腹腔鏡による腎盂尿管癌手術の成績と課題(長期予後,非再発率,膀胱再発)
腹腔鏡による腎盂・尿管癌手術は,1991年の登場以来多くの施設で行われるようになった.かつては,低侵襲手術として腹腔鏡下手術が優先される傾向にあったが,近年再び,開創手術が見直されている.腎癌に対する腎摘除術において,腹腔鏡手術か開創手術か,ではなく,全摘除術か部分切除術かと議論されることに比較すると,きわめて対照的である.これは,腎摘除術が腹腔鏡手術で行われるのは,cT3a程度の腎癌までであり,比較的早期癌を対象とした手術であること,また,局所進行性腎癌になると合併切除の可能性などにより腹腔鏡下手術では切除困難と判断されるケースがほとんどであることによる.腎盂・尿管癌においては,局所進行癌(...
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| Published in | Japanese Journal of Endourology Vol. 29; no. 1; pp. 80 - 84 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | Japanese |
| Published |
日本泌尿器内視鏡学会
2016
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 2186-1889 2187-4700 |
| DOI | 10.11302/jsejje.29.80 |
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| Abstract | 腹腔鏡による腎盂・尿管癌手術は,1991年の登場以来多くの施設で行われるようになった.かつては,低侵襲手術として腹腔鏡下手術が優先される傾向にあったが,近年再び,開創手術が見直されている.腎癌に対する腎摘除術において,腹腔鏡手術か開創手術か,ではなく,全摘除術か部分切除術かと議論されることに比較すると,きわめて対照的である.これは,腎摘除術が腹腔鏡手術で行われるのは,cT3a程度の腎癌までであり,比較的早期癌を対象とした手術であること,また,局所進行性腎癌になると合併切除の可能性などにより腹腔鏡下手術では切除困難と判断されるケースがほとんどであることによる.腎盂・尿管癌においては,局所進行癌(cT3,腎盂癌であればcT4でも)であっても,長期のoncological outcomeは別にして,surgical margin陰性を腹腔鏡で達成しようとすれば手技的には可能である.近年,リンパ節郭清の重要性が明らかになりつつあり,腹腔鏡による腎尿管全摘除術の長期成績が再評価されている.しかし,腹腔鏡下手術による低侵襲性の恩恵を受ける患者が多く存在することも事実であり,すべての症例で開創手術がよいわけでもない.適切な症例を選択し,適切な手術方法で行うことが腹腔鏡下手術においては必要である.本稿では,そのヒントとして腹腔鏡下腎尿管全摘除術の成績と課題(とくに長期予後,非再発率,膀胱再発)について検討した. |
|---|---|
| AbstractList | 腹腔鏡による腎盂・尿管癌手術は,1991年の登場以来多くの施設で行われるようになった.かつては,低侵襲手術として腹腔鏡下手術が優先される傾向にあったが,近年再び,開創手術が見直されている.腎癌に対する腎摘除術において,腹腔鏡手術か開創手術か,ではなく,全摘除術か部分切除術かと議論されることに比較すると,きわめて対照的である.これは,腎摘除術が腹腔鏡手術で行われるのは,cT3a程度の腎癌までであり,比較的早期癌を対象とした手術であること,また,局所進行性腎癌になると合併切除の可能性などにより腹腔鏡下手術では切除困難と判断されるケースがほとんどであることによる.腎盂・尿管癌においては,局所進行癌(cT3,腎盂癌であればcT4でも)であっても,長期のoncological outcomeは別にして,surgical margin陰性を腹腔鏡で達成しようとすれば手技的には可能である.近年,リンパ節郭清の重要性が明らかになりつつあり,腹腔鏡による腎尿管全摘除術の長期成績が再評価されている.しかし,腹腔鏡下手術による低侵襲性の恩恵を受ける患者が多く存在することも事実であり,すべての症例で開創手術がよいわけでもない.適切な症例を選択し,適切な手術方法で行うことが腹腔鏡下手術においては必要である.本稿では,そのヒントとして腹腔鏡下腎尿管全摘除術の成績と課題(とくに長期予後,非再発率,膀胱再発)について検討した. |
| Author | 佐々, 直人 後藤, 百万 |
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| References | 4) Waldert M, Remzi M, Klingler HC, et al. (2009) The oncological results of laparoscopic nephroureterectomy for upper urinary tract transitional cell cancer are equal to those of open nephroureterectomy. BJU Int. : 103 : 66-70 16) Terakawa T MH, Hara I, Takenaka A, et al. (2008) Retroperitoneoscopic nephroureterectomy for upper urinary tract cancer : a comparative study with conventional open retroperitoneal nephroureterectomy. J of Endourol : 22 : 1693-9 21) Yuan H, Chen X, Liu L, et al. (2014) Risk factors for intravesical recurrence after radical nephroureterectomy for upper tract urothelial carcinoma : a metaanalysis. Urol Oncolt : 32 : 989-1002 2) Greco F, Wagner S, Hoda RM, et al. (2009) Laparoscopic vs open radical nephroureterectomy for upper urinary tract urothelial cancer : oncological outcomes and 5-year follow-up. BJU Int. : 104 : 1274-8 1) Clayman RV KL, Figenshau RS, Chandhoke PS, et al. (1991) Laparoscopic nephroureterectomy : initial clinical case report. J Laparoendosc Surg. : 1 : 343-9 13) Roscigno M, Cozzarini C, Bertini R, et al. (2008) Prognostic value of lymph node dissection in patients with muscle-invasive transitional cell carcinoma of the upper urinary tract. Eur Urol : 53 : 794-802 20) Kamihira O, Hattori R, Yamaguchi A, et al. (2009) Laparoscopic radical nephroureterectomy : a multicenter analysis in Japan. Eur Urol : 55 : 1397-407 9) Simone G, Papalia R, Guaglianone S, et al. (2009) Laparoscopic versus open nephroureterectomy : perioperative and oncologic outcomes from a randomised prospective study. Eur Urol : 56 : 520-6 17) Kim HS, Ku