一酸化窒素合成酵素の多様な役割
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| Published in | 血管 Vol. 39; no. 3; pp. 81 - 91 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
日本心脈管作動物質学会
30.09.2016
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| Online Access | Get full text |
| ISSN | 0911-4637 2759-2286 |
| DOI | 10.60370/jjcircres.39.3_81 |
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| Author | 尾辻, 豊 下川, 宏明 迎, 寛 筒井, 正人 谷本, 昭英 矢寺, 和博 |
|---|---|
| Author_xml | – sequence: 1 fullname: 下川, 宏明 organization: 東北大学大学院医学系研究科循環器内科学 – sequence: 1 fullname: 矢寺, 和博 organization: 産業医科大学医学部呼吸器内科学 – sequence: 1 fullname: 尾辻, 豊 organization: 産業医科大学医学部第二内科学 – sequence: 1 fullname: 谷本, 昭英 organization: 鹿児島大学医歯学総合研究科病理学 – sequence: 1 fullname: 迎, 寛 organization: 長崎大学医学部第二内科学 – sequence: 1 fullname: 筒井, 正人 organization: 琉球大学大学院医学研究科薬理学 |
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| ContentType | Journal Article |
| Copyright | 2016 日本心脈管作動物質学会 |
| Copyright_xml | – notice: 2016 日本心脈管作動物質学会 |
| DOI | 10.60370/jjcircres.39.3_81 |
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| EISSN | 2759-2286 |
| EndPage | 91 |
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| References | Tsutsui M, Shimokawa H, Otsuji Y, Ueta Y, Sasaguri Y, Yanagihara N. Nitric oxide synthases and cardiovascular diseases: insights from genetically modified mice. Circ J. 2009;73:986-993. Thomas G, Ramwell PW. NW-nitro-L-arginine benzyl ester, a potent irreversible inhibitor of endothelium dependent relaxation. Biochem. Biophys. Res. Commun. 1991;179:1677-1682. Ninomiya T, Kiyohara Y, Tokuda Y, Doi Y, Arima H, Harada A, Ohashi Y, Ueshima H. Impact ofkidney disease and blood pressure on the development of cardiovascular disease: an overviewfrom the Japan Arteriosclerosis Longitudinal Study. Circulation. 2008;118:2694-2701. Matoba T, Shimokawa H, Kubota H, Morikawa K, Fujiki T, Kunihiro I, Mukai Y, Hirakawa Y, Takeshita A. Hydrogen peroxide is an endothelium- derived hyperpolarizing factor in human mesenteric arteries. Biochem Biophys Res Commun. 2002;290: 909-913. Ho KK, Pinsky JL, Kannel WB, Levy D. The epidemiology of heart failure: the Framingham Study. J. Am. Coll. Cardiol. 1993;22:6A-13A. Buchwalow IB, Podzuweit T, Bocker W, Samoilova VE, Thomas S, Wellner M, Baba HA, Robenek H, Schnekenburger J, Lerch MM. Vascular smooth muscle and nitric oxide synthase. FASEB J. 2002; 16:500-508. Buxton ILO, Cheek DJ, Eckman D, Westfall DP, Sanders KM, Keef KD. NG-nitro-L-arginine methyl ester and other alkyl esters of arginine are muscarinic receptor antagonists. Circ. Res. 1993;72: 387-395. Sabanai K, Tsutsui M, Sakai A, Hirasawa H, Tanaka S, Nakamura E, Tanimoto A, Sasaguri Y, ItoM, Shimokawa H, Nakamura T, Yanagihara N. Genetic disruption of all NO synthase isoformsenhances BMD and bone turnover in mice in vivo: involvement of the renin-angiotensin system. J Bone Miner Res. 2008;23:633-643. Tsutsui M, Shimokawa H, Otsuji Y, Yanagihara N. Pathophysiological relevance of NO signaling in the cardiovascular system: novel insight from mice lacking all NO synthases. Pharmacol Ther. 2010; 128:499-508. Kuncio GS, Neilson EG, Haverty T. Mechanisms of tubulointerstitial fibrosis. Kidney Int. 1991;39:550-556. Ignarro LJ. Biosynthesis and metabolism of endothelium-derived nitric oxide. Annu. Rev.Pharmacol. Toxicol. 