肝癌患者にみられる自己抗体について-抗核抗体を中心に
肝癌70例,肝癌以外の悪性腫瘍60例,慢性肝疾患63例,健常者145例について,抗核抗体,抗平滑筋抗体,抗ミトコンドリア抗体,リウマチ因子,LE因子,サイログロブリン抗体およびマイクロゾーム抗体の7項目の自己抗体を検索した.癌患者血清中の抗核抗体は肝癌24.3%,肝癌以外の悪性腫瘍23.3%と比較的高頻度に出現した.肝癌における抗核抗体はリウマチ因子,抗平滑筋抗体を含め他の自己抗体と相関はなく,またHBs抗原,性別,年齢との相関も認めなかった.経時的に検討しえた肝癌患者10例のうちで,慢性肝疾患から肝癌を発症し抗核抗体陽性となったものが2例,一方肝癌切除後抗核抗体が陰性となったものが1例あり,...
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| Published in | 肝臓 Vol. 27; no. 11; pp. 1539 - 1545 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
一般社団法人 日本肝臓学会
1986
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0451-4203 1881-3593 |
| DOI | 10.2957/kanzo.27.1539 |
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| Abstract | 肝癌70例,肝癌以外の悪性腫瘍60例,慢性肝疾患63例,健常者145例について,抗核抗体,抗平滑筋抗体,抗ミトコンドリア抗体,リウマチ因子,LE因子,サイログロブリン抗体およびマイクロゾーム抗体の7項目の自己抗体を検索した.癌患者血清中の抗核抗体は肝癌24.3%,肝癌以外の悪性腫瘍23.3%と比較的高頻度に出現した.肝癌における抗核抗体はリウマチ因子,抗平滑筋抗体を含め他の自己抗体と相関はなく,またHBs抗原,性別,年齢との相関も認めなかった.経時的に検討しえた肝癌患者10例のうちで,慢性肝疾患から肝癌を発症し抗核抗体陽性となったものが2例,一方肝癌切除後抗核抗体が陰性となったものが1例あり,腫瘍発生と抗核抗体の出現に何らかの係わりのあることが示唆された. |
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| AbstractList | 肝癌70例,肝癌以外の悪性腫瘍60例,慢性肝疾患63例,健常者145例について,抗核抗体,抗平滑筋抗体,抗ミトコンドリア抗体,リウマチ因子,LE因子,サイログロブリン抗体およびマイクロゾーム抗体の7項目の自己抗体を検索した.癌患者血清中の抗核抗体は肝癌24.3%,肝癌以外の悪性腫瘍23.3%と比較的高頻度に出現した.肝癌における抗核抗体はリウマチ因子,抗平滑筋抗体を含め他の自己抗体と相関はなく,またHBs抗原,性別,年齢との相関も認めなかった.経時的に検討しえた肝癌患者10例のうちで,慢性肝疾患から肝癌を発症し抗核抗体陽性となったものが2例,一方肝癌切除後抗核抗体が陰性となったものが1例あり,腫瘍発生と抗核抗体の出現に何らかの係わりのあることが示唆された. |
| Author | 金井, 正光 亀子, 光明 熊谷, 俊子 清沢, 研道 今井, 明彦 古田, 精市 |
| Author_xml | – sequence: 1 fullname: 古田, 精市 organization: 信州大学医学部第2内科 – sequence: 1 fullname: 今井, 明彦 organization: 信州大学医学部第2内科 – sequence: 1 fullname: 熊谷, 俊子 organization: 信州大学病院中央検査部 – sequence: 1 fullname: 亀子, 光明 organization: 信州大学病院中央検査部 – sequence: 1 fullname: 清沢, 研道 organization: 信州大学医学部第2内科 – sequence: 1 fullname: 金井, 正光 organization: 信州大学医学部臨床検査医学 |
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| References | 12) 岸本進,藤井隆:加齢・性差と免疫応答.日本臨床(春季増刊号)510号:882-889, 1984 6) Ablin RJ: Serum antibody in patients with prostatic cancer. Br J Urology 48: 355-361, 1976 17) Miyachi K, Fritzler MJ, Tan EM: Autoantibody to a nuclear antigen in proliferating cells. J Immunol 121: 2228-2234, 1978 20) Takasaki Y, Robinson WA, Tan EM: Proliferating cell nuclear antigen in blast crisis cells of patients with chronic myeloid leukemia. J National Cancer Inst 73: 655-661, 1984 1) Thomas PJ, Kaur JS, Tan EM,: Antinuclear, antinucleolar and anticytoplasmic antibodies in patients with malignant melanoma. Cancer Research 43: 1372-1380, 1983 4) Wasserman J, Glas U, Blomgren H: Autoantibodies in patients with carcinoma of the breast. Clin Exp Immunol 19: 417-422, 1975 19) Takasaki Y, Fishwild D, Tan EM: Characterization of proliferating cell nuclear antigen recongnized by autoantibodies in lupus sera. J Exp Med 159: 981-992, 1984 11) Kozin F, Fowler M, Koethe SM: A comparison of the sensitivities and specificities of different substrates for the fluorescent antinuclear antibody test. Am J Clin Pathol 74: 785-790, 1980 16) Hannestad K, Stollar BD: Certain rheumatoid factors react with nucleosomes. Nature 275: 671-673, 1978 9) Okayasu I, Mizutani H, Yanagisawa F: Cancer in collagen disease. A statistical analysis by reviewing the annual of pathological autopsy cases (Nippon Boken Shuho) in Japan. Cancer 54: 1841-1844, 1984 2) Steiner M, Klein E, Klein G: Antinuclear reactivity of sera in patients with leukemia and other neoplastic diseases. Clin Immunol Immunopathol 4: 374-381, 1975 7) Whitehouse JMA, Holborow EJ: Smooth muscle antibody in malignant disease. Br Med J 4: 511-513, 1971 13) Gray ES, McLay ALC, Home CHW: Non-organ specific autoantibodies in malignant diseases. Scot Med J 20: 203-208, 1975 15) Hurri L, Perttala Y: Observations on nonspecific Waaler-Rose and latex reactions in cancer patients. Ann Med Int Fenn 54: 181-183, 1965 14) Giuliano AE, Irie R, Morton DL: Rheumatoid factor in