Lactobacillus reuteri含有プロバイオティクスのHelicobacter pylori抑制効果に関する検討
この研究は, Lactobacillus reuteri strain SD 2112株 (L. reuteri) のH. pylori抑制効果の検討である.今回, 我々はL. reuteri含有整腸剤 [L. reuteri錠, Reuterina (ERINA CO., INC.)] の効果について検討を行った.[検討1]H. pylori菌量とUBT値の相関: H. pylori陽性消化性潰瘍患者の33名を, Group I (低菌量群), Group II (中菌量群), Group III (高菌量群) の3群に分類し, H. pylori培養と同時に尿素呼気試験 (UBT) を行っ...
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| Published in | 感染症学雑誌 Vol. 81; no. 4; pp. 387 - 393 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
一般社団法人 日本感染症学会
2007
|
| Online Access | Get full text |
| ISSN | 0387-5911 1884-569X |
| DOI | 10.11150/kansenshogakuzasshi1970.81.387 |
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| Abstract | この研究は, Lactobacillus reuteri strain SD 2112株 (L. reuteri) のH. pylori抑制効果の検討である.今回, 我々はL. reuteri含有整腸剤 [L. reuteri錠, Reuterina (ERINA CO., INC.)] の効果について検討を行った.[検討1]H. pylori菌量とUBT値の相関: H. pylori陽性消化性潰瘍患者の33名を, Group I (低菌量群), Group II (中菌量群), Group III (高菌量群) の3群に分類し, H. pylori培養と同時に尿素呼気試験 (UBT) を行った. [検討2]L. reuteriのH. pylori抑制効果: H. pylori陽性者35名と陰性者5名に, 二重盲検法による交差試験でL. reuteri錠またはplacebo錠を内服させた.UBTは基準値として測定した内服開始8週間前の値の他, 内服開始前, 開始後4週間および8週間に検査した.[成績1]H. pylori菌量とUBT値の間には, 正の相関が見られ, Group IとGroup IIIで有意差を認めた (p<0.05). [成績2]UBTは, L. reuteri錠の内服期間 (A群+B群) で, 前値100%から69.7±40% (p<0.05) と有意に減少した. 一方で, C群 (placebo内服群) ・D群 (H.pylori陰性L. reuteri錠内服群) では変動は認めなかった.[結論]L. reuteri含有整腸剤の内服により, UBT値は有意に減少した. また, L. reuteriはH. pylori菌量も減少させる可能性が示唆された. |
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| AbstractList | この研究は, Lactobacillus reuteri strain SD 2112株 (L. reuteri) のH. pylori抑制効果の検討である.今回, 我々はL. reuteri含有整腸剤 [L. reuteri錠, Reuterina (ERINA CO., INC.)] の効果について検討を行った.[検討1]H. pylori菌量とUBT値の相関: H. pylori陽性消化性潰瘍患者の33名を, Group I (低菌量群), Group II (中菌量群), Group III (高菌量群) の3群に分類し, H. pylori培養と同時に尿素呼気試験 (UBT) を行った. [検討2]L. reuteriのH. pylori抑制効果: H. pylori陽性者35名と陰性者5名に, 二重盲検法による交差試験でL. reuteri錠またはplacebo錠を内服させた.UBTは基準値として測定した内服開始8週間前の値の他, 内服開始前, 開始後4週間および8週間に検査した.[成績1]H. pylori菌量とUBT値の間には, 正の相関が見られ, Group IとGroup IIIで有意差を認めた (p<0.05). [成績2]UBTは, L. reuteri錠の内服期間 (A群+B群) で, 前値100%から69.7±40% (p<0.05) と有意に減少した. 一方で, C群 (placebo内服群) ・D群 (H.pylori陰性L. reuteri錠内服群) では変動は認めなかった.[結論]L. reuteri含有整腸剤の内服により, UBT値は有意に減少した. また, L. reuteriはH. pylori菌量も減少させる可能性が示唆された. |
| Author | 石田, 均 田中, 昭文 徳永, 健吾 菅野, 朝 高橋, 信一 今瀬, 教人 |
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| References | 11) Kobayashi D, Eishi Y, Ohkusa T, Ishige I, Suzuki T, Minami J, et al. Gastric mucosal density of Helicobacter pylori estimated by real-time PCR compared with results of urea breath test and histological grading. J Med Microbiol 2002; 51 305-11. 26) Wu J, Wang XX, Takasaki M, Ohta A, Higuchi M, Ishimi Y: Cooperative effects of exercise training and genistein administration on bone mass in ovariectomized mice. J Bone Miner Res 2001; 16: 1829-36. 16) McGroarty JA: Probiotic use of lactobacilli in the human female urogenital tract. FEMS Immunol Med icrobiol 1993; 6: 251-64. 19) Michetti P, Dorta G, Wiesel PH, Brassart D, Verdu E, Herranz M, et al. Effect of whey-based culture supernatant of Lactobacillus acidophilus (johnsonii) Lal on Helicobacter pylori infection in humans. Digestion 1999; 60: 203-9. 2) Asaka M, Sugiyama T, Kato M, Satoh K, Kuwayama H, Fukuda Y, et al.: A multicenter, double-blind study on triple therapy with lansoprazole, amoxicillin and clarithromycin for eradication of Helicobacter pylori in Japanese peptic ulcer patients. Helicobacter 2001; 6: 254-61. 