1990;30:535-560. Uchida T, Furuno Y, Tanimoto A, Toyohira Y, Arakaki K, Kina-Tanada M, Kubota H, Sakanashi M,Matsuzaki T, Noguchi K, Nakasone J, Igarashi T, Ueno S, Matsushita M, Ishiuchi S, Masuzaki H, Ohya Y, Yanagihara N, Shimokawa H, Otsuji Y, Tamura M, Tsutsui M. Development of an xperimentally useful model of acute myocardial infarction: 2/3 nephrectomized triple nitric oxide synthases-deficient mouse. J Mol Cell Cardiol. 2014;77:29-41. Shimokawa H. Primary endothelial dysfunction:atherosclerosis. J. Mol. Cell Cardiol. 1999;31:23-37. Nakata S, Tsutsui M, Shimokawa H, Yamashita T, Tanimoto A, Tasaki H, Ozumi K, Sabanai K, Morishita T, Suda O, Hirano H, Sasaguri Y, Nakashima Y, Yanagihara N. Statin treatment upregulates vascular neuronal nitric oxide synthase through Akt/NF- kappaB pathway. Arterioscler Thromb Vasc Biol. 2007;27:92-98. Moroi M, Zhang L, Yasuda T, Virmani R, Gold HK,Fishman MC, Huang PL. Interaction of geneticdeficiency of endothelial nitric oxide, gender, and pregnancy in vascular response to injury in mice. J. Clin. Invest. 1998;101:1225-1232. Kamezaki F, Tsutsui M, Takahashi M, Sonoda S, Kubo T, Fujino Y, Adachi T, Abe H, Takeuchi M,Mayumi T, Otsuji Y. Plasma levels of nitric oxide metabolites are markedly reduced in normotensive men with electrocardiographically determined left ventricular hypertrophy. Hypertension. 2014;64:516- 522. Ninomiya T, Kiyohara Y, Kubo M, Tanizaki Y, Doi Y, Okubo K, Wakugawa Y, Hata J, Oishi Y, Shikata K, Yonemoto K, Hirakata H, Iida M. Chronic kidney disease and cardiovascular disease in a generalJapanese population: the Hisayama Study. Kidney Int. 2005;68:228-236. Heim KF, Thomas G, Ramwell PW. Effect of substituted arginine compounds on superoxide production in the rabbit aorta. J. Pharmacol. Exp. Ther. 1991;257:1130-1135. Laine P, Kaartinen M, Penttila A, Panula P, Paavonen T, Kovanen PT. Association betweenmyocardial infarction and the mast cells in the adventitia of the infarct-related coronary artery.Circulation. 1999;99:361-369. Morishita T, Tsutsui M, Shimokawa H, Sabanai K,Tasaki H, Suda O, Nakata S, Tanimoto A, Wang KY,Ueta Y, Sasaguri Y, Nakashima Y, Yanagihara N. Nephrogenic diabetes insipidus in mice lacking all nitric oxide synthase isoforms. Proc Natl Acad Sci U S A. 2005;102:10616-10621. Son H, Hawkins RD, Martin K, Kiebler M, Huang PL, Fishman MC, Kandel ER. Long-term otentiationis reduced in mice that are doubly mutant in endothelial and neuronal nitric oxide synthase. Cell.1996;87:1015-1023. Pelletier CC, Koppe L, Croze ML, Kalbacher E, Vella RE, Guebre-Egziabher F, Geloen A, Badet L, Fouque D, Soulage CO. White adipose tissue overproduces the lipid-mobilizing factor zinc alpha2-glycoprotein in chronic kidney disease. Kidney Int. 2013;83:878-886. Suda O, Tsutsui M, Morishita T, Tasaki H, Ueno S, Nakata S, Tsujimoto T, Toyohira Y, Hayashida Y, Sasaguri Y, Ueta Y, Nakashima Y, Yanagihara N. Asymmetric dimethylarginine produces vascular lesions in endothelial nitric oxide synthase-deficient mice. Arterioscler Thromb Vasc Biol. 2004;24:1682- 1688. Bredt DS, Snyder SH. Nitric oxide: a physiological messenger molecule. Annu. Rev. Biochem. 