1．老化関連遺伝子と抗加齢医学
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| Published in | 日本老年医学会雑誌 Vol. 45; no. 2; pp. 141 - 144 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
一般社団法人 日本老年医学会
2008
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0300-9173 |
| DOI | 10.3143/geriatrics.45.141 |
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| Author | 勝谷, 友宏 楽木, 宏実 荻原, 俊男 |
|---|---|
| Author_xml | – sequence: 1 fullname: 楽木, 宏実 organization: 大阪大学大学院医学系研究科老年·腎臓内科学 – sequence: 1 fullname: 荻原, 俊男 organization: 大阪府立急性期·総合医療センター – sequence: 1 fullname: 勝谷, 友宏 organization: 大阪大学大学院医学系研究科老年·腎臓内科学 |
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| DOI | 10.3143/geriatrics.45.141 |
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| References | 2) Ramirez CL, Cadinanos J, Varela I, Freije JM, Lopez-Otin C: Human progeroid syndromes, aging and cancer: new genetic and epigenetic insights into old questions. Cell Mol Life Sci 2007; 64: 155-170. 11) Young SG, Meta M, Yang SH, Fong LG: Prelamin A farnesylation and progeroid syndromes. J Biol Chem 2006; 281: 39741-39745. 16) Torres PU, Prie D, Molina-Bletry V, Beck L, Silve C, Friedlander G: Klotho: an antiaging protein involved in mineral and vitamin D metabolism. Kidney Int 2007; 71: 730-737. 1) Martin GM: Genetic syndromes in man with potential relevance to the pathobiology of aging. Birth Defects Orig Artic Ser 1978; 14: 5-39. 12) Yang SH, Meta M, Qiao X, Frost D, Bauch J, Coffinier C, et al.: A farnesyltransferase inhibitor improves disease phenotypes in mice with a Hutchinson-Gilford progeria syndrome mutation. J Clin Invest 2006; 116: 2115-2121. 10) Davis T, Wyllie FS, Rokicki MJ, Bagley MC, Kipling D: The role of cellular senescence in Werner syndrome: toward therapeutic intervention in human premature aging. Ann N Y Acad Sci 2007; 1100: 455-469. 13) Katsuya T, Baba S, Ishikawa K, Mannami T, Fu Y, Inamoto N, et al.: Epsilon 4 allele of apolipoprotein E gene associates with lower blood pressure in young Japanese subjects: the Suita Study. J Hypertens 2002; 20: 2017-2021. 6) Kyng KJ, May A, Stevnsner T, Becker KG, Kolvra S, Bohr VA: Gene expression responses to DNA damage are altered in human aging and in Werner Syndrome. Oncogene 2005; 24: 5026-5042. 17) Conti B, Sanchez-Alavez M, Winsky-Sommerer R, Morale MC, Lucero J, Brownell S, et al.: Transgenic mice with a reduced core body temperature have an increased life span. Science 2006; 314: 825-828. 9) Fukuchi K, Katsuya T, Sugimoto K, Kuremura M, Kim HD, Li L, et al.: LMNA mutation in a 45 year old Japanese subject with Hutchinson-Gilford progeria syndrome. J Med Genet 2004; 41: e67. 15) Ikushima M, Rakugi H, Ishikawa K, Maekawa Y, Yamamoto K, Ohta J, et al.: Anti-apoptotic and anti-senescence effects of Klotho on vascular endothelial cells. Biochem Biophys Res Commun 2006; 339: 827-832. 14) Chihara Y, Rakugi H, Ishikawa K, Ikushima M, Maekawa Y, Ohta J, et al.: Klotho protein promotes adipocyte differentiation. Endocrinology 2006; 147: 3835-3842. 18) Belenky P, Racette FG, Bogan KL, McClure JM, Smith JS, Brenner C: Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+. Cell 2007; 129: 473-484. 4) Hu JS, Feng H, Zeng W, Lin GX, Xi XG: Solution structure of a multifunctional DNA- and protein-binding motif of human Werner syndrome protein. Proc Natl Acad Sci U S A 2005; 102: 18379-18384. 8) Ogihara T, Hata T, Tanaka K, Fukuchi K, Tabuchi Y, Kumahara Y: Hutchinson-Gilford progeria syndrome in a 45-year-old man. Am J Med 1986; 81: 135-138. 5) Huang S, Lee L, Hanson NB, Lenaerts C, Hoehn H, Poot M, et al.: The spectrum of WRN mutations in Werner syndrome patients. Hum Mutat 2006; 27: 558-567. 7) Chen L, Lee L, Kudlow BA, Dos Santos HG, Sletvold O, Shafeghati Y, et al.: LMNA mutations in atypical Werner's syndrome. Lancet 2003; 362: 440-445. 3) Yu CE, Oshima J, Fu YH, Wijsman EM, Hisama F, Alisch R, et al.: Positional cloning of the Werner's syndrome gene. Science 1996; 272: 258-262. |
