism of secondary palate closure in ther at. Arch. Oral Biol., 17: 683-690, 1972. 33) Ross, R. B. and Johnston, M. C.: Cleft Lip and Palate. 3-67, The Williams and Wilkins Co., Baltimore, 1972. 47) Shah, R. M., Crawford, B. J., Green, R. M., et al: In vitro development of the hamster and chick secondary palate. J. Craniofac. Genet. Dev. Biol., 5: 299-314, 1985. 70) Montenegro, M. A. and Palomino, H.: Induction of cleft palate in mice by inhibitors of prostaglandin synthesis. J. Craniofac. Genet. Dev. Biol., 10: 83-94, 1990. 12) Brinkley, L., Basehoar, G. and Branch, A.: New in vitro system for studying secondary palate development. J. Embryol. Exp. Morph., 34: 485-495, 1975. 23) Schapbach, P. M., Chamberlain, J. G. and Schroeder, H. E.: Development of the secondary palate in the rat: A scanning electoron microscopic study. J. Craniofac. Genet. Dev. Biol., 3: 159-177, 1983. 4) Green, R. M. and Pratt, R. M.: Developm ental aspects of secondary palate. J. Em bryol. Exp. Morph., 36: 225-245, 1976. 57) Fraser, F. C. and Fainstat, T. D.: Production of cong |
| References_xml | – reference: 18) Lessard, J. L., Wee, A. L. and Zimmerman, E. F.: Presence of contractile proteins in mouse foetal palate prior to shelf elevation. Telatology, 9: 113-126, 1974. – reference: 74) DeMyer, W.: Cleft lip and jaw induced in fetal rats by vincristine. Arch. Anat. Histol. Em bryol., 48: 180-186, 1965. – reference: 77) Sieber, S. M., Whang-Peng, J., Botkin, C., et al: Teratogenic and cytogenetic effects of some plant-derived antitumor agents (vincristine, colchicine, maytansine, VP-16-213 and VM-26) in mice. Teratology, 18: 31-48, 1978. – reference: 12) Brinkley, L., Basehoar, G. and Branch, A.: New in vitro system for studying secondary palate development. J. Embryol. Exp. Morph., 34: 485-495, 1975. – reference: 15) Babiarz, B. S., Allenspach, A. L. and Zim merman, E. F.: Ultrastructural evidence of c ontractile systems in mouse palates prior to ro tation. Dev. Biol., 47: 32-44, 1975. – reference: 17) Hassel, J. R. and Orkin, R. W.: Synthesis and distribution of collagen in the rat palate during shelf elevation. Dev. Biol., 49: 80-88, 1976. – reference: 36) Wragg, L. E., Smith, J. A. and Borden, C. S.: Myoneural maturation and function of rat tongue at the time of secondary palate closure. Arch. Oral Biol., 17: 673-682, 1972. – reference: 41) Smiley, G. R. and Koch, W. E.: An in vitro and in vivo study of single palatal processes. Anat. Res., 173: 405-416, 1972. – reference: 22) Bulleit, R. F. and Zimmerman, E. F.: The influence of the epithelium on palate shelf reorientation. J. Embryol. Exp. Morph., 88: 265-279, 1985. – reference: 28) Wragg, L. E., Klein, M., Steinvorth, G., et al: Facial growth accommodating secondary palate closure in rat and man. Arch. Oral Biol., 15: 705-719, 1970. – reference: 31) Hart, J. C., Smiley, G. R. and Dixon, A. D.: Sagittal growth trends of the craniofacial complex during formation of the secondary palate in mice. Teratology, 6: 43-50, 1972. – reference: 75)村上氏廣, 玉置勝, 亀山義郎, 他: 胎生環境の研究: 異常胎生環境による実験的奇形の成立: vincristine がラット胚におよぼす催奇形作用(予報1). 環境医学研究所年報, 18: 195-201, 1966. – reference: 79)北村信隆: Vincristineによる口唇裂の発生過程に関する走査電顕的および光顕的観察. 日口蓋誌, 13: 133-156, 1988. – reference: 27) Diewert, V. M.: Graphic reconstructions of craniofacial structures during secondary palat e development in rats. Teratology, 14: 291-314. 