1994;63: 175-195. MacPherson H, Noble BS, Ralston SH. Expression and functional role of nitric oxide synthase isoforms in human osteoblast-like cells. Bone. 1999;24:179-185. Ishikawa J, Ishikawa S, Kabutoya T, Gotoh T, Kayaba K, Schwartz JE, Pickering TG, Shimada K,Kario K. Cornell product left ventricular hypertrophy in electrocardiogram and the risk of stroke in a general population. Hypertension. 2009;53:28-34. Miyazaki-Anzai S, Levi M, Kratzer A, Ting TC, Lewis LB, Miyazaki M. Farnesoid X receptoractivation prevents the development of vascular calcification in ApoE-/- mice with chronic kidneydisease. Circ Res. 2010;106:1807-1817. Matsuzawa Y, Funahashi T, Kihara S, Shimomura I. Adiponectin and metabolic syndrome. Arterioscler Thromb Vasc Biol. 2004;24:29-33. Duplain H, Burcelin R, Sartori C, Cook S, Egli M, Lepori M, Vollenweider P, Pedrazzini T, Nicod P, Thorens B, Scherrer U. Insulin resistance, hyperlipidemia, and hypertension in mice lacking endothelial nitric oxide synthase. Circulation. 2001; 104:342-345. Akata K, Yatera K, Wang KY, Naito K, Ogoshi T, Noguchi S, Kido T, Toyohira Y, Shimokawa H,Yanagihara N, Tsutsui M, Mukae H. Decreased Bronchial Eosinophilic Inflammation and MucusHypersecretion in Asthmatic Mice Lacking All Nitric Oxide Synthase Isoforms. Lung. 2016;194:121-124. Brandi ML, Hukkanen M, Umeda T, Moradi- Bidhendi N, Bianchi S, Gross SS, Polak JM,MacIntyre I. Bidirectional regulation of osteoclast function by nitric oxide synthase isoforms. Proc Natl Acad Sci U S A. 1995;92:2954-2958. Miyajima A, Chen J, Poppas DP, Vaughan ED, Jr., Felsen D. Role of nitric oxide in renal tubularapoptosis of unilateral ureteral obstruction. Kidney Int. 2001;59:1290-1303. Forstermann U, Boissel JP, Kleinert H. Expressional control of the 'constitutive' isoforms of nitric oxide synthase (NOS I and NOS III). FASEB J. 1998;12: 773-790. Tsutsui M. Neuronal nitric oxide synthase as a novel anti-atherogenic factor. J Atheroscler Thromb. 2004;11:41-48. Noguchi S, Yatera K, Wang KY, Oda K, Akata K, Yamasaki K, Kawanami T, Ishimoto H, Toyohira Y, Shimokawa H, Yanagihara N, Tsutsui M, Mukae H. Nitric oxide exerts protective effects againstbleomycin-induced pulmonary fibrosis in mice. Respir Res. 2014;15:92. Shoji T, Abe T, Matsuo H, Egusa G, Yamasaki Y, Kashihara N, Shirai K, Kashiwagi A. Chronic kidneydisease, dyslipidemia, and atherosclerosis. J Atheroscler Thromb. 2012;19:299-315. Shibata K, Yatera Y, Furuno Y, Sabanai K, Morisada N, Nakata S, Morishita T, Yamazaki F,Tanimoto A, Sasaguri Y, Tasaki H, Nakashima Y, Shimokawa H, Yanagihara N, Otsuji Y, Tsutsui M. Spontaneous development of left ventricular hypertrophy and diastolic dysfunction in mice lacking all nitric oxide synthases. Circ J. 2010;74: 2681-2692. Furuno Y, Morishita T, Toyohira Y, Yamada S, Ueno S, Morisada N, Sugita K, Noguchi K, Sakanashi M, Miyata H, Tanimoto A, Sasaguri Y, Shimokawa H, Otsuji Y, Yanagihara N, Tamura M, Tsutsui M. Crucial vasculoprotective role of the whole nitric oxide synthase system in vascular lesion formation in mice: Involvement of bone marrow-derived cells. Nitric Oxide. 2011;25:350-359. Furchgott RF. The role of endothelium in the responses of vascular smooth muscle to drugs. Annu Rev Pharmacol Toxicol. 1984;24:175-197. Zile MR, Brutsaert DL. New concepts in diastolic dysfunction and diastolic heart failure: Part I:diagnosis, prognosis, and measurements of diastolic function. Circulation. 