| References_xml | – reference: 4) Hu JS, Feng H, Zeng W, Lin GX, Xi XG: Solution structure of a multifunctional DNA- and protein-binding motif of human Werner syndrome protein. Proc Natl Acad Sci U S A 2005; 102: 18379-18384. – reference: 11) Young SG, Meta M, Yang SH, Fong LG: Prelamin A farnesylation and progeroid syndromes. J Biol Chem 2006; 281: 39741-39745. – reference: 15) Ikushima M, Rakugi H, Ishikawa K, Maekawa Y, Yamamoto K, Ohta J, et al.: Anti-apoptotic and anti-senescence effects of Klotho on vascular endothelial cells. Biochem Biophys Res Commun 2006; 339: 827-832. – reference: 13) Katsuya T, Baba S, Ishikawa K, Mannami T, Fu Y, Inamoto N, et al.: Epsilon 4 allele of apolipoprotein E gene associates with lower blood pressure in young Japanese subjects: the Suita Study. J Hypertens 2002; 20: 2017-2021. – reference: 2) Ramirez CL, Cadinanos J, Varela I, Freije JM, Lopez-Otin C: Human progeroid syndromes, aging and cancer: new genetic and epigenetic insights into old questions. Cell Mol Life Sci 2007; 64: 155-170. – reference: 6) Kyng KJ, May A, Stevnsner T, Becker KG, Kolvra S, Bohr VA: Gene expression responses to DNA damage are altered in human aging and in Werner Syndrome. Oncogene 2005; 24: 5026-5042. – reference: 16) Torres PU, Prie D, Molina-Bletry V, Beck L, Silve C, Friedlander G: Klotho: an antiaging protein involved in mineral and vitamin D metabolism. Kidney Int 2007; 71: 730-737. – reference: 1) Martin GM: Genetic syndromes in man with potential relevance to the pathobiology of aging. Birth Defects Orig Artic Ser 1978; 14: 5-39. – reference: 3) Yu CE, Oshima J, Fu YH, Wijsman EM, Hisama F, Alisch R, et al.: Positional cloning of the Werner's syndrome gene. Science 1996; 272: 258-262. – reference: 9) Fukuchi K, Katsuya T, Sugimoto K, Kuremura M, Kim HD, Li L, et al.: LMNA mutation in a 45 year old Japanese subject with Hutchinson-Gilford progeria syndrome. J Med Genet 2004; 41: e67. – reference: 5) Huang S, Lee L, Hanson NB, Lenaerts C, Hoehn H, Poot M, et al.: The spectrum of WRN mutations in Werner syndrome patients. Hum Mutat 2006; 27: 558-567. – reference: 8) Ogihara T, Hata T, Tanaka K, Fukuchi K, Tabuchi Y, Kumahara Y: Hutchinson-Gilford progeria syndrome in a 45-year-old man. Am J Med 1986; 81: 135-138. – reference: 17) Conti B, Sanchez-Alavez M, Winsky-Sommerer R, Morale MC, Lucero J, Brownell S, et al.: Transgenic mice with a reduced core body temperature have an increased life span. Science 2006; 314: 825-828. – reference: 10) Davis T, Wyllie FS, Rokicki MJ, Bagley MC, Kipling D: The role of cellular senescence in Werner syndrome: toward therapeutic intervention in human premature aging. Ann N Y Acad Sci 2007; 1100: 455-469. – reference: 14) Chihara Y, Rakugi H, Ishikawa K, Ikushima M, Maekawa Y, Ohta J, et al.: Klotho protein promotes adipocyte differentiation. Endocrinology 2006; 147: 3835-3842. – reference: 12) Yang SH, Meta M, Qiao X, Frost D, Bauch J, Coffinier C, et al.: A farnesyltransferase inhibitor improves disease phenotypes in mice with a Hutchinson-Gilford progeria syndrome mutation. J Clin Invest 2006; 116: 2115-2121. – reference: 18) Belenky P, Racette FG, Bogan KL, McClure JM, Smith JS, Brenner C: Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+. Cell 2007; 129: 473-484. – reference: 7) Chen L, Lee L, Kudlow BA, Dos Santos HG, Sletvold O, Shafeghati Y, et al.: LMNA mutations in atypical Werner's syndrome. Lancet 2003; 362: 440-445. |
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| SubjectTerms | ヘリケース ラミンA 早老症 生活習慣病 酸化ストレス |
| Title | 1．老化関連遺伝子と抗加齢医学 |
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