5) Suzuki J, Mine T, Kobayasi I, Fujita T: Assessment of a new triple agent regimen for the eradication of Helicobacter pylori and the nature of H. pylori resistance to this therapy in Japan. Helicobacter 1998; 3: 59-63. 18) Sakamoto I, Igarashi M, Kimura K, Takagi A, Miwa T, Koga Y: Suppressive effect of Lactobacillus gasseri OLL 2716 (LG21) on Helicobacter pylori infection in humans. J Antimicrob Chemother 2001; 47: 709-10. 13) Hazell SL, Lee A: Campylobacter pyloridis, urease, hydrogen ion back diffusion, and gastric ulcers. Lancet 1986; 5: 15-7. 25) Johnson C, Dicksved J, Jonsson H, Roos S: Anti Helicobacter pylori activity among lactic acid bacteria isolated from gastric biopsies and strains of Lactobacillus reuteri. Helicobacter 2003; 8: 473. 22) Mukai T, Asasaka T, Sato E, Mori K, Matsumoto M, Ohori H: Inhibition of binding of Helicobacter pylori to the glycolipid receptors by probiotic Lactobacillus reuteri. FEMS Immunol Med Microbiol 2002; 32: 105-10. 14) Thomsen L, Tasman-Jones C, Morris A, Wiggins P, Lee S, Forlong C: Ammonia produced by Campylobacter pylori neutralizes H+ moving through gastric mucus. Scand J Gastroenterol 1989; 24: 761-8. 3) Miwa H, Nagahara A, Sato K, Ohkura R, Murai T, Shimizu H, et al.: Efficacy of 1 week omeprazole or lansoprazole-amoxycillin-clarithromycin therapy for Helicobacter pylori infection in the Japanese population. J Gastroenterol Hepatol 1999; 14: 317-21. 12) Chen X, Haruma K, Kamada T, Mihara M, Komoto K, Yoshihara M, et al. Factors that affect results of the 13C urea breath test in Japanese patients. Helicobacter 2000; 5: 98-103. 6) Uemura N, Okamoto S, Yamamoto S: Helocobacter pylori. Infection and the development of gastric cancer. N Engl J Med 2001; 345: 829-32. 7) Ohara S, Kato M, Asaka M, Toyota T: Studies of 13C-urea breath test for diagnosis of Helicobacter pylori infection in Japan. J Gastroenterol 1998; 33: 6-13. 1) Miwa H, Ohkura R, Murai T, Sato K, Nagahara A, Hirai S, et al.: Impact of rabeprazole, a new proton pump inhibitor, in triple therapy for Helicobacter pylori infection-comparison with omeprazole and lansoprazole. Aliment Pharmacol Ther 1999; 13: 741-6. 8) Logan RP, Polson RJ, Misiewicz JJ, Rao G, Karim NQ, Newell D, et al. Simplified single sample 13Carbon urea breath test for Helicobacter pylori: comparison with histology, culture, and ELISA serology. Gut 1991; 32: 1461-4. 15) Chang YW, Min SK, Kim KJ, Han YS, Lee JH, Dong SH, et al. Delta (13) C-urea breath test value is a useful indicator for Helicobacter pylori eradication in patients with functional dyspepsia. J Gastroenterol Hepatol 2003; 18: 726-31. 24) Talarico TL, Dobrogosz WJ: Chemical characterization of an antimicrobial substance produced by Lactobacillus reuteri. Antimicrob Agents Chemother 1989; 33: 674-9. 4) Miwa H, Ohkura R, Murai T, Nagahara A, Yamada T, Ogihara T, et al.: Effectiveness of omeprazole-amoxicillin-clarithromycin (OAC) therapy for Helicobacter pylori infection in a Japanese population. Helicobacter 1998; 3132-8. 21) Valeur N, Engel P, Carbaj al N, Connolly E, Ladefoged K: Colonization and immunomodulation by Lactobacillus reuteri ATCC 55730 in the human gastrointestinal tract Appl Environ Microbiol 2004; 70: 1176-81. 17) Reid G, Bruce AW, McGroarty JA, Cheng KJ, Costerton JW: Is there a role for lactobacilli in prevention of urogenital and intestinal infections? Clin Microbiol Rev 1990; 3: 335-44. 