melanoma patients. Alterations of humoral tumor immunity in vitro. Cancer 43: 1624-1629, 1979 5) Turnbull AR, Turner TL, Wright R: Autoantibodies in early breast cancer. A stagerelated phenomenon?. Br J Cancer 38: 461-463, 1978 10) Doniach D: Autoimmunity in liver disease. In: Progress in Clinical Immunology Vol. 1, Grune and Stratton New York, 1972, p45 3) Hodson ME, Turner-Warwick M: Autoantibodies in patients with bronchial carcinoma. Thorax 30: 367-370, 1975 8) Burnham TK: Antinuclear antibodies in patients with malignancies. Lancet 2: 436-437, 1972 18) Takasaki Y, Deng JS, Tan EM: A nuclear antigen associated with cell proliferation and blast transformation. Its distribution in synchronized cells. J Exp Med 154: 1899-1909, 1981 |
| References_xml | – reference: 15) Hurri L, Perttala Y: Observations on nonspecific Waaler-Rose and latex reactions in cancer patients. Ann Med Int Fenn 54: 181-183, 1965 – reference: 13) Gray ES, McLay ALC, Home CHW: Non-organ specific autoantibodies in malignant diseases. Scot Med J 20: 203-208, 1975 – reference: 9) Okayasu I, Mizutani H, Yanagisawa F: Cancer in collagen disease. A statistical analysis by reviewing the annual of pathological autopsy cases (Nippon Boken Shuho) in Japan. Cancer 54: 1841-1844, 1984 – reference: 5) Turnbull AR, Turner TL, Wright R: Autoantibodies in early breast cancer. A stagerelated phenomenon?. Br J Cancer 38: 461-463, 1978 – reference: 4) Wasserman J, Glas U, Blomgren H: Autoantibodies in patients with carcinoma of the breast. Clin Exp Immunol 19: 417-422, 1975 – reference: 8) Burnham TK: Antinuclear antibodies in patients with malignancies. Lancet 2: 436-437, 1972 – reference: 20) Takasaki Y, Robinson WA, Tan EM: Proliferating cell nuclear antigen in blast crisis cells of patients with chronic myeloid leukemia. J National Cancer Inst 73: 655-661, 1984 – reference: 1) Thomas PJ, Kaur JS, Tan EM,: Antinuclear, antinucleolar and anticytoplasmic antibodies in patients with malignant melanoma. Cancer Research 43: 1372-1380, 1983 – reference: 6) Ablin RJ: Serum antibody in patients with prostatic cancer. Br J Urology 48: 355-361, 1976 – reference: 11) Kozin F, Fowler M, Koethe SM: A comparison of the sensitivities and specificities of different substrates for the fluorescent antinuclear antibody test. Am J Clin Pathol 74: 785-790, 1980 – reference: 7) Whitehouse JMA, Holborow EJ: Smooth muscle antibody in malignant disease. Br Med J 4: 511-513, 1971 – reference: 19) Takasaki Y, Fishwild D, Tan EM: Characterization of proliferating cell nuclear antigen recongnized by autoantibodies in lupus sera. J Exp Med 159: 981-992, 1984 – reference: 14) Giuliano AE, Irie R, Morton DL: Rheumatoid factor in melanoma patients. Alterations of humoral tumor immunity in vitro. Cancer 43: 1624-1629, 1979 – reference: 18) Takasaki Y, Deng JS, Tan EM: A nuclear antigen associated with cell proliferation and blast transformation. Its distribution in synchronized cells. J Exp Med 154: 1899-1909, 1981 – reference: 3) Hodson ME, Turner-Warwick M: Autoantibodies in patients with bronchial carcinoma. Thorax 30: 367-370, 1975 – reference: 12) 岸本進,藤井隆:加齢・性差と免疫応答.日本臨床(春季増刊号)510号:882-889, 1984 – reference: 17) Miyachi K, Fritzler MJ, Tan EM: Autoantibody to a nuclear antigen in proliferating cells. J Immunol 121: 2228-2234, 1978 – reference: 2) Steiner M, Klein E, Klein G: Antinuclear reactivity of sera in patients with leukemia and other neoplastic diseases. Clin Immunol Immunopathol 4: 374-381, 1975 – reference: 16) Hannestad K, Stollar BD: Certain rheumatoid factors react with nucleosomes. Nature 275: 671-673, 1978 – reference: 10) Doniach D: Autoimmunity in liver disease. In: Progress in Clinical Immunology Vol. 1, Grune and Stratton New York, 1972, p45 |
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| Title | 肝癌患者にみられる自己抗体について-抗核抗体を中心に |
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