1976. – reference: 1) Fuchs, H.: Untersuchungen über Ontogenie und Phylogonie der Gaumenbildungen bei der Wirbeltieren. Erste Mitteilung, Z. f. Morph. u. Anthrop., Bd, 10, 1907. – reference: 14) Pratt, R. M. and King, C. T. G.: Collagen synthesis in the secondary palate of the developing rat. Arch. Oral Biol., 16: 1181-1185, 1971. – reference: 25) Zeiler, K. B., Weinsein, S. and Gibson, R. D.: A study of the morphology and the time of closure of the palate in the Albino rat. Arch. Oral Biol., 9: 545-554, 1964. – reference: 38) Green, R. M. and Kochhar, D. M.: Palatal closure in the mouse as demonstrated in f rozen sections. Am. J. Anat., 137: 477-482, 1973. – reference: 33) Ross, R. B. and Johnston, M. C.: Cleft Lip and Palate. 3-67, The Williams and Wilkins Co., Baltimore, 1972. – reference: 67) Abott, B. D. and Pratt, R. M.: Retinoids and epidermal growth factor alter embryonic mouse palatal epithelial and mesenchymal cell diffe rentiation in organ culture. J. Craniofac. Genet. Dev. Biol., 7: 219-240, 1987. – reference: 78)礒谷精彦: Vincristineによる催奇形実験. -とくに顔面異常と脳異常との関係について-. 日口蓋誌, 10: 9-31, 1985. – reference: 58) Walker, B. E. and Fraser, F. C.: The embryology of cortisone-induced cleft plate. J. Em bryol. Exp. Morph., 5: 201-209, 1957. – reference: 43) Smiley, G. R. and Dixon, A. D.: Fine structure of midline epithelium in the developing palate of the mouse. Anat. Rec., 161: 293-310, 1968. – reference: 56) Schtipbach, P. M.: Experimental induction of an incomplete hard-palate cleft in the rat. Oral Surg., 55: 2-9, 1983. – reference: 26) Diewert, V. M.: A cephalometric study of orofacial structures during secondary palate closure in the rat. Arch. Oral Biol., 19: 303-315, 1974. – reference: 2) Dursy, F.: Zur Entwickelungsgeschichte des Kopfes des Menschen und der höeren Wirbeltiere. 99, Verlag der H. Lauppschen Buchhadlung, Tubingen, 1869. – reference: 4) Green, R. M. and Pratt, R. M.: Developm ental aspects of secondary palate. J. Em bryol. Exp. Morph., 36: 225-245, 1976. – reference: 8) Lazzaro, C.: Sul m eccanismo di chiusura del palato secondario. Monit. Zool. Ital., 51: 249 -273, 1940. – reference: 9) Walke r, B. E. and Fraser, F. C.: Closure of the secondary palate in three strains of mice. J. Embryol. Exp. Morph., 4: 176-189, 1956. – reference: 19) Jelinek, R. and Dostal, M.: The role of mitotic activity in the formation of the secondaay palate. Acta chir. Plast., 15: 216-222, 1973. – reference: 57) Fraser, F. C. and Fainstat, T. D.: Production of congenital defects in the offspring of pregnant mice treated with cortisone. Pediatrics, 8: 527-533, 1951. – reference: 13) Walker, B. E.: The association of mucopolysaccharides with morphogenesis of the palate and other structures in mouse embryos. J. Embryol. Exp. Morph., 9: 22-31, 1961. – reference: 70) Montenegro, M. A. and Palomino, H.: Induction of cleft palate in mice by inhibitors of prostaglandin synthesis. J. Craniofac. Genet. Dev. Biol., 10: 83-94, 1990. – reference: 30) Harris, J. W. S.: Growth changes in the cranial base and lower jaw during the closure of the secondary palate in two strains of rat. J. Anat., 95: 286, 1961. – reference: 55) Trasler, D. G., Walker, B. E. and Fraser, F. C.: Congenital malformations produced by am niotic-sac puncture. Science, 124: 439-440, 1956. – reference: 42) Mato, M., Smiley, G. R. and Dixon, A. D.: Epithelial changes in the