23) Talarico TL, Casas IA, Chung TC, Dobrogosz WJ: Production and isolation of reuterin, a growth inhibitor produced by Lactobacillus reuteri. Antimicrob Agents Chemother 1988; 32: 1854-8. 10) Takahashi S, Igarashi H, Ishiyama N, Nakano M, Ozaki M, Ito M, et al. Serial change of gastric mucosa after challenging with Helicobacter pylori in the cynomolgus monkey. Zentralbl Bakteriol 1993; 280: 51-7. 20) Felley CP, Corthesy-Theulaz I, Rivero JL, Sipponen P, Kaufmann M, Bauerfeind P, et al. Favourable effect of an acidified milk (LC-1) on Helicobacter pylori gastritis in man. Eur J Gastroenterol Hepatol 2001; 13: 25-9. 9) Graham DY, Klein PD, Evans DJ Jr, Evans DG, Alpert LC, Opekun AR, et al. Campylobacter pylori detected noninvasively by the 13C-urea breath test. Lancet 1987; 23: 1174-7. |
| References_xml | – reference: 15) Chang YW, Min SK, Kim KJ, Han YS, Lee JH, Dong SH, et al. Delta (13) C-urea breath test value is a useful indicator for Helicobacter pylori eradication in patients with functional dyspepsia. J Gastroenterol Hepatol 2003; 18: 726-31. – reference: 19) Michetti P, Dorta G, Wiesel PH, Brassart D, Verdu E, Herranz M, et al. Effect of whey-based culture supernatant of Lactobacillus acidophilus (johnsonii) Lal on Helicobacter pylori infection in humans. Digestion 1999; 60: 203-9. – reference: 12) Chen X, Haruma K, Kamada T, Mihara M, Komoto K, Yoshihara M, et al. Factors that affect results of the 13C urea breath test in Japanese patients. Helicobacter 2000; 5: 98-103. – reference: 4) Miwa H, Ohkura R, Murai T, Nagahara A, Yamada T, Ogihara T, et al.: Effectiveness of omeprazole-amoxicillin-clarithromycin (OAC) therapy for Helicobacter pylori infection in a Japanese population. Helicobacter 1998; 3132-8. – reference: 10) Takahashi S, Igarashi H, Ishiyama N, Nakano M, Ozaki M, Ito M, et al. Serial change of gastric mucosa after challenging with Helicobacter pylori in the cynomolgus monkey. Zentralbl Bakteriol 1993; 280: 51-7. – reference: 8) Logan RP, Polson RJ, Misiewicz JJ, Rao G, Karim NQ, Newell D, et al. Simplified single sample 13Carbon urea breath test for Helicobacter pylori: comparison with histology, culture, and ELISA serology. Gut 1991; 32: 1461-4. – reference: 26) Wu J, Wang XX, Takasaki M, Ohta A, Higuchi M, Ishimi Y: Cooperative effects of exercise training and genistein administration on bone mass in ovariectomized mice. J Bone Miner Res 2001; 16: 1829-36. – reference: 20) Felley CP, Corthesy-Theulaz I, Rivero JL, Sipponen P, Kaufmann M, Bauerfeind P, et al. Favourable effect of an acidified milk (LC-1) on Helicobacter pylori gastritis in man. Eur J Gastroenterol Hepatol 2001; 13: 25-9. – reference: 11) Kobayashi D, Eishi Y, Ohkusa T, Ishige I, Suzuki T, Minami J, et al. Gastric mucosal density of Helicobacter pylori estimated by real-time PCR compared with results of urea breath test and histological grading. J Med Microbiol 2002; 51 305-11. – reference: 3) Miwa H, Nagahara A, Sato K, Ohkura R, Murai T, Shimizu H, et al.: Efficacy of 1 week omeprazole or lansoprazole-amoxycillin-clarithromycin therapy for Helicobacter pylori infection in the Japanese population. J Gastroenterol Hepatol 1999; 14: 317-21. – reference: 5) Suzuki J, Mine T, Kobayasi I, Fujita T: Assessment of a new triple agent regimen for the eradication of Helicobacter pylori and the nature of H. pylori resistance to