JH, Jeong CW, Kwak C, et al. (2015) Laparoscopic radical nephroureterectomy is associated with worse survival outcomes than open radical nephroureterectomy in patients with locally advanced upper tract urothelial carcinoma. World J Urol in press 14) 腎盂・尿管癌診療ガイドライン作成委員会. (2014) 腎盂・尿管癌診療ガイドライン2014年版. 7) Ni S, Tao W, Chen Q, et al. (2012) Laparoscopic versus open nephroureterectomy for the treatment of upper urinary tract urothelial carcinoma : a systematic review and cumulative analysis of comparative studies. Eur Urol. : 61 : 1142-53 10) Roscigno M, Shariat SF, Margulis V, et al. (2009) Impact of lymph node dissection on cancer specific survival in patients with upper tract urothelial carcinoma treated with radical nephroureterectomy. J Urol : 181 : 2482-9 5) Favaretto RL, Shariat SF, Chade DC, et al. (2010) Comparison between laparoscopic and open radical nephroureterectomy in a contemporary group of patients : are recurrence and disease-specific survival associated with surgical technique? Eur Uro. : 58 : 645-51 11) Roscigno M, Shariat SF, Margulis V, et al. (2009) The extent of lymphadenectomy seems to be associated with better survival in patients with nonmetastatic upper-tract urothelial carcinoma : how many lymph nodes should be removed? Eur Urol : 56 : 512-8 8) Fairey AS, Kassouf W, Estey E, et al. (2013) Comparison of oncological outcomes for open and laparoscopic radical nephroureterectomy : results from the Canadian Upper Tract Collaboration. BJU Int. : 112 : 791-7 12) Kondo T, Tanabe K. (2012) Role of lymphadenectomy in the management of urothelial carcinoma of the bladder and the upper urinary tract. Int J Urol : 19 : 710-21 19) Blackmur JP, Stewart GD, Egong EA, et al. (2015) Matched-pair analysis of open versus laparoscopic nephroureterectomy for upper urinary tract urothelial cell carcinoma. Urol Int : 94 : 156-62 3) Manabe D, Saika T, Ebara S, et al. (2007) Comparative study of oncologic outcome of laparoscopic nephroureterectomy and standard nephroureterectomy for upper urinary tract transitional cell carcinoma. Urology. : 69 : 457-61 6) Capitanio U, Shariat SF, Isbarn H, et al. (2009) Comparison of oncologic outcomes for open and laparoscopic nephroureterectomy : a multi-institutional analysis of 1249 cases. Eur Uro. : 56 : 1-9 15) Roupret M, Babjuk M, Comperat E et al. (2015) European guidelineson upper tract urothelial carcinomas : 2015 update. Eur Urol. ; 68 (5) : 868-79 18) Hanna N, Sun M, Trinh QD, et al. (2012) Propensity-score-matched comparison of perioperative outcomes between open and laparoscopic nephroureterectomy : a national series. Eur Urol : 61 : 715-21 |
| References_xml | – reference: 3) Manabe D, Saika T, Ebara S, et al. (2007) Comparative study of oncologic outcome of laparoscopic nephroureterectomy and standard nephroureterectomy for upper urinary tract transitional cell carcinoma. Urology. : 69 : 457-61 – reference: 6) Capitanio U, Shariat SF, Isbarn H, et al. (2009) Comparison of oncologic outcomes for open and laparoscopic nephroureterectomy : a multi-institutional analysis of 1249 cases. Eur Uro. : 56 : 1-9 – reference: 11) Roscigno M, Shariat SF, Margulis V, et al. (2009) The extent of lymphadenectomy seems to be associated with better survival in patients with nonmetastatic upper-tract urothelial carcinoma : how many lymph nodes should be removed? Eur Urol : 56 : 512-8 – reference: 15) Roupret M, Babjuk M, Comperat E et al. (2015) European guidelineson upper tract urothelial carcinomas : 2015 update. Eur Urol. ; 68 (5) : 868-79 – reference: 16) Terakawa T MH, Hara I, Takenaka A, et al. (2008) Retroperitoneoscopic nephroureterectomy for upper urinary tract cancer : a comparative