腹部大動脈瘤に対する人工血管置換術とステントグラフト内挿術における周術期の炎症・線溶凝固障害に関する血液学的比較分析
【目的】腹部大動脈瘤に対する人工血管置換術（O群）とステントグラフト内挿術（E群）の炎症・凝固線溶系を血液学的比較分析した。【方法】紡錘状腹部大動脈瘤径45 mm以上のO群16例とE群6例を比較。【結果】両群間の最大短径に差。高齢でも短入院期間はE群。術後合併症O群1例, E群1例。hsCRP値（ng/mL）は，術前有意差ないも，O群高値。TAT値はE群，PIC値はO群で高値。【結論】O群は高炎症，E群は高線溶，凝固は両群とも収束した。...
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| Published in | 脈管学 Vol. 58; no. 3; pp. 21 - 26 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
日本脈管学会
10.03.2018
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0387-1126 1880-8840 |
| DOI | 10.7133/jca.17-00030 |
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| Abstract | 【目的】腹部大動脈瘤に対する人工血管置換術（O群）とステントグラフト内挿術（E群）の炎症・凝固線溶系を血液学的比較分析した。【方法】紡錘状腹部大動脈瘤径45 mm以上のO群16例とE群6例を比較。【結果】両群間の最大短径に差。高齢でも短入院期間はE群。術後合併症O群1例, E群1例。hsCRP値（ng/mL）は，術前有意差ないも，O群高値。TAT値はE群，PIC値はO群で高値。【結論】O群は高炎症，E群は高線溶，凝固は両群とも収束した。 |
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| AbstractList | 【目的】腹部大動脈瘤に対する人工血管置換術（O群）とステントグラフト内挿術（E群）の炎症・凝固線溶系を血液学的比較分析した。【方法】紡錘状腹部大動脈瘤径45 mm以上のO群16例とE群6例を比較。【結果】両群間の最大短径に差。高齢でも短入院期間はE群。術後合併症O群1例, E群1例。hsCRP値（ng/mL）は，術前有意差ないも，O群高値。TAT値はE群，PIC値はO群で高値。【結論】O群は高炎症，E群は高線溶，凝固は両群とも収束した。 |
| Author | 伊達, 数馬 後藤, 博志 竹田, 誠 岡田, 拓 秋山, 大地 安藤, 敬 |
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| References | 8) Ranucci M, Frigiola A, Menicanti L, et al: Postoperative antithrombin levels and outcome in cardiac operations. Crit Care Med 2005; 33: 355–360 1) Yamazumi K, Ojiro M, Okumura H, et al: An activated state of blood coagulation and fibrinolysis in patients with abdominal aortic aneurysm. Am J Surg 1998; 175: 297–301 13) Chikazawa G, Hiraoka A, Totsugawa T, et al: Influencing factors for abdominal aortic aneurysm sac shrinkage and enlargement after EVAR: clinical reviews before introduction of preoperative coil embolization. Ann Vasc Dis 2014; 7: 280–285 7) Koster A, Chew D, Kuebler W, et al: High antithrombin III levels attenuate hemostatic activation and leukocyte activation during cardiopulmonary bypass. J Thorac Cardiovasc Surg 2003; 126: 906–907 4) Ridker PM, Cushman M, Stampfer MJ, et al: Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N Engl J Med 1997; 336: 973–979 10) Ikoma A, Nakai M, Sato M, et al: Changes in inflammatory, coagulopathic, and fibrinolytic responses after endovascular repair of an abdominal aortic aneurysm: relationship between fibrinogen degradation product levels and endoleaks. Jpn J Radiol 2014; 32: 347–355 3) Ando T, Nagai K, Chikada M, et al: Proteomic analyses of aortic wall in patients with abdominal aortic aneurysm. J Cardiovasc Surg (Torino) 2011; 52: 545–555 9) Davies RS, Abdelhamid M, Wall ML, et al: Coagulation, fibrinolysis, and platelet activation in patients undergoing open and endovascular repair of abdominal aortic aneurysm. J Vasc Surg 2011; 54: 865–878 5) Huang G, Wang A, Li X, et al: Change in high-sensitive C-reactive protein during abdominal aortic aneurysm formation. J Hypertens 2009; 27: 1829–1837 6) 家子正裕，高橋信彦：Soluble fibrin monomer complex soluble fibrin. Thrombosis Medicine 2011; 1: 177–181 14) Okada M, Handa N, Onohara T, et al; National Hospital Organization Network Study Group for Abdominal Aortic Aneurysm in Japan: Late sac behavior after endovascular aneurysm repair for abdominal aortic aneurysm. Ann Vasc Dis 2016; 9: 102–107 12) 善甫宜哉，上田晃志郎，金田好和，他：EVAR術後遠隔期エンドリークとその対策．J Jpn Coll Angiol 2013; 53: 171–177 2) Wallinder J, Bergqvist D, Henriksson AE: Haemostatic markers in patients with abdominal aortic aneurysm and the impact of aneurysm size. Thromb Res 2009; 124: 423–426 11) 丸藤 哲：急性期DIC診断基準の現状と今後の展開．Thrombosis Medicine 2015; 5: 39–43 |
