潜在性脳虚血病変による認知機能障害（vascular cognitive impairment）： 健常高齢者における検討
健常高齢者の潜在性脳虚血病変によって引き起こされる認知機能障害について概説した．潜在性脳梗塞と慢性腎臓病は遂行機能障害と関連があり，これは血管性認知障害（vascular cognitive impairment）としてとらえることができる．さらに，深部白質病変と短い教育歴がアパシーと相関し，アパシーは余暇の身体活動度と相関があった．低い身体活動度は認知症の危険因子であることが報告されており，我々の検討でも身体活動度低下とアルツハイマー病のバイオマーカーである海馬萎縮，記憶力低下に有意な関連があった．以上の結果から，高血圧など血管危険因子により潜在性脳病変と遂行機能障害を特徴とする血管性認知障...
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| Published in | 脳卒中 Vol. 39; no. 6; pp. 460 - 464 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Japanese |
| Published |
一般社団法人 日本脳卒中学会
2017
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0912-0726 1883-1923 |
| DOI | 10.3995/jstroke.10496 |
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| Abstract | 健常高齢者の潜在性脳虚血病変によって引き起こされる認知機能障害について概説した．潜在性脳梗塞と慢性腎臓病は遂行機能障害と関連があり，これは血管性認知障害（vascular cognitive impairment）としてとらえることができる．さらに，深部白質病変と短い教育歴がアパシーと相関し，アパシーは余暇の身体活動度と相関があった．低い身体活動度は認知症の危険因子であることが報告されており，我々の検討でも身体活動度低下とアルツハイマー病のバイオマーカーである海馬萎縮，記憶力低下に有意な関連があった．以上の結果から，高血圧など血管危険因子により潜在性脳病変と遂行機能障害を特徴とする血管性認知障害が引き起こされ，さらにvascular depression としてのアパシーは身体活動度の低下を介して，アルツハイマー病への過程を促進させる可能性があるのではないかという仮説を提唱した． |
|---|---|
| AbstractList | 健常高齢者の潜在性脳虚血病変によって引き起こされる認知機能障害について概説した．潜在性脳梗塞と慢性腎臓病は遂行機能障害と関連があり，これは血管性認知障害（vascular cognitive impairment）としてとらえることができる．さらに，深部白質病変と短い教育歴がアパシーと相関し，アパシーは余暇の身体活動度と相関があった．低い身体活動度は認知症の危険因子であることが報告されており，我々の検討でも身体活動度低下とアルツハイマー病のバイオマーカーである海馬萎縮，記憶力低下に有意な関連があった．以上の結果から，高血圧など血管危険因子により潜在性脳病変と遂行機能障害を特徴とする血管性認知障害が引き起こされ，さらにvascular depression としてのアパシーは身体活動度の低下を介して，アルツハイマー病への過程を促進させる可能性があるのではないかという仮説を提唱した． |
| Author | 八尾, 博史 |
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Br J Psychiatry 201: 40–45, 2012 27) Erickson KI, Leckie RL, Weinstein AM: Physical activity, fitness, and gray matter volume. Neurobiol Aging 35 Suppl 2: S20–28, 2014 28) Hashimoto M, Araki Y, Takashima Y, et al: Hippocampal atrophy and memory dysfunction associated with physical inactivity in community-dwelling elderly subjects: the Sefuri study. Brain and Behavior (in press 23) Erickson KI, Raji CA, Lopez OL, et al: Physical activity predicts gray matter volume in late adulthood: the Cardiovascular Health Study. Neurology 75: 1415–1422, 2010 1) Hachinski V, Iadecola C, Petersen RC, et al: National Institute of Neurological Disorders and Stroke-Canadian Stroke Network vascular cognitive impairment harmonization standards. Stroke 37: 2220–2241, 2006 2) Gorelick PB, Scuteri A, Black SE, et al: Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association. Stroke 42: 2672–2713, 2011 14) Bruce ML, Seeman TE, Merrill SS, et al: The impact of depressive symptomatology on physical disability: MacArthur Studies of Successful Aging. Am J Public Health 84: 1796–1799, 1994 8) Grool AM, Gerritsen L, Zuithoff NP, et al: Lacunar infarcts in deep white matter are associated with higher and more fluctuating depressive symptoms during three years follow-up. Biol Psychiatry 73: 169–176, 2013 22) Kishimoto H, Ohara T, Hata J, et al: The long-term association between physical activity and risk of dementia in the community: the Hisayama Study. Eur J Epidemiol 31: 267–274, 2016 11) Lavretsky H, Zheng L, Weiner MW, et al: The MRI brain correlates of depressed mood, anhedonia, apathy, and anergia in older adults with and without cognitive impairment or dementia. Int J Geriatr Psychiatry 23: 1040–1050, 2008 20) Yao H, Takashima Y, Araki Y, et al: Leisure-Time Physical Inactivity Associated with Vascular Depression or Apathy in Community-Dwelling Elderly Subjects: The Sefuri Study. J Stroke Cerebrovasc Dis 24: 2625–2631, 2015 9) Barry LC, Murphy TE, Gill TM: Depressive symptoms and functional transitions over time in older persons. Am J Geriatr Psychiatry 19: 783–791, 2011 18) Gons RA, Tuladhar AM, de Laat KF, et al: Physical activity is related to the structural integrity of cerebral white matter. Neurology 81: 971–976, 2013 10) Yao H, Takashima Y, Mori T, et al: Hypertension and white matter lesions are independently associated with apathetic behavior in healthy elderly subjects: the Sefuri brain MRI