presumptive resions of fusion during secondary palate formation. J. De nt. Res., 51: 1451-1456, 1972. – reference: 72) Pratt, R. M. and King, C. T. G.: Inhibitation of collagen crosslinkaging associated with 19-aminopropionitrileinduced cleft palate in the rat. Dev. Biol., 27: 322-328, 1972. – reference: 69) Bannigan, J. G., Cottell, D. C. and Morris, A.: Study of the mechanisms of BUdR -induced cleft palate in the mouse. Teratology, 42: 79-89, 1990. – reference: 5) Ferguson, M. W. J.: Palatal shelf elevation in the Wistar rat fetus. J. Anat., 125: 555-577, 1978. – reference: 71) Katz, R. A.: Effect of diazepam on the embryonic development of the palate in the rat. J. Craniofac. Genet. Dev. Biol., 8: 155-166, 1988. – reference: 6) Inoue, M.: Die Entwickelung des sekunda ren Gaumens einiger Saugetiere mit beson d erer Berucksichtigung der Bildungsvorgange am Gesic h te und des Umlagerungsprozesses der Ga u menplatten. Anat., 46: 1-164, 1912. – reference: 51) Sunk, K. K., Cook, C. S. and Webster, W. S.: Teratogens and craniofacial malformations: relationships to cell death. Dev., 103 (Suppl. )213-232,1988. – reference: 52)北野栄一郎: マウス口蓋の発生および生後発育過程における粘膜上皮表面の微細構造変化. 阪大歯学誌, 33: 27-53, 1987. – reference: 49)久保和子: ラット二次口蓋突起のin vitroにおける癒合過程とその過程に及ぼす風疹ウイルスならびにその変種株の影響. 阪大歯学誌, 24: 137-156, 1979. – reference: 29) Smiley, G. R.: A profile cephalometolic appraisal of normal growth parameters in embryonic mice. Anat. Rec., 157, 323, 1967. – reference: 37) Wragg, L. E., Diewert, V. M. and Klein, M.: Special relations in the oral cavity and the mechanism of secondary palate closure in ther at. Arch. Oral Biol., 17: 683-690, 1972. – reference: 44) Smiley, G. R.: Fine structure of mouse embryonic palatal epithelium prior to and after midline fusion. Arch. Oral Biol., 15: 287-296, 1970. – reference: 16) Babiarz, B. S., Wee, E. L. and Zimmerman, E. F.: Palate morphogenesis. III. C hanges in cell shape and orientation during shelf elevation. Teratology, 20: 249-278, 1979. – reference: 47) Shah, R. M., Crawford, B. J., Green, R. M., et al: In vitro development of the hamster and chick secondary palate. J. Craniofac. Genet. Dev. Biol., 5: 299-314, 1985. – reference: 46) Green, R. M. and Lloyd, M. R.: Effect of epidermal growth factor on synthesis of prosta glandins and cyclic AMP by embryonic p alate mesenchymal cells. Biochem. Biophys. Res. Commun, 130: 1037-1043, 1985. – reference: 3) His, W.: Beoba chtungen zur Geschichte der Nasen und Gaumenbildung beim menschlichen Embryo. Abb. Geb. Naturw., 27: 349-389, 1901. – reference: 40) Shapiro, B. L. and Sweney, L.: Electron microscopic and histochemical examination of oral epithelial-mesenchymal interaction(programed cell death). J. Dent. Res., 48: 652-660, 1969. – reference: 65) Watanabe, T., Goulding, E. H. and Pratt, R. M.: Alternations in craniofacial growth induce d by isotretionin (13-cis-retinoic acid) in mouse whole embryo and primary mesenchymal cell culture. J. Craniofac. Genet. Dev. Biol., 8: 21-33, 1988. – reference: 66) Abott, B. D., Adamson, E. S. and Pratt, R. M.: Retinoic acid alters EGF receptor expre ssion during palatogenesis. Dev., 102: 853-867, 1988. – reference: 34) Walker, B. E.: Correlation of embryonic movement with palatal closure in mice. Teratology, 2: 191-198, 1969. – reference: 63) Nanda, R.: Tritiated thymidine labelling of rat embryos with cleft palate induced