白血球におけるアラキドン酸代謝の制御とその意義
アラキドン酸代謝産物であるロイコトリエン (LT), プロスタグランディン (PG), トロンボキサン (TX) は, 細胞内部の核膜上で, 数種類の酵素の連続的な反応の結果合成される.最近10年間にこれらの合成酵素 (細胞質フォスフォリパーゼA2, プロスタグランディンH合成酵素タイプ1および2, 5一リポキシゲナーJビ, ロイコトリエンC4合成酵素, ロイコトリエンA4ヒドロラーゼなど) は大部分がクローニングされ, その生化学的な特徴や, 活性化の機構が明らかになってきた.これらの合成酵素の活性化の機構のひとつとして, 生体内外の活性化因子による遺伝子の転写や翻訳のレベルでの制御機構の存...
Saved in:
Published in | 日本小児血液学会雑誌 Vol. 13; no. 5; pp. 325 - 334 |
---|---|
Main Authors | , |
Format | Journal Article |
Language | Japanese |
Published |
特定非営利活動法人 日本小児血液・がん学会
31.10.1999
|
Online Access | Get full text |
ISSN | 0913-8706 1884-4723 |
DOI | 10.11412/jjph1987.13.325 |
Cover
Abstract | アラキドン酸代謝産物であるロイコトリエン (LT), プロスタグランディン (PG), トロンボキサン (TX) は, 細胞内部の核膜上で, 数種類の酵素の連続的な反応の結果合成される.最近10年間にこれらの合成酵素 (細胞質フォスフォリパーゼA2, プロスタグランディンH合成酵素タイプ1および2, 5一リポキシゲナーJビ, ロイコトリエンC4合成酵素, ロイコトリエンA4ヒドロラーゼなど) は大部分がクローニングされ, その生化学的な特徴や, 活性化の機構が明らかになってきた.これらの合成酵素の活性化の機構のひとつとして, 生体内外の活性化因子による遺伝子の転写や翻訳のレベルでの制御機構の存在が明らかとなってきている.これらの制御機構は炎症性疾患をはじめとする各種小児疾患の病態の発現に関与していることが推測される.この遺伝子レベルでの制御の機構は, 多核白血球においても存在する.本稿では, 最初にアラキドン酸代謝系の合成酵素について, 種々の細胞から得られた最近の一般的知見を総括し, そのあとで, 多核白血球における遺伝子レベルでの制御の機構について, みずからの知見を含めて述べる. |
---|---|
AbstractList | アラキドン酸代謝産物であるロイコトリエン (LT), プロスタグランディン (PG), トロンボキサン (TX) は, 細胞内部の核膜上で, 数種類の酵素の連続的な反応の結果合成される.最近10年間にこれらの合成酵素 (細胞質フォスフォリパーゼA2, プロスタグランディンH合成酵素タイプ1および2, 5一リポキシゲナーJビ, ロイコトリエンC4合成酵素, ロイコトリエンA4ヒドロラーゼなど) は大部分がクローニングされ, その生化学的な特徴や, 活性化の機構が明らかになってきた.これらの合成酵素の活性化の機構のひとつとして, 生体内外の活性化因子による遺伝子の転写や翻訳のレベルでの制御機構の存在が明らかとなってきている.これらの制御機構は炎症性疾患をはじめとする各種小児疾患の病態の発現に関与していることが推測される.この遺伝子レベルでの制御の機構は, 多核白血球においても存在する.本稿では, 最初にアラキドン酸代謝系の合成酵素について, 種々の細胞から得られた最近の一般的知見を総括し, そのあとで, 多核白血球における遺伝子レベルでの制御の機構について, みずからの知見を含めて述べる. |
Author | 在津, 正文 浜崎, 雄平 |
Author_xml | – sequence: 1 fullname: 在津, 正文 organization: 佐賀医科大学小児科 – sequence: 1 fullname: 浜崎, 雄平 organization: 佐賀医科大学小児科 |
BookMark | eNo9kEtLw0AcxBepYK29-yVS97-bze4epdYHFLzoOWzSjU2otSS9eDONgo-DevTgoXqx-LgIIoj9MmtN_RZWql5mGAaG4TePCu29tkZoEXAFwAayFEWdJkjBK0ArlLAZVAQhbMvmhBZQEUugluDYmUPlJAk9jJkQGNu8iGr51fu4f5BfZCa9N-mpSS9N78z0bkw2ML1Hk52Y7Pnr6PXj7Xb8cG3Sp9Hxy2jYN-mdSX_i5-F5PhwsoNlAtRJd_vUS2l6tbVXXrfrm2kZ1uW5FIBm2hK-YpEQw4hDNfEdx6UjuaEIaEIDEk09Ca-oTLnBANXhCB75gVDSk7SmsaQmtTHejpKt2tNuJw10V77sq7oZ-S7t_GFygLpvKhMZ_7TdV7EaKfgMNQXIE |
ContentType | Journal Article |
Copyright | (社)日本複写権センター |
Copyright_xml | – notice: (社)日本複写権センター |
DOI | 10.11412/jjph1987.13.325 |
DatabaseTitleList | |
DeliveryMethod | fulltext_linktorsrc |
EISSN | 1884-4723 |
EndPage | 334 |
ExternalDocumentID | article_jjph1987_13_5_13_5_325_article_char_ja |
GroupedDBID | ALMA_UNASSIGNED_HOLDINGS JSF KQ8 RJT |
ID | FETCH-LOGICAL-j1950-8ca593285262e5c6a796976e22d1f1908008ee3c2780f3e1b8efc8538d94ba0e3 |
ISSN | 0913-8706 |
IngestDate | Wed Sep 03 06:30:01 EDT 2025 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | false |
IsScholarly | true |
Issue | 5 |
Language | Japanese |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-j1950-8ca593285262e5c6a796976e22d1f1908008ee3c2780f3e1b8efc8538d94ba0e3 |
