利尿ペプチド
ナトリウム利尿ペプチドは 1984 年に寒川・松尾らによって分離同定され，利尿・血管拡張効果，レニンアンギオテンシン系 (RAS) 抑制効果，心筋線維化抑制などさまざまな効果が認められている．当施設においては，術中からの低容量持続投与により人工心肺の欠点を克服することにより非常に良好な結果を認めており，心臓手術におけるスタンダードとなっている．...
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| Published in | 日大医学雑誌 Vol. 72; no. 5; pp. 258 - 259 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
日本大学医学会
01.10.2013
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0029-0424 1884-0779 |
| DOI | 10.4264/numa.72.258 |
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| Abstract | ナトリウム利尿ペプチドは 1984 年に寒川・松尾らによって分離同定され，利尿・血管拡張効果，レニンアンギオテンシン系 (RAS) 抑制効果，心筋線維化抑制などさまざまな効果が認められている．当施設においては，術中からの低容量持続投与により人工心肺の欠点を克服することにより非常に良好な結果を認めており，心臓手術におけるスタンダードとなっている． |
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| AbstractList | ナトリウム利尿ペプチドは 1984 年に寒川・松尾らによって分離同定され，利尿・血管拡張効果，レニンアンギオテンシン系 (RAS) 抑制効果，心筋線維化抑制などさまざまな効果が認められている．当施設においては，術中からの低容量持続投与により人工心肺の欠点を克服することにより非常に良好な結果を認めており，心臓手術におけるスタンダードとなっている． |
| Author | 和久井, 真司 塩野, 元美 瀬在, 明 |
| Author_xml | – sequence: 1 fullname: 瀬在, 明 organization: 日本大学医学部外科学系心臓血管・呼吸器・総合外科学分野 – sequence: 1 fullname: 和久井, 真司 organization: 日本大学医学部外科学系心臓血管・呼吸器・総合外科学分野 – sequence: 1 fullname: 塩野, 元美 organization: 日本大学医学部外科学系心臓血管・呼吸器・総合外科学分野 |
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| References | 13) Kitakaze M, Asakura M, Kim J, et al. Human atrial natriuretic peptide and nicorandil as adjuncts to reperfusion treatment for acute myocardial infarction (J-WIND): two randomised trials. Lancet 2007; 370: 1483. 16) Sezai A, Hata M, Wakui S, et al. Efficacy of low-dose continuous infusion of alpha-human atrial natriuretic peptide (hANP) during cardiac surgery: possibility of postoperative left ventricular remodeling effect. Circ J 2006; 70: 1426-1431. 17) Sezai A, Hata M, Wakui S, et al. Efficacy of Continuous Low-Dose hANP Administration in Patients Undergoing Emergent Coronary Artery Bypass Grafting for Acute Coronary Syndrome. Circ J 2007; 71: 1401-1407. 10) Tokudome T, Horio T, Kishimoto I, et al. Calcineurin-nuclear factor of activated T cells pathway-dependent cardiac remodeling in mice atrial and brain natriuretic peptides. Circulation 2005; 111: 3095-3104. 18) Sezai A, Hata M, Niino T, et al. Continuous low-dose infusion of human atrial natriuretic peptide in patients with left ventricular dysfunction undergoing coronary artery bypass grafting: the NU-HIT (Nihon University working group study of low-dose Human ANP Infusion Therapy during cardiac surgery for left ventricular dysfunction. J Am Coll Cardiol 2010; 55: 1844-1851. 3) Weder AB, Sekkarie MA, Takiyyuddin M, et al. Antihypertensive and hypotensive effects of atrial natriuretic factor in men. Hypertension 1987; 10: 582-589. 4) Wedel B, Garbers D. The guanylyl cyclase family at Y2K. Annu Rev Physiol 2001; 63: 215-233. 15) Mentzer RM Jr, Oz MC, Sladen RN, et al. Effects of perio-peraive nesiritide in patients with left ventricular dysfunction undergoing cardiac surgery: the NAPA Trial. J Am Coll Cardiol 2007; 49: 716-726. 9) Li Y, Kishimoto I, Saito Y, et al. Guanylylcyclase-A inhibits angiotensin II type 1A receptor-mediated cardiac remodeling, an endogenous protective mechanism in the heart. Circulation 2002; 106: 1722-1728. 7) Mizuno Y, Yoshimura M, Yasue H, et al. Aldosterone production is activated in failing ventricle in humans. Circulation 2001; 103 (1): 72-77. 12) Sezai A, Hata M, Niino T, et al. Results of low-dose human atrial natriuretic peptide infusion in nondialysis patients with chronic kidney disease undergoing coronary artery bypass grafting. J Am Coll Cardiol 2011; 58: 897-901. 