by hyper vitaminosis A. Arch. Oral Biol., 16: 435-444, 1971. – reference: 64) Shah, R. M., Wong, D. T. and Suen, R. S.: Ultrastructural and cytochemical observations on 5-fluorouracil-induced cleft palate development in hamster. Am. J. Anat., 170: 567-580, 1984. – reference: 73) Ferm, V. H.: Congenital malformations in hamster embryos after treatment with vinblastine and vincristine. Science, 141: 426, 1963. – reference: 24) Srivastava, H. C. and Rao, P. P.: Movement of palatal shelves during secondary palatal closure in rat. Teratology, 19: 87-104, 1979. – reference: 61)大久保勉: トリアムシノロンによるマウス胎仔の口蓋裂形成の実験的研究. 歯基礎誌, 20: 844-862, 1978. – reference: 50)丹京子, 高島庸一郎: 発生過程における形態形成病態生理, 11: 897-905, 1987. – reference: 11) Pratt, R. M., Figueroa, A. A., Green, R. M., et al: Alterlations in macromolecular Synthesis related to abnormal palatal development. In Persaud, T. V. N. ed. Advances in the Study of Birth Defects, Vol. 3, Abnormal Embryogenesis, Cellular and Molecular Aspects. 161-176, M. T. P., Lancaster, 1979. – reference: 53) Zenk, W., Winkelmann, H. und Wagner, T.: Die teratogen beeinflusste Palatogenese bei der Uje: WIST-Ratte. 4. Mitteilung: Rasterelektro nemikroskopische Morphologie des E pithels wahrend der Bildung des sekundaren Gaumens. Zahn Mund Kieferheilkd, 77: 161-166, 1989. – reference: 45) Green, R. M. and Garbarino, M. P.: Role of cyclic AMP, prostaglandins, and catecholamines during normal palate development. Curr. Top. Dev. Biol., 19: 65-79, 1984. – reference: 32) Humphrey, T.: The relation between human fetal mouth opening reflexes and closure of the palate. Am. J. Anat., 125: 317-344, 1969. – reference: 76)村上氏廣, 菅原勉, 棚瀬久雄, 他: 胎生環境の研究: 異常胎生環境による実験的奇形の成立: vincristine がラット胚におよぼす催奇形作用(予報2), 連続投与と単一投与の影響の相違. 環境医学研究所年報, 18: 201-204, 1966. – reference: 10) Pratt, R. M., Goggins, J. R., Wilk, A. L., et al: Acid mucopolysaccharide synthesis in the secondary palate of the developing rat at the time of rotation and fusion. Dev. Biol., 32: 230 -237, 1973. – reference: 21) Brinkley, L. L. and Morris, W. J.: The role of extracellular matrices in palatal shelf closure. Curr. Top. Dev. Biol., 19: 17-36, 1984. – reference: 54)増山弥太郎: X線照射による口蓋裂の実験発生学的研究阪大歯学誌4: 847-870, 1959. – reference: 60)栗栖浩二郎, 佐々木茂, 大崎康吉, 他: マウス胎仔口蓋突起におけるcollagen合成に対する glucocorticoid の影響. 歯基礎誌, 241820-830, 1982. – reference: 7) Inoue, M.: Ober den Mec hanismus der Umlagerung der Gaumenplatten. Verh. D. Anat. Gesellsch., 39: 59-61, 1930. – reference: 23) Schapbach, P. M., Chamberlain, J. G. and Schroeder, H. E.: Development of the secondary palate in the rat: A scanning electoron microscopic study. J. Craniofac. Genet. Dev. Biol., 3: 159-177, 1983. – reference: 48)米田俊之, 北村昌也, 綾真一郎, 他: 培養ヒト胎児口蓋細胞によるプロスタグランディンE2(PGE2)合成によるEpidermal Growth Factor(EGF)の促進作用. 歯基礎誌24: 40-44, 1982. – reference: 62) Goldman, A. S.: Biochemical mechanism of glucocorticoid-and phenytoin-induced cleft palate. Curr. Top. Dev. Biol., 19: 217-237, 1984. – reference: 39) Smiley, G. R. and Koch, W. E.: Fine structure of mouse secondary palate development in vitro. J. Dent. Res., 50: 1671-1677, 1971. – reference: 20) Brinkley, L. L. and Vickerman, M. M.: Elevation of lesioned palatal shelves in vitro. J. Embryol. Exp. Morph., 54: 229-240, 1979. – reference: 35) Walker, B. E.: Palatal morphogenesis in the rabbit. Arch. Oral Biol., 16: 275-286, 1971. – reference: 59) Green, R. M. and Kochhar, D. M.: Special relations in the oral cavity of cortisone-treated mouse fetuses during the time of secondary palate closure. Teratology, 8: 153-162, 1972. – reference: 68) Gilliam, D. M., Kotch, L. E., Dudek, B. C., et al: Ethanol teratogenesis in mice selected for differences in alcohol sencitivility. Alcohol, 5: 513-519, 1989. |