OpenAccessLink | https://www.jstage.jst.go.jp/article/jjph1987/13/5/13_5_325/_article/-char/ja |
PageCount | 10 |
ParticipantIDs | jstage_primary_article_jjph1987_13_5_13_5_325_article_char_ja |
PublicationCentury | 1900 |
PublicationDate | 1999/10/31 |
PublicationDateYYYYMMDD | 1999-10-31 |
PublicationDate_xml | – month: 10 year: 1999 text: 1999/10/31 day: 31 |
PublicationDecade | 1990 |
PublicationTitle | 日本小児血液学会雑誌 |
PublicationTitleAlternate | 日小血会誌 |
PublicationYear | 1999 |
Publisher | 特定非営利活動法人 日本小児血液・がん学会 |
Publisher_xml | – name: 特定非営利活動法人 日本小児血液・がん学会 |
References | 7) Lin L-L, Wartman M, Lin AY, et al : cPLA2 is phospholyrated and activated by MAP kinase. Cell 72 : 269-278, 1993 32) Zaitsu M, Hamasaki Y, Yamamoto S, et al : Effect of dexamethasone on leukotriene synthesis in DMS0-stimulated HL-60 cells. Plostaglandin Leukotriene Essen Fat Acid 59 : 385-393, 1998 40) Niiro H, Otsuka T, Izuhata K, et al : Regulation by interleukin-10 and interleukin-4 of cyclooxygenase-2 expression in human neutrophils. Blood 89 : 1621-1628, 1997 38) Yu CL, Huang MH, Kung YY, et al : Interleukin-13 increases prostaglandin E2 (PGE2) production by normal human polumorphonuclear neutrophils by enhancing cyclooxygenase-2 (COX-2) gene expression. Inflammation Res 47 : 167-173, 1998 30) Hamasaki Y, Abe M, Matsumoto S, et al : Inhibition by dexamethasone of retinoic acid-induced enhancement of leukotriene C4 synthesis in rat basophilic leukemia-1 cells. Am J Respir Cell Mol Biol 11 : 49-56, 1994 5) Glover S, Bayburt T, Jonas M, et al : Translocation of 85-kDa phospholipase A2 from cytosol to the nuclear envelope in rat basophilic leukemia cells stimulated with calcium ionophore or IgE/antigen. J Biol Chem 270 : 15359-15367, 1995 14) Hla T, Neilson K : Human cyclooxygenase-2 cDNA. Proc Natl Acad Sci USA 89 : 7384-7388, 1992 26) Stankova J, Rola-Pleszczynski M, Dubois CM : Granulocyte-macrophage colony-stimulating factor increases 5-lipoxygenase gene transcription and protein expression in human neutrophils. Blood 85 : 3719-3726, 1995 8) Murakami M, Matsumoto R, Urade D, et al : c-Kit ligand mediates increased expression of cytosolic phospholipase A2, prostaglandin endoperoxide-1, and generation in immature mouse mast cells. J Biol Chem 270 : 3239-3246, 1995 22) Woods JW, Evans JF, Ethier D, et al : 5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes. J Exp Med 178 : 1935-1946, 1993 12) Hamasaki Y, Kitzler J, Hardman R, et al : Phorbol ester and epidermal growth factor enhance the expression of two inducible prostaglandin H synthase genes in rat tracheal epithelial cells. Arch Biochem Biophys 304 : 226-234, 1993 20) Ihara H, Yokoyama C, Miyata A, et al : Induction of thromboxane synthase and prostaglandin endoperoxide synthase mRNAs in human erythroleukemia cells by phorbol ester. FEBS Lett 306 : 161-164, 1992 13) Crofford LJ, Wilder RL, Ristimaki AP, et al : Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues. Effects of interleukin-1 beta, phorbol ester, and corticosteroids. J Clin Invest 93 : 1095-1101, 1994 4) Bonventre JV, Huang Z, Taheri MR : Reduced fertility and postischaemic brain injury in mice deficient in cytosolic phospholipase A2. Nature 390 : 622-625, 1997 18) Morham SG, Langenbach R, Loftin CD, et al : Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse. Cell 83 : 473-482, 1995 27) Dixon RAF, Diehl RE, Opas E, et al : Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis. Nature 343 : 282-284, 1990 19) Langenbach R, Morham SG, Tiano HF, et al : Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration. Cell 83 : 483-492, 1995 34) Orning L, Jones DA, Fitzpatrick FA : Mechanismbased inactivation of leukotriene A4 hydrolase during leukotriene B4 formation by human erythrocytes. J Biol Chem 265 : 14911-14916, 1990 2) Murakami M, Nakatani Y, Kudo I : Type II secretory phospholipase A2 associated with cell surfaces via C-terminal heparin-binding lysine residues augments stimulus-initiated delayed prostaglandin generation. J Biol Chem 271 : 30041-30051, 1996 29) Lam BK, Penrose JF, Freeman GJ, et al : Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced gluthathione to leukotriene C4. Proc Natl Acad Sci USA 91 : 7663-7667, 1994 10) Dunneic ZM, Netteshem P, Eling T : Stimulation of prostaglandin H synthase mRNA levels and prostaglandin biosynthesis by phorbol ester : Mediation by protein kinase C. Mol Pharmacol 39 : 164-170, 1991 33) Maclouf J, Murphy RC, Henson PM : Transcellular biosynthesis of sulfidopeptide leukotrienes during receptor-mediated stimulation of human neutrophil/platelet mixtures. Blood 76 : 1838-1844, 1990 42) Surette ME, Dallaire N, Jean N, et al : Mechanisms of the priming effect of lipopolysaccharides on the biosynthesis of leukotriene B4 in chemotactic peptidestimulated human neutrophils. FASEB J 12 : 1521-1531, 1998 17) Morita I, Schindler M, Regier MK, et al : Different intracellular locations for prostaglandin endoperoxide H synthase-1 and -2. J Biol Chem 270 : 10902-10908, 1995 25) Brock TG, McNish R, Bailie H, et al : Rapid import of cytosolic 5-lipoxygenase into the neucleus of neutrophils following in vivo recruitment and in vitro adherence. J Biol Chem 272 : 8276-8280, 1997 41) Niiro H, Otsuka T, Tanabe T, et al : Inhibition by interleukin-10 of inducible cyclooxygenase expression in lipopolysaccharide-stimulated monocytes : Its underlying mechanism in comparison with interleukin-4. Blood 85 : 3736-3745, 1995 11) Kujubu DA, Fletcher BS, Varnum BC, et al : TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue. J Biol Chem 266 : 12866-12872, 1991 37) Pouliot M, Gilbert C, Borgeat P, et al : Expression and activity of prostaglandin endoperoxide synthase-2 in agonist-activated human neutrophils. FASEB J 612 : 1109-1123, 1998 15) Zaitsu M, Hamasaki Y, Matsuo M, et al : Induction of cytosolic phospholipase A2 and prostaglandin H2 synthase by lipopolysaccharide in human polymorphonuclear leukocytes. Eur J Haematol 62 : 1-9, 1999 23) Woods JW, Coffey MJ, Brock TG, et al : 5-lipoxygenase is located