2002;105:1387-1393. Tsutsui M, Nakata S, Shimokawa H, Otsuji Y, Yanagihara N. Spontaneous myocardial infarction and nitric oxide synthase. Trends Cardiovasc Med. 2008;18:275-279. Nakamura K, Okamura T, Hayakawa T, Kadowaki T, Kita Y, Okayama A, Ueshima H. Electrocardiogram screening for left high R-wave predicts cardiovascular death in a Japanese community-based population: NIPPON DATA90. Hypertens Res. 2006;29:353-360. Kubota H, Noguchi K, Matsuzaki T, Hattori F, Sakanashi M, Kina-Tanada M, Uchida T, Nakasone J, Shimokawa H, Ohya Y, Kakinohana M, Sugahara S, Tsutsui M. Complete disruption of all nitric oxide synthase genes markedly reduces cerebral infarct size after middle cerebral artery occlusion in mice. Circ J. 2014;78(Suppl. I):I-853. Lamping KG, Nuno DW, Shesely EG, Maeda N, Faraci FM. Vasodilator mechanisms in the coronary circulation of endothelial nitric oxide synthase-deficient mice. Am J Physiol Heart Circ Physiol.2000;279:H1906-1912. Morrissey JJ, Ishidoya S, McCracken R, Klahr S. Nitric oxide generation ameliorates thetubulointerstitial fibrosis of obstructive nephropathy. J Am Soc Nephrol. 1996;7:2202-2212. Murad F. What are the molecular mechanisms for the antiproliferative effects of nitric oxide and cGMP in vascular smooth muscle? Circulation. 1997;95: 1101-1103. Nakata S |
| References_xml | – reference: Forstermann U, Boissel JP, Kleinert H. Expressional control of the 'constitutive' isoforms of nitric oxide synthase (NOS I and NOS III). FASEB J. 1998;12: 773-790. – reference: Yamamoto K, Sakata Y, Ohtani T, Takeda Y, Mano T. Heart failure with preserved ejectionfraction. Circ J. 2009;73:404-410. – reference: Uchida T, Furuno Y, Tanimoto A, Toyohira Y, Arakaki K, Kina-Tanada M, Kubota H, Sakanashi M,Matsuzaki T, Noguchi K, Nakasone J, Igarashi T, Ueno S, Matsushita M, Ishiuchi S, Masuzaki H, Ohya Y, Yanagihara N, Shimokawa H, Otsuji Y, Tamura M, Tsutsui M. Development of an xperimentally useful model of acute myocardial infarction: 2/3 nephrectomized triple nitric oxide synthases-deficient mouse. J Mol Cell Cardiol. 2014;77:29-41. – reference: Huang A, Sun D, Shesely EG, Levee EM, Koller A, Kaley G. Neuronal NOS-dependent dilation to flow in coronary arteries of male eNOS-KO mice. Am J Physiol Heart Circ Physiol. 2002;282:H429-436. – reference: Morishita T, Tsutsui M, Shimokawa H, Sabanai K,Tasaki H, Suda O, Nakata S, Tanimoto A, Wang KY,Ueta Y, Sasaguri Y, Nakashima Y, Yanagihara N. Nephrogenic diabetes insipidus in mice lacking all nitric oxide synthase isoforms. Proc Natl Acad Sci U S A. 2005;102:10616-10621. – reference: Wilcox JN, Subramanian RR, Sundell CL, Tracey WR, Pollock JS, Harrison DG, Marsden PA. Expression of multiple isoforms of nitric oxide synthase in normal and atherosclerotic vessels. Arterioscler. Thromb. Vasc. Biol. 1997;17:2479-2488. – reference: Murad F. What are the molecular mechanisms for the antiproliferative effects of nitric oxide and cGMP in vascular smooth muscle? Circulation. 1997;95: 1101-1103. – reference: Thomas G, Ramwell PW. NW-nitro-L-arginine benzyl ester, a potent irreversible inhibitor of endothelium dependent relaxation. Biochem. Biophys. Res. Commun. 