this therapy in Japan. Helicobacter 1998; 3: 59-63. – reference: 7) Ohara S, Kato M, Asaka M, Toyota T: Studies of 13C-urea breath test for diagnosis of Helicobacter pylori infection in Japan. J Gastroenterol 1998; 33: 6-13. – reference: 23) Talarico TL, Casas IA, Chung TC, Dobrogosz WJ: Production and isolation of reuterin, a growth inhibitor produced by Lactobacillus reuteri. Antimicrob Agents Chemother 1988; 32: 1854-8. – reference: 13) Hazell SL, Lee A: Campylobacter pyloridis, urease, hydrogen ion back diffusion, and gastric ulcers. Lancet 1986; 5: 15-7. – reference: 16) McGroarty JA: Probiotic use of lactobacilli in the human female urogenital tract. FEMS Immunol Med icrobiol 1993; 6: 251-64. – reference: 14) Thomsen L, Tasman-Jones C, Morris A, Wiggins P, Lee S, Forlong C: Ammonia produced by Campylobacter pylori neutralizes H+ moving through gastric mucus. Scand J Gastroenterol 1989; 24: 761-8. – reference: 1) Miwa H, Ohkura R, Murai T, Sato K, Nagahara A, Hirai S, et al.: Impact of rabeprazole, a new proton pump inhibitor, in triple therapy for Helicobacter pylori infection-comparison with omeprazole and lansoprazole. Aliment Pharmacol Ther 1999; 13: 741-6. – reference: 2) Asaka M, Sugiyama T, Kato M, Satoh K, Kuwayama H, Fukuda Y, et al.: A multicenter, double-blind study on triple therapy with lansoprazole, amoxicillin and clarithromycin for eradication of Helicobacter pylori in Japanese peptic ulcer patients. Helicobacter 2001; 6: 254-61. – reference: 21) Valeur N, Engel P, Carbaj al N, Connolly E, Ladefoged K: Colonization and immunomodulation by Lactobacillus reuteri ATCC 55730 in the human gastrointestinal tract Appl Environ Microbiol 2004; 70: 1176-81. – reference: 17) Reid G, Bruce AW, McGroarty JA, Cheng KJ, Costerton JW: Is there a role for lactobacilli in prevention of urogenital and intestinal infections? Clin Microbiol Rev 1990; 3: 335-44. – reference: 9) Graham DY, Klein PD, Evans DJ Jr, Evans DG, Alpert LC, Opekun AR, et al. Campylobacter pylori detected noninvasively by the 13C-urea breath test. Lancet 1987; 23: 1174-7. – reference: 24) Talarico TL, Dobrogosz WJ: Chemical characterization of an antimicrobial substance produced by Lactobacillus reuteri. Antimicrob Agents Chemother 1989; 33: 674-9. – reference: 25) Johnson C, Dicksved J, Jonsson H, Roos S: Anti Helicobacter pylori activity among lactic acid bacteria isolated from gastric biopsies and strains of Lactobacillus reuteri. Helicobacter 2003; 8: 473. – reference: 22) Mukai T, Asasaka T, Sato E, Mori K, Matsumoto M, Ohori H: Inhibition of binding of Helicobacter pylori to the glycolipid receptors by probiotic Lactobacillus reuteri. FEMS Immunol Med Microbiol 2002; 32: 105-10. – reference: 18) Sakamoto I, Igarashi M, Kimura K, Takagi A, Miwa T, Koga Y: Suppressive effect of Lactobacillus gasseri OLL 2716 (LG21) on Helicobacter pylori infection in humans. J Antimicrob Chemother 2001; 47: 709-10. – reference: 6) Uemura N, Okamoto S, Yamamoto S: Helocobacter pylori. Infection and the development of gastric cancer. 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| Snippet | この研究は, Lactobacillus reuteri strain SD 2112株 (L. reuteri) のH. pylori抑制効果の検討である.今回, 我々はL. reuteri含有整腸剤 [L. reuteri錠, Reuterina (ERINA... |
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| Title | Lactobacillus reuteri含有プロバイオティクスのHelicobacter pylori抑制効果に関する検討 |
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