in the euchromatin of the nucleus in resting human alveolar macrophages and translocates to the nuclear envelope upon cell activation. J Clin Invest 95 : 2035-2046, 1995 35) Seeds MC, Jones DF, Chilton FH, et al : Secretory and cytosolic phospholipase A2 are activated during TNF priming of human neutrophils. Biochim Biophys Acta 1389 : 273-284, 1998 44) Stenke L, Sjolinder M, Miale TD, et al : Novel enzymatic abnormalities in AML and CML in blast crisis : Elevated leucocyte leukotriene C4 synthase activity paralleled by deficient leukotriene biosynthesis from endogenous substrate. Br J Haematol 101 : 728-736, 1998 3) Lin L-L, Lin AY, Knopf JL : Cytosolic phospholipase A2 is coupled to hormonally regulated release of arachidonic acid. Proc Natl Acad Sci USA 89 : 6147-6151, 1992 16) Kulmacz RJ, Wang L-H : Comparison of hydroperoxide initiator requirements for the cyclooxygenase activities of prostaglandin synthase-1 and -2. J Biol Chem 270 : 24019-24023, 1995 24) Brock TG, McNish RW, Peter-Golden M : Translocation and leukotriene synthetic capacity of nuclear 5-lipoxygenase in rat basophilic leukemia cells and alveolar macrophages. J Biol Chem 270 : 21652-21658, 1995 28) Pouliot M, McDonald P, Borgeat P : Granulocyte/ macrophage colony-stimulating factor stimulates the expression of the 5-lipoxygenase-activating protein (FLAP) in human neutrophils. J Exp Med 179 : 1225-1232, 1994 21) Malaviya R, Malaviya R, Jakschik BA : Reversible translocation of 5-lipoxygenase in mast cells upon IgE/antigen stimulation. J Biol Chem 268 : 4939-4944, 1993 39) Maloney CG, Kutchera WA, Albertine KH, et al : Inflammatory agonists induce cyclooxygenase type 2 expression by human neutrophils. J Immunol 160 : 1402-1410, 1998 45) Sano H, Kawahito Y, Wilder RL, et al : Expression of cyclooxygenase-1 and -2 in human colorectal cancer. Cancer Res 55 : 3785-3789, 1995 9) Rosen GD, Birkenmeier TM, Raz A, et al : Identification of a cyclooxygenase-related gene and its potential role in prostaglandin formation. Biochem Biophys Res Commun 164 : 1358-1365, 1989 36) Seeds MC, Nixon AB, Wykle RL, et al : Differential activation of human neutrophil cytosolic phospholipase A2 and secretory phospholipase A2 during priming by 1, 2-diacyl- and 1-o-alkyl-2-acylglycerol. Biochim Biophys Acta 1394 : 224-234, 1998 31) Hamasaki Y, Miyazaki S : Retinoic acid stimulates peptide leukotriene synthesis in rat basophilic leukemia-1 (RBL-1) cells. Biochim Biophys Acta 1082 : 126-129, 1991 43) Reid GK, Kargman S, Vickers PJ, et al : Correlation between expression of 5-lipoxygenase-activating protein, 5-lipoxygenase, and cellular leukotriene synthesis. J Biol Chem 265 : 19818-19823, 1990 1) Devchand PR, Keller H, Peters JM, et al : The PPARalpha-leukotriene B4 pathway to inflammation control. Nature 384 : 39-43, 1996 6) Schienvella AR, Regier MK, Smith WL, et al : Calcium-mediated translocation of cytosolic phospholipase A2 to the nuclear envelope and endoplasmic reticulum. J Biol Chem 270 : 30479-30754, 1995 |