8) Kishimoto I, Rossi K, Garbers DL. Agenetic model provides evides evidence that the receptor for atrial natriuretic peptide (guanylylcyclase-A) inhibits cardiac ventricular myocyte hypertrophy. Proc Natl Acad Sci USA 2001; 98: 2703-2706. 2) Maack T, Marion DN, Camargo MJ, et al. Effects of auriculin (atrial natriuretic factor) on blood pressure, renal function and the renin-aldosterone system in dogs. Am J Med 1984; 77: 1069-1075. 1) Kanagawa K, Matsuo H. Purification and complete amino acid sequence of alpha-human atrial natriuretic polypeptide. Biochem Biophys Res Commum 1984; 118: 131-139. 19) Sezai A, Shiono M, Orime Y, et al. Low-dose continuous infusion of human atrial natriuretic peptide during and after cardiac surgery. Ann Thorac Surg 2000; 69: 732-738. 6) Ito T, Yoshimura M, Nakamura S, et al. Inhibitory effect of natriuretic peptides on aldosterone synthase gene expression in cultured neonatal rat cardiocytes. Circulation 2003; 107: 807-810. 5) Venugopal J. Cardiac natriuretic peptides-hope or hype? J Clin Pharm Ther 2001; 26: 15-31. 22) Sezai A, Wakui S, Akiyama K, et al. Myocardial protective effect of human atrial natriuretic Peptide in cardiac surgery.--“hANP Shot” in clinical safety trial--. A Circ J 2011; 75 (9): 2144-2150. Epub 2011, Jul 14. 14) C.M. O’Connor, R.C. Starling, A.F. Hernandez, et al. Effect of Nesiritide in Patients with Acute Decompensated Heart Failure N Engl J Med 2011 Jul 7; 365 (1): 32-43. 11) Sezai A, Hata M, Niino T, et al. Influence of continuous infusion of low-dose human arterial natriuretic peptide on renal function during cardiac surgery: a randomized controlled study. J Am Coll Cardiol 2009; 54: 1058-1064. 20) Wakui S. Experimental study on myocardial protection by adjunct use of carperitide (hANP) in crdiac surgery. Ann Thorac Cardiovasc Surg 2005; 11: 12-20. 21) Wakui S, Sezai A, Tenderich G, et al. An Experimental Investigation of Direct Myocardial Protective Effect of Atrial natriuretic peptide in Cardiac Surgery-Possibility of “hANP shot” The Journal of thoracic and cardiovascular surgery 2010; 139 (4): 918-925. |
| References_xml | – reference: 19) Sezai A, Shiono M, Orime Y, et al. Low-dose continuous infusion of human atrial natriuretic peptide during and after cardiac surgery. Ann Thorac Surg 2000; 69: 732-738. – reference: 22) Sezai A, Wakui S, Akiyama K, et al. Myocardial protective effect of human atrial natriuretic Peptide in cardiac surgery.--“hANP Shot” in clinical safety trial--. A Circ J 2011; 75 (9): 2144-2150. Epub 2011, Jul 14. – reference: 6) Ito T, Yoshimura M, Nakamura S, et al. Inhibitory effect of natriuretic peptides on aldosterone synthase gene expression in cultured neonatal rat cardiocytes. Circulation 2003; 107: 807-810. – reference: 17) Sezai A, Hata M, Wakui S, et al. Efficacy of Continuous Low-Dose hANP Administration in Patients Undergoing Emergent Coronary Artery Bypass Grafting for Acute Coronary Syndrome. Circ J 2007; 71: 1401-1407. – reference: 20) Wakui S. Experimental study on myocardial protection by adjunct use of carperitide (hANP) in crdiac surgery. Ann Thorac Cardiovasc Surg 2005; 11: 12-20. – reference: 5) Venugopal J. Cardiac natriuretic peptides-hope or hype? J Clin Pharm Ther 2001; 26: 15-31. – reference: 8) Kishimoto I, Rossi K, Garbers DL. Agenetic model provides evides evidence that the receptor for atrial natriuretic