| SSID | ssj0003236723 ssib002828992 |
| Score | 1.2847828 |
| Snippet | 口蓋裂の発生機序解明を目的として,妊娠8日12時間のWistar系ラットにvincristine 0.2mg/kgを単一腹腔内投与し,胎齢14日18時間から19日0時間まで6時間ごとの胎仔二次口蓋の... |
| SourceID | jstage |
| SourceType | Publisher |
| StartPage | 201 |
| SubjectTerms | ビンクリスニン ラット 二次口蓋発生 口蓋裂 走査電顕 |
| Title | Vincristine によるラット胎仔の口蓋裂発生に関する走査電子顕微鏡的および光学顕微鏡的観察 |
| URI | https://www.jstage.jst.go.jp/article/cleftpalate1976/17/3/17_201/_article/-char/ja |
| Volume | 17 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| ispartofPNX | 日本口蓋裂学会雑誌, 1992/07/30, Vol.17(3), pp.201-226 |
| journalDatabaseRights | – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 2186-5701 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0003236723 issn: 0386-5185 databaseCode: KQ8 dateStart: 19760101 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3da9RAEA-lgvgiior1iwruk-RMdpPs7uPmmqMICkIrfQv5RA-ppVxf9Ol6CtWCFaxC9aHUQkGkVSi-eOA_E8_e_RfObnIh9YtahRAmc7Mzv93JsrNzm11NuxIZKeXgWT2hKdOtOKQ6jwJbT3AEAbTBwziSqYEbN53Jaev6jD0zMjpWWbW00Apr0YNffldyGK8CD_wqv5L9C8-WSoEBNPgX7uBhuB_Ix7fvzkaqk8pI0SMQFSLhKgIjxoZEzpH_hxcEXAUBMkwRHvIs5LqIW0M9wLERayBBpAwnSg-Tj6DTo4hz5ApFWIg3KtY54g4SuOBwXoHBkGsj10CeI4u4ubCrCBuJCcQNyRFQypYc11MwuIJhKlsCsSFCJvbX1EQuUZjh4oVC4RxMIZOSeXHRAGzVkF2hpUjYiqgjUf9jy5R2oT3rUn9eR24qGTBXpqUVEIrYhFI8IdHB-14od1lhLl9XnCdm5CLeshMpC0yuVJE-ZAoXwLSkHtABNiVAVS1Ze0u6yxVX_7E6lYGDMEe3zfwopFqiePLoMd2mReJoOPLRSg8n1WGskMsjIpzvafDzYAvhH3QRePXT1lxwD9rBhOC2ZtIa8UsN-_YyL3qK_0MR36Q-kTco5Zcyd4J5vwlTnyOYQhAp11vcqsyMVaYAl-lUIncixPlh6EXtj2qXhyiv_Q4jxJ1NmIUNV3CqoHLqhHa8mA2OixzMSW2kGZzSHla69XjWfp8tLmWLy1nnXdbpZJ2lfufZ1-5q1t7prWz2Xyz3Nxf31j7vra6D5ODV26y9BsL9Tx-_rXcHb7q97eeDjZe9LzuDlY2914-y9lOprb3be_ykt71V_am_tdv7sH5am254U_VJvTgjRW9ikwQ65qncA9SKI4PQiBoOTiOI-AlPeWJZGKcxhOBxTO0kIRzmQkYoU5g0ieI0Dpw0Ime00dn7s8lZbdxmUUyskAQWxVbAaUAhUApgpAkNMwhNPKa5eVv5c_lGOP4h3Hnufyg5rx3LV83LTOgFbbQ1v5BchLlBK7yk3pLv87PuCQ |
| linkProvider | Colorado Alliance of Research Libraries |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Vincristine+%E3%81%AB%E3%82%88%E3%82%8B%E3%83%A9%E3%83%83%E3%83%88%E8%83%8E%E4%BB%94%E3%81%AE%E5%8F%A3%E8%93%8B%E8%A3%82%E7%99%BA%E7%94%9F%E3%81%AB%E9%96%A2%E3%81%99%E3%82%8B%E8%B5%B0%E6%9F%BB%E9%9B%BB%E5%AD%90%E9%A1%95%E5%BE%AE%E9%8F%A1%E7%9A%84%E3%81%8A%E3%82%88%E3%81%B3%E5%85%89%E5%AD%A6%E9%A1%95%E5%BE%AE%E9%8F%A1%E7%9A%84%E8%A6%B3%E5%AF%9F&rft.jtitle=%E6%97%A5%E6%9C%AC%E5%8F%A3%E8%93%8B%E8%A3%82%E5%AD%A6%E4%BC%9A%E9%9B%91%E8%AA%8C&rft.au=%E9%87%8D%E6%9D%BE%2C+%E5%8F%B8%E6%9C%97&rft.date=1992&rft.pub=%E4%B8%80%E8%88%AC%E7%A4%BE%E5%9B%A3%E6%B3%95%E4%BA%BA+%E6%97%A5%E6%9C%AC%E5%8F%A3%E8%93%8B%E8%A3%82%E5%AD%A6%E4%BC%9A&rft.issn=0386-5185&rft.eissn=2186-5701&rft.volume=17&rft.issue=3&rft.spage=201&rft.epage=226&rft_id=info:doi/10.11224%2Fcleftpalate1976.17.3_201&rft.externalDocID=article_cleftpalate1976_17_3_17_201_article_char_ja |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0386-5185&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0386-5185&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0386-5185&client=summon |