References_xml | – reference: 23) Woods JW, Coffey MJ, Brock TG, et al : 5-lipoxygenase is located in the euchromatin of the nucleus in resting human alveolar macrophages and translocates to the nuclear envelope upon cell activation. J Clin Invest 95 : 2035-2046, 1995 – reference: 17) Morita I, Schindler M, Regier MK, et al : Different intracellular locations for prostaglandin endoperoxide H synthase-1 and -2. J Biol Chem 270 : 10902-10908, 1995 – reference: 19) Langenbach R, Morham SG, Tiano HF, et al : Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration. Cell 83 : 483-492, 1995 – reference: 5) Glover S, Bayburt T, Jonas M, et al : Translocation of 85-kDa phospholipase A2 from cytosol to the nuclear envelope in rat basophilic leukemia cells stimulated with calcium ionophore or IgE/antigen. J Biol Chem 270 : 15359-15367, 1995 – reference: 35) Seeds MC, Jones DF, Chilton FH, et al : Secretory and cytosolic phospholipase A2 are activated during TNF priming of human neutrophils. Biochim Biophys Acta 1389 : 273-284, 1998 – reference: 9) Rosen GD, Birkenmeier TM, Raz A, et al : Identification of a cyclooxygenase-related gene and its potential role in prostaglandin formation. Biochem Biophys Res Commun 164 : 1358-1365, 1989 – reference: 22) Woods JW, Evans JF, Ethier D, et al : 5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes. J Exp Med 178 : 1935-1946, 1993 – reference: 32) Zaitsu M, Hamasaki Y, Yamamoto S, et al : Effect of dexamethasone on leukotriene synthesis in DMS0-stimulated HL-60 cells. Plostaglandin Leukotriene Essen Fat Acid 59 : 385-393, 1998 – reference: 37) Pouliot M, Gilbert C, Borgeat P, et al : Expression and activity of prostaglandin endoperoxide synthase-2 in agonist-activated human neutrophils. FASEB J 612 : 1109-1123, 1998 – reference: 34) Orning L, Jones DA, Fitzpatrick FA : Mechanismbased inactivation of leukotriene A4 hydrolase during leukotriene B4 formation by human erythrocytes. J Biol Chem 265 : 14911-14916, 1990 – reference: 36) Seeds MC, Nixon AB, Wykle RL, et al : Differential activation of human neutrophil cytosolic phospholipase A2 and secretory phospholipase A2 during priming by 1, 2-diacyl- and 1-o-alkyl-2-acylglycerol. Biochim Biophys Acta 1394 : 224-234, 1998 – reference: 2) Murakami M, Nakatani Y, Kudo I : Type II secretory phospholipase A2 associated with cell surfaces via C-terminal heparin-binding lysine residues augments stimulus-initiated delayed prostaglandin generation. J Biol Chem 271 : 30041-30051, 1996 – reference: 38) Yu CL, Huang MH, Kung YY, et al : Interleukin-13 increases prostaglandin E2 (PGE2) production by normal human polumorphonuclear neutrophils by enhancing cyclooxygenase-2 (COX-2) gene expression. Inflammation Res 47 : 167-173, 1998 – reference: 44) Stenke L, Sjolinder M, Miale TD, et al : Novel enzymatic abnormalities in AML and CML in blast crisis : Elevated leucocyte leukotriene C4 synthase activity paralleled by deficient leukotriene biosynthesis from endogenous substrate. Br