1991;179:1677-1682. – reference: Shimokawa H, Tsutsui M. Nitric oxide synthases in the pathogenesis of cardiovascular disease: lessons from genetically modified mice. Pflugers Arch. 2010; 459:959-967. – reference: Akata K, Yatera K, Wang KY, Naito K, Ogoshi T, Noguchi S, Kido T, Toyohira Y, Shimokawa H,Yanagihara N, Tsutsui M, Mukae H. Decreased Bronchial Eosinophilic Inflammation and MucusHypersecretion in Asthmatic Mice Lacking All Nitric Oxide Synthase Isoforms. Lung. 2016;194:121-124. – reference: Miyajima A, Chen J, Poppas DP, Vaughan ED, Jr., Felsen D. Role of nitric oxide in renal tubularapoptosis of unilateral ureteral obstruction. Kidney Int. 2001;59:1290-1303. – reference: Kubota H, Noguchi K, Matsuzaki T, Hattori F, Sakanashi M, Kina-Tanada M, Uchida T, Nakasone J, Shimokawa H, Ohya Y, Kakinohana M, Sugahara S, Tsutsui M. Complete disruption of all nitric oxide synthase genes markedly reduces cerebral infarct size after middle cerebral artery occlusion in mice. Circ J. 2014;78(Suppl. I):I-853. – reference: Kuncio GS, Neilson EG, Haverty T. Mechanisms of tubulointerstitial fibrosis. Kidney Int. 1991;39:550-556. – reference: Heim KF, Thomas G, Ramwell PW. Effect of substituted arginine compounds on superoxide production in the rabbit aorta. J. Pharmacol. Exp. Ther. 1991;257:1130-1135. – reference: Furuno Y, Morishita T, Toyohira Y, Yamada S, Ueno S, Morisada N, Sugita K, Noguchi K, Sakanashi M, Miyata H, Tanimoto A, Sasaguri Y, Shimokawa H, Otsuji Y, Yanagihara N, Tamura M, Tsutsui M. Crucial vasculoprotective role of the whole nitric oxide synthase system in vascular lesion formation in mice: Involvement of bone marrow-derived cells. Nitric Oxide. 2011;25:350-359. – reference: Shoji T, Abe T, Matsuo H, Egusa G, Yamasaki Y, Kashihara N, Shirai K, Kashiwagi A. Chronic kidneydisease, dyslipidemia, and atherosclerosis. J Atheroscler Thromb. 2012;19:299-315. – reference: Matsuzawa Y, Funahashi T, Kihara S, Shimomura I. Adiponectin and metabolic syndrome. Arterioscler Thromb Vasc Biol. 2004;24:29-33. – reference: Morishita T, Tsutsui M, Shimokawa H, Horiuchi M, Tanimoto A, Suda O, Tasaki H, Huang PL,Sasaguri Y, Yanagihara N, Nakashima Y. Vasculoprotective roles of neuronal nitric oxide synthase. FASEB J. 2002;16:1994-1996. – reference: Nakata S, Tsutsui M, Shimokawa H, Suda O, Morishita T, Shibata K, Yatera Y, Sabanai K,Tanimoto A, Nagasaki M, Tasaki H, Sasaguri Y, Nakashima Y, Otsuji Y, Yanagihara N. Spontaneousmyocardial infarction in mice lacking all nitric oxide synthase isoforms. Circulation. 2008;117:2211-2223. – reference: Ho KK, Pinsky JL, Kannel WB, Levy D. The epidemiology of heart failure: the Framingham Study. J. Am. Coll. Cardiol. 1993;22:6A-13A. – reference: Tsutsui M. Neuronal nitric oxide synthase as a novel anti-atherogenic factor. J Atheroscler Thromb. 2004;11:41-48. – reference: Son H, Hawkins RD, Martin K, Kiebler M, Huang PL, Fishman MC, Kandel ER. Long-term otentiationis reduced in mice that are doubly mutant in endothelial and neuronal nitric oxide synthase. Cell.1996;87:1015-1023. – reference: Sasaguri Y, Wang KY, Tanimoto A, Tsutsui M, Ueno H, Murata Y, Kohno Y, Yamada S, Ohtsu H.Role of histamine produced by bone marrow-derived vascular cells in pathogenesis of atherosclerosis. Circ Res. 2005;96:974-981. – reference: Ignarro LJ. Biosynthesis and metabolism of endothelium-derived nitric oxide. Annu. Rev.Pharmacol. Toxicol. 