study with conventional open retroperitoneal nephroureterectomy. J of Endourol : 22 : 1693-9 – reference: 4) Waldert M, Remzi M, Klingler HC, et al. (2009) The oncological results of laparoscopic nephroureterectomy for upper urinary tract transitional cell cancer are equal to those of open nephroureterectomy. BJU Int. : 103 : 66-70 – reference: 8) Fairey AS, Kassouf W, Estey E, et al. (2013) Comparison of oncological outcomes for open and laparoscopic radical nephroureterectomy : results from the Canadian Upper Tract Collaboration. BJU Int. : 112 : 791-7 – reference: 9) Simone G, Papalia R, Guaglianone S, et al. (2009) Laparoscopic versus open nephroureterectomy : perioperative and oncologic outcomes from a randomised prospective study. Eur Urol : 56 : 520-6 – reference: 20) Kamihira O, Hattori R, Yamaguchi A, et al. (2009) Laparoscopic radical nephroureterectomy : a multicenter analysis in Japan. Eur Urol : 55 : 1397-407 – reference: 19) Blackmur JP, Stewart GD, Egong EA, et al. (2015) Matched-pair analysis of open versus laparoscopic nephroureterectomy for upper urinary tract urothelial cell carcinoma. Urol Int : 94 : 156-62 – reference: 2) Greco F, Wagner S, Hoda RM, et al. (2009) Laparoscopic vs open radical nephroureterectomy for upper urinary tract urothelial cancer : oncological outcomes and 5-year follow-up. BJU Int. : 104 : 1274-8 – reference: 18) Hanna N, Sun M, Trinh QD, et al. (2012) Propensity-score-matched comparison of perioperative outcomes between open and laparoscopic nephroureterectomy : a national series. Eur Urol : 61 : 715-21 – reference: 21) Yuan H, Chen X, Liu L, et al. (2014) Risk factors for intravesical recurrence after radical nephroureterectomy for upper tract urothelial carcinoma : a metaanalysis. Urol Oncolt : 32 : 989-1002 – reference: 13) Roscigno M, Cozzarini C, Bertini R, et al. (2008) Prognostic value of lymph node dissection in patients with muscle-invasive transitional cell carcinoma of the upper urinary tract. Eur Urol : 53 : 794-802 – reference: 5) Favaretto RL, Shariat SF, Chade DC, et al. (2010) Comparison between laparoscopic and open radical nephroureterectomy in a contemporary group of patients : are recurrence and disease-specific survival associated with surgical technique? Eur Uro. : 58 : 645-51 – reference: 12) Kondo T, Tanabe K. (2012) Role of lymphadenectomy in the management of urothelial carcinoma of the bladder and the upper urinary tract. Int J Urol : 19 : 710-21 – reference: 17) Kim HS, Ku JH, Jeong CW, Kwak C, et al. (2015) Laparoscopic radical nephroureterectomy is associated with worse survival outcomes than open radical nephroureterectomy in patients with locally advanced upper tract urothelial carcinoma. World J Urol in press – reference: 1) Clayman RV KL, Figenshau RS, Chandhoke PS, et al. (1991) Laparoscopic nephroureterectomy : initial clinical case report. J Laparoendosc Surg. : 1 : 343-9 – reference: 14) 腎盂・尿管癌診療ガイドライン作成委員会. (2014) 腎盂・尿管癌診療ガイドライン2014年版. – reference: 10) Roscigno M, Shariat SF, Margulis V, et al. (2009) Impact of lymph node dissection on cancer specific survival in patients with upper tract urothelial carcinoma treated with radical nephroureterectomy. J Urol : 181 : 2482-9 – reference: 7) Ni S, Tao W, Chen Q, et al. (2012) Laparoscopic versus open nephroureterectomy for the treatment of upper urinary tract urothelial carcinoma : a systematic review and cumulative analysis of comparative studies. Eur Urol. : 61 : 1142-53 |
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| SubjectTerms | 尿管癌 腎盂癌 腹腔鏡下腎尿管全摘除術 膀胱再発 開創腎尿管全摘除術 |
| Title | 腹腔鏡による腎盂尿管癌手術の成績と課題(長期予後,非再発率,膀胱再発) |
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