J Haematol 101 : 728-736, 1998 – reference: 3) Lin L-L, Lin AY, Knopf JL : Cytosolic phospholipase A2 is coupled to hormonally regulated release of arachidonic acid. Proc Natl Acad Sci USA 89 : 6147-6151, 1992 – reference: 39) Maloney CG, Kutchera WA, Albertine KH, et al : Inflammatory agonists induce cyclooxygenase type 2 expression by human neutrophils. J Immunol 160 : 1402-1410, 1998 – reference: 13) Crofford LJ, Wilder RL, Ristimaki AP, et al : Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues. Effects of interleukin-1 beta, phorbol ester, and corticosteroids. J Clin Invest 93 : 1095-1101, 1994 – reference: 45) Sano H, Kawahito Y, Wilder RL, et al : Expression of cyclooxygenase-1 and -2 in human colorectal cancer. Cancer Res 55 : 3785-3789, 1995 – reference: 1) Devchand PR, Keller H, Peters JM, et al : The PPARalpha-leukotriene B4 pathway to inflammation control. Nature 384 : 39-43, 1996 – reference: 8) Murakami M, Matsumoto R, Urade D, et al : c-Kit ligand mediates increased expression of cytosolic phospholipase A2, prostaglandin endoperoxide-1, and generation in immature mouse mast cells. J Biol Chem 270 : 3239-3246, 1995 – reference: 31) Hamasaki Y, Miyazaki S : Retinoic acid stimulates peptide leukotriene synthesis in rat basophilic leukemia-1 (RBL-1) cells. Biochim Biophys Acta 1082 : 126-129, 1991 – reference: 40) Niiro H, Otsuka T, Izuhata K, et al : Regulation by interleukin-10 and interleukin-4 of cyclooxygenase-2 expression in human neutrophils. Blood 89 : 1621-1628, 1997 – reference: 43) Reid GK, Kargman S, Vickers PJ, et al : Correlation between expression of 5-lipoxygenase-activating protein, 5-lipoxygenase, and cellular leukotriene synthesis. J Biol Chem 265 : 19818-19823, 1990 – reference: 28) Pouliot M, McDonald P, Borgeat P : Granulocyte/ macrophage colony-stimulating factor stimulates the expression of the 5-lipoxygenase-activating protein (FLAP) in human neutrophils. J Exp Med 179 : 1225-1232, 1994 – reference: 20) Ihara H, Yokoyama C, Miyata A, et al : Induction of thromboxane synthase and prostaglandin endoperoxide synthase mRNAs in human erythroleukemia cells by phorbol ester. FEBS Lett 306 : 161-164, 1992 – reference: 6) Schienvella AR, Regier MK, Smith WL, et al : Calcium-mediated translocation of cytosolic phospholipase A2 to the nuclear envelope and endoplasmic reticulum. J Biol Chem 270 : 30479-30754, 1995 – reference: 27) Dixon RAF, Diehl RE, Opas E, et al : Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis. Nature 343 : 282-284, 1990 – reference: 26) Stankova J, Rola-Pleszczynski M, Dubois CM : Granulocyte-macrophage colony-stimulating factor increases 5-lipoxygenase gene transcription and protein expression in human neutrophils. Blood 85 : 3719-3726, 1995 – reference: 18) Morham SG, Langenbach R, Loftin CD, et al : Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse. Cell 83 : 473-482, 1995 – reference: 15) Zaitsu M, Hamasaki Y, Matsuo M, et al : Induction of cytosolic phospholipase A2 and prostaglandin