耐糖能異常者における小粒子径低比重リポ蛋白と血中脂質, 肥満およびインスリン感受性との関係

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Published in動脈硬化 Vol. 20; no. 11; pp. 899 - 907
Main Authors 橋本, 浩三, 大野, 文俊, 末廣, 正, 住吉, 良太
Format Journal Article
LanguageJapanese
Published 一般社団法人 日本動脈硬化学会 01.11.1992
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ISSN0386-2682
2185-8284
DOI10.5551/jat1973.20.11_899

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Author 住吉, 良太
末廣, 正
大野, 文俊
橋本, 浩三
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  fullname: 末廣, 正
  organization: 高知医科大学第二内科学教室
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  fullname: 住吉, 良太
  organization: 高知医科大学第二内科学教室
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References 26) Kissebah, A. H. and Peiris, A. N.: Biology of regional body fat distribution: Relationship to noninsulin-dependent diabetes mellitus. Diab. Metab. Rev., 5: 83-109 (1989).
37) Williams, R. R., Hunt, S. C., Hopkins, P. N., Stults, B. M., Wu, L. L., Hasstedt, S. J., Barlow, G. K., Stephenson, S. H., Lalouel, J.-M. and Kuida, H.: Familial dyslipidemic hypertension. Evidence from 58 Utah families for a syndrome present in approximately 12% of patients with essential hypertension. J. A. M. A., 259: 3579-3586 (1988).
36) Saad, M. F., Knowler, W. C., Pettitt, D. J., Nelson, R. G., Mott, D. M. and Bennett, P. H.: Insulin and hypertension. Relationship to obesity and glucose intolerance in Pima Indians. Diabetes, 39: 1430-1435 (1990).
31) Roncari, D. A. K., Kindler, S. and Hollenberg, C. H.: Excessive proliferation in culture of reverted adipocytes from massively obese persons. Metabolism, 35: 1-4 (1986).
17) Austin, M. A., Breslow, J. L., Hennekens, C. H., Buring, J. E., Willett, W. C. and Krauss, R. M.: Low-density lipoprotein subclass patterns and risk of myocardial infarction. J. A. M. A., 260: 1917-1921 (1988).
20) Austin, M. A., Brunzell, J. D., Fitch, W. L. and Krauss, R. M.: Inheritance of low density lipoprotein subclass patterns in familial combined hyperlipidemia. Arteriosclerosis, 10: 520-530 (1990).
27) Reaven, G. M. and Miller, R. G.: An attempt to define the nature of chemical diabetes using a multidimensional analysis. Diabetologia, 16: 17-24 (1979).
4) Adams, G. H. and Schumaker, V. N.: Polydispersity of human low-density lipoproteins. Ann. N. Y. Acad. Sci., 164: 130-146 (1969).
32) Svedberg, J., Björntorp, P., Smith, U. and Lönnroth, P.: Free-fatty acid inhibition of insulin binding, degradation, and action in isolated rat hepatocytes. Diabetes, 39: 570-574 (1990).
11) Tokunaga, K., Matsuzawa, Y., Ishikawa, K. and Tarui, S.: A novel technique for the determination of body fat by computed tomography. I. J. Obesity, 7: 437-445 (1983).
22) McNamara, J. R., Campos, H., Ordovas, J. M., Peterson, J., Wilson, P. W. F. and Schaefer, E. J.: Effect of gender, age, and lipid status on low density lipoprotein subfraction distribution. Results from the Framingham offspring study. Arteriosclerosis, 7: 483-490 (1987).
1) Reaven, G. M.: Role of insulin resistance in human disease. Diabetes, 37: 1595-1607 (1988).
14) 川田益意, 末廣正, 高松和永, 安岡伸和, 吉田健三, 岸野和貴子, 久武邦彦, 宇賀茂敏, 山野利尚, 大野文俊: デキストラン硫酸沈澱法によるHDL2-, HDL3-Cholesterol測定法の検討と臨床成績. 動脈硬化, 12: 887-894 (1984).
25) Evans, D. J., Hoffmann, R. G., Kalkhoff, R. K, and Kissebah, A. H.: Relationship of body fat topography to insulin sensitivity and metabolic profiles in pre menopausal women. Metabolism, 33: 68-75 (1984).
16) Austin, M. A. and Krauss, R. M.: Genetic control of low-density-lipoprotein subclasses. Lancet, 13: 592-595 (1986).
3) DeFronzo, R. A. and Ferrannini, E.: Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care, 14: 173-194 (1991).
34) Christlieb, A. R., Janka, H.-U., Kraus, B., Gleason, R. E., Icasas-Cabral, E. A., Aiello, L. M., Cabral, B. V. and Solano, A.: Vascular reactivity to angiotensin II and to norepinephrine in diabetic subjects. Diabetes, 25: 268-274 (1976).