1990;30:535-560. – reference: Laine P, Kaartinen M, Penttila A, Panula P, Paavonen T, Kovanen PT. Association betweenmyocardial infarction and the mast cells in the adventitia of the infarct-related coronary artery.Circulation. 1999;99:361-369. – reference: Dudzinski DM, Igarashi J, Greif D, Michel T. The regulation and pharmacology of endothelial nitric oxide synthase. Annu Rev Pharmacol Toxicol. 2006; 46:235-276. – reference: Lamping KG, Nuno DW, Shesely EG, Maeda N, Faraci FM. Vasodilator mechanisms in the coronary circulation of endothelial nitric oxide synthase-deficient mice. Am J Physiol Heart Circ Physiol.2000;279:H1906-1912. – reference: Kasten TP, Collin-Osdoby P, Patel N, Osdoby P, Krukowski M, Misko TP, Settle SL, Currie MG,Nickols GA. Potentiation of osteoclast bone- resorption activity by inhibition of nitric oxidesynthase. Proc Natl Acad Sci U S A. 1994;91:3569-3573. – reference: Zile MR, Brutsaert DL. New concepts in diastolic dysfunction and diastolic heart failure: Part I:diagnosis, prognosis, and measurements of diastolic function. Circulation. 2002;105:1387-1393. – reference: Tsutsui M, Shimokawa H, Otsuji Y, Yanagihara N. Pathophysiological relevance of NO signaling in the cardiovascular system: novel insight from mice lacking all NO synthases. Pharmacol Ther. 2010; 128:499-508. – reference: Riancho JA, Salas E, Zarrabeitia MT, Olmos JM, Amado JA, Fernandez-Luna JL, Gonzalez-Macias J. Expression and functional role of nitric oxide synthase in osteoblast-like cells. J Bone Miner Res. 1995;10:439-446. – reference: Bredt DS, Snyder SH. Nitric oxide: a physiological messenger molecule. Annu. Rev. Biochem. 1994;63: 175-195. – reference: Kamezaki F, Tsutsui M, Takahashi M, Sonoda S, Kubo T, Fujino Y, Adachi T, Abe H, Takeuchi M,Mayumi T, Otsuji Y. Plasma levels of nitric oxide metabolites are markedly reduced in normotensive men with electrocardiographically determined left ventricular hypertrophy. Hypertension. 2014;64:516- 522. – reference: Suda O, Tsutsui M, Morishita T, Tasaki H, Ueno S, Nakata S, Tsujimoto T, Toyohira Y, Hayashida Y, Sasaguri Y, Ueta Y, Nakashima Y, Yanagihara N. Asymmetric dimethylarginine produces vascular lesions in endothelial nitric oxide synthase-deficient mice. Arterioscler Thromb Vasc Biol. 2004;24:1682- 1688. – reference: Buxton ILO, Cheek DJ, Eckman D, Westfall DP, Sanders KM, Keef KD. NG-nitro-L-arginine methyl ester and other alkyl esters of arginine are muscarinic receptor antagonists. Circ. Res. 1993;72: 387-395. – reference: Moroi M, Zhang L, Yasuda T, Virmani R, Gold HK,Fishman MC, Huang PL. Interaction of geneticdeficiency of endothelial nitric oxide, gender, and pregnancy in vascular response to injury in mice. J. Clin. Invest. 1998;101:1225-1232. – reference: Matoba T, Shimokawa H, Kubota H, Morikawa K, Fujiki T, Kunihiro I, Mukai Y, Hirakawa Y, Takeshita A. Hydrogen peroxide is an endothelium- derived hyperpolarizing factor in human mesenteric arteries. Biochem Biophys Res Commun. 2002;290: 909-913. – reference: Matoba T, Shimokawa H, Nakashima M, Hirakawa Y, Mukai Y, Hirano K, Kanaide H, Takeshita A.Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in mice [In Process Citation]. J Clin Invest. 