H2 synthase by lipopolysaccharide in human polymorphonuclear leukocytes. Eur J Haematol 62 : 1-9, 1999 – reference: 30) Hamasaki Y, Abe M, Matsumoto S, et al : Inhibition by dexamethasone of retinoic acid-induced enhancement of leukotriene C4 synthesis in rat basophilic leukemia-1 cells. Am J Respir Cell Mol Biol 11 : 49-56, 1994 – reference: 10) Dunneic ZM, Netteshem P, Eling T : Stimulation of prostaglandin H synthase mRNA levels and prostaglandin biosynthesis by phorbol ester : Mediation by protein kinase C. Mol Pharmacol 39 : 164-170, 1991 – reference: 41) Niiro H, Otsuka T, Tanabe T, et al : Inhibition by interleukin-10 of inducible cyclooxygenase expression in lipopolysaccharide-stimulated monocytes : Its underlying mechanism in comparison with interleukin-4. Blood 85 : 3736-3745, 1995 – reference: 24) Brock TG, McNish RW, Peter-Golden M : Translocation and leukotriene synthetic capacity of nuclear 5-lipoxygenase in rat basophilic leukemia cells and alveolar macrophages. J Biol Chem 270 : 21652-21658, 1995 – reference: 7) Lin L-L, Wartman M, Lin AY, et al : cPLA2 is phospholyrated and activated by MAP kinase. Cell 72 : 269-278, 1993 – reference: 4) Bonventre JV, Huang Z, Taheri MR : Reduced fertility and postischaemic brain injury in mice deficient in cytosolic phospholipase A2. Nature 390 : 622-625, 1997 – reference: 29) Lam BK, Penrose JF, Freeman GJ, et al : Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced gluthathione to leukotriene C4. Proc Natl Acad Sci USA 91 : 7663-7667, 1994 – reference: 11) Kujubu DA, Fletcher BS, Varnum BC, et al : TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue. J Biol Chem 266 : 12866-12872, 1991 – reference: 14) Hla T, Neilson K : Human cyclooxygenase-2 cDNA. Proc Natl Acad Sci USA 89 : 7384-7388, 1992 – reference: 16) Kulmacz RJ, Wang L-H : Comparison of hydroperoxide initiator requirements for the cyclooxygenase activities of prostaglandin synthase-1 and -2. J Biol Chem 270 : 24019-24023, 1995 – reference: 33) Maclouf J, Murphy RC, Henson PM : Transcellular biosynthesis of sulfidopeptide leukotrienes during receptor-mediated stimulation of human neutrophil/platelet mixtures. Blood 76 : 1838-1844, 1990 – reference: 21) Malaviya R, Malaviya R, Jakschik BA : Reversible translocation of 5-lipoxygenase in mast cells upon IgE/antigen stimulation. J Biol Chem 268 : 4939-4944, 1993 – reference: 42) Surette ME, Dallaire N, Jean N, et al : Mechanisms of the priming effect of lipopolysaccharides on the biosynthesis of leukotriene B4 in chemotactic peptidestimulated human neutrophils. FASEB J 12 : 1521-1531, 1998 – reference: 12) Hamasaki Y, Kitzler J, Hardman R, et al : Phorbol ester and epidermal growth factor enhance the expression of two inducible prostaglandin H synthase genes in rat tracheal epithelial cells. Arch Biochem Biophys 304 : 226-234, 1993 – reference: 25) Brock TG, McNish R, Bailie H, et al : Rapid import of cytosolic 5-lipoxygenase into the neucleus of neutrophils following in vivo recruitment and in vitro adherence. J Biol Chem 272 : 8276-8280, 1997 |