10) Larsson, B., Svärdsudd, K., Welin, L., Wilhelmsen, L., Björntorp, P. and Tibblin, G.: Abdominal adipose tissue distribution, obesity, and risk of cardiovascular disease and death: 13 year follow up of participants in the study of men born in 1913. Brit. Med. J., 288: 1401-1404 (1984).
7) 大黒隆司, 末廣正, 大野文俊: NIDDM患者におけるLDL亜分画pattern B (small, dense LDL) の検討. 動脈硬化, 19: 161-169 (1991).
33) DeFronzo, R. A.: The effect of insulin on renal sodium metabolism. A review with clinical implications. Diabetologia, 21: 165-171(1981).
6) Fisher, W. R.: Heterogeneity of plasma low density lipoproteins manifestations of the physiologic phenomenon in man. Metabolism, 32: 283-291 (1983).
15) 岡村浩司, 川田益意, 末廣正, 大野文俊: 脳梗塞患者におけるsmall, dense low density lipoproteinの検討. 動脈硬化, 19: 1079-1088 (1991).
9) Williams, P. T., Krauss, R. M., Nichols, A. V., Vranizan, K. M, and Wood, P. D. S.: Identifying the predominant peak diameter of high-density and lowdensity lipoproteins by electrophoresis. J. Lipid Res., 31: 1131-1139 (1990).
13) DeFronzo, R. A., Tobin, J. D, and Andres, R.: Glucose clamp technique: A method for quantifying insulin secretion and resistance. Am. J. Physiol., 237: E214-223 (1979).
18) Austin, M. A., King, M.-C., Vranizan, K. M., Newman, B. and Krauss, R. M.: Inheritance of low-density lipoprotein subclass patterns: Results of complex segregation analysis. Am. J. Hum. Genet., 43: 838-846 (1988).
21) Teng, B., Thompson, G. R., Sniderman, A. D., Forte, T. M., Krauss, R. M. and Kwiterovich, P. O. Jr.: Composition and distribution of low density lipoprotein fractions in hyperapobetalipoproteinemia, normolipidemia, and familial hypercholesterolemia. Proc. Natl. Acad. Sci. U.S.A., 80: 6662-6666 (1983).
28) Yoshioka, N., Kuzuya, T., Matsuda, A. and Iwamoto, Y.: Effects of dietary treatment on serum insulin and proinsulin response in newly diagnosed NIDDM. Diabetes, 38: 262-266 (1989).
2) Kaplan, N. M.: The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension. Arch. Intern. Med., 149: 1514-1520 (1989).
5) Krauss, R. M. and Burke, D. J.: Identification of multiple subclasses of plasma low density lipoproteins in normal humans. J. Lipid Res., 23: 97-104 (1982).
23) Deckelbaum, R. J., Granot, E., Oschry, Y., Rose, L. and Eisenberg, S.: Plasma triglyceride determines structure-composition in low and high density lipoproteins. Arteriosclerosis, 4: 225-231 (1984).
30) Karnieli, E., Barzilai, A., Rafaeloff, R. and Armoni, M.: Distribution of glucose transporters in membrane fractions isolated from human adipose cells. Relation to cell size. J. Clin. Invest., 78: 1051-1055 (1986).
24) Vague, J.: The degree of masculine differentiation of obesities: A factor determining predisposition to diabetes, atherosclerosis, gout, and uric calculous disease. Am. J. Clin. Nutr., 4: 20-34 (1956).
19) Austin, M. A., King, M.-C., Vranizan, K. M. and Krauss, R. M.: Atherogenic lipoprotein phenotype. A proposed genetic marker for coronary heart disease risk. Circulation, 82: 495-506 (1990).
29) Olefsky, J. M.: Decreased insulin binding to adipocytes and circulating monocytes from obese subjects. J. Clin. Invest., 57: 1165-1172 (1976).
8) Eisenberg, S., Gavish, D., Oschry, Y., Fainaru, M. and Deckelbaum, R. J.: Abnormalities in very low, low, and high density lipoproteins in hypertriglyceridemia. Reversal toward normal with bezafibrate treatment. J. Clin. Invest., 74: 470-482 (1984).
35) Saad, M. F., Lillioja, S., Nyomba, B. L., Castillo, C., Ferraro, R., DeGregorio, M., Ravussin, E., Knowler, W. C., Bennett, P. H., Howard, B. V. and Bogardus, C.: Racial differences in the relation between blood pressure and insulin resistance. N. Engl. J. Med., 324: 733-739 (1991).
12) Fujioka, S., Matsuzawa, Y., Tokunaga, K. and Tarui, S.: Contribution of intra-abdominal fat accumulation to the impairment of glucose and lipid metabolism in human obesity. Metabolism, 36: 54-59 (1987).