study. Hypertens Res 32: 586–590, 2009 4) Yao H, Araki Y, Takashima Y, et al: Chronic kidney disease and subclinical brain infarction increase the risk of vascular cognitive impairment: the Sefuri study. J Stroke Cerebrovasc Dis (in press 17) Clarke DE, Ko JY, Lyketsos C, et al: Apathy and cognitive and functional decline in community-dwelling older adults: results from the Baltimore ECA longitudinal study. Int Psychogeriatr 22: 819–829, 2010 3) Yao H, Miwa Y, Takashima Y, et al: Chronic kidney disease and subclinical lacunar infarction are independently associated with frontal lobe dysfunction in community-dwelling elderly subjects: the Sefuri brain MRI study. Hypertens Res 34: 1023–1028, 2011 24) Gow AJ, Bastin ME, Muñoz Maniega S, et al: Neuroprotective lifestyles and the aging brain: activity, atrophy, and white matter integrity. Neurology 79: 1802–1808, 2012 5) Taylor WD, Aizenstein HJ, Alexopoulos GS: The vascular depression hypothesis: mechanisms linking vascular disease with depression. Mol Psychiatry 18: 963–974, 2013 12) Grool AM, Geerlings MI, Sigurdsson S, et al: Structural MRI correlates of apathy symptoms in older persons without dementia: AGES-Reykjavik Study. Neurology 82: 1628–1635, 2014 16) Brookes RL, Herbert V, Lawrence AJ, et al: Depression in small-vessel disease relates to white matter ultrastructural damage, not disability. Neurology 83: 1417–1423, 2014 26) Varma VR, Chuang YF, Harris GC, et al: Low-intensity daily walking activity is associated with hippocampal volume in older adults. Hippocampus 25: 605–615, 2015 21) Yoshitake T, Kiyohara Y, Kato I, et al: Incidence and risk factors of vascular dementia and Alzheimer’s disease in a defined elderly Japanese population: the Hisayama Study. Neurology 45: 1161–1168, 1995 19) Franco MR, Tong A, Howard K, et al: Older people’s perspectives on participation in physical activity: a systematic review and thematic synthesis of qualitative literature. Br J Sport Med 49: 1268–1276, 2015 |
| References_xml | – reference: 24) Gow AJ, Bastin ME, Muñoz Maniega S, et al: Neuroprotective lifestyles and the aging brain: activity, atrophy, and white matter integrity. Neurology 79: 1802–1808, 2012 – reference: 10) Yao H, Takashima Y, Mori T, et al: Hypertension and white matter lesions are independently associated with apathetic behavior in healthy elderly subjects: the Sefuri brain MRI study. Hypertens Res 32: 586–590, 2009 – reference: 23) Erickson KI, Raji CA, Lopez OL, et al: Physical activity predicts gray matter volume in late adulthood: the Cardiovascular Health Study. Neurology 75: 1415–1422, 2010 – reference: 1) Hachinski V, Iadecola C, Petersen RC, et al: National Institute of Neurological Disorders and Stroke-Canadian Stroke Network vascular cognitive impairment harmonization standards. Stroke 37: 2220–2241, 2006 – reference: 15) Hybels CF, Pieper CF, Blazer DG: The complex relationship between depressive symptoms and functional limitations in community-dwelling older adults: the impact of subthreshold depression. Psychol Med 39: 1677–1688, 2009 – reference: 6) Hajjar I, Quach L, Yang F, et al: Hypertension, white matter hyperintensities, and concurrent impairments in mobility, cognition, and mood: the Cardiovascular Health Study. Circulation 123: 858–865, 2011 – reference: 13) Penninx BW, Guralnik JM, Ferrucci L, et al: Depressive symptoms and physical decline in community-dwelling older persons. JAMA 279: 1720–1726, 1998 – reference: 21) Yoshitake T, Kiyohara Y, Kato I, et al: Incidence and risk factors of vascular dementia and Alzheimer’s disease in a defined elderly Japanese population: the Hisayama Study. Neurology 45: 1161–1168, 1995 – reference: 11) Lavretsky H, Zheng L, Weiner MW, et al: The MRI brain correlates of depressed mood, anhedonia, apathy, and anergia in older adults with and without cognitive impairment or dementia. Int J Geriatr Psychiatry 23: 1040–1050, 2008 – reference: 2) Gorelick PB, Scuteri A, Black SE, et al: Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association. Stroke 42: 2672–2713, 2011 – reference: 5) Taylor WD, Aizenstein HJ, Alexopoulos GS: The vascular depression hypothesis: mechanisms linking vascular disease with depression. Mol Psychiatry 18: 963–974, 2013 – reference: 20) Yao H, Takashima Y, Araki Y, et al: Leisure-Time Physical Inactivity Associated with Vascular Depression or Apathy in Community-Dwelling Elderly Subjects: The Sefuri Study. J Stroke Cerebrovasc Dis 24: 2625–2631, 2015 – reference: 26) Varma VR, Chuang YF, Harris GC, et al: Low-intensity daily walking activity is associated with hippocampal volume in older adults. Hippocampus 25: 605–615, 2015 – reference: 28) Hashimoto M, Araki Y, Takashima Y, et al: Hippocampal atrophy and memory dysfunction associated with physical inactivity in community-dwelling elderly subjects: the Sefuri study. Brain and Behavior (in press) – reference: 14) Bruce ML, Seeman TE, Merrill SS, et al: The impact of depressive symptomatology on physical disability: MacArthur Studies of Successful Aging. Am J Public Health 84: 1796–1799, 1994 – reference: 16) Brookes RL, Herbert V, Lawrence AJ, et al: Depression in small-vessel disease relates to white matter ultrastructural damage, not disability. Neurology 83: 1417–1423, 2014 – reference: 25) Erickson KI, Voss MW, Prakash RS, et al: Exercise training increases size of hippocampus and improves memory. Proc Natl Acad Sci USA 108: 3017–3022, 2011 – reference: 7) Firbank MJ, Teodorczuk A, van der Flier WM, et al: Relationship between progression of brain white matter changes and late-life depression: 3-year results from the LADIS study. Br J Psychiatry 201: 40–45, 2012 – reference: 9) Barry LC, Murphy TE, Gill TM: Depressive symptoms and functional transitions over time in older persons. Am J Geriatr Psychiatry 19: 783–791, 2011 – reference: 4) Yao H, Araki Y, Takashima Y, et al: Chronic kidney disease and subclinical brain infarction increase the risk of vascular cognitive impairment: the Sefuri study. J Stroke Cerebrovasc Dis (in press) – reference: 22) Kishimoto H, Ohara T, Hata J, et al: The long-term association between physical activity and risk of dementia in the community: the Hisayama Study. Eur J Epidemiol 31: 267–274, 2016 – reference: 3) Yao H, Miwa Y, Takashima Y, et al: Chronic kidney disease and subclinical lacunar infarction are independently associated with frontal lobe dysfunction in community-dwelling elderly subjects: the Sefuri brain MRI study. Hypertens Res 34: 1023–1028, 2011 – reference: 27) Erickson KI, Leckie RL, Weinstein AM: Physical activity, fitness, and gray matter volume. Neurobiol Aging 35 Suppl 2: S20–28, 2014 – reference: 12) Grool AM, Geerlings MI, Sigurdsson S, et al: Structural MRI correlates of apathy symptoms in older persons without dementia: AGES-Reykjavik Study. Neurology 82: 1628–1635, 2014 – reference: 19) Franco MR, Tong A, Howard K, et al: Older people’s perspectives on participation in physical activity: a systematic review and thematic synthesis of qualitative literature. Br J Sport Med 49: 1268–1276, 2015 – reference: 17) Clarke DE, Ko JY, Lyketsos C, et al: Apathy and cognitive and functional decline in community-dwelling older adults: results from the Baltimore ECA longitudinal study. Int Psychogeriatr 22: 819–829, 2010 – reference: 18) Gons RA, Tuladhar AM, de Laat KF, et al: Physical activity is related to the structural integrity of cerebral white matter. Neurology 81: 971–976, 2013 – reference: 8) Grool AM, Gerritsen L, Zuithoff NP, et al: Lacunar infarcts in deep white matter are associated with higher and more fluctuating depressive symptoms during three years follow-up. Biol Psychiatry 73: 169–176, 2013 |
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| Snippet | 健常高齢者の潜在性脳虚血病変によって引き起こされる認知機能障害について概説した．潜在性脳梗塞と慢性腎臓病は遂行機能障害と関連があり，これは血管性認知障... |
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| SubjectTerms | apathy executive function memory vascular cognitive impairment vascular depression |
| Title | 潜在性脳虚血病変による認知機能障害（vascular cognitive impairment）： 健常高齢者における検討 |
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