SSID | ssib005880047 ssj0003236711 ssib053390765 ssib002003923 ssib058493933 |
Score | 1.5187656 |
Snippet | アラキドン酸代謝産物であるロイコトリエン (LT), プロスタグランディン (PG), トロンボキサン (TX) は, 細胞内部の核膜上で, 数種類の酵素の連続的な反応の結果合... |
SourceID | jstage |
SourceType | Publisher |
StartPage | 325 |
Title | 白血球におけるアラキドン酸代謝の制御とその意義 |
URI | https://www.jstage.jst.go.jp/article/jjph1987/13/5/13_5_325/_article/-char/ja |
Volume | 13 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
ispartofPNX | 日本小児血液学会雑誌, 1999/10/31, Vol.13(5), pp.325-334 |
journalDatabaseRights | – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 1884-4723 dateEnd: 20081231 omitProxy: true ssIdentifier: ssj0003236711 issn: 0913-8706 databaseCode: KQ8 dateStart: 19870101 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpR1Na9RANJSK4EUUFb_pwTlmTTKZyZuDh2Q3pSgKQgu9hSSbIHuopbQXT25XwY-DevTgoXqx-HERRBD7Z2Ld-i98bzLZjdaDrbCEty9vZt7HhPfefFrWFcfvu6nqS7tMhbB99LE2FFmGgVyG3anMOc9oRvfmLbmw5F9fFsszs0dbq5Y21rNOfu-v-0oOY1XEoV1pl-wBLDupFBEIo33xiRbG5z_ZmMUBU4pFPRYDC11atUAYhwFnMccgkYWRASA0gHI14DGIDBB6GqAJ8wbTMxhQBoiwQsVAsAhY7LMoYiHXjXaZ6jVtxSwWDIBFkoAoJpbMK2habxNLBhjJzhPPRKzagTK9VQELhQa61BDV6Wh6QZygmFOpJTUaefQKmQ-lZhJ5C4ltFWmpkThkMBkVJlqqGHRpn5rC7kZ_qAau20UOgyk9kukixAgyHtf0un4UhLBoCz4dR9FnL0wdEPV8khWVioTEadww2GNKK09JozzUIllDM4bKJgwKoZWBpiAA8SH9SJ2O0cFhFFabd9JNuqYLKL5fl-1hXZfbNHdd-_faqQH4th_U-7onXo-3vm7RcmG83ohuoiFeDzXvd7S-Syf3Dgard2jYquPyzqTgb8eXm48jaSgTlyeifmCBpHlNewyTASY6R7xASrqK5MbtVh5MW8hbcaxAr9OaLsaURTnBdLoeg2rFlcljKCTjdE6hvot7op9myQLKcfUPKTAYHWBq1izr1JHm4gnruEkR58Ka55PWzCA9ZcXjl9_2tu6Pn4-q4btq-KQavqg2n1abr6vRdrX5oRo9rkaffj788v3rm733r6rhx91Hn3d3tqrh22pIf388eDbe2T5tLc3Hi90F21yBYg_ofmYb8lRghgXCk14hcpkGSmICUXhe3y0xlkc1QFHw3AvAKXnhZlCUOUbg0Fd-ljoFP2PNrtxdKc5ac26apnlaup50Sj8QQVqWedB30gyg8EDCOetaLXWyWp9zkxzMdOf_s_wF69j0s7xoza6vbRSXMOBfzy7rzvALWZ_Fow |
linkProvider | Colorado Alliance of Research Libraries |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%E7%99%BD%E8%A1%80%E7%90%83%E3%81%AB%E3%81%8A%E3%81%91%E3%82%8B%E3%82%A2%E3%83%A9%E3%82%AD%E3%83%89%E3%83%B3%E9%85%B8%E4%BB%A3%E8%AC%9D%E3%81%AE%E5%88%B6%E5%BE%A1%E3%81%A8%E3%81%9D%E3%81%AE%E6%84%8F%E7%BE%A9&rft.jtitle=%E6%97%A5%E6%9C%AC%E5%B0%8F%E5%85%90%E8%A1%80%E6%B6%B2%E5%AD%A6%E4%BC%9A%E9%9B%91%E8%AA%8C&rft.au=%E5%9C%A8%E6%B4%A5%2C+%E6%AD%A3%E6%96%87&rft.au=%E6%B5%9C%E5%B4%8E%2C+%E9%9B%84%E5%B9%B3&rft.date=1999-10-31&rft.pub=%E7%89%B9%E5%AE%9A%E9%9D%9E%E5%96%B6%E5%88%A9%E6%B4%BB%E5%8B%95%E6%B3%95%E4%BA%BA%E3%80%80%E6%97%A5%E6%9C%AC%E5%B0%8F%E5%85%90%E8%A1%80%E6%B6%B2%E3%83%BB%E3%81%8C%E3%82%93%E5%AD%A6%E4%BC%9A&rft.issn=0913-8706&rft.eissn=1884-4723&rft.volume=13&rft.issue=5&rft.spage=325&rft.epage=334&rft_id=info:doi/10.11412%2Fjjph1987.13.325&rft.externalDocID=article_jjph1987_13_5_13_5_325_article_char_ja |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0913-8706&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0913-8706&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0913-8706&client=summon |