2000;106:1521-1530. – reference: Tsutsui M, Nakata S, Shimokawa H, Otsuji Y, Yanagihara N. Spontaneous myocardial infarction and nitric oxide synthase. Trends Cardiovasc Med. 2008;18:275-279. – reference: Miyazaki-Anzai S, Levi M, Kratzer A, Ting TC, Lewis LB, Miyazaki M. Farnesoid X receptoractivation prevents the development of vascular calcification in ApoE-/- mice with chronic kidneydisease. Circ Res. 2010;106:1807-1817. – reference: Ninomiya T, Kiyohara Y, Tokuda Y, Doi Y, Arima H, Harada A, Ohashi Y, Ueshima H. Impact ofkidney disease and blood pressure on the development of cardiovascular disease: an overviewfrom the Japan Arteriosclerosis Longitudinal Study. Circulation. 2008;118:2694-2701. – reference: Noguchi S, Yatera K, Wang KY, Oda K, Akata K, Yamasaki K, Kawanami T, Ishimoto H, Toyohira Y, Shimokawa H, Yanagihara N, Tsutsui M, Mukae H. Nitric oxide exerts protective effects againstbleomycin-induced pulmonary fibrosis in mice. Respir Res. 2014;15:92. – reference: Ortiz PA, Garvin JL. Cardiovascular and renal control in NOS-deficient mouse models. Am J Physiol Regul Integr Comp Physiol. 2003;284:R628-638. – reference: 53.Yatera Y, Shibata K, Furuno Y, Sabanai K,Morisada N, Nakata S, Morishita T, Toyohira Y,Wang KY, Tanimoto A, Sasaguri Y, Tasaki H,Nakashima Y, Shimokawa H, Yanagihara N, Otsuji Y, Tsutsui M. Severe Dyslipidemia, Atherosclerosis, and Sudden Cardiac Death in Mice Lacking All NO Synthases Fed a High-Fat Diet. Cardiovasc Res. 2010;87:675-682. – reference: Morisada N, Nomura M, Nishii H, Furuno Y, Sakanashi M, Sabanai K, Toyohira Y, Ueno S,Watanabe S, Tamura M, Matsumoto T, Tanimoto A, Sasaguri Y, Shimokawa H, Kusuhara K, Yanagihara N, Shirahata A, Tsutsui M. Complete disruption of all nitric oxide synthase genes causes markedly accelerated renal lesion formation following unilateral ureteral obstruction in mice in vivo. J Pharmacol Sci. 2010;114:379-389. – reference: Ninomiya T, Kiyohara Y, Kubo M, Tanizaki Y, Doi Y, Okubo K, Wakugawa Y, Hata J, Oishi Y, Shikata K, Yonemoto K, Hirakata H, Iida M. Chronic kidney disease and cardiovascular disease in a generalJapanese population: the Hisayama Study. Kidney Int. 2005;68:228-236. – reference: Pelletier CC, Koppe L, Croze ML, Kalbacher E, Vella RE, Guebre-Egziabher F, Geloen A, Badet L, Fouque D, Soulage CO. White adipose tissue overproduces the lipid-mobilizing factor zinc alpha2-glycoprotein in chronic kidney disease. Kidney Int. 2013;83:878-886. – reference: Brandi ML, Hukkanen M, Umeda T, Moradi- Bidhendi N, Bianchi S, Gross SS, Polak JM,MacIntyre I. Bidirectional regulation of osteoclast function by nitric oxide synthase isoforms. Proc Natl Acad Sci U S A. 1995;92:2954-2958. – reference: Takaki A, Morikawa K, Tsutsui M, Murayama Y, Tekes E, Yamagishi H, Ohashi J, Yada T, Yanagihara N, Shimokawa H. Crucial role of nitric oxide synthases system in endothelium-dependent hyperpolarization in mice. J Exp Med. 2008;205:2053- 2063. – reference: Sabanai K, Tsutsui M, Sakai A, Hirasawa H, Tanaka S, Nakamura E, Tanimoto A, Sasaguri Y, ItoM, Shimokawa H, Nakamura T, Yanagihara N. Genetic disruption of all NO synthase isoformsenhances BMD and bone turnover in mice in vivo: involvement of the renin-angiotensin system. J Bone Miner Res. 2008;23:633-643. – reference: Shimokawa H. Primary endothelial dysfunction:atherosclerosis. J. Mol. Cell Cardiol. 