| References_xml | – reference: 4) Ridker PM, Cushman M, Stampfer MJ, et al: Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N Engl J Med 1997; 336: 973–979 – reference: 8) Ranucci M, Frigiola A, Menicanti L, et al: Postoperative antithrombin levels and outcome in cardiac operations. Crit Care Med 2005; 33: 355–360 – reference: 12) 善甫宜哉，上田晃志郎，金田好和，他：EVAR術後遠隔期エンドリークとその対策．J Jpn Coll Angiol 2013; 53: 171–177 – reference: 5) Huang G, Wang A, Li X, et al: Change in high-sensitive C-reactive protein during abdominal aortic aneurysm formation. J Hypertens 2009; 27: 1829–1837 – reference: 11) 丸藤 哲：急性期DIC診断基準の現状と今後の展開．Thrombosis Medicine 2015; 5: 39–43 – reference: 14) Okada M, Handa N, Onohara T, et al; National Hospital Organization Network Study Group for Abdominal Aortic Aneurysm in Japan: Late sac behavior after endovascular aneurysm repair for abdominal aortic aneurysm. Ann Vasc Dis 2016; 9: 102–107 – reference: 9) Davies RS, Abdelhamid M, Wall ML, et al: Coagulation, fibrinolysis, and platelet activation in patients undergoing open and endovascular repair of abdominal aortic aneurysm. J Vasc Surg 2011; 54: 865–878 – reference: 3) Ando T, Nagai K, Chikada M, et al: Proteomic analyses of aortic wall in patients with abdominal aortic aneurysm. J Cardiovasc Surg (Torino) 2011; 52: 545–555 – reference: 6) 家子正裕，高橋信彦：Soluble fibrin monomer complex soluble fibrin. Thrombosis Medicine 2011; 1: 177–181 – reference: 10) Ikoma A, Nakai M, Sato M, et al: Changes in inflammatory, coagulopathic, and fibrinolytic responses after endovascular repair of an abdominal aortic aneurysm: relationship between fibrinogen degradation product levels and endoleaks. Jpn J Radiol 2014; 32: 347–355 – reference: 2) Wallinder J, Bergqvist D, Henriksson AE: Haemostatic markers in patients with abdominal aortic aneurysm and the impact of aneurysm size. Thromb Res 2009; 124: 423–426 – reference: 1) Yamazumi K, Ojiro M, Okumura H, et al: An activated state of blood coagulation and fibrinolysis in patients with abdominal aortic aneurysm. Am J Surg 1998; 175: 297–301 – reference: 13) Chikazawa G, Hiraoka A, Totsugawa T, et al: Influencing factors for abdominal aortic aneurysm sac shrinkage and enlargement after EVAR: clinical reviews before introduction of preoperative coil embolization. Ann Vasc Dis 2014; 7: 280–285 – reference: 7) Koster A, Chew D, Kuebler W, et al: High antithrombin III levels attenuate hemostatic activation and leukocyte activation during cardiopulmonary bypass. J Thorac Cardiovasc Surg 2003; 126: 906–907 |
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| SubjectTerms | abdominal aortic aneurysm endovascular aortic aneurysm repair fibrinolysis coagulation disorder inflammation open vascular prosthesis replacement |
| Title | 腹部大動脈瘤に対する人工血管置換術とステントグラフト内挿術における周術期の炎症・線溶凝固障害に関する血液学的比較分析 |
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