References_xml – reference: 18) Austin, M. A., King, M.-C., Vranizan, K. M., Newman, B. and Krauss, R. M.: Inheritance of low-density lipoprotein subclass patterns: Results of complex segregation analysis. Am. J. Hum. Genet., 43: 838-846 (1988).
– reference: 21) Teng, B., Thompson, G. R., Sniderman, A. D., Forte, T. M., Krauss, R. M. and Kwiterovich, P. O. Jr.: Composition and distribution of low density lipoprotein fractions in hyperapobetalipoproteinemia, normolipidemia, and familial hypercholesterolemia. Proc. Natl. Acad. Sci. U.S.A., 80: 6662-6666 (1983).
– reference: 15) 岡村浩司, 川田益意, 末廣正, 大野文俊: 脳梗塞患者におけるsmall, dense low density lipoproteinの検討. 動脈硬化, 19: 1079-1088 (1991).
– reference: 23) Deckelbaum, R. J., Granot, E., Oschry, Y., Rose, L. and Eisenberg, S.: Plasma triglyceride determines structure-composition in low and high density lipoproteins. Arteriosclerosis, 4: 225-231 (1984).
– reference: 30) Karnieli, E., Barzilai, A., Rafaeloff, R. and Armoni, M.: Distribution of glucose transporters in membrane fractions isolated from human adipose cells. Relation to cell size. J. Clin. Invest., 78: 1051-1055 (1986).
– reference: 13) DeFronzo, R. A., Tobin, J. D, and Andres, R.: Glucose clamp technique: A method for quantifying insulin secretion and resistance. Am. J. Physiol., 237: E214-223 (1979).
– reference: 9) Williams, P. T., Krauss, R. M., Nichols, A. V., Vranizan, K. M, and Wood, P. D. S.: Identifying the predominant peak diameter of high-density and lowdensity lipoproteins by electrophoresis. J. Lipid Res., 31: 1131-1139 (1990).
– reference: 2) Kaplan, N. M.: The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension. Arch. Intern. Med., 149: 1514-1520 (1989).
– reference: 28) Yoshioka, N., Kuzuya, T., Matsuda, A. and Iwamoto, Y.: Effects of dietary treatment on serum insulin and proinsulin response in newly diagnosed NIDDM. Diabetes, 38: 262-266 (1989).
– reference: 11) Tokunaga, K., Matsuzawa, Y., Ishikawa, K. and Tarui, S.: A novel technique for the determination of body fat by computed tomography. I. J. Obesity, 7: 437-445 (1983).
– reference: 37) Williams, R. R., Hunt, S. C., Hopkins, P. N., Stults, B. M., Wu, L. L., Hasstedt, S. J., Barlow, G. K., Stephenson, S. H., Lalouel, J.-M. and Kuida, H.: Familial dyslipidemic hypertension. Evidence from 58 Utah families for a syndrome present in approximately 12% of patients with essential hypertension. J. A. M. A., 259: 3579-3586 (1988).
– reference: 26) Kissebah, A. H. and Peiris, A. N.: Biology of regional body fat distribution: Relationship to noninsulin-dependent diabetes mellitus. Diab. Metab. Rev., 5: 83-109 (1989).
– reference: 20) Austin, M. A., Brunzell, J. D., Fitch, W. L. and Krauss, R. M.: Inheritance of low density lipoprotein subclass patterns in familial combined hyperlipidemia. Arteriosclerosis, 10: 520-530 (1990).
– reference: 10) Larsson, B., Svärdsudd, K., Welin, L., Wilhelmsen, L., Björntorp, P. and Tibblin, G.: Abdominal adipose tissue distribution, obesity, and risk of cardiovascular disease and death: 13 year follow up of participants in the study of men born in 1913. Brit. Med. J., 288: 1401-1404 (1984).
– reference: 31) Roncari, D. A. K., Kindler, S. and Hollenberg, C. H.: Excessive proliferation in culture of reverted adipocytes from massively obese persons. Metabolism, 35: 1-4 (1986).
– reference: 32) Svedberg, J., Björntorp, P., Smith, U. and Lönnroth, P.: Free-fatty acid inhibition of insulin binding, degradation, and action in isolated rat hepatocytes. Diabetes, 39: 570-574 (1990).
– reference: 22) McNamara, J. R., Campos, H., Ordovas, J. M., Peterson, J., Wilson, P. W. F. and Schaefer, E. J.: Effect of gender, age, and lipid status on low density lipoprotein subfraction distribution. Results from the Framingham offspring study. Arteriosclerosis, 7: 483-490 (1987).