1999;31:23-37. – reference: Shibata K, Yatera Y, Furuno Y, Sabanai K, Morisada N, Nakata S, Morishita T, Yamazaki F,Tanimoto A, Sasaguri Y, Tasaki H, Nakashima Y, Shimokawa H, Yanagihara N, Otsuji Y, Tsutsui M. Spontaneous development of left ventricular hypertrophy and diastolic dysfunction in mice lacking all nitric oxide synthases. Circ J. 2010;74: 2681-2692. – reference: Nakamura K, Okamura T, Hayakawa T, Kadowaki T, Kita Y, Okayama A, Ueshima H. Electrocardiogram screening for left high R-wave predicts cardiovascular death in a Japanese community-based population: NIPPON DATA90. Hypertens Res. 2006;29:353-360. – reference: Suda O, Tsutsui M, Morishita T, Tanimoto A, Horiuchi M, Tasaki H, Huang PL, Sasaguri Y, Yanagihara N, Nakashima Y. Long-term treatment with N(omega)-nitro-L-arginine methyl ester causes arteriosclerotic coronary lesions in endothelial nitric oxide synthase-deficient mice. Circulation. 2002;106: 1729-1735. – reference: Moncada S, Palmer RMJ, Higgs EA. Nitric oxide:physiology, pathophysiology, and pharmacology.Pharmacol. Rev. 1991;43:109-142. – reference: Buchwalow IB, Podzuweit T, Bocker W, Samoilova VE, Thomas S, Wellner M, Baba HA, Robenek H, Schnekenburger J, Lerch MM. Vascular smooth muscle and nitric oxide synthase. FASEB J. 2002; 16:500-508. – reference: Peterson DA, Peterson DC, Archer S, Weir EK. The nonspecificity of specific nitric oxide synthase inhibitors. Biochem. Biophys. Res. Commun. 1992; 187:797-801. – reference: Ishikawa J, Ishikawa S, Kabutoya T, Gotoh T, Kayaba K, Schwartz JE, Pickering TG, Shimada K,Kario K. Cornell product left ventricular hypertrophy in electrocardiogram and the risk of stroke in a general population. Hypertension. 2009;53:28-34. – reference: Nakata S, Tsutsui M, Shimokawa H, Yamashita T, Tanimoto A, Tasaki H, Ozumi K, Sabanai K, Morishita T, Suda O, Hirano H, Sasaguri Y, Nakashima Y, Yanagihara N. Statin treatment upregulates vascular neuronal nitric oxide synthase through Akt/NF- kappaB pathway. Arterioscler Thromb Vasc Biol. 2007;27:92-98. – reference: Morrissey JJ, Ishidoya S, McCracken R, Klahr S. Nitric oxide generation ameliorates thetubulointerstitial fibrosis of obstructive nephropathy. J Am Soc Nephrol. 1996;7:2202-2212. – reference: Nakata S, Tsutsui M, Shimokawa H, Tamura M, Tasaki H, Morishita T, Suda O, Ueno S, Toyohira Y, Nakashima Y, Yanagihara N. Vascular neuronal NO synthase is selectively upregulated by platelet- derived growth factor. Arterioscler Thromb Vasc Biol. 2005. – reference: Tsutsui M, Shimokawa H, Otsuji Y, Ueta Y, Sasaguri Y, Yanagihara N. Nitric oxide synthases and cardiovascular diseases: insights from genetically modified mice. Circ J. 2009;73:986-993. – reference: MacPherson H, Noble BS, Ralston SH. Expression and functional role of nitric oxide synthase isoforms in human osteoblast-like cells. Bone. 1999;24:179-185. – reference: Duplain H, Burcelin R, Sartori C, Cook S, Egli M, Lepori M, Vollenweider P, Pedrazzini T, Nicod P, Thorens B, Scherrer U. Insulin resistance, hyperlipidemia, and hypertension in mice lacking endothelial nitric oxide synthase. Circulation. 2001; 104:342-345. – reference: Furchgott RF. The role of endothelium in the responses of vascular smooth muscle to drugs. Annu Rev Pharmacol Toxicol. 1984;24:175-197. |
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