peptide (guanylylcyclase-A) inhibits cardiac ventricular myocyte hypertrophy. Proc Natl Acad Sci USA 2001; 98: 2703-2706. – reference: 18) Sezai A, Hata M, Niino T, et al. Continuous low-dose infusion of human atrial natriuretic peptide in patients with left ventricular dysfunction undergoing coronary artery bypass grafting: the NU-HIT (Nihon University working group study of low-dose Human ANP Infusion Therapy during cardiac surgery for left ventricular dysfunction. J Am Coll Cardiol 2010; 55: 1844-1851. – reference: 2) Maack T, Marion DN, Camargo MJ, et al. Effects of auriculin (atrial natriuretic factor) on blood pressure, renal function and the renin-aldosterone system in dogs. Am J Med 1984; 77: 1069-1075. – reference: 10) Tokudome T, Horio T, Kishimoto I, et al. Calcineurin-nuclear factor of activated T cells pathway-dependent cardiac remodeling in mice atrial and brain natriuretic peptides. Circulation 2005; 111: 3095-3104. – reference: 4) Wedel B, Garbers D. The guanylyl cyclase family at Y2K. Annu Rev Physiol 2001; 63: 215-233. – reference: 21) Wakui S, Sezai A, Tenderich G, et al. An Experimental Investigation of Direct Myocardial Protective Effect of Atrial natriuretic peptide in Cardiac Surgery-Possibility of “hANP shot” The Journal of thoracic and cardiovascular surgery 2010; 139 (4): 918-925. – reference: 14) C.M. O’Connor, R.C. Starling, A.F. Hernandez, et al. Effect of Nesiritide in Patients with Acute Decompensated Heart Failure N Engl J Med 2011 Jul 7; 365 (1): 32-43. – reference: 16) Sezai A, Hata M, Wakui S, et al. Efficacy of low-dose continuous infusion of alpha-human atrial natriuretic peptide (hANP) during cardiac surgery: possibility of postoperative left ventricular remodeling effect. Circ J 2006; 70: 1426-1431. – reference: 3) Weder AB, Sekkarie MA, Takiyyuddin M, et al. Antihypertensive and hypotensive effects of atrial natriuretic factor in men. Hypertension 1987; 10: 582-589. – reference: 7) Mizuno Y, Yoshimura M, Yasue H, et al. Aldosterone production is activated in failing ventricle in humans. Circulation 2001; 103 (1): 72-77. – reference: 11) Sezai A, Hata M, Niino T, et al. Influence of continuous infusion of low-dose human arterial natriuretic peptide on renal function during cardiac surgery: a randomized controlled study. J Am Coll Cardiol 2009; 54: 1058-1064. – reference: 1) Kanagawa K, Matsuo H. Purification and complete amino acid sequence of alpha-human atrial natriuretic polypeptide. Biochem Biophys Res Commum 1984; 118: 131-139. – reference: 9) Li Y, Kishimoto I, Saito Y, et al. Guanylylcyclase-A inhibits angiotensin II type 1A receptor-mediated cardiac remodeling, an endogenous protective mechanism in the heart. Circulation 2002; 106: 1722-1728. – reference: 12) Sezai A, Hata M, Niino T, et al. Results of low-dose human atrial natriuretic peptide infusion in nondialysis patients with chronic kidney disease undergoing coronary artery bypass grafting. J Am Coll Cardiol 2011; 58: 897-901. – reference: 13) Kitakaze M, Asakura M, Kim J, et al. Human atrial natriuretic peptide and nicorandil as adjuncts to reperfusion treatment for acute myocardial infarction (J-WIND): two randomised trials. Lancet 2007; 370: 1483. – reference: 15) Mentzer RM Jr, Oz MC, Sladen RN, et al. Effects of perio-peraive nesiritide in patients with left ventricular dysfunction undergoing cardiac surgery: the NAPA Trial. J Am Coll Cardiol 2007; 49: 716-726. |
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