– reference: 29) Olefsky, J. M.: Decreased insulin binding to adipocytes and circulating monocytes from obese subjects. J. Clin. Invest., 57: 1165-1172 (1976).
– reference: 17) Austin, M. A., Breslow, J. L., Hennekens, C. H., Buring, J. E., Willett, W. C. and Krauss, R. M.: Low-density lipoprotein subclass patterns and risk of myocardial infarction. J. A. M. A., 260: 1917-1921 (1988).
– reference: 12) Fujioka, S., Matsuzawa, Y., Tokunaga, K. and Tarui, S.: Contribution of intra-abdominal fat accumulation to the impairment of glucose and lipid metabolism in human obesity. Metabolism, 36: 54-59 (1987).
– reference: 14) 川田益意, 末廣正, 高松和永, 安岡伸和, 吉田健三, 岸野和貴子, 久武邦彦, 宇賀茂敏, 山野利尚, 大野文俊: デキストラン硫酸沈澱法によるHDL2-, HDL3-Cholesterol測定法の検討と臨床成績. 動脈硬化, 12: 887-894 (1984).
– reference: 27) Reaven, G. M. and Miller, R. G.: An attempt to define the nature of chemical diabetes using a multidimensional analysis. Diabetologia, 16: 17-24 (1979).
– reference: 4) Adams, G. H. and Schumaker, V. N.: Polydispersity of human low-density lipoproteins. Ann. N. Y. Acad. Sci., 164: 130-146 (1969).
– reference: 33) DeFronzo, R. A.: The effect of insulin on renal sodium metabolism. A review with clinical implications. Diabetologia, 21: 165-171(1981).
– reference: 19) Austin, M. A., King, M.-C., Vranizan, K. M. and Krauss, R. M.: Atherogenic lipoprotein phenotype. A proposed genetic marker for coronary heart disease risk. Circulation, 82: 495-506 (1990).
– reference: 7) 大黒隆司, 末廣正, 大野文俊: NIDDM患者におけるLDL亜分画pattern B (small, dense LDL) の検討. 動脈硬化, 19: 161-169 (1991).
– reference: 5) Krauss, R. M. and Burke, D. J.: Identification of multiple subclasses of plasma low density lipoproteins in normal humans. J. Lipid Res., 23: 97-104 (1982).
– reference: 3) DeFronzo, R. A. and Ferrannini, E.: Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care, 14: 173-194 (1991).
– reference: 36) Saad, M. F., Knowler, W. C., Pettitt, D. J., Nelson, R. G., Mott, D. M. and Bennett, P. H.: Insulin and hypertension. Relationship to obesity and glucose intolerance in Pima Indians. Diabetes, 39: 1430-1435 (1990).
– reference: 35) Saad, M. F., Lillioja, S., Nyomba, B. L., Castillo, C., Ferraro, R., DeGregorio, M., Ravussin, E., Knowler, W. C., Bennett, P. H., Howard, B. V. and Bogardus, C.: Racial differences in the relation between blood pressure and insulin resistance. N. Engl. J. Med., 324: 733-739 (1991).
– reference: 1) Reaven, G. M.: Role of insulin resistance in human disease. Diabetes, 37: 1595-1607 (1988).
– reference: 25) Evans, D. J., Hoffmann, R. G., Kalkhoff, R. K, and Kissebah, A. H.: Relationship of body fat topography to insulin sensitivity and metabolic profiles in pre menopausal women. Metabolism, 33: 68-75 (1984).
– reference: 24) Vague, J.: The degree of masculine differentiation of obesities: A factor determining predisposition to diabetes, atherosclerosis, gout, and uric calculous disease. Am. J. Clin. Nutr., 4: 20-34 (1956).
– reference: 16) Austin, M. A. and Krauss, R. M.: Genetic control of low-density-lipoprotein subclasses. Lancet, 13: 592-595 (1986).
– reference: 6) Fisher, W. R.: Heterogeneity of plasma low density lipoproteins manifestations of the physiologic phenomenon in man. Metabolism, 32: 283-291 (1983).
– reference: 8) Eisenberg, S., Gavish, D., Oschry, Y., Fainaru, M. and Deckelbaum, R. J.: Abnormalities in very low, low, and high density lipoproteins in hypertriglyceridemia. Reversal toward normal with bezafibrate treatment. J. Clin. Invest., 74: 470-482 (1984).
– reference: 34) Christlieb, A. R., Janka, H.-U., Kraus, B., Gleason, R. E., Icasas-Cabral, E. A., Aiello, L. M., Cabral, B. V. and Solano, A.: Vascular reactivity to angiotensin II and to norepinephrine in diabetic subjects. Diabetes, 25: 268-274 (1976).
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Title 耐糖能異常者における小粒子径低比重リポ蛋白と血中脂質, 肥満およびインスリン感受性との関係
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